ISMARA results: Hnf1a

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hnf1a

Z-value: 5.04

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Transcription factors associated with Hnf1a

Gene Symbol	Gene ID	Gene Info
Hnf1a NCBI RGD Ensembl	ENSRNOG00000001183	HNF1 homeobox A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hnf1a	rn6_v1_chr12_+_47407811_47407811	0.84	1.4e-85	Click!

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_19132208 Show fit	885.57	ENSRNOT00000060535	Afm NCBI RGD Ensembl Show fit	afamin
chr14_+_20266891 Show fit	500.56	ENSRNOT00000004174	Gc NCBI RGD Ensembl Show fit	group specific component
chr1_+_213511874 Show fit	488.37	ENSRNOT00000078080 ENSRNOT00000016883	Cyp2e1 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily e, polypeptide 1
chr20_-_5123073 Show fit	472.26	ENSRNOT00000001126	Apom NCBI RGD Ensembl Show fit	apolipoprotein M
chr2_+_182006242 Show fit	467.11	ENSRNOT00000064091	Fga NCBI RGD Ensembl Show fit	fibrinogen alpha chain
chr6_-_127620296 Show fit	443.67	ENSRNOT00000012577	Serpina1 NCBI RGD Ensembl Show fit	serpin family A member 1
chr10_+_89285855 Show fit	437.75	ENSRNOT00000028033	G6pc NCBI RGD Ensembl Show fit	glucose-6-phosphatase, catalytic subunit
chr3_+_159902441 Show fit	419.40	ENSRNOT00000089893 ENSRNOT00000011978	Hnf4a NCBI RGD Ensembl Show fit	hepatocyte nuclear factor 4, alpha
chr18_-_38185812 Show fit	415.85	ENSRNOT00000017969	Spink1l NCBI RGD Ensembl Show fit	serine peptidase inhibitor, Kazal type 1-like
chr3_-_14229067 Show fit	410.25	ENSRNOT00000025534 ENSRNOT00000092865	C5 NCBI RGD Ensembl Show fit	complement C5

Showing 1 to 10 of 87 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
33.8	1386.1	GO:0051180	vitamin transport(GO:0051180)
84.5	845.0	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
168.9	844.7	GO:0043152	induction of bacterial agglutination(GO:0043152)
169.5	678.1	GO:1902569	regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
178.7	536.0	GO:0010133	proline catabolic process to glutamate(GO:0010133)
97.7	488.4	GO:0016098	monoterpenoid metabolic process(GO:0016098)
37.0	481.2	GO:0052695	cellular glucuronidation(GO:0052695)
157.4	472.3	GO:0034444	regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
2.3	453.9	GO:0007596	blood coagulation(GO:0007596)
29.9	448.9	GO:0015868	purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)

Showing 1 to 10 of 63 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
21.1	2486.2	GO:0072562	blood microparticle(GO:0072562)
1.7	2318.4	GO:0005615	extracellular space(GO:0005615)
9.3	1271.3	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)
105.6	844.7	GO:0005577	fibrinogen complex(GO:0005577)
2.0	794.2	GO:0005667	transcription factor complex(GO:0005667)
0.6	791.6	GO:0005739	mitochondrion(GO:0005739)
0.3	666.9	GO:0005576	extracellular region(GO:0005576)
0.1	634.3	GO:0016021	integral component of membrane(GO:0016021)
1.3	595.8	GO:0005743	mitochondrial inner membrane(GO:0005743)
94.5	472.3	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)

Showing 1 to 10 of 34 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
13.0	1508.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
10.1	885.6	GO:0019842	vitamin binding(GO:0019842)
6.5	870.0	GO:0030674	protein binding, bridging(GO:0030674)
169.0	845.0	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
97.1	679.7	GO:0001849	complement component C1q binding(GO:0001849)
56.5	678.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
3.0	635.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
178.7	536.0	GO:0004657	proline dehydrogenase activity(GO:0004657)
83.4	500.6	GO:0005499	vitamin D binding(GO:0005499)
30.5	488.4	GO:0010181	FMN binding(GO:0010181)

Showing 1 to 10 of 56 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
51.6	2840.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
4.0	916.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
27.2	844.7	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
8.9	443.7	PID HNF3A PATHWAY	FOXA1 transcription factor network
9.3	381.9	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
7.0	355.9	PID IL6 7 PATHWAY	IL6-mediated signaling events
1.1	335.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
2.4	207.4	PID CMYB PATHWAY	C-MYB transcription factor network
6.8	202.6	PID CD40 PATHWAY	CD40/CD40L signaling
3.0	181.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
98.0	1568.5	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
24.3	1095.3	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
33.0	892.1	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
36.5	766.2	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
37.3	745.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
45.8	595.6	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
17.8	588.8	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
162.8	488.4	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
25.3	481.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
5.0	443.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+

Showing 1 to 10 of 28 entries

Results for Hnf1a

Z-value: 5.04

Motif logo

Transcription factors associated with Hnf1a

Activity-expression correlation:

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: