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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hnf1a

Z-value: 5.04

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Transcription factors associated with Hnf1a

Gene Symbol Gene ID Gene Info
Hnf1a
ENSRNOG00000001183 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf1arn6_v1_chr12_+_47407811_474078110.841.4e-85Click!

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_19132208 885.57 ENSRNOT00000060535
Afm
afamin
chr14_+_20266891 500.56 ENSRNOT00000004174
Gc
group specific component
chr1_+_213511874 488.37 ENSRNOT00000078080
ENSRNOT00000016883
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr20_-_5123073 472.26 ENSRNOT00000001126
Apom
apolipoprotein M
chr2_+_182006242 467.11 ENSRNOT00000064091
Fga
fibrinogen alpha chain
chr6_-_127620296 443.67 ENSRNOT00000012577
Serpina1
serpin family A member 1
chr10_+_89285855 437.75 ENSRNOT00000028033
G6pc
glucose-6-phosphatase, catalytic subunit
chr3_+_159902441 419.40 ENSRNOT00000089893
ENSRNOT00000011978
Hnf4a
hepatocyte nuclear factor 4, alpha
chr18_-_38185812 415.85 ENSRNOT00000017969
Spink1l
serine peptidase inhibitor, Kazal type 1-like
chr3_-_14229067 410.25 ENSRNOT00000025534
ENSRNOT00000092865
C5
complement C5
chr10_+_89286047 407.23 ENSRNOT00000085831
G6pc
glucose-6-phosphatase, catalytic subunit
chr1_+_261291870 393.37 ENSRNOT00000049914
Hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr3_-_80543031 390.28 ENSRNOT00000022233
F2
coagulation factor II
chrX_+_71272042 389.02 ENSRNOT00000076034
ENSRNOT00000076816
Gjb1
gap junction protein, beta 1
chr14_-_19191863 386.02 ENSRNOT00000003921
Alb
albumin
chr1_-_48563776 381.91 ENSRNOT00000023368
Plg
plasminogen
chr2_-_182035032 377.55 ENSRNOT00000009813
Fgb
fibrinogen beta chain
chr14_+_87448692 363.25 ENSRNOT00000077177
Igfbp1
insulin-like growth factor binding protein 1
chr6_-_127534247 361.06 ENSRNOT00000012500
Serpina6
serpin family A member 6
chr13_+_91080341 355.95 ENSRNOT00000000058
Crp
C-reactive protein
chr2_+_235264219 344.36 ENSRNOT00000086245
Cfi
complement factor I
chr14_-_80973456 335.31 ENSRNOT00000013257
Hgfac
HGF activator
chr13_+_56598957 333.52 ENSRNOT00000016944
ENSRNOT00000080335
ENSRNOT00000089913
F13b
coagulation factor XIII B chain
chr13_-_91427575 323.72 ENSRNOT00000012092
Apcs
amyloid P component, serum
chr9_+_95295701 300.42 ENSRNOT00000025045
Ugt1a5
UDP glucuronosyltransferase family 1 member A5
chr1_+_277068761 299.72 ENSRNOT00000044183
ENSRNOT00000022382
Habp2
hyaluronan binding protein 2
chr8_-_77398156 292.65 ENSRNOT00000091858
ENSRNOT00000085349
ENSRNOT00000082763
Lipc
lipase C, hepatic type
chr6_-_127508452 288.21 ENSRNOT00000073709
LOC100909524
protein Z-dependent protease inhibitor-like
chr1_+_88955440 273.76 ENSRNOT00000091101
Prodh2
proline dehydrogenase 2
chr1_+_88955135 262.20 ENSRNOT00000083550
Prodh2
proline dehydrogenase 2
chr3_+_159936856 258.71 ENSRNOT00000078703
Hnf4a
hepatocyte nuclear factor 4, alpha
chr20_-_27117663 258.28 ENSRNOT00000000434
Pbld1
phenazine biosynthesis-like protein domain containing 1
chr13_-_50549981 252.95 ENSRNOT00000003918
ENSRNOT00000080486
Golt1a
golgi transport 1A
chr1_+_250426158 252.79 ENSRNOT00000067643
A1cf
APOBEC1 complementation factor
chr13_-_47377703 251.28 ENSRNOT00000005461
C4bpa
complement component 4 binding protein, alpha
chr6_-_26385761 250.30 ENSRNOT00000073228
Gckr
glucokinase regulator
chr15_+_28023018 247.86 ENSRNOT00000090272
Rnase4
ribonuclease A family member 4
chr2_-_100372252 213.96 ENSRNOT00000011890
Hnf4g
hepatocyte nuclear factor 4, gamma
chr1_-_141579871 207.38 ENSRNOT00000020002
Anpep
alanyl aminopeptidase, membrane
chr5_-_79008363 193.35 ENSRNOT00000010040
Kif12
kinesin family member 12
chrX_-_32153794 192.65 ENSRNOT00000005348
Tmem27
transmembrane protein 27
chr4_+_68849033 189.16 ENSRNOT00000016912
Mgam
maltase-glucoamylase
chr1_+_107262659 181.29 ENSRNOT00000022499
Gas2
growth arrest-specific 2
chr14_+_22251499 180.79 ENSRNOT00000087991
ENSRNOT00000002705
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr4_+_175814118 178.51 ENSRNOT00000013409
ENSRNOT00000013514
Slco1b2
solute carrier organic anion transporter family, member 1B2
chr14_-_19159923 177.56 ENSRNOT00000003879
Afp
alpha-fetoprotein
chr17_-_69711689 169.21 ENSRNOT00000041925
Akr1c12
aldo-keto reductase family 1, member C12
chr5_+_33784715 166.86 ENSRNOT00000035685
Slc7a13
solute carrier family 7 member 13
chr3_-_127500709 157.33 ENSRNOT00000006330
Hao1
hydroxyacid oxidase 1
chr2_-_88763733 152.94 ENSRNOT00000059424
LOC688389
similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr1_+_214203861 143.78 ENSRNOT00000023219
Rassf7
Ras association domain family member 7
chr8_-_84320714 138.81 ENSRNOT00000079356
ENSRNOT00000088487
Tinag
tubulointerstitial nephritis antigen
chr19_+_568287 131.24 ENSRNOT00000016419
Cdh16
cadherin 16
chr7_-_68549763 122.19 ENSRNOT00000078014
Slc16a7
solute carrier family 16 member 7
chr14_-_82975263 117.95 ENSRNOT00000024165
Slc5a1
solute carrier family 5 member 1
chr4_-_51199570 109.24 ENSRNOT00000010788
Slc13a1
solute carrier family 13 member 1
chr20_+_41266566 106.88 ENSRNOT00000000653
Frk
fyn-related Src family tyrosine kinase
chr8_+_22856539 105.62 ENSRNOT00000015381
Angptl8
angiopoietin-like 8
chr13_+_42008842 103.82 ENSRNOT00000038811
Gpr39
G protein-coupled receptor 39
chr17_-_10004321 100.08 ENSRNOT00000042394
Fgfr4
fibroblast growth factor receptor 4
chr17_+_69634890 97.96 ENSRNOT00000029049
Akr1c13
aldo-keto reductase family 1, member C13
chr2_-_166682325 97.39 ENSRNOT00000091198
ENSRNOT00000012422
Sptssb
serine palmitoyltransferase, small subunit B
chr11_-_80981415 88.85 ENSRNOT00000002499
ENSRNOT00000002496
St6gal1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr10_-_71491743 88.65 ENSRNOT00000038955
LOC102552988
uncharacterized LOC102552988
chr1_-_266428239 88.23 ENSRNOT00000027160
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
chr2_-_88660449 80.53 ENSRNOT00000051741
Slc7a12
solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr3_+_117421604 76.41 ENSRNOT00000008860
ENSRNOT00000008857
Slc12a1
solute carrier family 12 member 1
chr2_-_158156444 73.77 ENSRNOT00000088559
Veph1
ventricular zone expressed PH domain-containing 1
chr2_-_158156150 72.43 ENSRNOT00000016621
Veph1
ventricular zone expressed PH domain-containing 1
chr20_+_32717564 69.96 ENSRNOT00000030642
Rfx6
regulatory factor X, 6
chr8_+_49713190 68.40 ENSRNOT00000022074
Fxyd2
FXYD domain-containing ion transport regulator 2
chr4_-_82295470 64.30 ENSRNOT00000091073
Hoxa10
homeobox A10
chr4_-_82209933 62.66 ENSRNOT00000091106
LOC100912608
homeobox protein Hox-A10-like
chr3_-_11452529 59.88 ENSRNOT00000020206
Slc25a25
solute carrier family 25 member 25
chr19_-_54761670 59.72 ENSRNOT00000025848
Ca5a
carbonic anhydrase 5A
chr13_-_53870428 51.83 ENSRNOT00000000812
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr5_+_157416897 50.70 ENSRNOT00000023358
Rnf186
ring finger protein 186
chr19_-_39267928 48.78 ENSRNOT00000027686
Tmed6
transmembrane p24 trafficking protein 6
chr2_-_88553086 46.95 ENSRNOT00000042494
LOC361914
similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr2_+_56887987 38.28 ENSRNOT00000041288
Gdnf
glial cell derived neurotrophic factor
chr5_-_158439078 33.30 ENSRNOT00000025517
Klhdc7a
kelch domain containing 7A
chr7_-_98270110 32.71 ENSRNOT00000064847
Anxa13
annexin A13
chr6_+_101603319 25.32 ENSRNOT00000030470
Gphn
gephyrin
chr15_-_52320385 24.94 ENSRNOT00000067776
Dmtn
dematin actin binding protein
chr8_-_127912860 12.05 ENSRNOT00000040498
LOC685081
similar to solute carrier family 22 (organic cation transporter), member 13
chr9_+_119542328 7.57 ENSRNOT00000082005
Lpin2
lipin 2
chr11_+_64882288 6.10 ENSRNOT00000077727
Pla1a
phospholipase A1 member A

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
178.7 536.0 GO:0010133 proline catabolic process to glutamate(GO:0010133)
169.5 678.1 GO:1902569 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
168.9 844.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
157.4 472.3 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
147.9 443.7 GO:0033986 response to methanol(GO:0033986)
130.1 390.3 GO:1905225 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) response to thyrotropin-releasing hormone(GO:1905225)
127.3 381.9 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
127.0 380.9 GO:0010034 response to acetate(GO:0010034)
98.3 393.4 GO:0009436 glyoxylate catabolic process(GO:0009436)
97.7 488.4 GO:0016098 monoterpenoid metabolic process(GO:0016098)
86.1 258.3 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
84.5 845.0 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
83.8 251.3 GO:0045959 negative regulation of complement activation, classical pathway(GO:0045959)
80.9 323.7 GO:1903015 modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422) regulation of exo-alpha-sialidase activity(GO:1903015)
74.9 299.7 GO:1904975 response to bleomycin(GO:1904975)
68.4 410.2 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
64.3 386.0 GO:0070541 killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004) response to platinum ion(GO:0070541)
63.2 252.8 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) cytidine to uridine editing(GO:0016554)
59.3 355.9 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
50.1 250.3 GO:0009732 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) negative regulation of glucokinase activity(GO:0033132) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) negative regulation of hexokinase activity(GO:1903300)
39.3 157.3 GO:0009441 glycolate metabolic process(GO:0009441)
37.0 481.2 GO:0052695 cellular glucuronidation(GO:0052695)
34.6 103.8 GO:0035483 gastric emptying(GO:0035483)
33.8 1386.1 GO:0051180 vitamin transport(GO:0051180)
29.9 448.9 GO:0015868 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
29.6 88.8 GO:1990743 protein sialylation(GO:1990743)
26.0 415.9 GO:1902572 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
25.5 76.4 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
25.0 100.1 GO:0007037 vacuolar phosphate transport(GO:0007037) positive regulation of parathyroid hormone secretion(GO:2000830)
24.4 122.2 GO:1901475 pyruvate transmembrane transport(GO:1901475)
24.3 97.4 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
23.6 117.9 GO:0001951 intestinal D-glucose absorption(GO:0001951)
21.4 192.6 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
17.3 207.4 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
14.4 361.1 GO:0008211 glucocorticoid metabolic process(GO:0008211)
14.0 363.2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
13.2 344.4 GO:0006958 complement activation, classical pathway(GO:0006958)
12.8 140.8 GO:0006857 oligopeptide transport(GO:0006857)
12.7 177.6 GO:0042448 progesterone metabolic process(GO:0042448)
11.5 447.3 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
10.4 51.8 GO:0061113 pancreas morphogenesis(GO:0061113)
9.6 38.3 GO:0072107 regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107)
8.4 25.3 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
7.3 131.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
7.0 105.6 GO:0050746 regulation of lipoprotein metabolic process(GO:0050746)
7.0 70.0 GO:0003310 pancreatic A cell differentiation(GO:0003310)
6.8 109.2 GO:1902358 sulfate transmembrane transport(GO:1902358)
6.2 24.9 GO:0070560 protein secretion by platelet(GO:0070560)
4.3 68.4 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
2.3 453.9 GO:0007596 blood coagulation(GO:0007596)
1.9 64.3 GO:0060065 uterus development(GO:0060065)
1.7 247.9 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
1.6 59.7 GO:0006730 one-carbon metabolic process(GO:0006730)
1.5 106.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.0 214.0 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.9 12.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.8 193.4 GO:0007018 microtubule-based movement(GO:0007018)
0.7 143.8 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.2 7.6 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.2 60.7 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.2 179.5 GO:0055114 oxidation-reduction process(GO:0055114)
0.1 123.9 GO:0016192 vesicle-mediated transport(GO:0016192)
0.0 6.1 GO:0016042 lipid catabolic process(GO:0016042)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
105.6 844.7 GO:0005577 fibrinogen complex(GO:0005577)
95.5 381.9 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
94.5 472.3 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
68.4 410.2 GO:0005579 membrane attack complex(GO:0005579)
50.3 251.3 GO:0043159 acrosomal matrix(GO:0043159)
36.1 252.8 GO:0045293 mRNA editing complex(GO:0045293)
21.1 2486.2 GO:0072562 blood microparticle(GO:0072562)
18.5 389.0 GO:0005922 connexon complex(GO:0005922)
17.2 292.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
16.0 207.4 GO:0031983 vesicle lumen(GO:0031983)
12.2 97.4 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
9.9 88.8 GO:0000138 Golgi trans cisterna(GO:0000138)
9.3 1271.3 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
8.3 24.9 GO:0031095 platelet dense tubular network membrane(GO:0031095)
5.7 68.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
3.1 355.9 GO:0030175 filopodium(GO:0030175)
3.1 422.0 GO:0001669 acrosomal vesicle(GO:0001669)
3.0 335.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
2.8 193.4 GO:0005871 kinesin complex(GO:0005871)
2.0 794.2 GO:0005667 transcription factor complex(GO:0005667)
2.0 170.5 GO:0031526 brush border membrane(GO:0031526)
1.7 2318.4 GO:0005615 extracellular space(GO:0005615)
1.3 595.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
1.1 157.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.0 132.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.6 791.6 GO:0005739 mitochondrion(GO:0005739)
0.4 458.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.4 33.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 666.9 GO:0005576 extracellular region(GO:0005576)
0.2 97.9 GO:0005815 microtubule organizing center(GO:0005815)
0.2 120.8 GO:0005886 plasma membrane(GO:0005886)
0.1 634.3 GO:0016021 integral component of membrane(GO:0016021)
0.1 67.2 GO:0005856 cytoskeleton(GO:0005856)
0.1 7.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
178.7 536.0 GO:0004657 proline dehydrogenase activity(GO:0004657)
169.0 845.0 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
136.7 410.2 GO:0031714 C5a anaphylatoxin chemotactic receptor binding(GO:0031714)
98.3 393.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
97.1 679.7 GO:0001849 complement component C1q binding(GO:0001849)
83.4 500.6 GO:0005499 vitamin D binding(GO:0005499)
56.5 678.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
49.8 298.7 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
48.8 390.3 GO:0070053 thrombospondin receptor activity(GO:0070053)
48.2 192.6 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
47.3 189.2 GO:0016160 amylase activity(GO:0016160)
40.4 363.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
39.3 157.3 GO:0003973 (S)-2-hydroxy-acid oxidase activity(GO:0003973)
35.8 250.3 GO:0070095 fructose-6-phosphate binding(GO:0070095)
30.5 488.4 GO:0010181 FMN binding(GO:0010181)
29.4 381.9 GO:1990405 protein antigen binding(GO:1990405)
27.8 389.0 GO:0005243 gap junction channel activity(GO:0005243)
25.5 76.4 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
24.4 122.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
23.5 140.8 GO:0015198 oligopeptide transporter activity(GO:0015198)
22.7 386.0 GO:0015643 toxic substance binding(GO:0015643)
22.2 88.8 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
20.9 251.3 GO:0001848 complement binding(GO:0001848)
19.5 97.4 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
15.5 481.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
13.0 1508.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
12.5 100.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
10.1 885.6 GO:0019842 vitamin binding(GO:0019842)
9.0 207.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
7.6 405.0 GO:0005044 scavenger receptor activity(GO:0005044)
6.8 109.2 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
6.7 59.9 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
6.5 870.0 GO:0030674 protein binding, bridging(GO:0030674)
6.3 88.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
5.9 447.3 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
5.2 472.3 GO:0016209 antioxidant activity(GO:0016209)
4.9 68.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
4.6 59.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
4.1 32.7 GO:1901611 phosphatidylglycerol binding(GO:1901611)
3.8 265.8 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
3.0 635.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
3.0 252.8 GO:0003725 double-stranded RNA binding(GO:0003725)
2.3 247.9 GO:0004540 ribonuclease activity(GO:0004540)
2.2 193.4 GO:0003777 microtubule motor activity(GO:0003777)
1.9 106.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
1.7 38.3 GO:0048018 receptor agonist activity(GO:0048018)
1.4 236.6 GO:0016853 isomerase activity(GO:0016853)
0.9 12.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.9 24.9 GO:0030507 spectrin binding(GO:0030507)
0.8 181.3 GO:0008017 microtubule binding(GO:0008017)
0.7 105.6 GO:0005179 hormone activity(GO:0005179)
0.3 134.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.3 201.2 GO:0016491 oxidoreductase activity(GO:0016491)
0.2 131.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 7.6 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 50.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
51.6 2840.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
27.2 844.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
9.3 381.9 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
8.9 443.7 PID HNF3A PATHWAY FOXA1 transcription factor network
7.0 355.9 PID IL6 7 PATHWAY IL6-mediated signaling events
6.8 202.6 PID CD40 PATHWAY CD40/CD40L signaling
4.0 916.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
3.0 181.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
2.6 64.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
2.4 207.4 PID CMYB PATHWAY C-MYB transcription factor network
1.9 100.1 PID FGF PATHWAY FGF signaling pathway
1.5 38.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
1.1 335.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.7 138.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
162.8 488.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
98.0 1568.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
45.8 595.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
38.6 386.0 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
37.3 745.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
36.5 766.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
33.0 892.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
25.9 155.5 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
25.3 481.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
24.3 1095.3 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
21.6 389.0 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
17.8 588.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
17.2 292.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
16.5 231.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
8.1 323.7 REACTOME AMYLOIDS Genes involved in Amyloids
7.1 100.1 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
6.7 181.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
5.9 88.8 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
5.0 443.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
4.3 51.8 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
1.7 252.8 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
1.4 68.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
1.3 117.9 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.8 157.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.7 76.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5 7.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.5 25.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 63.2 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)