ISMARA results: Hmga2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hmga2

Z-value: 0.95

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Transcription factors associated with Hmga2

Gene Symbol	Gene ID	Gene Info
Hmga2 NCBI RGD Ensembl	ENSRNOG00000042460	high mobility group AT-hook 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hmga2	rn6_v1_chr7_-_65275408_65275408	-0.21	2.0e-04	Click!

Activity profile of Hmga2 motif

Sorted Z-values of Hmga2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_55219773 Show fit	46.79	ENSRNOT00000041610	RGD1561667 NCBI RGD Ensembl Show fit	similar to putative protein kinase
chr2_+_74360622 Show fit	24.43	ENSRNOT00000014013	Cdh18 NCBI RGD Ensembl Show fit	cadherin 18
chr1_-_148119857 Show fit	21.59	ENSRNOT00000040325	LOC100361547 NCBI RGD Ensembl Show fit	Cytochrome P450, family 2, subfamily c, polypeptide 7-like
chr6_+_113898420 Show fit	20.48	ENSRNOT00000064872	Nrxn3 NCBI RGD Ensembl Show fit	neurexin 3
chr19_+_209926 Show fit	19.98	ENSRNOT00000071393	LOC108348293 NCBI RGD Ensembl Show fit	uncharacterized LOC108348293
chr8_+_41657566 Show fit	19.82	ENSRNOT00000042860	Rup2 NCBI RGD Ensembl Show fit	urinary protein 2
chr4_+_70776046 Show fit	19.30	ENSRNOT00000040403	Prss1 NCBI RGD Ensembl Show fit	protease, serine 1
chr1_-_258766881 Show fit	18.79	ENSRNOT00000015801	Cyp2c12 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily c, polypeptide 12
chr8_-_36760742 Show fit	18.23	ENSRNOT00000017307	Ddx25 NCBI RGD Ensembl Show fit	DEAD-box helicase 25
chr4_-_70628470 Show fit	18.10	ENSRNOT00000029319	Try5 NCBI RGD Ensembl Show fit	trypsin 5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmga2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	69.4	GO:0019373	epoxygenase P450 pathway(GO:0019373)
3.1	62.5	GO:0035404	histone-serine phosphorylation(GO:0035404)
0.4	60.0	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.1	20.5	GO:0090129	positive regulation of synapse maturation(GO:0090129)
0.8	19.3	GO:0030574	collagen catabolic process(GO:0030574)
0.4	18.8	GO:0010501	RNA secondary structure unwinding(GO:0010501)
2.2	17.9	GO:0051835	positive regulation of synapse structural plasticity(GO:0051835)
0.1	16.9	GO:0031638	zymogen activation(GO:0031638)
5.6	16.7	GO:0033693	neurofilament bundle assembly(GO:0033693)
3.3	16.3	GO:0019521	aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)

Showing 1 to 10 of 105 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.5	62.5	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	21.8	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.9	18.2	GO:0033391	chromatoid body(GO:0033391)
0.1	17.9	GO:0043197	dendritic spine(GO:0043197)
0.0	17.4	GO:0036477	somatodendritic compartment(GO:0036477)
5.6	16.7	GO:0033596	TSC1-TSC2 complex(GO:0033596)
1.8	16.3	GO:0071821	FANCM-MHF complex(GO:0071821)
1.0	15.2	GO:0005883	neurofilament(GO:0005883)
1.2	15.1	GO:0042627	chylomicron(GO:0042627)
0.1	14.3	GO:0001669	acrosomal vesicle(GO:0001669)

Showing 1 to 10 of 66 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	62.5	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.1	59.6	GO:0005509	calcium ion binding(GO:0005509)
2.0	59.5	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
0.2	51.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	25.6	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.5	23.8	GO:0005246	calcium channel regulator activity(GO:0005246)
0.8	23.3	GO:0015020	glucuronosyltransferase activity(GO:0015020)
1.6	23.0	GO:0015250	water channel activity(GO:0015250)
0.3	18.2	GO:0003724	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.2	17.9	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)

Showing 1 to 10 of 91 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	65.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	10.1	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.4	9.0	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	6.8	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	6.0	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	5.8	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	3.2	PID BARD1 PATHWAY	BARD1 signaling events
0.1	1.7	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	1.3	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.8	PID MTOR 4PATHWAY	mTOR signaling pathway

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	45.9	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.8	31.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.7	19.3	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.9	16.7	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.2	14.0	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.3	13.3	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.3	12.9	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
1.1	12.7	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.2	10.5	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.9	10.4	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators

Showing 1 to 10 of 41 entries

Results for Hmga2

Z-value: 0.95

Motif logo

Transcription factors associated with Hmga2

Activity-expression correlation:

Activity profile of Hmga2 motif

Sorted Z-values of Hmga2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmga2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: