ISMARA results: Hmga1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hmga1

Z-value: 1.01

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Transcription factors associated with Hmga1

Gene Symbol	Gene ID	Gene Info
Hmga1 NCBI RGD Ensembl	ENSRNOG00000000488	high mobility group AT-hook 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hmga1	rn6_v1_chr20_+_7136007_7136007	0.31	1.1e-08	Click!

Activity profile of Hmga1 motif

Sorted Z-values of Hmga1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_28967980 Show fit	46.75	ENSRNOT00000048175	Adgrl3 NCBI RGD Ensembl Show fit	adhesion G protein-coupled receptor L3
chr15_+_17834635 Show fit	40.66	ENSRNOT00000085530	LOC361016 NCBI RGD Ensembl Show fit	similar to RIKEN cDNA 4933406L09
chr6_+_107603580 Show fit	39.48	ENSRNOT00000036430	Dnal1 NCBI RGD Ensembl Show fit	dynein, axonemal, light chain 1
chr4_-_135069970 Show fit	37.32	ENSRNOT00000008221	Cntn3 NCBI RGD Ensembl Show fit	contactin 3
chr16_-_73827488 Show fit	33.31	ENSRNOT00000064070	Ank1 NCBI RGD Ensembl Show fit	ankyrin 1
chr2_-_231648122 Show fit	30.82	ENSRNOT00000014962	Ank2 NCBI RGD Ensembl Show fit	ankyrin 2
chr11_+_20474483 Show fit	26.98	ENSRNOT00000082417 ENSRNOT00000002895	Ncam2 NCBI RGD Ensembl Show fit	neural cell adhesion molecule 2
chr8_-_53899669 Show fit	26.56	ENSRNOT00000082257	Ncam1 NCBI RGD Ensembl Show fit	neural cell adhesion molecule 1
chr4_-_16654811 Show fit	26.23	ENSRNOT00000008637	Pclo NCBI RGD Ensembl Show fit	piccolo (presynaptic cytomatrix protein)
chrX_-_29648359 Show fit	26.01	ENSRNOT00000086721 ENSRNOT00000006777	Gpm6b NCBI RGD Ensembl Show fit	glycoprotein m6b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmga1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	144.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.3	46.8	GO:0031987	locomotion involved in locomotory behavior(GO:0031987)
1.1	34.2	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779)
0.2	33.8	GO:0071805	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
7.7	30.8	GO:0036309	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.4	27.1	GO:0031103	axon regeneration(GO:0031103)
1.0	27.0	GO:0007413	axonal fasciculation(GO:0007413)
8.9	26.6	GO:0001928	regulation of exocyst assembly(GO:0001928)
4.4	26.2	GO:0016080	synaptic vesicle targeting(GO:0016080) presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
5.2	26.0	GO:0051581	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)

Showing 1 to 10 of 96 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	144.4	GO:0005911	cell-cell junction(GO:0005911)
0.1	115.0	GO:0005887	integral component of plasma membrane(GO:0005887)
1.2	46.2	GO:0043034	costamere(GO:0043034)
0.5	45.6	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.8	37.3	GO:0046658	anchored component of plasma membrane(GO:0046658)
3.3	33.3	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.5	30.8	GO:0031225	anchored component of membrane(GO:0031225)
8.7	26.2	GO:0044317	rod spherule(GO:0044317)
0.1	26.0	GO:0045121	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.5	22.2	GO:0005834	heterotrimeric G-protein complex(GO:0005834)

Showing 1 to 10 of 68 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	130.7	GO:0005509	calcium ion binding(GO:0005509)
0.8	35.3	GO:0030507	spectrin binding(GO:0030507)
6.7	33.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.2	27.9	GO:0017124	SH3 domain binding(GO:0017124)
1.2	26.6	GO:0030275	LRR domain binding(GO:0030275)
1.5	26.2	GO:0005522	profilin binding(GO:0005522)
0.3	24.3	GO:0015179	L-amino acid transmembrane transporter activity(GO:0015179)
3.7	22.1	GO:0051430	corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.8	21.9	GO:0008046	axon guidance receptor activity(GO:0008046)
0.1	21.6	GO:0045296	cadherin binding(GO:0045296)

Showing 1 to 10 of 74 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	26.6	PID FGF PATHWAY	FGF signaling pathway
0.3	22.0	PID CDC42 PATHWAY	CDC42 signaling events
0.6	20.9	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
1.4	20.6	PID S1P S1P4 PATHWAY	S1P4 pathway
0.8	18.9	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.4	18.4	PID ARF6 PATHWAY	Arf6 signaling events
0.3	16.2	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.4	14.7	ST GA13 PATHWAY	G alpha 13 Pathway
0.4	11.9	PID NECTIN PATHWAY	Nectin adhesion pathway
0.4	11.8	PID EPHB FWD PATHWAY	EPHB forward signaling

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	35.7	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.8	34.5	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1
1.0	33.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.5	21.9	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.7	21.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.8	21.0	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
1.4	19.9	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.5	18.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.4	18.4	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	16.0	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases

Showing 1 to 10 of 35 entries

Results for Hmga1

Z-value: 1.01

Motif logo

Transcription factors associated with Hmga1

Activity-expression correlation:

Activity profile of Hmga1 motif

Sorted Z-values of Hmga1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmga1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: