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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Hlf
Z-value: 0.88
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Transcription factors associated with Hlf
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hlf | rn6_v1_chr10_-_77918191_77918191 | -0.00 | 9.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hlf
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 77.1 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 14.1 | 56.3 | GO:0045917 | positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259) |
| 18.2 | 54.5 | GO:0019626 | short-chain fatty acid catabolic process(GO:0019626) |
| 1.0 | 39.3 | GO:0035036 | sperm-egg recognition(GO:0035036) |
| 4.0 | 28.0 | GO:0009804 | coumarin metabolic process(GO:0009804) |
| 2.8 | 25.3 | GO:0060763 | mammary duct terminal end bud growth(GO:0060763) |
| 7.4 | 22.3 | GO:0097037 | heme export(GO:0097037) |
| 0.4 | 22.2 | GO:0009250 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.9 | 22.1 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 1.4 | 19.8 | GO:0030449 | regulation of complement activation(GO:0030449) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 168.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 121.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.9 | 69.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.7 | 60.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 39.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.3 | 35.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.3 | 22.7 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 5.6 | 22.3 | GO:0061474 | phagolysosome membrane(GO:0061474) |
| 0.7 | 20.3 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 6.3 | 19.0 | GO:0046691 | intracellular canaliculus(GO:0046691) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 105.0 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.3 | 59.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 11.3 | 56.3 | GO:0005534 | galactose binding(GO:0005534) |
| 13.6 | 54.5 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 1.8 | 42.1 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.7 | 21.6 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 1.7 | 20.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 2.7 | 19.1 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 1.4 | 19.0 | GO:0015250 | water channel activity(GO:0015250) |
| 2.3 | 16.3 | GO:0045340 | mercury ion binding(GO:0045340) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 70.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 35.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 22.0 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.4 | 18.4 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.8 | 16.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 14.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 10.2 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.5 | 9.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.3 | 6.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 5.6 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 56.3 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.9 | 34.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 22.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 21.2 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 1.4 | 19.8 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.4 | 19.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.6 | 19.0 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.9 | 16.3 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.6 | 14.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 1.3 | 12.0 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |