ISMARA results: Hivep1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hivep1

Z-value: 1.08

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Transcription factors associated with Hivep1

Gene Symbol	Gene ID	Gene Info
Hivep1 NCBI RGD Ensembl	ENSRNOG00000014460	human immunodeficiency virus type I enhancer binding protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hivep1	rn6_v1_chr17_-_22311392_22311392	0.10	8.1e-02	Click!

Activity profile of Hivep1 motif

Sorted Z-values of Hivep1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_163049084 Show fit	77.23	ENSRNOT00000091644	Cd69 NCBI RGD Ensembl Show fit	Cd69 molecule
chr6_+_139405966 Show fit	37.09	ENSRNOT00000088974	AABR07065693.3 NCBI RGD Ensembl Show fit
chr6_+_109562587 Show fit	34.30	ENSRNOT00000011563	Batf NCBI RGD Ensembl Show fit	basic leucine zipper ATF-like transcription factor
chr20_-_4698718 Show fit	34.28	ENSRNOT00000047527	RT1-CE7 NCBI RGD Ensembl Show fit	RT1 class I, locus CE7
chr20_-_4921348 Show fit	32.74	ENSRNOT00000082497 ENSRNOT00000041151	RT1-CE4 NCBI RGD Ensembl Show fit	RT1 class I, locus CE4
chr20_+_2057878 Show fit	31.88	ENSRNOT00000051480	RT1-M6-1 NCBI RGD Ensembl Show fit	RT1 class I, locus M6, gene 1
chr4_+_69384145 Show fit	31.32	ENSRNOT00000084834	Trbv13-2 NCBI RGD Ensembl Show fit	T cell receptor beta, variable 13-2
chr20_-_157665 Show fit	30.16	ENSRNOT00000048858 ENSRNOT00000079494	RT1-CE10 NCBI RGD Ensembl Show fit	RT1 class I, locus CE10
chr10_+_88764732 Show fit	30.05	ENSRNOT00000026662	Stat5a NCBI RGD Ensembl Show fit	signal transducer and activator of transcription 5A
chr14_+_43810119 Show fit	29.19	ENSRNOT00000003327	Rbm47 NCBI RGD Ensembl Show fit	RNA binding motif protein 47

Showing 1 to 10 of 130 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hivep1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	160.3	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
5.5	77.2	GO:0001867	complement activation, lectin pathway(GO:0001867)
6.0	42.0	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
3.1	34.3	GO:0072540	T-helper 17 cell lineage commitment(GO:0072540)
1.4	33.5	GO:0060644	mammary gland epithelial cell differentiation(GO:0060644)
8.1	32.2	GO:0060375	regulation of mast cell differentiation(GO:0060375)
7.3	29.2	GO:0016554	cytidine to uridine editing(GO:0016554)
2.8	28.4	GO:0022614	membrane to membrane docking(GO:0022614)
1.4	26.6	GO:0048535	lymph node development(GO:0048535)
7.9	23.8	GO:0002462	tolerance induction to nonself antigen(GO:0002462)

Showing 1 to 10 of 87 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	149.5	GO:0009897	external side of plasma membrane(GO:0009897)
7.0	111.2	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	102.9	GO:0005654	nucleoplasm(GO:0005654)
5.1	45.5	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
7.1	28.4	GO:0071065	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
1.0	23.3	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.1	23.2	GO:0000790	nuclear chromatin(GO:0000790)
2.6	23.1	GO:0001940	male pronucleus(GO:0001940)
0.3	22.2	GO:0005811	lipid particle(GO:0005811)
2.4	21.7	GO:0016461	unconventional myosin complex(GO:0016461)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	103.0	GO:0042605	peptide antigen binding(GO:0042605)
14.6	72.8	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.2	69.9	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1	41.2	GO:0030246	carbohydrate binding(GO:0030246)
0.1	31.9	GO:0000975	regulatory region DNA binding(GO:0000975)
2.6	28.4	GO:0008131	primary amine oxidase activity(GO:0008131)
0.3	27.5	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
3.0	26.6	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
4.1	24.5	GO:0046979	TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	24.1	GO:0003723	RNA binding(GO:0003723)

Showing 1 to 10 of 65 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	45.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
2.3	41.3	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
1.8	30.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.8	23.3	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
1.7	21.8	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.7	21.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.7	21.2	PID IL12 2PATHWAY	IL12-mediated signaling events
0.7	20.0	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
1.1	19.8	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.6	18.0	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling

Showing 1 to 10 of 24 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	75.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.8	41.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
2.3	39.0	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
1.8	33.2	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
2.0	30.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.9	21.8	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
1.5	20.8	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
1.4	20.5	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1	18.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.4	17.7	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

Showing 1 to 10 of 27 entries

Results for Hivep1

Z-value: 1.08

Motif logo

Transcription factors associated with Hivep1

Activity-expression correlation:

Activity profile of Hivep1 motif

Sorted Z-values of Hivep1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hivep1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: