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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hif1a

Z-value: 0.67

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Transcription factors associated with Hif1a

Gene Symbol Gene ID Gene Info
Hif1a
ENSRNOG00000008292 hypoxia inducible factor 1 alpha subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hif1arn6_v1_chr6_+_96810907_96810907-0.441.2e-16Click!

Activity profile of Hif1a motif

Sorted Z-values of Hif1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_58973020 21.01 ENSRNOT00000020379
Smtnl2
smoothelin-like 2
chr4_-_115157263 18.68 ENSRNOT00000015296
Tet3
tet methylcytosine dioxygenase 3
chr19_+_25120128 16.67 ENSRNOT00000081243
Samd1
sterile alpha motif domain containing 1
chr5_-_24631679 16.45 ENSRNOT00000010846
ENSRNOT00000067129
Esrp1
epithelial splicing regulatory protein 1
chr4_-_10517832 14.42 ENSRNOT00000039953
ENSRNOT00000083964
Gsap
gamma-secretase activating protein
chr1_+_33910912 14.31 ENSRNOT00000044690
Irx1
iroquois homeobox 1
chr1_+_102900286 13.94 ENSRNOT00000017468
Ldha
lactate dehydrogenase A
chr1_-_85220237 13.26 ENSRNOT00000026907
Sycn
syncollin
chr8_-_6203515 12.97 ENSRNOT00000087278
ENSRNOT00000031189
ENSRNOT00000008074
ENSRNOT00000085285
ENSRNOT00000007866
Yap1
yes-associated protein 1
chr5_+_153507093 12.76 ENSRNOT00000086650
ENSRNOT00000083645
Runx3
runt-related transcription factor 3
chr3_+_164822111 12.08 ENSRNOT00000014568
Pard6b
par-6 family cell polarity regulator beta
chr6_+_43829945 11.05 ENSRNOT00000086548
Klf11
Kruppel-like factor 11
chr10_-_29450644 10.26 ENSRNOT00000087937
Adra1b
adrenoceptor alpha 1B
chr3_-_5976244 10.19 ENSRNOT00000009893
Vav2
vav guanine nucleotide exchange factor 2
chr10_+_47961056 10.06 ENSRNOT00000027312
Fam83g
family with sequence similarity 83, member G
chr11_+_7210209 9.69 ENSRNOT00000076695
Gbe1
1,4-alpha-glucan branching enzyme 1
chr1_+_101397828 9.08 ENSRNOT00000028189
Kcna7
potassium voltage-gated channel subfamily A member 7
chr5_-_35831712 8.73 ENSRNOT00000010126
Prdm13
PR/SET domain 13
chr3_-_5975734 8.58 ENSRNOT00000081376
Vav2
vav guanine nucleotide exchange factor 2
chr9_+_19917603 8.25 ENSRNOT00000038239
Tdrd6
tudor domain containing 6
chr8_+_116325286 8.03 ENSRNOT00000017461
Hyal2
hyaluronoglucosaminidase 2
chr10_+_46906115 7.79 ENSRNOT00000034006
Alkbh5
alkB homolog 5, RNA demethylase
chr3_+_119776925 7.52 ENSRNOT00000018549
Dusp2
dual specificity phosphatase 2
chr5_+_169506138 7.40 ENSRNOT00000014904
Rpl22
ribosomal protein L22
chr4_-_132171153 7.34 ENSRNOT00000015058
ENSRNOT00000015075
Prok2
prokineticin 2
chr2_-_84531192 7.10 ENSRNOT00000065312
ENSRNOT00000090540
Ropn1l
rhophilin associated tail protein 1-like
chr4_+_140886545 7.08 ENSRNOT00000088273
Edem1
ER degradation enhancing alpha-mannosidase like protein 1
chr3_+_6430201 6.94 ENSRNOT00000086352
Col5a1
collagen type V alpha 1 chain
chr4_+_120671489 6.91 ENSRNOT00000029125
Mgll
monoglyceride lipase
chr7_+_144547939 6.59 ENSRNOT00000021580
Hoxc12
homeo box C12
chr1_+_260732485 6.48 ENSRNOT00000076842
ENSRNOT00000076073
Lcor
ligand dependent nuclear receptor corepressor
chr10_-_89338739 6.30 ENSRNOT00000073923
Ptges3l
prostaglandin E synthase 3 like
chr5_-_78379346 6.29 ENSRNOT00000020625
Alad
aminolevulinate dehydratase
chr7_-_75422268 6.24 ENSRNOT00000080218
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr1_-_263845762 5.77 ENSRNOT00000017268
Erlin1
ER lipid raft associated 1
chr19_-_55367353 5.76 ENSRNOT00000091139
Piezo1
piezo-type mechanosensitive ion channel component 1
chr3_-_176958880 5.68 ENSRNOT00000078661
Zbtb46
zinc finger and BTB domain containing 46
chr4_-_98593664 5.66 ENSRNOT00000007927
Rpia
ribose 5-phosphate isomerase A
chr14_+_83510278 5.66 ENSRNOT00000081161
Patz1
POZ (BTB) and AT hook containing zinc finger 1
chr15_-_3435888 5.60 ENSRNOT00000016709
Adk
adenosine kinase
chr8_+_114897011 5.56 ENSRNOT00000074683
Twf2
twinfilin actin-binding protein 2
chr6_+_128750795 5.53 ENSRNOT00000005781
Glrx5
glutaredoxin 5
chr3_+_147643250 5.47 ENSRNOT00000000013
Tcf15
transcription factor 15
chr2_-_43393207 5.45 ENSRNOT00000017968
LOC100912399
mitogen-activated protein kinase kinase kinase 1-like
chr2_+_9526209 5.36 ENSRNOT00000021818
Lysmd3
LysM domain containing 3
chr9_-_93404883 5.21 ENSRNOT00000025024
Nmur1
neuromedin U receptor 1
chr10_-_59049482 5.17 ENSRNOT00000078272
Spns2
spinster homolog 2
chr16_-_75855745 5.08 ENSRNOT00000031291
Agpat5
1-acylglycerol-3-phosphate O-acyltransferase 5
chr9_-_16612136 5.04 ENSRNOT00000023495
Mea1
male-enhanced antigen 1
chr14_-_77321977 4.94 ENSRNOT00000084093
Lyar
Ly1 antibody reactive
chr12_-_31323810 4.90 ENSRNOT00000001247
Ran
RAN, member RAS oncogene family
chr14_-_80544342 4.82 ENSRNOT00000012304
Hmx1
H6 family homeobox 1
chr11_+_80255790 4.82 ENSRNOT00000002522
Bcl6
B-cell CLL/lymphoma 6
chr6_+_52122085 4.70 ENSRNOT00000013043
Nampt
nicotinamide phosphoribosyltransferase
chr4_-_82127051 4.61 ENSRNOT00000083658
ENSRNOT00000007807
Hoxa1
homeo box A1
chr19_+_39087990 4.57 ENSRNOT00000027553
Utp4
UTP4 small subunit processome component
chr6_+_134804141 4.56 ENSRNOT00000086143
Ppp2r5c
protein phosphatase 2, regulatory subunit B', gamma
chr13_-_90832469 4.47 ENSRNOT00000086508
Igsf9
immunoglobulin superfamily, member 9
chr14_-_77321783 4.43 ENSRNOT00000007154
Lyar
Ly1 antibody reactive
chr16_+_9563218 4.32 ENSRNOT00000035915
Arhgap22
Rho GTPase activating protein 22
chr3_+_93495106 4.25 ENSRNOT00000029922
ENSRNOT00000085760
Abtb2
ankyrin repeat and BTB domain containing 2
chr9_+_15068399 4.22 ENSRNOT00000064229
ENSRNOT00000087107
Foxp4
forkhead box P4
chr10_-_83898527 3.99 ENSRNOT00000009815
Atp5g1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr2_-_148891900 3.71 ENSRNOT00000018488
Siah2
siah E3 ubiquitin protein ligase 2
chr13_-_90832138 3.69 ENSRNOT00000010930
Igsf9
immunoglobulin superfamily, member 9
chr17_+_36335804 3.67 ENSRNOT00000091334
E2f3
E2F transcription factor 3
chr2_+_205783252 3.54 ENSRNOT00000025633
ENSRNOT00000025600
Trim33
tripartite motif-containing 33
chr10_+_61432819 3.53 ENSRNOT00000003687
ENSRNOT00000092478
Cluh
clustered mitochondria homolog
chr15_+_106257650 3.33 ENSRNOT00000014859
ENSRNOT00000072538
Ipo5
importin 5
chr7_+_126939925 3.32 ENSRNOT00000022746
Gramd4
GRAM domain containing 4
chr19_-_39087880 3.25 ENSRNOT00000070822
Chtf8
chromosome transmission fidelity factor 8
chr11_+_27004320 3.16 ENSRNOT00000002182
N6amt1
N-6 adenine-specific DNA methyltransferase 1 (putative)
chr13_-_79088127 3.11 ENSRNOT00000034583
Prdx6
peroxiredoxin 6
chr4_+_114807765 3.07 ENSRNOT00000084616
LOC103692169
39S ribosomal protein L53, mitochondrial
chr14_+_60657686 3.03 ENSRNOT00000070892
Sepsecs
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr3_+_159305345 2.91 ENSRNOT00000008427
Srsf6
serine and arginine rich splicing factor 6
chr8_+_55279373 2.87 ENSRNOT00000064290
Ppp2r1b
protein phosphatase 2 scaffold subunit A beta
chr20_+_46429222 2.72 ENSRNOT00000076818
Foxo3
forkhead box O3
chr9_+_16612433 2.68 ENSRNOT00000023979
Klhdc3
kelch domain containing 3
chr10_+_59529785 2.43 ENSRNOT00000064840
ENSRNOT00000065181
Atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr10_+_72197977 2.40 ENSRNOT00000003886
Myo19
myosin XIX
chr9_-_16611899 2.39 ENSRNOT00000089168
Mea1
male-enhanced antigen 1
chr1_-_129780356 2.36 ENSRNOT00000077479
Arrdc4
arrestin domain containing 4
chr10_+_4411766 2.32 ENSRNOT00000003213
LOC100911685
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
chr1_-_222178725 2.27 ENSRNOT00000028697
Esrra
estrogen related receptor, alpha
chr7_-_92882068 2.20 ENSRNOT00000037809
Ext1
exostosin glycosyltransferase 1
chr10_-_104054805 2.04 ENSRNOT00000004853
Nt5c
5', 3'-nucleotidase, cytosolic
chr3_+_151032952 2.01 ENSRNOT00000064013
Acss2
acyl-CoA synthetase short-chain family member 2
chr2_-_44504354 2.01 ENSRNOT00000013035
Ddx4
DEAD-box helicase 4
chr17_-_75886523 1.99 ENSRNOT00000046266
Usp6nl
USP6 N-terminal like
chr1_+_127802978 1.91 ENSRNOT00000055877
Adamts17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr1_+_12823363 1.87 ENSRNOT00000086790
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr12_+_24669449 1.86 ENSRNOT00000044449
Wbscr22
Williams Beuren syndrome chromosome region 22
chr9_-_61690956 1.79 ENSRNOT00000066589
Hspd1
heat shock protein family D member 1
chr10_-_35058870 1.79 ENSRNOT00000079481
AABR07029573.3

chr4_-_129846642 1.75 ENSRNOT00000010717
Frmd4b
FERM domain containing 4B
chr3_+_9643047 1.73 ENSRNOT00000035805
Ntmt1
N-terminal Xaa-Pro-Lys N-methyltransferase 1
chr8_+_22291445 1.70 ENSRNOT00000075174
ENSRNOT00000083194
Atg4d
autophagy related 4D, cysteine peptidase
chr8_+_44047592 1.60 ENSRNOT00000085084
Zfp202
zinc finger protein 202
chr17_-_27112820 1.60 ENSRNOT00000018359
Bmp6
bone morphogenetic protein 6
chr20_-_19825150 1.58 ENSRNOT00000032159
Ccdc6
coiled-coil domain containing 6
chr16_-_71125316 1.50 ENSRNOT00000020900
Plpp5
phospholipid phosphatase 5
chr4_-_117234928 1.49 ENSRNOT00000073135
Pradc1
protease-associated domain containing 1
chr3_+_6061940 1.43 ENSRNOT00000011556
Wdr5
WD repeat domain 5
chr12_-_24669464 1.37 ENSRNOT00000043393
Dnajc30
DnaJ heat shock protein family (Hsp40) member C30
chr1_+_163445527 1.33 ENSRNOT00000020520
Lrrc32
leucine rich repeat containing 32
chr1_+_219759183 1.32 ENSRNOT00000026316
Pc
pyruvate carboxylase
chr14_+_61136746 1.22 ENSRNOT00000005126
Dhx15
DEAH-box helicase 15
chr5_-_50362344 1.22 ENSRNOT00000035808
Zfp292
zinc finger protein 292
chr7_-_24668250 1.16 ENSRNOT00000083806
Tmem263
transmembrane protein 263
chr7_-_97759852 1.14 ENSRNOT00000007484
Derl1
derlin 1
chr8_+_76977822 1.11 ENSRNOT00000090268
Sltm
SAFB-like, transcription modulator
chr10_+_39435227 0.87 ENSRNOT00000042144
ENSRNOT00000077185
P4ha2
prolyl 4-hydroxylase subunit alpha 2
chr5_-_136748980 0.70 ENSRNOT00000026844
Ipo13
importin 13
chr7_-_11824742 0.58 ENSRNOT00000051467
Dot1l
DOT1 like histone lysine methyltransferase
chrX_+_33599671 0.54 ENSRNOT00000006843
Txlng
taxilin gamma
chr15_-_43667029 0.52 ENSRNOT00000014798
Bnip3l
BCL2/adenovirus E1B interacting protein 3-like
chr3_+_56125924 0.46 ENSRNOT00000011380
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr10_+_55687050 0.46 ENSRNOT00000057136
Per1
period circadian clock 1
chr7_-_70467453 0.19 ENSRNOT00000052288
Slc26a10
solute carrier family 26, member 10
chr8_-_104221342 0.17 ENSRNOT00000015476
Atp1b3
ATPase Na+/K+ transporting subunit beta 3
chr1_+_165170645 0.15 ENSRNOT00000022879
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr19_-_601469 0.14 ENSRNOT00000016462
Pdp2
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr9_+_16543688 0.12 ENSRNOT00000021868
Cnpy3
canopy FGF signaling regulator 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Hif1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 18.7 GO:0044725 chromatin reprogramming in the zygote(GO:0044725)
3.6 14.3 GO:0072268 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
3.4 10.3 GO:0045819 baroreceptor response to decreased systemic arterial blood pressure(GO:0001982) positive regulation of glycogen catabolic process(GO:0045819)
2.4 7.1 GO:1904380 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) endoplasmic reticulum mannose trimming(GO:1904380)
2.3 13.9 GO:0019659 fermentation(GO:0006113) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
1.9 7.8 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
1.9 5.6 GO:0009153 purine deoxyribonucleotide biosynthetic process(GO:0009153) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216) AMP salvage(GO:0044209) adenosine biosynthetic process(GO:0046086)
1.8 5.5 GO:0009249 protein lipoylation(GO:0009249)
1.7 6.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.7 6.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.6 13.0 GO:0060449 bud elongation involved in lung branching(GO:0060449) metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
1.6 8.0 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
1.5 4.6 GO:0021570 rhombomere 3 development(GO:0021569) rhombomere 4 development(GO:0021570)
1.4 14.4 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
1.4 5.7 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.4 5.7 GO:0006014 D-ribose metabolic process(GO:0006014)
1.2 4.8 GO:0048294 regulation of mast cell cytokine production(GO:0032763) negative regulation of isotype switching to IgE isotypes(GO:0048294)
1.0 6.3 GO:0070541 response to vitamin B1(GO:0010266) response to platinum ion(GO:0070541)
1.0 6.2 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.0 5.8 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
1.0 5.8 GO:0033634 positive regulation of integrin activation(GO:0033625) positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.9 1.8 GO:0002424 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840)
0.7 11.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.7 2.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.7 4.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.7 5.6 GO:0042989 sequestering of actin monomers(GO:0042989)
0.7 2.0 GO:0019541 acetate metabolic process(GO:0006083) propionate metabolic process(GO:0019541)
0.6 4.2 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.6 2.3 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.6 12.8 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.6 1.7 GO:0006480 N-terminal protein amino acid methylation(GO:0006480) peptidyl-glycine modification(GO:0018201)
0.6 1.7 GO:0051697 protein delipidation(GO:0051697)
0.5 16.5 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.5 3.7 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.5 2.0 GO:0009223 pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.5 2.9 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.5 18.8 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.5 3.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.5 5.2 GO:0048069 eye pigmentation(GO:0048069)
0.5 1.9 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.5 2.7 GO:0071386 cellular response to corticosterone stimulus(GO:0071386) response to water-immersion restraint stress(GO:1990785)
0.4 3.0 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.4 5.5 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.4 4.6 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.4 3.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.4 1.6 GO:2000860 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.3 1.3 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.3 4.7 GO:0009435 NAD biosynthetic process(GO:0009435)
0.3 2.0 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.3 7.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.3 7.1 GO:0048240 sperm capacitation(GO:0048240)
0.2 1.4 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.2 0.5 GO:0097167 circadian regulation of translation(GO:0097167)
0.2 3.5 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.2 7.3 GO:0045987 positive regulation of smooth muscle contraction(GO:0045987)
0.2 9.7 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2 3.1 GO:0032060 bleb assembly(GO:0032060)
0.1 0.6 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.1 0.9 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 4.0 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 5.2 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.1 1.3 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 2.0 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 13.3 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)
0.1 6.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 1.1 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 4.3 GO:0097237 cellular response to toxic substance(GO:0097237)
0.1 2.4 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.1 2.3 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.1 4.6 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 10.7 GO:0030509 BMP signaling pathway(GO:0030509)
0.1 11.9 GO:0008213 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.1 8.2 GO:0050807 regulation of synapse organization(GO:0050807)
0.0 0.7 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
0.0 0.1 GO:0009758 carbohydrate utilization(GO:0009758)
0.0 3.7 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 0.2 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.0 21.3 GO:0007283 spermatogenesis(GO:0007283)
0.0 0.5 GO:0042048 olfactory behavior(GO:0042048)
0.0 5.1 GO:0006639 acylglycerol metabolic process(GO:0006639)
0.0 0.7 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0 9.1 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 2.7 GO:0051321 meiotic cell cycle(GO:0051321)
0.0 0.2 GO:0019532 sulfate transport(GO:0008272) oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.0 0.5 GO:0030500 regulation of bone mineralization(GO:0030500)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 13.0 GO:0071148 TEAD-1-YAP complex(GO:0071148) TEAD-2-YAP complex(GO:0071149)
2.1 18.7 GO:0001940 male pronucleus(GO:0001940)
1.7 6.9 GO:0005588 collagen type V trimer(GO:0005588)
1.4 5.6 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.9 4.6 GO:0034455 t-UTP complex(GO:0034455)
0.9 7.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.8 13.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.6 2.3 GO:0018444 translation release factor complex(GO:0018444)
0.5 10.3 GO:0033391 chromatoid body(GO:0033391)
0.4 1.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.4 8.0 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.4 3.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.3 6.9 GO:0043196 varicosity(GO:0043196)
0.3 5.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.3 4.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 1.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.3 6.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 0.9 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.2 8.2 GO:0060077 inhibitory synapse(GO:0060077)
0.2 4.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 13.3 GO:0030667 secretory granule membrane(GO:0030667)
0.1 10.3 GO:0014704 intercalated disc(GO:0014704)
0.1 1.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 1.1 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.1 9.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 12.1 GO:0005923 bicellular tight junction(GO:0005923)
0.1 2.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 7.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 14.4 GO:0005802 trans-Golgi network(GO:0005802)
0.1 4.8 GO:0005657 replication fork(GO:0005657)
0.1 43.3 GO:0016604 nuclear body(GO:0016604)
0.1 2.3 GO:0045171 intercellular bridge(GO:0045171)
0.1 5.6 GO:0030175 filopodium(GO:0030175)
0.1 17.3 GO:0000790 nuclear chromatin(GO:0000790)
0.0 7.1 GO:0031514 motile cilium(GO:0031514)
0.0 2.4 GO:0016459 myosin complex(GO:0016459)
0.0 2.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 10.3 GO:0031965 nuclear membrane(GO:0031965)
0.0 6.1 GO:0005769 early endosome(GO:0005769)
0.0 0.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 5.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 7.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.1 GO:0005840 ribosome(GO:0005840)
0.0 1.8 GO:0001726 ruffle(GO:0001726)
0.0 3.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 3.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 18.7 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
3.5 13.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
3.4 10.3 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
3.2 9.7 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
2.7 8.0 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
2.1 6.3 GO:0004655 porphobilinogen synthase activity(GO:0004655)
1.9 7.8 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
1.2 4.9 GO:0070883 pre-miRNA binding(GO:0070883)
1.2 4.7 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.9 5.2 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.8 2.4 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.6 7.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.6 5.8 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.6 1.7 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.6 5.7 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.5 6.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.5 2.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.5 6.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.5 7.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 1.3 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.4 14.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.4 5.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.4 13.0 GO:0070064 proline-rich region binding(GO:0070064)
0.4 18.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.4 4.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.4 6.2 GO:0008143 poly(A) binding(GO:0008143)
0.4 3.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.4 5.6 GO:0019206 nucleoside kinase activity(GO:0019206)
0.4 1.8 GO:0043559 apolipoprotein A-I binding(GO:0034186) insulin binding(GO:0043559)
0.3 3.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 1.9 GO:0050693 LBD domain binding(GO:0050693)
0.3 8.2 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.2 0.9 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.2 3.5 GO:0070410 co-SMAD binding(GO:0070410)
0.2 4.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 2.3 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 5.6 GO:0003785 actin monomer binding(GO:0003785)
0.2 2.0 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.2 10.7 GO:0042054 histone methyltransferase activity(GO:0042054)
0.1 1.6 GO:0070700 BMP receptor binding(GO:0070700)
0.1 4.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 3.2 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 2.9 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 2.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 5.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 1.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 3.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 20.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 5.5 GO:0009055 electron carrier activity(GO:0009055)
0.1 9.1 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 2.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 4.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 3.0 GO:0000049 tRNA binding(GO:0000049)
0.1 11.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 7.4 GO:0008201 heparin binding(GO:0008201)
0.0 0.2 GO:0016415 octanoyltransferase activity(GO:0016415)
0.0 0.5 GO:0005521 lamin binding(GO:0005521)
0.0 6.5 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 23.4 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 6.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 4.0 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 4.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 2.7 GO:0003682 chromatin binding(GO:0003682)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 18.8 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.4 4.9 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.3 13.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 4.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 12.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 4.8 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.2 16.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 10.3 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.2 6.9 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 6.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 5.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 1.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 3.3 PID P73PATHWAY p73 transcription factor network
0.0 10.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 7.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.6 8.0 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.6 13.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.5 7.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.5 6.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4 6.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.4 12.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.4 5.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 6.7 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.3 6.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.3 4.9 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.3 10.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.3 2.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 4.0 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 2.0 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 3.7 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 9.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.2 2.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.2 6.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 10.7 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 2.9 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 2.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 2.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 4.2 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 1.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 5.7 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 2.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 4.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 5.2 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression