ISMARA results: Hic2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hic2

Z-value: 1.60

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Transcription factors associated with Hic2

Gene Symbol	Gene ID	Gene Info
Hic2 NCBI RGD Ensembl	ENSRNOG00000051458	HIC ZBTB transcriptional repressor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hic2	rn6_v1_chr11_-_88016825_88016825	0.06	2.5e-01	Click!

Activity profile of Hic2 motif

Sorted Z-values of Hic2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_+_80517536 Show fit	101.07	ENSRNOT00000004386	Myoc NCBI RGD Ensembl Show fit	myocilin
chr5_+_1417478 Show fit	66.21	ENSRNOT00000008153 ENSRNOT00000085564	Jph1 NCBI RGD Ensembl Show fit	junctophilin 1
chr8_+_49441106 Show fit	65.85	ENSRNOT00000030152	Scn4b NCBI RGD Ensembl Show fit	sodium voltage-gated channel beta subunit 4
chr17_+_47397558 Show fit	62.77	ENSRNOT00000085923	Epdr1 NCBI RGD Ensembl Show fit	ependymin related 1
chr4_+_7076759 Show fit	62.35	ENSRNOT00000066598	Smarcd3 NCBI RGD Ensembl Show fit	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr3_-_159775643 Show fit	56.73	ENSRNOT00000010939	Jph2 NCBI RGD Ensembl Show fit	junctophilin 2
chr7_+_94375020 Show fit	51.61	ENSRNOT00000011904	Nov NCBI RGD Ensembl Show fit	nephroblastoma overexpressed
chr10_+_92289107 Show fit	48.34	ENSRNOT00000050070	Mapt NCBI RGD Ensembl Show fit	microtubule-associated protein tau
chr1_+_80321585 Show fit	48.23	ENSRNOT00000022895	Ckm NCBI RGD Ensembl Show fit	creatine kinase, M-type
chr10_+_92288910 Show fit	47.69	ENSRNOT00000006947 ENSRNOT00000045127	Mapt NCBI RGD Ensembl Show fit	microtubule-associated protein tau

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hic2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
12.1	109.1	GO:1900454	positive regulation of long term synaptic depression(GO:1900454)
25.4	101.7	GO:0038128	ERBB2 signaling pathway(GO:0038128)
2.0	90.1	GO:0003009	skeletal muscle contraction(GO:0003009)
8.2	82.5	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
3.7	65.9	GO:0086016	AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
3.4	64.7	GO:0031581	hemidesmosome assembly(GO:0031581)
15.6	62.4	GO:0003219	cardiac right ventricle formation(GO:0003219)
0.4	59.5	GO:0007519	skeletal muscle tissue development(GO:0007519)
8.1	56.7	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0	56.2	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Showing 1 to 10 of 368 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	105.6	GO:0005743	mitochondrial inner membrane(GO:0005743)
33.7	101.1	GO:1990015	mesaxon(GO:0097453) ensheathing process(GO:1990015)
24.0	96.0	GO:0045298	tubulin complex(GO:0045298)
4.5	89.6	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.2	80.0	GO:0031012	extracellular matrix(GO:0031012)
0.4	73.9	GO:0005802	trans-Golgi network(GO:0005802)
2.6	71.6	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
5.9	71.1	GO:0005859	muscle myosin complex(GO:0005859)
2.0	69.3	GO:0016528	sarcoplasm(GO:0016528)
3.3	68.4	GO:0030056	hemidesmosome(GO:0030056)

Showing 1 to 10 of 148 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	174.1	GO:0005509	calcium ion binding(GO:0005509)
4.3	161.5	GO:0008307	structural constituent of muscle(GO:0008307)
21.3	127.9	GO:0032027	myosin light chain binding(GO:0032027)
6.6	106.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
24.0	96.0	GO:0099609	microtubule lateral binding(GO:0099609)
11.7	81.7	GO:0004111	creatine kinase activity(GO:0004111)
2.9	73.1	GO:0005520	insulin-like growth factor binding(GO:0005520)
8.2	65.9	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2	64.9	GO:0030695	GTPase regulator activity(GO:0030695)
2.7	62.4	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)

Showing 1 to 10 of 254 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	243.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
7.4	96.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
1.6	76.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
2.5	64.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
1.0	63.9	PID LKB1 PATHWAY	LKB1 signaling events
0.7	61.8	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.9	38.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.8	38.7	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.6	37.9	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.9	33.0	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Showing 1 to 10 of 52 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.6	133.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
2.5	99.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
2.5	69.4	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.2	53.1	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.3	49.4	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.9	46.5	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
2.4	43.4	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
1.2	40.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
1.9	38.7	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
2.5	37.6	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex

Showing 1 to 10 of 85 entries

Results for Hic2

Z-value: 1.60

Motif logo

Transcription factors associated with Hic2

Activity-expression correlation:

Activity profile of Hic2 motif

Sorted Z-values of Hic2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hic2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: