ISMARA results: Hic1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hic1

Z-value: 2.20

Motif logo

Transcription factors associated with Hic1

Gene Symbol	Gene ID	Gene Info
Hic1 NCBI RGD Ensembl	ENSRNOG00000046405	HIC ZBTB transcriptional repressor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hic1	rn6_v1_chr10_-_62009582_62009582	0.05	3.4e-01	Click!

Activity profile of Hic1 motif

Sorted Z-values of Hic1 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_86297623 Show fit	100.97	ENSRNOT00000067162 ENSRNOT00000081607 ENSRNOT00000085265	Camk2b NCBI RGD Ensembl Show fit	calcium/calmodulin-dependent protein kinase II beta
chr3_+_6773813 Show fit	86.93	ENSRNOT00000065953 ENSRNOT00000013443	Olfm1 NCBI RGD Ensembl Show fit	olfactomedin 1
chr15_+_344360 Show fit	85.55	ENSRNOT00000077671	Kcnma1 NCBI RGD Ensembl Show fit	potassium calcium-activated channel subfamily M alpha 1
chr4_+_99618622 Show fit	73.88	ENSRNOT00000064772	Reep1 NCBI RGD Ensembl Show fit	receptor accessory protein 1
chr3_-_1924827 Show fit	73.11	ENSRNOT00000006162	Cacna1b NCBI RGD Ensembl Show fit	calcium voltage-gated channel subunit alpha1 B
chr7_-_113937941 Show fit	71.36	ENSRNOT00000012408	Kcnk9 NCBI RGD Ensembl Show fit	potassium two pore domain channel subfamily K member 9
chr15_+_344685 Show fit	68.97	ENSRNOT00000065542 ENSRNOT00000066928	Kcnma1 NCBI RGD Ensembl Show fit	potassium calcium-activated channel subfamily M alpha 1
chr6_-_105097054 Show fit	65.79	ENSRNOT00000048606	Slc8a3 NCBI RGD Ensembl Show fit	solute carrier family 8 member A3
chr1_+_226435979 Show fit	60.79	ENSRNOT00000048704 ENSRNOT00000036232 ENSRNOT00000035576 ENSRNOT00000036180 ENSRNOT00000036168 ENSRNOT00000047964 ENSRNOT00000036283 ENSRNOT00000007429	Syt7 NCBI RGD Ensembl Show fit	synaptotagmin 7
chr2_-_24923128 Show fit	59.57	ENSRNOT00000044087	Pde8b NCBI RGD Ensembl Show fit	phosphodiesterase 8B
chr2_-_229718659 Show fit	56.01	ENSRNOT00000012676	Ugt8 NCBI RGD Ensembl Show fit	UDP glycosyltransferase 8
chr7_-_121029754 Show fit	54.73	ENSRNOT00000004703	Nptxr NCBI RGD Ensembl Show fit	neuronal pentraxin receptor
chr4_+_9347528 Show fit	52.87	ENSRNOT00000010521	Reln NCBI RGD Ensembl Show fit	reelin
chr4_+_58053041 Show fit	52.84	ENSRNOT00000072698	Mest NCBI RGD Ensembl Show fit	mesoderm specific transcript
chr5_-_62621737 Show fit	50.79	ENSRNOT00000011573	Gabbr2 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type B receptor subunit 2
chr4_-_16130563 Show fit	50.64	ENSRNOT00000090240 ENSRNOT00000034969	Cacna2d1 NCBI RGD Ensembl Show fit	calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr6_+_57516713 Show fit	50.62	ENSRNOT00000063874	Dgkb NCBI RGD Ensembl Show fit	diacylglycerol kinase, beta
chr8_+_118333706 Show fit	50.47	ENSRNOT00000028278	Cspg5 NCBI RGD Ensembl Show fit	chondroitin sulfate proteoglycan 5
chr6_-_132958546 Show fit	50.07	ENSRNOT00000041903	Begain NCBI RGD Ensembl Show fit	brain-enriched guanylate kinase-associated
chr7_-_116607408 Show fit	48.60	ENSRNOT00000076009 ENSRNOT00000056554	Ly6h NCBI RGD Ensembl Show fit	lymphocyte antigen 6 complex, locus H
chr1_+_173607101 Show fit	46.76	ENSRNOT00000074636	Tub NCBI RGD Ensembl Show fit	tubby bipartite transcription factor
chr5_+_64326733 Show fit	46.66	ENSRNOT00000065775	Tmeff1 NCBI RGD Ensembl Show fit	transmembrane protein with EGF-like and two follistatin-like domains 1
chr14_-_78902063 Show fit	45.99	ENSRNOT00000088469	Ppp2r2c NCBI RGD Ensembl Show fit	protein phosphatase 2, regulatory subunit B, gamma
chr1_+_1702696 Show fit	45.72	ENSRNOT00000019181	Lrp11 NCBI RGD Ensembl Show fit	LDL receptor related protein 11
chr14_+_25589762 Show fit	44.91	ENSRNOT00000043938 ENSRNOT00000067439 ENSRNOT00000002793	Epha5 NCBI RGD Ensembl Show fit	EPH receptor A5
chr9_-_85626094 Show fit	44.74	ENSRNOT00000020919	Serpine2 NCBI RGD Ensembl Show fit	serpin family E member 2
chr14_+_60764409 Show fit	43.51	ENSRNOT00000005168	Lgi2 NCBI RGD Ensembl Show fit	leucine-rich repeat LGI family, member 2
chr5_+_156876706 Show fit	42.96	ENSRNOT00000021864	Camk2n1 NCBI RGD Ensembl Show fit	calcium/calmodulin-dependent protein kinase II inhibitor 1
chr7_+_128500011 Show fit	42.85	ENSRNOT00000074625	Fam19a5 NCBI RGD Ensembl Show fit	family with sequence similarity 19 member A5, C-C motif chemokine like
chr4_-_16130848 Show fit	42.30	ENSRNOT00000042914	Cacna2d1 NCBI RGD Ensembl Show fit	calcium voltage-gated channel auxiliary subunit alpha2delta 1
chrX_-_106558366 Show fit	41.78	ENSRNOT00000042126	Bex2 NCBI RGD Ensembl Show fit	brain expressed X-linked 2
chr4_-_145147397 Show fit	41.75	ENSRNOT00000010347	Lhfpl4 NCBI RGD Ensembl Show fit	lipoma HMGIC fusion partner-like 4
chr1_-_220467159 Show fit	41.71	ENSRNOT00000075365	Tmem151a NCBI RGD Ensembl Show fit	transmembrane protein 151A
chr5_-_166133274 Show fit	41.61	ENSRNOT00000078830	Kif1b NCBI RGD Ensembl Show fit	kinesin family member 1B
chr8_-_117382715 Show fit	41.14	ENSRNOT00000027466	P4htm NCBI RGD Ensembl Show fit	prolyl 4-hydroxylase, transmembrane
chr12_+_28381982 Show fit	40.94	ENSRNOT00000076101	Wbscr17 NCBI RGD Ensembl Show fit	Williams-Beuren syndrome chromosome region 17
chr16_+_49266903 Show fit	40.91	ENSRNOT00000014704	Slc25a4 NCBI RGD Ensembl Show fit	solute carrier family 25 member 4
chr10_+_90342051 Show fit	40.73	ENSRNOT00000028487	Rundc3a NCBI RGD Ensembl Show fit	RUN domain containing 3A
chr3_+_2262253 Show fit	40.68	ENSRNOT00000042100 ENSRNOT00000061303 ENSRNOT00000048137 ENSRNOT00000048353 ENSRNOT00000012129	Nsmf NCBI RGD Ensembl Show fit	NMDA receptor synaptonuclear signaling and neuronal migration factor
chr7_+_11556192 Show fit	40.61	ENSRNOT00000046078	Diras1 NCBI RGD Ensembl Show fit	DIRAS family GTPase 1
chr5_-_17061361 Show fit	40.51	ENSRNOT00000089318	Penk NCBI RGD Ensembl Show fit	proenkephalin
chr1_-_31122093 Show fit	40.49	ENSRNOT00000016712	NEWGENE_1307525 NCBI RGD Ensembl Show fit	SOGA family member 3
chr3_+_145032200 Show fit	40.44	ENSRNOT00000068210	Syndig1 NCBI RGD Ensembl Show fit	synapse differentiation inducing 1
chr1_-_261669584 Show fit	40.31	ENSRNOT00000020568 ENSRNOT00000076555	Crtac1 NCBI RGD Ensembl Show fit	cartilage acidic protein 1
chr5_-_166133491 Show fit	39.99	ENSRNOT00000087739 ENSRNOT00000089099	Kif1b NCBI RGD Ensembl Show fit	kinesin family member 1B
chr10_-_76813386 Show fit	39.93	ENSRNOT00000032388	Nog NCBI RGD Ensembl Show fit	noggin
chr8_-_94564525 Show fit	39.75	ENSRNOT00000084437	Snap91 NCBI RGD Ensembl Show fit	synaptosomal-associated protein 91
chr19_-_9777465 Show fit	39.38	ENSRNOT00000017413	Ndrg4 NCBI RGD Ensembl Show fit	NDRG family member 4
chr19_+_58823814 Show fit	39.23	ENSRNOT00000027058 ENSRNOT00000088626	Kcnk1 NCBI RGD Ensembl Show fit	potassium two pore domain channel subfamily K member 1
chr14_-_80732010 Show fit	39.06	ENSRNOT00000012322	Adra2c NCBI RGD Ensembl Show fit	adrenoceptor alpha 2C
chr20_+_13044104 Show fit	38.72	ENSRNOT00000066017	Dip2a NCBI RGD Ensembl Show fit	disco-interacting protein 2 homolog A
chr2_+_34186091 Show fit	38.70	ENSRNOT00000016129	Sgtb NCBI RGD Ensembl Show fit	small glutamine rich tetratricopeptide repeat containing beta
chr10_-_63952726 Show fit	38.64	ENSRNOT00000090461	Doc2b NCBI RGD Ensembl Show fit	double C2 domain beta
chr3_-_10602672 Show fit	38.20	ENSRNOT00000011648	Ncs1 NCBI RGD Ensembl Show fit	neuronal calcium sensor 1
chr3_-_8924032 Show fit	37.72	ENSRNOT00000023527 ENSRNOT00000085042	Sh3glb2 NCBI RGD Ensembl Show fit	SH3 domain-containing GRB2-like endophilin B2
chr7_-_136853957 Show fit	37.68	ENSRNOT00000008985	Nell2 NCBI RGD Ensembl Show fit	neural EGFL like 2
chr3_+_142739781 Show fit	37.59	ENSRNOT00000006181	Sstr4 NCBI RGD Ensembl Show fit	somatostatin receptor 4
chr1_-_112947162 Show fit	37.39	ENSRNOT00000014573 ENSRNOT00000083894	Gabra5 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor alpha 5 subunit
chr16_-_64806050 Show fit	36.69	ENSRNOT00000015725	Dusp26 NCBI RGD Ensembl Show fit	dual specificity phosphatase 26
chr7_-_76488216 Show fit	36.66	ENSRNOT00000080024	Ncald NCBI RGD Ensembl Show fit	neurocalcin delta
chr17_-_18592750 Show fit	36.52	ENSRNOT00000065742	Cap2 NCBI RGD Ensembl Show fit	CAP, adenylate cyclase-associated protein, 2 (yeast)
chr16_-_55002322 Show fit	36.12	ENSRNOT00000036092	Zdhhc2 NCBI RGD Ensembl Show fit	zinc finger, DHHC-type containing 2
chr11_+_30550141 Show fit	36.08	ENSRNOT00000002866	Hunk NCBI RGD Ensembl Show fit	hormonally upregulated Neu-associated kinase
chr4_+_147037179 Show fit	35.85	ENSRNOT00000011292	Syn2 NCBI RGD Ensembl Show fit	synapsin II
chr1_-_200696928 Show fit	35.79	ENSRNOT00000068183 ENSRNOT00000022253 ENSRNOT00000065448 ENSRNOT00000022331	Fgfr2 NCBI RGD Ensembl Show fit	fibroblast growth factor receptor 2
chr1_-_64405149 Show fit	35.68	ENSRNOT00000089944	Cacng7 NCBI RGD Ensembl Show fit	calcium voltage-gated channel auxiliary subunit gamma 7
chr10_-_110585376 Show fit	35.68	ENSRNOT00000054917	Rab40b NCBI RGD Ensembl Show fit	Rab40b, member RAS oncogene family
chr2_-_172459165 Show fit	35.62	ENSRNOT00000057473	Schip1 NCBI RGD Ensembl Show fit	schwannomin interacting protein 1
chr2_-_5579894 Show fit	35.53	ENSRNOT00000020044	Nr2f1 NCBI RGD Ensembl Show fit	nuclear receptor subfamily 2, group F, member 1
chr9_+_70133969 Show fit	35.43	ENSRNOT00000040525	Adam23 NCBI RGD Ensembl Show fit	ADAM metallopeptidase domain 23
chr8_-_94563760 Show fit	34.94	ENSRNOT00000032792	Snap91 NCBI RGD Ensembl Show fit	synaptosomal-associated protein 91
chr5_+_166533181 Show fit	34.78	ENSRNOT00000045063	Clstn1 NCBI RGD Ensembl Show fit	calsyntenin 1
chr9_+_82674202 Show fit	34.44	ENSRNOT00000027208	Tmem198 NCBI RGD Ensembl Show fit	transmembrane protein 198
chr10_-_68517564 Show fit	34.30	ENSRNOT00000086961	Asic2 NCBI RGD Ensembl Show fit	acid sensing ion channel subunit 2
chr3_+_111597102 Show fit	33.85	ENSRNOT00000081462	Tyro3 NCBI RGD Ensembl Show fit	TYRO3 protein tyrosine kinase
chr17_+_13670520 Show fit	33.66	ENSRNOT00000019442	Shc3 NCBI RGD Ensembl Show fit	SHC adaptor protein 3
chr15_-_42638392 Show fit	33.55	ENSRNOT00000022020	Scara3 NCBI RGD Ensembl Show fit	scavenger receptor class A, member 3
chr3_-_2803574 Show fit	33.17	ENSRNOT00000040995	RGD1560470 NCBI RGD Ensembl Show fit	similar to Gene model 996
chr10_+_11392625 Show fit	32.97	ENSRNOT00000072802	Adcy9 NCBI RGD Ensembl Show fit	adenylate cyclase 9
chr8_+_65611570 Show fit	32.97	ENSRNOT00000017147	Larp6 NCBI RGD Ensembl Show fit	La ribonucleoprotein domain family, member 6
chr5_-_58019836 Show fit	32.81	ENSRNOT00000066977	Enho NCBI RGD Ensembl Show fit	energy homeostasis associated
chr17_+_41798783 Show fit	32.44	ENSRNOT00000023519	Nrsn1 NCBI RGD Ensembl Show fit	neurensin 1
chr1_+_25173242 Show fit	32.13	ENSRNOT00000016518	Clvs2 NCBI RGD Ensembl Show fit	clavesin 2
chr8_-_83421612 Show fit	32.01	ENSRNOT00000015824	Hcrtr2 NCBI RGD Ensembl Show fit	hypocretin receptor 2
chr5_-_142857131 Show fit	31.98	ENSRNOT00000038055	Maneal NCBI RGD Ensembl Show fit	mannosidase, endo-alpha-like
chr17_+_15924048 Show fit	31.90	ENSRNOT00000050696	Wnk2 NCBI RGD Ensembl Show fit	WNK lysine deficient protein kinase 2
chr14_+_60857989 Show fit	31.79	ENSRNOT00000034411	Ccdc149 NCBI RGD Ensembl Show fit	coiled-coil domain containing 149
chr5_+_169519212 Show fit	31.72	ENSRNOT00000024732	Chd5 NCBI RGD Ensembl Show fit	chromodomain helicase DNA binding protein 5
chr12_+_17416327 Show fit	31.58	ENSRNOT00000089590 ENSRNOT00000092186	Adap1 NCBI RGD Ensembl Show fit	ArfGAP with dual PH domains 1
chr1_+_266953139 Show fit	31.33	ENSRNOT00000054696	Neurl1 NCBI RGD Ensembl Show fit	neuralized E3 ubiquitin protein ligase 1
chr8_+_56179816 Show fit	31.15	ENSRNOT00000059078	Arhgap20 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 20
chr9_+_82647071 Show fit	30.87	ENSRNOT00000027135	Asic4 NCBI RGD Ensembl Show fit	acid sensing ion channel subunit family member 4
chr7_-_136853154 Show fit	30.87	ENSRNOT00000087376	Nell2 NCBI RGD Ensembl Show fit	neural EGFL like 2
chr5_+_139783951 Show fit	30.83	ENSRNOT00000081333	Rims3 NCBI RGD Ensembl Show fit	regulating synaptic membrane exocytosis 3
chr1_-_89560719 Show fit	30.69	ENSRNOT00000028653	Scn1b NCBI RGD Ensembl Show fit	sodium voltage-gated channel beta subunit 1
chr14_-_82287706 Show fit	30.41	ENSRNOT00000080695	Fgfr3 NCBI RGD Ensembl Show fit	fibroblast growth factor receptor 3
chr1_-_261575557 Show fit	30.10	ENSRNOT00000076068	Crtac1 NCBI RGD Ensembl Show fit	cartilage acidic protein 1
chr14_+_87312203 Show fit	30.06	ENSRNOT00000088032	Adcy1 NCBI RGD Ensembl Show fit	adenylate cyclase 1
chr10_+_70627401 Show fit	30.04	ENSRNOT00000076897	Rasl10b NCBI RGD Ensembl Show fit	RAS-like, family 10, member B
chr15_+_37806836 Show fit	30.03	ENSRNOT00000076285	Il17d NCBI RGD Ensembl Show fit	interleukin 17D
chr16_-_6405117 Show fit	29.91	ENSRNOT00000047737	Cacna1d NCBI RGD Ensembl Show fit	calcium voltage-gated channel subunit alpha1 D
chr4_-_146016325 Show fit	29.85	ENSRNOT00000067931	Atp2b2 NCBI RGD Ensembl Show fit	ATPase plasma membrane Ca2+ transporting 2
chr4_+_22445414 Show fit	29.72	ENSRNOT00000087657 ENSRNOT00000030224	Rundc3b NCBI RGD Ensembl Show fit	RUN domain containing 3B
chr6_-_94980004 Show fit	29.62	ENSRNOT00000006373	Rtn1 NCBI RGD Ensembl Show fit	reticulon 1
chr1_-_15301998 Show fit	29.62	ENSRNOT00000016400	Slc35d3 NCBI RGD Ensembl Show fit	solute carrier family 35, member D3
chr6_+_126018841 Show fit	29.60	ENSRNOT00000089840 ENSRNOT00000088089	Slc24a4 NCBI RGD Ensembl Show fit	solute carrier family 24 member 4
chr4_+_66405166 Show fit	29.46	ENSRNOT00000077486 ENSRNOT00000067097	Clec2l NCBI RGD Ensembl Show fit	C-type lectin domain family 2, member L
chr3_-_165477771 Show fit	29.46	ENSRNOT00000071672	Atp9a NCBI RGD Ensembl Show fit	ATPase phospholipid transporting 9A (putative)
chr5_-_165083487 Show fit	29.45	ENSRNOT00000036647	Disp3 NCBI RGD Ensembl Show fit	dispatched RND transporter family member 3
chr8_+_56179637 Show fit	29.34	ENSRNOT00000035989	Arhgap20 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 20
chr19_-_58399816 Show fit	29.30	ENSRNOT00000026843	Sipa1l2 NCBI RGD Ensembl Show fit	signal-induced proliferation-associated 1 like 2
chr12_-_24710019 Show fit	29.22	ENSRNOT00000049601	Stx1a NCBI RGD Ensembl Show fit	syntaxin 1A
chr13_-_73819896 Show fit	28.92	ENSRNOT00000036392	Fam163a NCBI RGD Ensembl Show fit	family with sequence similarity 163, member A
chr9_-_45505767 Show fit	28.80	ENSRNOT00000033964	Lonrf2 NCBI RGD Ensembl Show fit	LON peptidase N-terminal domain and ring finger 2
chr1_+_113034227 Show fit	28.75	ENSRNOT00000081831 ENSRNOT00000077877 ENSRNOT00000077594	Gabrb3 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor beta 3 subunit
chr3_-_147143576 Show fit	28.66	ENSRNOT00000091811 ENSRNOT00000012727	Snph NCBI RGD Ensembl Show fit	syntaphilin
chr3_-_11885311 Show fit	28.66	ENSRNOT00000021189 ENSRNOT00000021178	Stxbp1 NCBI RGD Ensembl Show fit	syntaxin binding protein 1
chr3_-_104502471 Show fit	28.57	ENSRNOT00000040306	Ryr3 NCBI RGD Ensembl Show fit	ryanodine receptor 3
chr8_+_119566509 Show fit	28.45	ENSRNOT00000028633	Trank1 NCBI RGD Ensembl Show fit	tetratricopeptide repeat and ankyrin repeat containing 1
chr8_+_83070545 Show fit	28.35	ENSRNOT00000014926	Hmgcll1 NCBI RGD Ensembl Show fit	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
chrX_+_20351486 Show fit	28.29	ENSRNOT00000093675 ENSRNOT00000047444	Wnk3 NCBI RGD Ensembl Show fit	WNK lysine deficient protein kinase 3
chr19_-_11669578 Show fit	28.21	ENSRNOT00000026373	Gnao1 NCBI RGD Ensembl Show fit	G protein subunit alpha o1
chr1_-_212622537 Show fit	27.98	ENSRNOT00000025609	Sprn NCBI RGD Ensembl Show fit	shadow of prion protein homolog (zebrafish)
chr2_-_186245342 Show fit	27.95	ENSRNOT00000057062 ENSRNOT00000022292	Dclk2 NCBI RGD Ensembl Show fit	doublecortin-like kinase 2
chr12_+_22026075 Show fit	27.84	ENSRNOT00000029041	LOC100910838 NCBI RGD Ensembl Show fit	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1-like
chr8_+_79606789 Show fit	27.74	ENSRNOT00000087114	Pygo1 NCBI RGD Ensembl Show fit	pygopus family PHD finger 1
chr5_-_172769421 Show fit	27.66	ENSRNOT00000021285	Prkcz NCBI RGD Ensembl Show fit	protein kinase C, zeta
chr1_-_146556171 Show fit	27.66	ENSRNOT00000017636	Arnt2 NCBI RGD Ensembl Show fit	aryl hydrocarbon receptor nuclear translocator 2
chr3_-_92290919 Show fit	27.57	ENSRNOT00000007077	Fjx1 NCBI RGD Ensembl Show fit	four jointed box 1
chr17_-_10208360 Show fit	27.46	ENSRNOT00000087397	Unc5a NCBI RGD Ensembl Show fit	unc-5 netrin receptor A
chr8_+_128972311 Show fit	27.46	ENSRNOT00000025460	Myrip NCBI RGD Ensembl Show fit	myosin VIIA and Rab interacting protein
chr3_+_124896618 Show fit	27.30	ENSRNOT00000028888	Cds2 NCBI RGD Ensembl Show fit	CDP-diacylglycerol synthase 2
chr9_+_82120059 Show fit	27.26	ENSRNOT00000057368	Cdk5r2 NCBI RGD Ensembl Show fit	cyclin-dependent kinase 5 regulatory subunit 2
chr1_-_270472866 Show fit	27.20	ENSRNOT00000015979	Sorcs1 NCBI RGD Ensembl Show fit	sortilin-related VPS10 domain containing receptor 1
chrX_+_106823491 Show fit	27.05	ENSRNOT00000045997	Bex3 NCBI RGD Ensembl Show fit	brain expressed X-linked 3
chr1_+_263186235 Show fit	26.98	ENSRNOT00000021876	Cnnm1 NCBI RGD Ensembl Show fit	cyclin and CBS domain divalent metal cation transport mediator 1
chr3_+_79713567 Show fit	26.94	ENSRNOT00000012110	C1qtnf4 NCBI RGD Ensembl Show fit	C1q and tumor necrosis factor related protein 4
chr16_-_20439206 Show fit	26.89	ENSRNOT00000026391	Rab3a NCBI RGD Ensembl Show fit	RAB3A, member RAS oncogene family
chr4_+_9347779 Show fit	26.87	ENSRNOT00000061858	Reln NCBI RGD Ensembl Show fit	reelin
chrX_-_10772633 Show fit	26.73	ENSRNOT00000035153	Ube2q2l NCBI RGD Ensembl Show fit	ubiquitin-conjugating enzyme E2Q family member 2-like
chr9_-_94601852 Show fit	26.59	ENSRNOT00000022485	Ngef NCBI RGD Ensembl Show fit	neuronal guanine nucleotide exchange factor
chr12_+_943006 Show fit	26.48	ENSRNOT00000001449	Kl NCBI RGD Ensembl Show fit	Klotho
chr7_-_135630654 Show fit	26.44	ENSRNOT00000047388 ENSRNOT00000088223 ENSRNOT00000074793	Adamts20 NCBI RGD Ensembl Show fit	ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr1_-_84491466 Show fit	26.28	ENSRNOT00000034609	Map3k10 NCBI RGD Ensembl Show fit	mitogen activated protein kinase kinase kinase 10
chr19_+_52086325 Show fit	26.17	ENSRNOT00000020341	Necab2 NCBI RGD Ensembl Show fit	N-terminal EF-hand calcium binding protein 2
chr7_-_116607674 Show fit	26.12	ENSRNOT00000076014	Ly6h NCBI RGD Ensembl Show fit	lymphocyte antigen 6 complex, locus H
chr8_+_408001 Show fit	26.11	ENSRNOT00000046058	Gucy1a2 NCBI RGD Ensembl Show fit	guanylate cyclase 1 soluble subunit alpha 2
chr1_-_112947399 Show fit	26.08	ENSRNOT00000093306 ENSRNOT00000093259	Gabra5 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor alpha 5 subunit
chr3_+_22640545 Show fit	26.05	ENSRNOT00000064507 ENSRNOT00000014452	Lhx2 NCBI RGD Ensembl Show fit	LIM homeobox 2
chr3_+_161433410 Show fit	25.96	ENSRNOT00000024657	Slc12a5 NCBI RGD Ensembl Show fit	solute carrier family 12 member 5
chr15_-_62200837 Show fit	25.93	ENSRNOT00000017599	Pcdh8 NCBI RGD Ensembl Show fit	protocadherin 8
chr12_-_12025549 Show fit	25.73	ENSRNOT00000001331	Nptx2 NCBI RGD Ensembl Show fit	neuronal pentraxin 2
chr13_+_69797880 Show fit	25.71	ENSRNOT00000030109	Colgalt2 NCBI RGD Ensembl Show fit	collagen beta(1-O)galactosyltransferase 2
chr9_+_17841410 Show fit	25.62	ENSRNOT00000031706	Tmem151b NCBI RGD Ensembl Show fit	transmembrane protein 151B
chr19_-_57192095 Show fit	25.52	ENSRNOT00000058080	Pgbd5 NCBI RGD Ensembl Show fit	piggyBac transposable element derived 5
chr13_+_110920830 Show fit	25.39	ENSRNOT00000077014 ENSRNOT00000076362	Kcnh1 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily H member 1
chr8_+_6811543 Show fit	25.36	ENSRNOT00000008905 ENSRNOT00000042553	Trpc6 NCBI RGD Ensembl Show fit	transient receptor potential cation channel, subfamily C, member 6
chr1_-_91462603 Show fit	25.22	ENSRNOT00000015384	Lrp3 NCBI RGD Ensembl Show fit	LDL receptor related protein 3
chr7_+_11737293 Show fit	25.10	ENSRNOT00000046059	Lingo3 NCBI RGD Ensembl Show fit	leucine rich repeat and Ig domain containing 3
chr10_+_39655455 Show fit	25.07	ENSRNOT00000058817	Acsl6 NCBI RGD Ensembl Show fit	acyl-CoA synthetase long-chain family member 6
chr1_-_42587666 Show fit	24.96	ENSRNOT00000083225 ENSRNOT00000025355	Rgs17 NCBI RGD Ensembl Show fit	regulator of G-protein signaling 17
chr10_-_108691367 Show fit	24.94	ENSRNOT00000005067	Nptx1 NCBI RGD Ensembl Show fit	neuronal pentraxin 1
chr1_+_224882439 Show fit	24.91	ENSRNOT00000024785	Chrm1 NCBI RGD Ensembl Show fit	cholinergic receptor, muscarinic 1
chr18_-_18079560 Show fit	24.86	ENSRNOT00000072093	AABR07031533.1 NCBI RGD Ensembl Show fit
chr15_+_19547871 Show fit	24.71	ENSRNOT00000036235	Gpr137c NCBI RGD Ensembl Show fit	G protein-coupled receptor 137C
chr2_-_179704629 Show fit	24.61	ENSRNOT00000083361 ENSRNOT00000077941	Gria2 NCBI RGD Ensembl Show fit	glutamate ionotropic receptor AMPA type subunit 2
chr6_-_122897997 Show fit	24.52	ENSRNOT00000057601	Eml5 NCBI RGD Ensembl Show fit	echinoderm microtubule associated protein like 5
chr5_-_39215102 Show fit	24.34	ENSRNOT00000050653	Klhl32 NCBI RGD Ensembl Show fit	kelch-like family member 32
chr8_+_28352772 Show fit	24.09	ENSRNOT00000012391	Igsf9b NCBI RGD Ensembl Show fit	immunoglobulin superfamily, member 9B
chr10_-_14937336 Show fit	24.04	ENSRNOT00000025494	Sox8 NCBI RGD Ensembl Show fit	SRY box 8
chr15_-_43542939 Show fit	23.93	ENSRNOT00000012996	Dpysl2 NCBI RGD Ensembl Show fit	dihydropyrimidinase-like 2
chr2_-_26699333 Show fit	23.91	ENSRNOT00000024459	Sv2c NCBI RGD Ensembl Show fit	synaptic vesicle glycoprotein 2c
chr13_-_111765944 Show fit	23.87	ENSRNOT00000073041	Syt14 NCBI RGD Ensembl Show fit	synaptotagmin 14
chr1_-_241875864 Show fit	23.86	ENSRNOT00000091282	Fam189a2 NCBI RGD Ensembl Show fit	family with sequence similarity 189, member A2
chr6_-_65319527 Show fit	23.82	ENSRNOT00000005618	Stxbp6 NCBI RGD Ensembl Show fit	syntaxin binding protein 6
chr18_-_63357194 Show fit	23.64	ENSRNOT00000089408 ENSRNOT00000066103	Spire1 NCBI RGD Ensembl Show fit	spire-type actin nucleation factor 1
chr17_+_18059382 Show fit	23.59	ENSRNOT00000031656	Nhlrc1 NCBI RGD Ensembl Show fit	NHL repeat containing E3 ubiquitin protein ligase 1
chr3_-_124724252 Show fit	23.48	ENSRNOT00000028885	Slc23a2 NCBI RGD Ensembl Show fit	solute carrier family 23 member 2
chr8_+_111600532 Show fit	23.45	ENSRNOT00000081952	Rab6b NCBI RGD Ensembl Show fit	RAB6B, member RAS oncogene family
chr13_+_101181994 Show fit	23.39	ENSRNOT00000052407	Susd4 NCBI RGD Ensembl Show fit	sushi domain containing 4
chr2_-_186245163 Show fit	23.38	ENSRNOT00000089339	Dclk2 NCBI RGD Ensembl Show fit	doublecortin-like kinase 2
chr10_-_14788617 Show fit	23.27	ENSRNOT00000043626	Cacna1h NCBI RGD Ensembl Show fit	calcium voltage-gated channel subunit alpha1 H
chr1_-_102106127 Show fit	23.24	ENSRNOT00000028685	Kcnj11 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily J member 11
chr14_+_77380262 Show fit	23.24	ENSRNOT00000008030	Nsg1 NCBI RGD Ensembl Show fit	neuron specific gene family member 1
chr5_-_58078545 Show fit	23.17	ENSRNOT00000075777	Cntfr NCBI RGD Ensembl Show fit	ciliary neurotrophic factor receptor
chr1_+_162817611 Show fit	23.04	ENSRNOT00000091952	Pak1 NCBI RGD Ensembl Show fit	p21 (RAC1) activated kinase 1
chrX_+_76083549 Show fit	23.01	ENSRNOT00000003573	Magee1 NCBI RGD Ensembl Show fit	MAGE family member E1
chr6_+_133576568 Show fit	22.98	ENSRNOT00000085933	Dlk1 NCBI RGD Ensembl Show fit	delta like non-canonical Notch ligand 1
chr1_-_112811936 Show fit	22.92	ENSRNOT00000093339	Gabrg3 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor gamma 3 subunit
chr4_+_146106386 Show fit	22.87	ENSRNOT00000008342	Slc6a11 NCBI RGD Ensembl Show fit	solute carrier family 6 member 11
chr20_-_8574082 Show fit	22.66	ENSRNOT00000048845	Mdga1 NCBI RGD Ensembl Show fit	MAM domain containing glycosylphosphatidylinositol anchor 1
chr19_+_37305248 Show fit	22.61	ENSRNOT00000068299	Slc9a5 NCBI RGD Ensembl Show fit	solute carrier family 9 member A5
chrX_+_40363646 Show fit	22.55	ENSRNOT00000010135	Sms NCBI RGD Ensembl Show fit	spermine synthase
chr18_-_37819097 Show fit	22.38	ENSRNOT00000025880	Dpysl3 NCBI RGD Ensembl Show fit	dihydropyrimidinase-like 3
chr7_-_126465723 Show fit	22.24	ENSRNOT00000021196	Wnt7b NCBI RGD Ensembl Show fit	wingless-type MMTV integration site family, member 7B
chr5_+_148193710 Show fit	22.22	ENSRNOT00000088568	Adgrb2 NCBI RGD Ensembl Show fit	adhesion G protein-coupled receptor B2
chr14_-_78308933 Show fit	22.19	ENSRNOT00000065334	Crmp1 NCBI RGD Ensembl Show fit	collapsin response mediator protein 1
chr14_+_78640620 Show fit	22.19	ENSRNOT00000034730	Wfs1 NCBI RGD Ensembl Show fit	wolframin ER transmembrane glycoprotein
chr8_-_103190243 Show fit	21.91	ENSRNOT00000075305	Chst2 NCBI RGD Ensembl Show fit	carbohydrate sulfotransferase 2
chr14_+_60123169 Show fit	21.76	ENSRNOT00000006610	Sel1l3 NCBI RGD Ensembl Show fit	SEL1L family member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Hic1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
51.5	154.5	GO:0060082	eye blink reflex(GO:0060082)
33.7	101.0	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
20.3	60.8	GO:1990926	short-term synaptic potentiation(GO:1990926)
18.7	56.0	GO:0006682	galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
16.9	101.2	GO:0023041	neuronal signal transduction(GO:0023041)
16.3	81.6	GO:0019521	aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
16.2	145.5	GO:0021769	orbitofrontal cortex development(GO:0021769)
15.5	92.9	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
14.9	59.6	GO:0035106	operant conditioning(GO:0035106)
13.5	40.5	GO:0051867	general adaptation syndrome, behavioral process(GO:0051867)
13.3	39.9	GO:1905006	regulation of cytokine activity(GO:0060300) fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905006) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
12.2	36.7	GO:1902310	positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
12.2	73.0	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
12.0	48.0	GO:0021586	pons maturation(GO:0021586)
11.2	44.7	GO:0061107	seminal vesicle development(GO:0061107)
10.8	43.3	GO:0035624	receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
10.7	74.7	GO:0016185	synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
10.6	21.3	GO:1904057	negative regulation of sensory perception of pain(GO:1904057)
10.4	20.8	GO:0051582	positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
10.2	40.9	GO:2000277	positive regulation of oxidative phosphorylation uncoupler activity(GO:2000277)
10.1	50.4	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
10.0	30.0	GO:0003050	regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
9.4	28.3	GO:2000688	positive regulation of rubidium ion transport(GO:2000682) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688)
8.9	17.9	GO:1901204	regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
8.9	70.8	GO:1990034	calcium ion export from cell(GO:1990034)
8.4	25.1	GO:0010747	positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
8.3	24.9	GO:0035544	negative regulation of SNARE complex assembly(GO:0035544)
7.9	23.6	GO:0070649	formin-nucleated actin cable assembly(GO:0070649)
7.8	15.7	GO:0032349	positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
7.8	23.5	GO:0070904	L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
7.8	23.4	GO:1902748	positive regulation of lens fiber cell differentiation(GO:1902748)
7.8	23.4	GO:0045959	negative regulation of complement activation, classical pathway(GO:0045959)
7.5	15.1	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
7.4	22.2	GO:0072054	renal outer medulla development(GO:0072054)
7.4	22.2	GO:0036500	ATF6-mediated unfolded protein response(GO:0036500)
7.3	44.0	GO:0097500	receptor localization to nonmotile primary cilium(GO:0097500)
7.2	21.6	GO:0090027	negative regulation of monocyte chemotaxis(GO:0090027)
7.1	28.3	GO:0046951	ketone body biosynthetic process(GO:0046951)
7.1	21.2	GO:0061744	motor behavior(GO:0061744)
7.0	111.3	GO:0070050	neuron cellular homeostasis(GO:0070050)
6.9	41.4	GO:0051964	negative regulation of synapse assembly(GO:0051964)
6.8	20.3	GO:0046078	dUMP metabolic process(GO:0046078)
6.7	40.4	GO:0097091	synaptic vesicle clustering(GO:0097091)
6.7	26.9	GO:0050975	sensory perception of touch(GO:0050975)
6.4	19.1	GO:0042489	negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
6.3	37.6	GO:0038170	somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
6.2	12.5	GO:0032286	central nervous system myelin maintenance(GO:0032286)
6.2	80.6	GO:1900121	negative regulation of receptor binding(GO:1900121)
6.1	104.4	GO:0032793	positive regulation of CREB transcription factor activity(GO:0032793)
6.0	24.0	GO:0072034	renal vesicle induction(GO:0072034)
6.0	29.9	GO:1901660	calcium ion export(GO:1901660)
5.9	23.8	GO:0070086	ubiquitin-dependent endocytosis(GO:0070086)
5.9	5.9	GO:1902162	regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162)
5.8	17.4	GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
5.8	23.0	GO:0061534	gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
5.6	11.3	GO:0060160	negative regulation of dopamine receptor signaling pathway(GO:0060160)
5.6	33.8	GO:0033278	cell proliferation in midbrain(GO:0033278)
5.6	39.2	GO:0060075	regulation of resting membrane potential(GO:0060075)
5.6	33.5	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
5.6	11.1	GO:1902256	apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
5.5	22.2	GO:1904616	regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
5.5	27.7	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
5.5	21.9	GO:0014053	negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
5.4	10.9	GO:0043397	corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
5.2	20.7	GO:0014826	vein smooth muscle contraction(GO:0014826)
5.1	40.7	GO:0031284	positive regulation of guanylate cyclase activity(GO:0031284)
5.0	24.9	GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
4.9	34.3	GO:0050915	sensory perception of sour taste(GO:0050915)
4.7	28.5	GO:1903286	regulation of potassium ion import(GO:1903286)
4.6	27.5	GO:0033564	anterior/posterior axon guidance(GO:0033564)
4.6	32.0	GO:0010840	regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746)
4.6	13.7	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
4.4	17.6	GO:0036394	amylase secretion(GO:0036394)
4.4	17.6	GO:1904428	negative regulation of tubulin deacetylation(GO:1904428)
4.4	39.4	GO:2001135	regulation of endocytic recycling(GO:2001135)
4.4	4.4	GO:1902460	regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
4.3	26.0	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
4.3	77.5	GO:0001956	positive regulation of neurotransmitter secretion(GO:0001956) positive regulation of neurotransmitter transport(GO:0051590)
4.3	21.5	GO:0097112	gamma-aminobutyric acid receptor clustering(GO:0097112)
4.3	12.8	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
4.2	12.7	GO:0061002	negative regulation of dendritic spine morphogenesis(GO:0061002)
4.2	12.7	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
4.1	20.7	GO:0055118	negative regulation of cardiac muscle contraction(GO:0055118)
4.1	73.9	GO:0071786	endoplasmic reticulum tubular network organization(GO:0071786)
4.1	20.5	GO:0042940	D-amino acid transport(GO:0042940)
4.1	172.0	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
4.0	23.8	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
4.0	102.8	GO:0098926	postsynaptic signal transduction(GO:0098926)
3.9	15.8	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
3.9	54.9	GO:0035865	cellular response to potassium ion(GO:0035865)
3.9	7.8	GO:0075509	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
3.9	38.8	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
3.9	38.6	GO:0006655	phosphatidylglycerol biosynthetic process(GO:0006655)
3.9	15.4	GO:0042339	keratan sulfate metabolic process(GO:0042339)
3.8	22.9	GO:0021853	cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
3.8	3.8	GO:0008355	olfactory learning(GO:0008355)
3.8	11.3	GO:0061441	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587) metanephric part of ureteric bud development(GO:0035502) renal artery morphogenesis(GO:0061441) kidney smooth muscle tissue development(GO:0072194)
3.8	18.8	GO:0060024	rhythmic synaptic transmission(GO:0060024)
3.7	18.5	GO:0046959	habituation(GO:0046959)
3.7	11.0	GO:0014916	regulation of lung blood pressure(GO:0014916) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137)
3.6	10.9	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
3.6	25.4	GO:0000160	phosphorelay signal transduction system(GO:0000160)
3.6	10.9	GO:0006713	glucocorticoid catabolic process(GO:0006713)
3.5	7.1	GO:0031394	positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
3.5	38.6	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
3.5	17.4	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
3.5	13.9	GO:0090154	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
3.4	17.0	GO:0001777	T cell homeostatic proliferation(GO:0001777)
3.4	10.2	GO:2000474	regulation of opioid receptor signaling pathway(GO:2000474)
3.4	13.5	GO:0097117	guanylate kinase-associated protein clustering(GO:0097117)
3.3	10.0	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
3.3	9.9	GO:0032898	neurotrophin production(GO:0032898) nerve growth factor production(GO:0032902)
3.3	46.3	GO:0007256	activation of JNKK activity(GO:0007256)
3.3	45.7	GO:0097151	positive regulation of inhibitory postsynaptic potential(GO:0097151)
3.3	13.0	GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
3.2	9.7	GO:1990401	regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling(GO:0060683) embryonic lung development(GO:1990401)
3.2	9.7	GO:2000630	positive regulation of miRNA metabolic process(GO:2000630)
3.2	44.9	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
3.2	44.5	GO:0070262	peptidyl-serine dephosphorylation(GO:0070262)
3.2	6.4	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
3.1	18.3	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)
3.0	21.1	GO:0097623	potassium ion export across plasma membrane(GO:0097623)
3.0	8.9	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)
3.0	8.9	GO:0071691	cardiac muscle thin filament assembly(GO:0071691)
2.9	14.7	GO:0039689	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
2.9	5.8	GO:1903233	regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233)
2.8	8.5	GO:0071847	TNFSF11-mediated signaling pathway(GO:0071847) negative regulation of osteoclast development(GO:2001205)
2.8	50.8	GO:0021860	pyramidal neuron development(GO:0021860)
2.8	8.5	GO:0090370	negative regulation of cholesterol efflux(GO:0090370)
2.8	19.3	GO:0003139	secondary heart field specification(GO:0003139)
2.8	27.6	GO:0007614	short-term memory(GO:0007614)
2.7	21.6	GO:0006498	N-terminal protein lipidation(GO:0006498)
2.6	18.5	GO:0021960	anterior commissure morphogenesis(GO:0021960)
2.6	15.8	GO:2000172	regulation of branching morphogenesis of a nerve(GO:2000172)
2.6	7.9	GO:0032417	positive regulation of sodium:proton antiporter activity(GO:0032417)
2.6	44.5	GO:0021978	telencephalon regionalization(GO:0021978)
2.6	26.1	GO:0030828	positive regulation of cGMP biosynthetic process(GO:0030828)
2.6	12.9	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
2.6	30.9	GO:0005513	detection of calcium ion(GO:0005513)
2.5	10.2	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
2.5	12.7	GO:0035799	ureter maturation(GO:0035799)
2.5	15.1	GO:0097461	ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
2.5	10.0	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
2.5	5.0	GO:0051957	positive regulation of amino acid transport(GO:0051957)
2.5	12.5	GO:1904684	negative regulation of metalloendopeptidase activity(GO:1904684)
2.5	22.1	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
2.4	24.3	GO:0015886	heme transport(GO:0015886)
2.4	21.7	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
2.4	7.2	GO:0046950	cellular ketone body metabolic process(GO:0046950)
2.4	14.3	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
2.4	14.2	GO:0006528	asparagine metabolic process(GO:0006528)
2.4	7.1	GO:0001661	conditioned taste aversion(GO:0001661)
2.4	7.1	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
2.3	96.1	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
2.3	2.3	GO:0072237	metanephric proximal tubule development(GO:0072237)
2.3	31.9	GO:2000651	positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
2.2	6.7	GO:0035927	RNA import into mitochondrion(GO:0035927)
2.2	6.5	GO:1904350	regulation of protein catabolic process in the vacuole(GO:1904350)
2.1	15.0	GO:0010825	positive regulation of centrosome duplication(GO:0010825) negative regulation of bicellular tight junction assembly(GO:1903347)
2.1	10.7	GO:0002035	brain renin-angiotensin system(GO:0002035)
2.1	23.2	GO:0071316	cellular response to nicotine(GO:0071316)
2.1	58.7	GO:0006182	cGMP biosynthetic process(GO:0006182)
2.1	35.3	GO:0006044	N-acetylglucosamine metabolic process(GO:0006044)
2.1	22.9	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
2.1	66.3	GO:1901798	positive regulation of signal transduction by p53 class mediator(GO:1901798)
2.1	26.8	GO:1904259	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
2.0	26.6	GO:0006596	polyamine biosynthetic process(GO:0006596)
2.0	10.2	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
2.0	12.2	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
2.0	26.4	GO:0032486	Rap protein signal transduction(GO:0032486)
2.0	9.9	GO:2000586	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586)
2.0	5.9	GO:0006433	prolyl-tRNA aminoacylation(GO:0006433) threonyl-tRNA aminoacylation(GO:0006435)
1.9	9.6	GO:0035095	behavioral response to nicotine(GO:0035095)
1.9	3.8	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
1.9	7.6	GO:0036151	phosphatidylcholine acyl-chain remodeling(GO:0036151)
1.9	22.5	GO:0097369	sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
1.8	7.4	GO:0038180	nerve growth factor signaling pathway(GO:0038180)
1.8	55.0	GO:0018345	protein palmitoylation(GO:0018345)
1.8	5.5	GO:1903660	negative regulation of complement-dependent cytotoxicity(GO:1903660)
1.8	35.4	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
1.7	6.9	GO:0070127	tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
1.7	20.7	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
1.7	13.8	GO:0001920	negative regulation of receptor recycling(GO:0001920)
1.7	5.1	GO:0019343	cysteine biosynthetic process via cystathionine(GO:0019343)
1.7	5.1	GO:1903849	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
1.7	35.6	GO:0008210	estrogen metabolic process(GO:0008210)
1.7	5.0	GO:0010265	SCF complex assembly(GO:0010265)
1.6	9.8	GO:0042747	circadian sleep/wake cycle, REM sleep(GO:0042747)
1.6	9.8	GO:0042851	L-alanine metabolic process(GO:0042851)
1.6	4.9	GO:0014846	esophagus smooth muscle contraction(GO:0014846)
1.6	43.2	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
1.6	17.5	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
1.5	1.5	GO:0021898	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
1.5	12.2	GO:0071318	cellular response to ATP(GO:0071318)
1.5	13.7	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
1.5	10.6	GO:2000973	regulation of pro-B cell differentiation(GO:2000973)
1.5	4.5	GO:0060214	endocardium morphogenesis(GO:0003160) endocardium formation(GO:0060214)
1.5	17.6	GO:0046069	cGMP catabolic process(GO:0046069)
1.5	5.9	GO:0046726	positive regulation by virus of viral protein levels in host cell(GO:0046726)
1.4	15.9	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
1.4	2.9	GO:0015966	diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
1.4	21.6	GO:0051764	actin crosslink formation(GO:0051764)
1.4	29.9	GO:0009414	response to water deprivation(GO:0009414)
1.4	5.6	GO:2001170	negative regulation of ATP biosynthetic process(GO:2001170) negative regulation of glucose import in response to insulin stimulus(GO:2001274)
1.4	29.5	GO:0034138	toll-like receptor 3 signaling pathway(GO:0034138)
1.4	18.1	GO:0015693	magnesium ion transport(GO:0015693)
1.4	24.4	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
1.3	23.4	GO:0097062	dendritic spine maintenance(GO:0097062)
1.3	31.0	GO:0010842	retina layer formation(GO:0010842)
1.3	39.9	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
1.3	16.5	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
1.3	2.5	GO:0098903	regulation of membrane repolarization during action potential(GO:0098903)
1.3	25.4	GO:0006828	manganese ion transport(GO:0006828)
1.3	2.5	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
1.2	3.7	GO:0070428	regulation of Toll signaling pathway(GO:0008592) negative regulation of Toll signaling pathway(GO:0045751) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
1.2	6.2	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
1.2	15.9	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
1.2	3.6	GO:0000189	MAPK import into nucleus(GO:0000189)
1.2	13.1	GO:0006677	glycosylceramide metabolic process(GO:0006677)
1.2	30.2	GO:0097009	energy homeostasis(GO:0097009)
1.1	19.4	GO:0001919	regulation of receptor recycling(GO:0001919)
1.1	4.5	GO:0003383	apical constriction(GO:0003383)
1.1	4.5	GO:0019401	glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
1.1	7.8	GO:0031943	regulation of glucocorticoid metabolic process(GO:0031943)
1.1	10.0	GO:0042135	neurotransmitter catabolic process(GO:0042135)
1.1	5.4	GO:0002329	pre-B cell differentiation(GO:0002329)
1.1	4.3	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
1.1	6.4	GO:0010045	response to nickel cation(GO:0010045)
1.0	3.1	GO:0071529	cementum mineralization(GO:0071529)
1.0	22.6	GO:0097186	amelogenesis(GO:0097186)
1.0	11.1	GO:0032060	bleb assembly(GO:0032060)
1.0	26.0	GO:0008038	neuron recognition(GO:0008038)
1.0	3.0	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
1.0	6.9	GO:0061042	vascular wound healing(GO:0061042)
1.0	16.8	GO:0003159	morphogenesis of an endothelium(GO:0003159) endothelial tube morphogenesis(GO:0061154)
1.0	5.9	GO:0015670	carbon dioxide transport(GO:0015670)
1.0	17.3	GO:0031581	hemidesmosome assembly(GO:0031581)
1.0	1.9	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.9	3.8	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.9	12.3	GO:0090161	Golgi ribbon formation(GO:0090161)
0.9	1.9	GO:0051695	actin filament uncapping(GO:0051695)
0.9	8.4	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.9	1.9	GO:0010796	regulation of multivesicular body size(GO:0010796)
0.9	2.8	GO:0060689	cell differentiation involved in salivary gland development(GO:0060689)
0.9	13.7	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.9	21.6	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.9	17.7	GO:0071625	vocalization behavior(GO:0071625)
0.9	8.8	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.9	1.8	GO:1900625	monocyte aggregation(GO:0070487) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.9	3.5	GO:0044691	tooth eruption(GO:0044691)
0.9	6.0	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.9	8.6	GO:1902916	positive regulation of protein polyubiquitination(GO:1902916)
0.9	2.6	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.9	3.4	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.8	18.6	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.8	6.7	GO:2000009	negative regulation of protein localization to cell surface(GO:2000009)
0.8	33.3	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
0.8	21.6	GO:0007616	long-term memory(GO:0007616)
0.8	11.6	GO:0040023	nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.8	4.1	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368)
0.8	2.5	GO:0006244	pyrimidine nucleotide catabolic process(GO:0006244)
0.8	13.8	GO:0042749	regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.8	1.6	GO:0061741	vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741)
0.8	25.0	GO:0045761	regulation of adenylate cyclase activity(GO:0045761)
0.8	33.7	GO:0010883	regulation of lipid storage(GO:0010883)
0.8	9.6	GO:0008090	retrograde axonal transport(GO:0008090)
0.8	29.6	GO:0035249	synaptic transmission, glutamatergic(GO:0035249)
0.8	5.5	GO:0035900	response to isolation stress(GO:0035900)
0.8	6.2	GO:0015705	iodide transport(GO:0015705)
0.8	18.5	GO:0006301	postreplication repair(GO:0006301)
0.8	4.6	GO:0021684	cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.8	43.7	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.8	5.3	GO:0034497	protein localization to pre-autophagosomal structure(GO:0034497)
0.8	3.0	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.8	10.5	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.7	5.9	GO:1901897	regulation of relaxation of cardiac muscle(GO:1901897)
0.7	3.7	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.7	2.9	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.7	2.8	GO:0043988	histone H3-S28 phosphorylation(GO:0043988)
0.7	10.7	GO:0051597	response to methylmercury(GO:0051597)
0.7	15.5	GO:0003301	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.7	2.1	GO:0043323	regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.7	6.3	GO:0006968	cellular defense response(GO:0006968)
0.7	5.6	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.7	12.5	GO:0010663	positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.7	5.6	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
0.7	13.5	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.7	6.7	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.7	6.0	GO:0030002	cellular anion homeostasis(GO:0030002) cellular monovalent inorganic anion homeostasis(GO:0030320) cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.6	12.9	GO:0003016	respiratory system process(GO:0003016)
0.6	80.9	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.6	3.1	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.6	29.7	GO:0007040	lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.6	8.0	GO:0046325	negative regulation of glucose import(GO:0046325)
0.6	6.8	GO:0090036	regulation of protein kinase C signaling(GO:0090036)
0.6	3.0	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.6	20.1	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.6	8.3	GO:2001224	positive regulation of neuron migration(GO:2001224)
0.6	4.7	GO:1900364	negative regulation of mRNA polyadenylation(GO:1900364)
0.6	31.6	GO:0045921	positive regulation of exocytosis(GO:0045921)
0.6	2.9	GO:0035063	nuclear speck organization(GO:0035063)
0.6	5.6	GO:0045838	positive regulation of membrane potential(GO:0045838)
0.6	2.2	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.5	3.3	GO:0006621	protein retention in ER lumen(GO:0006621)
0.5	1.6	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.5	2.1	GO:0099515	vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.5	3.7	GO:0070257	positive regulation of mucus secretion(GO:0070257)
0.5	3.6	GO:0034389	lipid particle organization(GO:0034389)
0.5	10.9	GO:0008306	associative learning(GO:0008306)
0.5	0.5	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.5	8.3	GO:0061098	positive regulation of protein tyrosine kinase activity(GO:0061098)
0.5	10.0	GO:0008333	endosome to lysosome transport(GO:0008333)
0.5	3.3	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.5	1.4	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.5	2.3	GO:1901525	negative regulation of macromitophagy(GO:1901525)
0.5	2.3	GO:0010544	negative regulation of platelet activation(GO:0010544)
0.5	12.2	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.4	1.3	GO:0018343	protein farnesylation(GO:0018343)
0.4	4.8	GO:0006013	mannose metabolic process(GO:0006013)
0.4	5.5	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.4	15.1	GO:0003073	regulation of systemic arterial blood pressure(GO:0003073)
0.4	89.5	GO:0007268	chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916)
0.4	4.4	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.4	15.8	GO:0007218	neuropeptide signaling pathway(GO:0007218)
0.4	18.8	GO:0032024	positive regulation of insulin secretion(GO:0032024)
0.4	8.1	GO:0030195	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.4	22.4	GO:0035725	sodium ion transmembrane transport(GO:0035725)
0.4	5.8	GO:0033622	integrin activation(GO:0033622)
0.4	14.2	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.4	2.5	GO:0070314	G1 to G0 transition(GO:0070314)
0.4	2.9	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.4	4.6	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.3	1.0	GO:0006408	snRNA export from nucleus(GO:0006408)
0.3	1.3	GO:0050812	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.3	8.1	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.3	21.6	GO:0006836	neurotransmitter transport(GO:0006836)
0.3	5.7	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.3	4.1	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.3	1.2	GO:0045821	transformation of host cell by virus(GO:0019087) positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197)
0.3	6.0	GO:1903959	regulation of anion transmembrane transport(GO:1903959)
0.3	13.9	GO:0015914	phospholipid transport(GO:0015914)
0.3	7.0	GO:0043001	Golgi to plasma membrane protein transport(GO:0043001)
0.3	5.2	GO:0042058	regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.3	9.8	GO:0051693	actin filament capping(GO:0051693)
0.3	3.2	GO:0021533	cell differentiation in hindbrain(GO:0021533)
0.3	8.5	GO:0042446	hormone biosynthetic process(GO:0042446)
0.3	0.6	GO:0048194	Golgi vesicle budding(GO:0048194)
0.3	2.5	GO:0044803	multi-organism membrane organization(GO:0044803)
0.3	0.8	GO:0051697	protein delipidation(GO:0051697)
0.3	2.4	GO:0045540	regulation of cholesterol biosynthetic process(GO:0045540)
0.3	3.5	GO:0048488	synaptic vesicle endocytosis(GO:0048488)
0.3	11.7	GO:0071277	cellular response to calcium ion(GO:0071277)
0.3	3.0	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.2	104.0	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.2	2.4	GO:0017121	phospholipid scrambling(GO:0017121)
0.2	2.1	GO:0042407	cristae formation(GO:0042407)
0.2	11.3	GO:0097581	lamellipodium organization(GO:0097581)
0.2	3.9	GO:0032981	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2	2.9	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.2	1.1	GO:0048069	eye pigmentation(GO:0048069)
0.2	3.7	GO:0008053	mitochondrial fusion(GO:0008053)
0.2	2.9	GO:0006541	glutamine metabolic process(GO:0006541)
0.2	4.2	GO:0016126	sterol biosynthetic process(GO:0016126)
0.1	0.3	GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) positive regulation of transcription by glucose(GO:0046016)
0.1	2.5	GO:0043982	histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1	6.8	GO:0051865	protein autoubiquitination(GO:0051865)
0.1	6.0	GO:0000187	activation of MAPK activity(GO:0000187)
0.1	2.0	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1	1.4	GO:0016540	protein autoprocessing(GO:0016540)
0.1	13.0	GO:0006898	receptor-mediated endocytosis(GO:0006898)
0.1	1.4	GO:0051457	maintenance of protein location in nucleus(GO:0051457)
0.1	1.1	GO:2000234	positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.1	5.0	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.1	0.4	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1	0.3	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.1	0.5	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1	1.3	GO:0045026	plasma membrane fusion(GO:0045026)
0.1	0.3	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340)
0.1	0.5	GO:0034214	protein hexamerization(GO:0034214)
0.1	0.8	GO:0042659	regulation of cell fate specification(GO:0042659)
0.1	0.3	GO:0010990	regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.1	0.4	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1	0.7	GO:0032025	response to cobalt ion(GO:0032025)
0.1	2.7	GO:0046785	microtubule polymerization(GO:0046785)
0.0	0.4	GO:0007288	sperm axoneme assembly(GO:0007288)
0.0	0.1	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.0	2.7	GO:0009062	fatty acid catabolic process(GO:0009062)
0.0	1.6	GO:0030534	adult behavior(GO:0030534)
0.0	0.4	GO:0006509	membrane protein ectodomain proteolysis(GO:0006509)
0.0	0.5	GO:0015804	neutral amino acid transport(GO:0015804)
0.0	0.2	GO:0035563	positive regulation of chromatin binding(GO:0035563)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
24.9	74.7	GO:0098830	presynaptic endosome(GO:0098830)
21.2	212.4	GO:0048787	presynaptic active zone membrane(GO:0048787)
16.9	50.8	GO:0038039	G-protein coupled receptor heterodimeric complex(GO:0038039)
16.0	48.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
12.5	149.4	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
9.1	81.6	GO:0071821	FANCM-MHF complex(GO:0071821)
8.5	136.6	GO:0031045	dense core granule(GO:0031045)
7.7	23.2	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
7.2	21.5	GO:0016935	glycine-gated chloride channel complex(GO:0016935) GABA-ergic synapse(GO:0098982)
6.8	40.5	GO:0032280	symmetric synapse(GO:0032280)
5.9	76.9	GO:0032591	dendritic spine membrane(GO:0032591)
5.9	201.0	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
5.8	23.2	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
5.2	15.5	GO:0034667	integrin alpha3-beta1 complex(GO:0034667)
5.1	177.2	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
4.6	23.2	GO:0098845	postsynaptic endosome(GO:0098845)
4.6	9.3	GO:0098888	extrinsic component of presynaptic membrane(GO:0098888)
4.5	13.6	GO:0060187	cell pole(GO:0060187)
4.0	92.2	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
3.9	121.6	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
3.7	29.9	GO:0098839	postsynaptic density membrane(GO:0098839)
3.7	44.7	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
3.6	21.5	GO:0030478	actin cap(GO:0030478)
3.5	88.6	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
3.5	14.1	GO:0034657	GID complex(GO:0034657)
3.5	10.5	GO:0031230	intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
3.5	27.7	GO:0043203	axon hillock(GO:0043203)
3.3	40.0	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
3.2	105.5	GO:0097440	apical dendrite(GO:0097440)
3.1	21.5	GO:0036449	microtubule minus-end(GO:0036449)
3.0	12.1	GO:0097196	Shu complex(GO:0097196)
3.0	27.1	GO:0000813	ESCRT I complex(GO:0000813)
2.8	16.9	GO:0008091	spectrin(GO:0008091)
2.8	11.2	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
2.8	69.0	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
2.6	21.1	GO:0001740	Barr body(GO:0001740)
2.5	25.4	GO:0036056	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
2.4	12.2	GO:0005927	muscle tendon junction(GO:0005927)
2.4	99.9	GO:0016528	sarcoplasm(GO:0016528)
2.3	27.7	GO:0071437	invadopodium(GO:0071437)
2.2	13.3	GO:0000137	Golgi cis cisterna(GO:0000137)
2.2	50.4	GO:0033268	node of Ranvier(GO:0033268)
2.1	2.1	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
2.1	33.1	GO:0045180	basal cortex(GO:0045180)
2.0	6.1	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
2.0	10.0	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
1.9	78.8	GO:0032589	neuron projection membrane(GO:0032589)
1.9	9.3	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
1.8	14.5	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
1.8	1.8	GO:0034457	Mpp10 complex(GO:0034457)
1.8	14.3	GO:0043083	synaptic cleft(GO:0043083)
1.8	47.9	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
1.7	10.4	GO:0016461	unconventional myosin complex(GO:0016461)
1.7	54.7	GO:0060077	inhibitory synapse(GO:0060077)
1.6	52.5	GO:0048786	presynaptic active zone(GO:0048786)
1.6	9.8	GO:0070852	cell body fiber(GO:0070852)
1.6	6.4	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
1.6	9.5	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
1.5	75.7	GO:0031201	SNARE complex(GO:0031201)
1.5	250.1	GO:0043204	perikaryon(GO:0043204)
1.4	225.7	GO:0045211	postsynaptic membrane(GO:0045211)
1.4	17.3	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
1.4	12.7	GO:0031143	pseudopodium(GO:0031143)
1.4	30.7	GO:0000145	exocyst(GO:0000145)
1.3	6.7	GO:0042583	chromaffin granule(GO:0042583)
1.3	5.4	GO:0032584	growth cone membrane(GO:0032584)
1.3	56.2	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
1.3	9.3	GO:0005683	U7 snRNP(GO:0005683)
1.3	9.2	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
1.3	29.4	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
1.3	6.3	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
1.3	15.0	GO:0031616	spindle pole centrosome(GO:0031616)
1.3	12.5	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
1.3	186.7	GO:0008021	synaptic vesicle(GO:0008021)
1.2	2.5	GO:0031166	integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
1.2	4.7	GO:0032044	DSIF complex(GO:0032044)
1.2	43.9	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
1.2	10.4	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
1.1	5.6	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
1.1	10.0	GO:0032059	bleb(GO:0032059)
1.1	41.4	GO:0055038	recycling endosome membrane(GO:0055038)
1.1	3.3	GO:0097233	lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
1.1	5.4	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
1.1	73.5	GO:0005798	Golgi-associated vesicle(GO:0005798)
1.1	126.5	GO:0030133	transport vesicle(GO:0030133)
1.0	29.6	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
1.0	21.2	GO:0019013	viral nucleocapsid(GO:0019013)
1.0	12.0	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.9	63.2	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.9	21.1	GO:0042734	presynaptic membrane(GO:0042734)
0.9	30.7	GO:0009925	basal plasma membrane(GO:0009925)
0.9	18.4	GO:0000421	autophagosome membrane(GO:0000421)
0.8	11.8	GO:0016514	SWI/SNF complex(GO:0016514)
0.8	109.9	GO:0005802	trans-Golgi network(GO:0005802)
0.8	55.1	GO:0043679	axon terminus(GO:0043679)
0.8	4.7	GO:0005655	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.8	5.5	GO:0097524	sperm plasma membrane(GO:0097524)
0.7	83.0	GO:0030427	site of polarized growth(GO:0030427)
0.7	7.8	GO:0042405	nuclear inclusion body(GO:0042405)
0.7	17.3	GO:0005923	bicellular tight junction(GO:0005923)
0.7	4.8	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.7	2.0	GO:0036195	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.7	16.7	GO:0031594	neuromuscular junction(GO:0031594)
0.6	4.9	GO:0061700	GATOR2 complex(GO:0061700)
0.6	45.1	GO:0043197	dendritic spine(GO:0043197)
0.6	1.9	GO:0000814	ESCRT II complex(GO:0000814)
0.6	3.0	GO:0016600	flotillin complex(GO:0016600)
0.6	10.6	GO:0043218	compact myelin(GO:0043218)
0.6	23.2	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.6	22.5	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.6	31.1	GO:0031225	anchored component of membrane(GO:0031225)
0.6	4.4	GO:0043194	axon initial segment(GO:0043194)
0.5	3.7	GO:0043296	apical junction complex(GO:0043296)
0.5	4.2	GO:1990023	mitotic spindle midzone(GO:1990023)
0.5	18.1	GO:0035869	ciliary transition zone(GO:0035869)
0.5	11.0	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.5	5.9	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.5	28.4	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.4	1.2	GO:0005899	insulin receptor complex(GO:0005899)
0.3	3.1	GO:0000439	core TFIIH complex(GO:0000439)
0.3	1.0	GO:0005642	annulate lamellae(GO:0005642)
0.3	5.5	GO:0042101	T cell receptor complex(GO:0042101)
0.3	33.7	GO:0030027	lamellipodium(GO:0030027)
0.3	39.4	GO:0030425	dendrite(GO:0030425)
0.3	2.5	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.3	3.9	GO:0030119	AP-type membrane coat adaptor complex(GO:0030119)
0.3	36.8	GO:0043209	myelin sheath(GO:0043209)
0.3	1.7	GO:0005869	dynactin complex(GO:0005869)
0.3	5.2	GO:0030175	filopodium(GO:0030175)
0.3	3.0	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.3	6.0	GO:0034707	chloride channel complex(GO:0034707)
0.3	4.3	GO:1904115	axon cytoplasm(GO:1904115)
0.2	3.8	GO:0043034	costamere(GO:0043034)
0.2	10.2	GO:0016324	apical plasma membrane(GO:0016324)
0.2	1.8	GO:0042629	mast cell granule(GO:0042629)
0.2	7.2	GO:0005776	autophagosome(GO:0005776)
0.2	106.0	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.2	1.4	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750)
0.2	2.3	GO:0051233	spindle midzone(GO:0051233)
0.2	1.5	GO:0030891	VCB complex(GO:0030891)
0.2	3.5	GO:0005905	clathrin-coated pit(GO:0005905)
0.2	28.6	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1	0.7	GO:0043293	apoptosome(GO:0043293)
0.1	10.8	GO:0060076	excitatory synapse(GO:0060076)
0.1	2.6	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.1	1.0	GO:0042587	glycogen granule(GO:0042587)
0.1	8.7	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	639.6	GO:0016021	integral component of membrane(GO:0016021)
0.1	0.4	GO:1990716	axonemal central apparatus(GO:1990716)
0.1	1.1	GO:0031901	early endosome membrane(GO:0031901)
0.1	2.4	GO:0005770	late endosome(GO:0005770)
0.1	0.4	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0	1.2	GO:0030686	90S preribosome(GO:0030686)
0.0	1.4	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	1.5	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	1.0	GO:0015030	Cajal body(GO:0015030)
0.0	0.1	GO:0000974	Prp19 complex(GO:0000974)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
38.6	154.5	GO:0060072	large conductance calcium-activated potassium channel activity(GO:0060072)
31.0	92.9	GO:0086057	voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
18.2	54.7	GO:0001847	opsonin receptor activity(GO:0001847)
14.8	73.9	GO:0031849	olfactory receptor binding(GO:0031849)
14.4	43.3	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
14.0	56.0	GO:0008489	UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
13.8	55.2	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
13.6	81.6	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
12.7	50.8	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
12.2	36.7	GO:0004647	phosphoserine phosphatase activity(GO:0004647)
11.6	46.3	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
11.4	79.7	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
10.6	31.7	GO:0061628	H3K27me3 modified histone binding(GO:0061628)
10.1	60.4	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
9.5	75.6	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
9.4	65.8	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
9.2	46.0	GO:0022841	potassium ion leak channel activity(GO:0022841)
9.1	27.3	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
8.8	26.5	GO:0004566	beta-glucuronidase activity(GO:0004566)
8.5	50.8	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
8.3	74.7	GO:0032050	clathrin heavy chain binding(GO:0032050)
8.0	39.9	GO:0048763	calcium-induced calcium release activity(GO:0048763)
7.9	47.6	GO:0001515	opioid peptide activity(GO:0001515)
7.8	23.5	GO:0015229	L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
7.8	23.3	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
7.5	37.5	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
7.5	29.9	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
7.4	22.2	GO:1902379	chemoattractant activity involved in axon guidance(GO:1902379)
7.4	7.4	GO:0010465	nerve growth factor receptor activity(GO:0010465)
7.2	21.6	GO:0016015	morphogen activity(GO:0016015)
7.1	28.3	GO:0016833	oxo-acid-lyase activity(GO:0016833)
7.0	21.0	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
6.9	20.7	GO:0031708	endothelin B receptor binding(GO:0031708)
6.8	20.5	GO:2001070	starch binding(GO:2001070)
6.8	27.0	GO:0005163	nerve growth factor receptor binding(GO:0005163)
6.4	63.6	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
6.3	37.6	GO:0004994	somatostatin receptor activity(GO:0004994)
5.9	41.0	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
5.8	75.7	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
5.8	40.7	GO:0010853	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
5.8	23.2	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
5.6	5.6	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
5.5	27.5	GO:0005042	netrin receptor activity(GO:0005042)
5.4	32.5	GO:0032051	clathrin light chain binding(GO:0032051)
5.3	21.2	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
5.1	87.1	GO:0050811	GABA receptor binding(GO:0050811)
5.0	24.9	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
4.9	24.6	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
4.9	29.5	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
4.9	112.7	GO:0043274	phospholipase binding(GO:0043274)
4.8	57.5	GO:0019869	chloride channel inhibitor activity(GO:0019869)
4.6	32.4	GO:0005173	stem cell factor receptor binding(GO:0005173)
4.5	40.9	GO:0005347	ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
4.4	62.1	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
4.2	29.6	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
4.2	21.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
4.2	29.4	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
4.1	28.7	GO:0022851	GABA-gated chloride ion channel activity(GO:0022851)
3.9	11.6	GO:0022840	leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
3.8	22.9	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
3.8	34.3	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
3.7	25.8	GO:0004065	arylsulfatase activity(GO:0004065)
3.7	36.5	GO:0008179	adenylate cyclase binding(GO:0008179)
3.6	25.4	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
3.6	121.7	GO:0001540	beta-amyloid binding(GO:0001540)
3.6	17.9	GO:0004517	nitric-oxide synthase activity(GO:0004517)
3.5	28.2	GO:0035374	chondroitin sulfate binding(GO:0035374)
3.4	44.5	GO:0004143	diacylglycerol kinase activity(GO:0004143)
3.4	13.6	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
3.3	30.0	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
3.3	59.1	GO:0004383	guanylate cyclase activity(GO:0004383)
3.3	9.8	GO:0004021	L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635)
3.1	9.3	GO:0071209	U7 snRNA binding(GO:0071209)
3.1	27.7	GO:0031995	insulin-like growth factor II binding(GO:0031995)
3.1	21.5	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
3.0	21.3	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
3.0	9.0	GO:0072320	volume-sensitive chloride channel activity(GO:0072320)
3.0	8.9	GO:0002114	interleukin-33 receptor activity(GO:0002114)
2.8	11.3	GO:0031750	D3 dopamine receptor binding(GO:0031750)
2.8	19.4	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
2.7	5.5	GO:0017098	sulfonylurea receptor binding(GO:0017098)
2.7	24.3	GO:0015232	heme transporter activity(GO:0015232)
2.7	10.7	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
2.6	13.1	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
2.6	164.8	GO:0030276	clathrin binding(GO:0030276)
2.6	13.0	GO:0004969	histamine receptor activity(GO:0004969)
2.5	10.2	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
2.5	10.2	GO:0031749	D2 dopamine receptor binding(GO:0031749)
2.5	15.1	GO:0008823	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
2.5	17.6	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
2.5	5.0	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
2.4	9.8	GO:0047751	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
2.4	19.4	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
2.4	63.7	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
2.3	13.8	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
2.3	39.0	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
2.3	22.5	GO:0015386	potassium:proton antiporter activity(GO:0015386)
2.2	11.2	GO:0097016	L27 domain binding(GO:0097016)
2.2	13.3	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
2.2	50.3	GO:0031489	myosin V binding(GO:0031489)
2.2	8.7	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
2.1	38.7	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
2.1	12.7	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
2.0	14.2	GO:1990459	transferrin receptor binding(GO:1990459)
2.0	4.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
2.0	10.0	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
2.0	60.2	GO:0017075	syntaxin-1 binding(GO:0017075)
2.0	5.9	GO:0004827	proline-tRNA ligase activity(GO:0004827) threonine-tRNA ligase activity(GO:0004829)
2.0	23.6	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
2.0	21.5	GO:0051011	microtubule minus-end binding(GO:0051011)
2.0	5.9	GO:0102345	3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
1.9	13.5	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
1.8	9.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
1.8	11.0	GO:0036122	BMP binding(GO:0036122)
1.8	14.4	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
1.8	59.4	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
1.7	17.4	GO:0043008	ATP-dependent protein binding(GO:0043008)
1.7	5.2	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
1.7	10.4	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
1.7	20.5	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
1.7	6.8	GO:0042731	PH domain binding(GO:0042731)
1.7	10.0	GO:0043495	protein anchor(GO:0043495)
1.6	100.6	GO:0048306	calcium-dependent protein binding(GO:0048306)
1.6	14.4	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
1.6	7.8	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
1.5	6.2	GO:0015111	iodide transmembrane transporter activity(GO:0015111)
1.5	22.9	GO:0016917	GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
1.4	40.4	GO:0030506	ankyrin binding(GO:0030506)
1.4	17.3	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
1.4	9.9	GO:0048406	nerve growth factor binding(GO:0048406)
1.4	7.1	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
1.4	9.6	GO:0045504	dynein heavy chain binding(GO:0045504)
1.4	23.0	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
1.3	23.8	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.3	7.8	GO:0031748	D1 dopamine receptor binding(GO:0031748)
1.3	97.3	GO:0005249	voltage-gated potassium channel activity(GO:0005249)
1.3	28.4	GO:0031418	L-ascorbic acid binding(GO:0031418)
1.3	30.9	GO:0005272	sodium channel activity(GO:0005272)
1.3	3.8	GO:0004774	succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775)
1.3	27.8	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
1.3	6.3	GO:0030911	TPR domain binding(GO:0030911)
1.2	11.2	GO:0019855	calcium channel inhibitor activity(GO:0019855)
1.2	46.2	GO:0046875	ephrin receptor binding(GO:0046875)
1.1	25.0	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
1.1	12.0	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
1.1	13.1	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
1.0	8.3	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
1.0	10.3	GO:0102338	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
1.0	47.4	GO:0030544	Hsp70 protein binding(GO:0030544)
1.0	8.8	GO:0070016	armadillo repeat domain binding(GO:0070016)
1.0	8.8	GO:0015266	protein channel activity(GO:0015266)
1.0	2.9	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.9	10.4	GO:0008242	omega peptidase activity(GO:0008242)
0.9	7.6	GO:0016413	O-acetyltransferase activity(GO:0016413)
0.9	5.6	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.9	11.9	GO:0030215	semaphorin receptor binding(GO:0030215)
0.9	8.2	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.9	12.7	GO:0051378	serotonin binding(GO:0051378)
0.9	5.4	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.9	21.6	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.9	4.5	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.9	9.8	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.8	3.3	GO:0046923	ER retention sequence binding(GO:0046923)
0.8	49.2	GO:0005080	protein kinase C binding(GO:0005080)
0.8	5.5	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.8	6.3	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.8	11.8	GO:0030552	cAMP binding(GO:0030552)
0.8	2.3	GO:0005135	interleukin-3 receptor binding(GO:0005135)
0.7	5.1	GO:1904047	oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) S-adenosyl-L-methionine binding(GO:1904047)
0.7	6.5	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.7	41.9	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.7	2.8	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.7	7.1	GO:0016909	JUN kinase activity(GO:0004705) cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) SAP kinase activity(GO:0016909)
0.7	67.3	GO:0044325	ion channel binding(GO:0044325)
0.7	15.4	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.7	21.0	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.7	23.7	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.7	10.4	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.7	17.7	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.7	24.3	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
0.7	6.7	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.7	11.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.7	1.3	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.6	9.6	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.6	12.1	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.6	8.9	GO:0005523	tropomyosin binding(GO:0005523)
0.6	15.5	GO:0001968	fibronectin binding(GO:0001968)
0.6	2.5	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.6	1.8	GO:0042134	rRNA primary transcript binding(GO:0042134)
0.6	10.6	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.6	6.5	GO:0070700	BMP receptor binding(GO:0070700)
0.6	25.7	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.6	8.7	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.6	2.9	GO:0050816	phosphothreonine binding(GO:0050816)
0.6	10.9	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.5	5.4	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.5	6.8	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.5	23.3	GO:0035254	glutamate receptor binding(GO:0035254)
0.5	19.2	GO:0048365	Rac GTPase binding(GO:0048365)
0.5	1.9	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.5	6.4	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.5	51.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.5	12.8	GO:0005158	insulin receptor binding(GO:0005158)
0.5	5.9	GO:0015250	water channel activity(GO:0015250)
0.5	52.9	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.4	9.8	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.4	8.9	GO:0004993	G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.4	18.6	GO:0017022	myosin binding(GO:0017022)
0.4	4.4	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.4	40.6	GO:0005516	calmodulin binding(GO:0005516)
0.4	11.7	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.4	111.0	GO:0003924	GTPase activity(GO:0003924)
0.4	5.6	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.4	89.5	GO:0005096	GTPase activator activity(GO:0005096)
0.4	31.6	GO:0019955	cytokine binding(GO:0019955)
0.4	1.6	GO:0097109	neuroligin family protein binding(GO:0097109)
0.4	3.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.4	8.0	GO:0005540	hyaluronic acid binding(GO:0005540)
0.4	4.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.4	1.8	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.4	2.1	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.4	10.9	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.3	42.4	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.3	1.3	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.3	13.5	GO:0019894	kinesin binding(GO:0019894)
0.3	15.7	GO:0017046	peptide hormone binding(GO:0017046)
0.3	6.9	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3	4.3	GO:0005522	profilin binding(GO:0005522)
0.3	1.8	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.3	2.9	GO:0004551	nucleotide diphosphatase activity(GO:0004551)
0.3	3.7	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.3	4.5	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.3	3.1	GO:0000182	rDNA binding(GO:0000182)
0.3	2.4	GO:0042609	CD4 receptor binding(GO:0042609)
0.2	4.9	GO:0016864	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2	7.1	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.2	2.8	GO:0046527	glucosyltransferase activity(GO:0046527)
0.2	27.2	GO:0005179	hormone activity(GO:0005179)
0.2	12.3	GO:0008081	phosphoric diester hydrolase activity(GO:0008081)
0.2	16.7	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2	3.0	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2	3.5	GO:0052866	phosphatidylinositol phosphate phosphatase activity(GO:0052866)
0.2	6.7	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2	3.3	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.2	3.6	GO:0004806	triglyceride lipase activity(GO:0004806)
0.2	2.5	GO:0005351	sugar:proton symporter activity(GO:0005351)
0.2	6.6	GO:0005044	scavenger receptor activity(GO:0005044)
0.2	4.2	GO:0070412	R-SMAD binding(GO:0070412)
0.1	1.0	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.1	2.9	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	3.7	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	1.2	GO:0016594	glycine binding(GO:0016594)
0.1	55.3	GO:0005509	calcium ion binding(GO:0005509)
0.1	6.9	GO:0000049	tRNA binding(GO:0000049)
0.1	3.8	GO:0019905	syntaxin binding(GO:0019905)
0.1	24.5	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.1	5.9	GO:0017137	Rab GTPase binding(GO:0017137)
0.1	5.1	GO:0005518	collagen binding(GO:0005518)
0.1	24.0	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.1	3.1	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1	0.7	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.1	1.6	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.1	2.2	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1	0.5	GO:0002151	G-quadruplex RNA binding(GO:0002151)
0.1	0.4	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1	4.1	GO:0005178	integrin binding(GO:0005178)
0.1	0.8	GO:0048018	receptor agonist activity(GO:0048018)
0.1	0.5	GO:0043139	5'-3' DNA helicase activity(GO:0043139)
0.1	0.4	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.1	4.7	GO:0008080	N-acetyltransferase activity(GO:0008080)
0.0	2.1	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	0.6	GO:0097602	cullin family protein binding(GO:0097602)
0.0	1.1	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.3	GO:0070410	co-SMAD binding(GO:0070410)
0.0	1.0	GO:0015175	neutral amino acid transmembrane transporter activity(GO:0015175)
0.0	0.6	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.3	GO:0016755	transferase activity, transferring amino-acyl groups(GO:0016755)
0.0	0.1	GO:0071987	WD40-repeat domain binding(GO:0071987)
0.0	0.4	GO:0030515	snoRNA binding(GO:0030515)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.6	119.6	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
3.5	13.9	PID CERAMIDE PATHWAY	Ceramide signaling pathway
3.1	122.6	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
3.0	62.5	PID LPA4 PATHWAY	LPA4-mediated signaling events
2.2	26.0	PID S1P S1P4 PATHWAY	S1P4 pathway
2.0	27.8	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
1.9	70.1	PID EPHA FWDPATHWAY	EPHA forward signaling
1.8	7.1	PID FOXO PATHWAY	FoxO family signaling
1.8	47.7	PID NETRIN PATHWAY	Netrin-mediated signaling events
1.4	16.5	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
1.2	57.6	PID BMP PATHWAY	BMP receptor signaling
1.2	42.8	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
1.2	72.9	PID FGF PATHWAY	FGF signaling pathway
1.1	14.4	PID NECTIN PATHWAY	Nectin adhesion pathway
1.0	29.2	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
1.0	9.3	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
1.0	36.8	ST JNK MAPK PATHWAY	JNK MAPK Pathway
1.0	31.6	PID ARF6 PATHWAY	Arf6 signaling events
1.0	23.5	PID CDC42 PATHWAY	CDC42 signaling events
1.0	13.7	PID S1P S1P1 PATHWAY	S1P1 pathway
1.0	13.5	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.9	7.8	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.9	50.5	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.8	5.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.8	19.7	PID ENDOTHELIN PATHWAY	Endothelins
0.8	188.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.8	115.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6	10.1	ST G ALPHA I PATHWAY	G alpha i Pathway
0.6	25.4	PID RAC1 PATHWAY	RAC1 signaling pathway
0.6	17.6	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.5	10.2	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.5	114.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.5	5.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.5	15.5	PID IL23 PATHWAY	IL23-mediated signaling events
0.5	5.5	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.5	7.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.5	8.2	PID IL1 PATHWAY	IL1-mediated signaling events
0.4	9.1	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.4	5.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.4	9.9	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.4	7.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.3	2.0	PID EPHB FWD PATHWAY	EPHB forward signaling
0.3	1.5	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3	5.2	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.3	7.2	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.2	2.3	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.2	3.2	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.2	4.3	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.2	8.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	1.8	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.1	2.1	PID ARF 3PATHWAY	Arf1 pathway
0.1	2.9	PID MYC PATHWAY	C-MYC pathway
0.1	1.7	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	3.8	PID ATR PATHWAY	ATR signaling pathway
0.1	2.2	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	1.6	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.3	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	0.4	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.8	PID SHP2 PATHWAY	SHP2 signaling
0.0	0.4	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.5	PID ATM PATHWAY	ATM pathway
0.0	0.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
8.5	110.0	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
8.0	120.6	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
6.8	115.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
6.8	121.5	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
5.1	126.8	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
4.9	88.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
4.2	62.5	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
3.8	98.7	REACTOME FGFR LIGAND BINDING AND ACTIVATION	Genes involved in FGFR ligand binding and activation
3.5	52.7	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
3.2	9.7	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
3.0	47.9	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
2.9	35.0	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
2.6	12.8	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
2.2	82.9	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
2.2	31.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
2.1	20.9	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
2.1	24.7	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
2.0	21.5	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
1.9	40.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.9	53.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
1.9	74.1	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
1.8	54.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.8	125.6	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
1.7	30.8	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
1.6	30.2	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
1.6	44.0	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
1.6	20.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
1.5	22.9	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
1.5	13.5	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
1.5	22.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
1.5	4.4	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
1.4	34.4	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
1.4	22.7	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
1.4	15.4	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
1.3	34.5	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
1.2	117.3	REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	Genes involved in Transmission across Chemical Synapses
1.2	8.2	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
1.1	19.4	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
1.1	32.9	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
1.0	39.7	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
1.0	18.7	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
1.0	42.8	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
1.0	7.8	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
1.0	21.4	REACTOME NEURONAL SYSTEM	Genes involved in Neuronal System
1.0	32.7	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
1.0	17.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.9	5.5	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.9	27.2	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.9	20.8	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.9	30.1	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.8	9.8	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.8	7.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.8	70.5	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.7	11.1	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.7	120.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.7	55.7	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.7	7.8	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.7	9.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.7	8.5	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.6	8.7	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.6	6.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.6	22.4	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.6	5.8	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.6	9.6	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.6	5.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.5	12.4	REACTOME AQUAPORIN MEDIATED TRANSPORT	Genes involved in Aquaporin-mediated transport
0.5	11.9	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.5	9.6	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.5	2.8	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.5	9.8	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.4	6.9	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4	6.0	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.4	3.9	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3	3.9	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.3	3.5	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.3	22.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	8.3	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.2	8.1	REACTOME AMYLOIDS	Genes involved in Amyloids
0.2	4.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.2	3.3	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.2	2.3	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	1.3	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.1	14.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	2.9	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	0.9	REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX	Genes involved in TRAF6 mediated induction of TAK1 complex
0.1	0.6	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.1	2.1	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.1	0.9	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.4	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)

Results for Hic1

Z-value: 2.20

Motif logo

Transcription factors associated with Hic1

Activity-expression correlation:

Activity profile of Hic1 motif

Sorted Z-values of Hic1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hic1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: