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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Hic1
Z-value: 2.20
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Transcription factors associated with Hic1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hic1 | rn6_v1_chr10_-_62009582_62009582 | 0.05 | 3.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hic1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 172.0 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 51.5 | 154.5 | GO:0060082 | eye blink reflex(GO:0060082) |
| 16.2 | 145.5 | GO:0021769 | orbitofrontal cortex development(GO:0021769) |
| 7.0 | 111.3 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 6.1 | 104.4 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.2 | 104.0 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 4.0 | 102.8 | GO:0098926 | postsynaptic signal transduction(GO:0098926) |
| 16.9 | 101.2 | GO:0023041 | neuronal signal transduction(GO:0023041) |
| 33.7 | 101.0 | GO:0032430 | positive regulation of phospholipase A2 activity(GO:0032430) |
| 2.3 | 96.1 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 639.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.5 | 250.1 | GO:0043204 | perikaryon(GO:0043204) |
| 1.4 | 225.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 21.2 | 212.4 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 5.9 | 201.0 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 1.3 | 186.7 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 5.1 | 177.2 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 12.5 | 149.4 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 8.5 | 136.6 | GO:0031045 | dense core granule(GO:0031045) |
| 1.1 | 126.5 | GO:0030133 | transport vesicle(GO:0030133) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 164.8 | GO:0030276 | clathrin binding(GO:0030276) |
| 38.6 | 154.5 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 3.6 | 121.7 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 4.9 | 112.7 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.4 | 111.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.6 | 100.6 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 1.3 | 97.3 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 31.0 | 92.9 | GO:0086057 | voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057) |
| 0.4 | 89.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 5.1 | 87.1 | GO:0050811 | GABA receptor binding(GO:0050811) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 188.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 3.1 | 122.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 4.6 | 119.6 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.8 | 115.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 114.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.2 | 72.9 | PID FGF PATHWAY | FGF signaling pathway |
| 1.9 | 70.1 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 3.0 | 62.5 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 1.2 | 57.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.9 | 50.5 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 126.8 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 1.8 | 125.6 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 6.8 | 121.5 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 8.0 | 120.6 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.7 | 120.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.2 | 117.3 | REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 6.8 | 115.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 8.5 | 110.0 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 3.8 | 98.7 | REACTOME FGFR LIGAND BINDING AND ACTIVATION | Genes involved in FGFR ligand binding and activation |
| 4.9 | 88.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |