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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hey2

Z-value: 0.64

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Transcription factors associated with Hey2

Gene Symbol Gene ID Gene Info
Hey2
ENSRNOG00000013364 hes-related family bHLH transcription factor with YRPW motif 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hey2rn6_v1_chr1_+_29191192_291911920.532.2e-24Click!

Activity profile of Hey2 motif

Sorted Z-values of Hey2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_26906716 34.00 ENSRNOT00000064297
Cpe
carboxypeptidase E
chr3_-_9262628 19.87 ENSRNOT00000013286
Aif1l
allograft inflammatory factor 1-like
chr8_+_72405748 15.54 ENSRNOT00000023952
Car12
carbonic anhydrase 12
chr11_+_81972219 15.22 ENSRNOT00000002452
Dgkg
diacylglycerol kinase, gamma
chr19_+_37476095 13.78 ENSRNOT00000092794
ENSRNOT00000023130
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr1_+_101682172 12.54 ENSRNOT00000028540
Car11
carbonic anhydrase 11
chr3_-_146470293 11.74 ENSRNOT00000009627
Acss1
acyl-CoA synthetase short-chain family member 1
chr15_-_108210826 11.45 ENSRNOT00000064705
Dock9
dedicator of cytokinesis 9
chr16_+_48120864 11.02 ENSRNOT00000068562
Stox2
storkhead box 2
chr13_-_111765944 10.54 ENSRNOT00000073041
Syt14
synaptotagmin 14
chr9_+_41348449 10.48 ENSRNOT00000019419
Plekhb2
pleckstrin homology domain containing B2
chr2_-_46544457 10.26 ENSRNOT00000015680
Fst
follistatin
chr14_+_89253373 9.99 ENSRNOT00000035922
LOC688553
hypothetical protein LOC688553
chr2_+_115337439 9.57 ENSRNOT00000015779
Eif5a2
eukaryotic translation initiation factor 5A2
chr14_-_92117923 9.11 ENSRNOT00000044726
Grb10
growth factor receptor bound protein 10
chrX_+_39711201 9.01 ENSRNOT00000080512
ENSRNOT00000009802
Cnksr2
connector enhancer of kinase suppressor of Ras 2
chr2_+_207923775 8.97 ENSRNOT00000019997
ENSRNOT00000051835
Kcnd3
potassium voltage-gated channel subfamily D member 3
chr6_-_28464118 8.77 ENSRNOT00000068214
Efr3b
EFR3 homolog B
chr1_-_47331412 8.67 ENSRNOT00000046746
Ezr
ezrin
chr12_+_39553903 8.64 ENSRNOT00000001738
Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
chr2_-_197991198 8.49 ENSRNOT00000056322
Ciart
circadian associated repressor of transcription
chr12_+_39554171 8.41 ENSRNOT00000024347
Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
chr4_-_120817377 8.01 ENSRNOT00000021826
Podxl2
podocalyxin-like 2
chr14_-_10395047 7.55 ENSRNOT00000002936
Gpat3
glycerol-3-phosphate acyltransferase 3
chr16_-_21347968 7.24 ENSRNOT00000068554
Lpar2
lysophosphatidic acid receptor 2
chr9_-_45505767 6.88 ENSRNOT00000033964
Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr10_+_47961056 6.75 ENSRNOT00000027312
Fam83g
family with sequence similarity 83, member G
chr2_-_197991574 6.62 ENSRNOT00000085632
Ciart
circadian associated repressor of transcription
chr7_+_97559841 6.55 ENSRNOT00000007326
Zhx2
zinc fingers and homeoboxes 2
chr8_+_65686648 6.34 ENSRNOT00000017233
Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr10_+_92018562 5.99 ENSRNOT00000006483
Arf2
ADP-ribosylation factor 2
chr9_+_98073038 5.69 ENSRNOT00000026795
Mlph
melanophilin
chr5_-_25584278 5.49 ENSRNOT00000090579
ENSRNOT00000090376
Pdp1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr1_-_82452281 5.44 ENSRNOT00000027995
Bckdha
branched chain ketoacid dehydrogenase E1, alpha polypeptide
chr12_-_30566032 5.31 ENSRNOT00000093378
Gbas
glioblastoma amplified sequence
chr15_+_18399515 5.26 ENSRNOT00000071273
Fam107a
family with sequence similarity 107, member A
chr8_+_5893249 5.15 ENSRNOT00000014041
Mmp7
matrix metallopeptidase 7
chr8_+_40001030 5.08 ENSRNOT00000083778
Esam
endothelial cell adhesion molecule
chr19_-_44158621 5.05 ENSRNOT00000031243
ENSRNOT00000088297
Tmem231
transmembrane protein 231
chr13_-_70174565 5.02 ENSRNOT00000067135
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr2_+_142262236 4.98 ENSRNOT00000019057
Lhfp
lipoma HMGIC fusion partner
chr3_-_82236664 4.94 ENSRNOT00000011650
Tspan18
tetraspanin 18
chr13_-_90832138 4.92 ENSRNOT00000010930
Igsf9
immunoglobulin superfamily, member 9
chr14_+_77712240 4.78 ENSRNOT00000009101
Msx1
msh homeobox 1
chr16_+_48121430 4.71 ENSRNOT00000090839
Stox2
storkhead box 2
chr14_+_7169519 4.69 ENSRNOT00000003026
Klhl8
kelch-like family member 8
chr17_-_15511972 4.58 ENSRNOT00000074041
Aspnl1
asporin-like 1
chr14_-_80169431 4.51 ENSRNOT00000079769
ENSRNOT00000058315
Ablim2
actin binding LIM protein family, member 2
chr7_+_94795214 4.50 ENSRNOT00000005722
Deptor
DEP domain containing MTOR-interacting protein
chr17_-_13812615 4.41 ENSRNOT00000019473
ENSRNOT00000085581
S1pr3
sphingosine-1-phosphate receptor 3
chr7_-_126913585 4.35 ENSRNOT00000036025
Celsr1
cadherin, EGF LAG seven-pass G-type receptor 1
chr11_+_32211115 4.33 ENSRNOT00000087452
Mrps6
mitochondrial ribosomal protein S6
chr10_-_82852660 4.33 ENSRNOT00000005641
Pdk2
pyruvate dehydrogenase kinase 2
chr16_-_21348391 4.29 ENSRNOT00000083537
Lpar2
lysophosphatidic acid receptor 2
chr10_+_3338808 3.97 ENSRNOT00000004384
ENSRNOT00000093444
Mpv17l
MPV17 mitochondrial inner membrane protein like
chr5_-_161035368 3.96 ENSRNOT00000091640
AABR07050321.2

chr4_-_66002444 3.51 ENSRNOT00000018645
Zc3hav1l
zinc finger CCCH-type containing, antiviral 1 like
chr6_+_110624856 3.46 ENSRNOT00000014017
Vash1
vasohibin 1
chr7_+_27309966 3.30 ENSRNOT00000031871
Nt5dc3
5'-nucleotidase domain containing 3
chr9_-_113900190 3.18 ENSRNOT00000016965
Ndufv2
NADH:ubiquinone oxidoreductase core subunit V2
chr8_-_47393503 3.12 ENSRNOT00000059868
Arhgef12
Rho guanine nucleotide exchange factor 12
chr17_+_33408722 2.99 ENSRNOT00000023691
Gmds
GDP-mannose 4, 6-dehydratase
chr1_+_113034227 2.90 ENSRNOT00000081831
ENSRNOT00000077877
ENSRNOT00000077594
Gabrb3
gamma-aminobutyric acid type A receptor beta 3 subunit
chr9_+_80118029 2.74 ENSRNOT00000023068
Igfbp2
insulin-like growth factor binding protein 2
chr16_+_9563218 2.73 ENSRNOT00000035915
Arhgap22
Rho GTPase activating protein 22
chr18_-_56534415 2.71 ENSRNOT00000024374
Slc26a2
solute carrier family 26 member 2
chr7_+_122979021 2.66 ENSRNOT00000085707
Zc3h7b
zinc finger CCCH-type containing 7B
chr13_-_76049363 2.45 ENSRNOT00000075865
ENSRNOT00000007455
Brinp2
BMP/retinoic acid inducible neural specific 2
chr3_+_58084606 2.42 ENSRNOT00000084797
Metap1d
methionyl aminopeptidase type 1D (mitochondrial)
chr17_-_6244612 2.41 ENSRNOT00000042145
ENSRNOT00000090914
ENSRNOT00000082611
Ntrk2
neurotrophic receptor tyrosine kinase 2
chr7_-_123088279 2.40 ENSRNOT00000071998
Tob2
transducer of ERBB2, 2
chr3_-_51297852 2.33 ENSRNOT00000001607
Cobll1
cordon-bleu WH2 repeat protein-like 1
chr1_-_87937516 2.29 ENSRNOT00000087522
Eif3k
eukaryotic translation initiation factor 3, subunit K
chr5_-_160070916 2.24 ENSRNOT00000067517
ENSRNOT00000055791
Spen
spen family transcriptional repressor
chr9_-_15393131 2.22 ENSRNOT00000018523
ENSRNOT00000088314
Med20
mediator complex subunit 20
chr13_-_90832469 2.13 ENSRNOT00000086508
Igsf9
immunoglobulin superfamily, member 9
chr10_-_61744976 2.10 ENSRNOT00000079926
ENSRNOT00000092314
ENSRNOT00000034298
Sgsm2
small G protein signaling modulator 2
chr5_+_90419020 2.10 ENSRNOT00000058893
Rasef
RAS and EF hand domain containing
chr6_-_109162267 2.03 ENSRNOT00000077518
Nek9
NIMA-related kinase 9
chr7_+_77678968 1.98 ENSRNOT00000006917
Atp6v1c1
ATPase H+ transporting V1 subunit C1
chr3_-_168033457 1.98 ENSRNOT00000055111
Bcas1
breast carcinoma amplified sequence 1
chr10_+_61685241 1.97 ENSRNOT00000092606
Mnt
MAX network transcriptional repressor
chr3_+_119698652 1.96 ENSRNOT00000088834
ENSRNOT00000066114
Stard7
StAR-related lipid transfer domain containing 7
chr15_+_33108671 1.92 ENSRNOT00000015468
Lrp10
LDL receptor related protein 10
chr1_+_221673590 1.91 ENSRNOT00000038016
Cdc42bpg
CDC42 binding protein kinase gamma
chr5_+_156215417 1.88 ENSRNOT00000067616
ENSRNOT00000077742
Ece1
endothelin converting enzyme 1
chr8_+_56179637 1.85 ENSRNOT00000035989
Arhgap20
Rho GTPase activating protein 20
chr19_+_41710102 1.84 ENSRNOT00000021866
ENSRNOT00000079730
Marveld3
MARVEL domain containing 3
chr3_+_164822111 1.66 ENSRNOT00000014568
Pard6b
par-6 family cell polarity regulator beta
chr12_+_24761210 1.60 ENSRNOT00000002003
Cldn4
claudin 4
chr14_-_11198194 1.57 ENSRNOT00000003083
Enoph1
enolase-phosphatase 1
chr5_+_135735825 1.52 ENSRNOT00000068267
Zswim5
zinc finger, SWIM-type containing 5
chr9_+_20213776 1.42 ENSRNOT00000071439
LOC100911515
triosephosphate isomerase-like
chr10_-_81653717 1.37 ENSRNOT00000003611
Nme2
NME/NM23 nucleoside diphosphate kinase 2
chr3_-_156905892 1.32 ENSRNOT00000022424
Emilin3
elastin microfibril interfacer 3
chr16_+_71787966 1.29 ENSRNOT00000080084
Htra4
HtrA serine peptidase 4
chr1_+_86914137 1.19 ENSRNOT00000027006
Fbxo17
F-box protein 17
chr2_-_143104412 1.19 ENSRNOT00000058116
Ufm1
ubiquitin-fold modifier 1
chr15_-_33589522 1.08 ENSRNOT00000022514
Efs
embryonal Fyn-associated substrate
chr7_-_12779862 0.91 ENSRNOT00000080292
Tmem259
transmembrane protein 259
chr14_+_85351358 0.88 ENSRNOT00000031914
Rhbdd3
rhomboid domain containing 3
chr16_+_73564243 0.88 ENSRNOT00000030960
Golga7
golgin A7
chr7_-_11330278 0.86 ENSRNOT00000027730
Matk
megakaryocyte-associated tyrosine kinase
chr15_+_58554374 0.84 ENSRNOT00000058206
Tsc22d1
TSC22 domain family, member 1
chr3_+_175408629 0.80 ENSRNOT00000081344
Lsm14b
LSM family member 14B
chr7_+_80351774 0.73 ENSRNOT00000081948
Oxr1
oxidation resistance 1
chr3_+_134413170 0.53 ENSRNOT00000074338
AABR07054000.1

chr5_-_173339890 0.50 ENSRNOT00000067704
ENSRNOT00000078453
Pusl1
pseudouridylate synthase-like 1
chr4_-_98593664 0.50 ENSRNOT00000007927
Rpia
ribose 5-phosphate isomerase A
chr9_-_37231291 0.50 ENSRNOT00000016237
Ptp4a1
protein tyrosine phosphatase type IVA, member 1
chr9_+_66495832 0.39 ENSRNOT00000022676
ENSRNOT00000091283
Nop58
NOP58 ribonucleoprotein
chr1_-_221087449 0.35 ENSRNOT00000016987
Fam89b
family with sequence similarity 89, member B
chr6_+_73345392 0.33 ENSRNOT00000088378
Arhgap5
Rho GTPase activating protein 5
chr1_-_112947399 0.24 ENSRNOT00000093306
ENSRNOT00000093259
Gabra5
gamma-aminobutyric acid type A receptor alpha 5 subunit
chr1_-_200163106 0.19 ENSRNOT00000027644
Mcmbp
minichromosome maintenance complex binding protein
chr10_+_62674561 0.17 ENSRNOT00000019946
ENSRNOT00000056110
Ankrd13b
ankyrin repeat domain 13B
chr6_-_92527711 0.13 ENSRNOT00000007529
Nin
ninein
chr7_-_97944491 0.11 ENSRNOT00000008454
Zhx1
zinc fingers and homeoboxes 1
chr19_+_25123724 0.08 ENSRNOT00000007407
LOC686013
hypothetical protein LOC686013
chr4_+_6559545 0.03 ENSRNOT00000067183
Prkag2
protein kinase AMP-activated non-catalytic subunit gamma 2
chr9_+_94880053 0.01 ENSRNOT00000024445
Atg16l1
autophagy related 16-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hey2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 34.0 GO:0030070 insulin processing(GO:0030070) negative regulation of branching morphogenesis of a nerve(GO:2000173)
5.7 17.0 GO:1903233 positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233) calcium ion import into sarcoplasmic reticulum(GO:1990036)
3.9 11.7 GO:0019541 acetate metabolic process(GO:0006083) propionate metabolic process(GO:0019541)
2.2 8.7 GO:1902896 terminal web assembly(GO:1902896)
1.7 5.2 GO:0002777 antimicrobial peptide biosynthetic process(GO:0002777) antibacterial peptide biosynthetic process(GO:0002780)
1.6 9.6 GO:0045901 regulation of translational termination(GO:0006449) positive regulation of translational elongation(GO:0045901)
1.6 4.8 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of mesenchymal cell apoptotic process(GO:2001055)
1.6 15.5 GO:0055064 chloride ion homeostasis(GO:0055064)
1.5 10.3 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
1.5 4.4 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
1.1 4.3 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
1.0 3.0 GO:0042350 GDP-L-fucose biosynthetic process(GO:0042350)
1.0 4.0 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.9 3.5 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.9 13.8 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.8 7.5 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.8 2.4 GO:0070084 protein initiator methionine removal(GO:0070084)
0.7 9.0 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.7 2.1 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.7 9.1 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.6 1.9 GO:0010813 neuropeptide catabolic process(GO:0010813)
0.6 15.1 GO:0045475 locomotor rhythm(GO:0045475)
0.5 15.2 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.4 5.4 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.4 11.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.4 4.4 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.4 5.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.3 4.5 GO:0045792 negative regulation of cell size(GO:0045792)
0.3 6.3 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.3 2.4 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.3 15.7 GO:0001893 maternal placenta development(GO:0001893)
0.3 1.6 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.3 8.0 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.2 1.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.2 5.7 GO:0032400 melanosome localization(GO:0032400)
0.2 2.9 GO:0071420 cellular response to histamine(GO:0071420)
0.2 1.8 GO:1902414 protein localization to cell junction(GO:1902414)
0.2 10.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 1.4 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.2 0.4 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.2 2.7 GO:1902358 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.1 3.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 2.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.1 0.5 GO:0006014 D-ribose metabolic process(GO:0006014)
0.1 0.9 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.1 0.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 2.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 0.5 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 4.6 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 2.4 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.1 12.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.4 GO:0048254 snoRNA localization(GO:0048254)
0.1 0.7 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 5.1 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.1 1.4 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 4.1 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 0.9 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.1 2.0 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 1.1 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 6.7 GO:0090002 establishment of protein localization to plasma membrane(GO:0090002)
0.0 2.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 4.2 GO:0030509 BMP signaling pathway(GO:0030509)
0.0 2.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 13.4 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 1.9 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.3 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.0 1.2 GO:0007569 cell aging(GO:0007569)
0.0 0.1 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 1.6 GO:0048839 inner ear development(GO:0048839)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.0 GO:0090534 longitudinal sarcoplasmic reticulum(GO:0014801) calcium ion-transporting ATPase complex(GO:0090534)
2.2 8.7 GO:0036398 TCR signalosome(GO:0036398) microspike(GO:0044393)
2.1 34.0 GO:0031045 dense core granule(GO:0031045)
1.4 4.3 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
1.3 6.3 GO:0043293 apoptosome(GO:0043293)
1.1 5.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.6 5.7 GO:0016461 unconventional myosin complex(GO:0016461)
0.4 9.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.4 2.0 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.3 1.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 5.1 GO:0036038 MKS complex(GO:0036038)
0.3 2.3 GO:0033290 eukaryotic 43S preinitiation complex(GO:0016282) eukaryotic 48S preinitiation complex(GO:0033290)
0.3 9.9 GO:0060077 inhibitory synapse(GO:0060077)
0.2 19.9 GO:0005884 actin filament(GO:0005884)
0.1 4.6 GO:0046930 pore complex(GO:0046930)
0.1 0.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 2.2 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 1.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 4.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 3.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.4 GO:0070761 pre-snoRNP complex(GO:0070761)
0.1 2.4 GO:0048786 presynaptic active zone(GO:0048786)
0.0 14.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.2 GO:0016592 mediator complex(GO:0016592)
0.0 7.2 GO:0030139 endocytic vesicle(GO:0030139)
0.0 5.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 7.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.1 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 5.1 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 4.5 GO:0030016 myofibril(GO:0030016)
0.0 0.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 2.7 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.9 GO:0045177 apical part of cell(GO:0045177)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.8 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
2.9 11.7 GO:0003987 acetate-CoA ligase activity(GO:0003987)
2.8 34.0 GO:0050897 cobalt ion binding(GO:0050897)
1.8 5.5 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
1.8 9.0 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
1.4 25.7 GO:0044548 S100 protein binding(GO:0044548)
1.3 7.5 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
1.2 15.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
1.1 15.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
1.1 4.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.0 5.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.8 10.3 GO:0048185 activin binding(GO:0048185)
0.6 5.4 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.6 3.0 GO:0070401 NADP+ binding(GO:0070401)
0.5 2.4 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.5 1.4 GO:0004807 triose-phosphate isomerase activity(GO:0004807)
0.4 4.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.4 9.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 2.9 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.3 9.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 15.1 GO:0070888 E-box binding(GO:0070888)
0.3 2.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 7.1 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.2 2.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 2.4 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 4.6 GO:0015288 porin activity(GO:0015288)
0.2 3.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 2.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 1.4 GO:0004673 protein histidine kinase activity(GO:0004673)
0.2 10.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.9 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 12.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 2.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.8 GO:0031489 myosin V binding(GO:0031489)
0.1 2.3 GO:0003785 actin monomer binding(GO:0003785)
0.1 11.5 GO:0030165 PDZ domain binding(GO:0030165)
0.1 0.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 7.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 8.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 7.2 GO:0051015 actin filament binding(GO:0051015)
0.0 2.3 GO:0043022 ribosome binding(GO:0043022)
0.0 0.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 6.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 1.9 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 4.5 GO:0003779 actin binding(GO:0003779)
0.0 2.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.3 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.0 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.2 GO:0001948 glycoprotein binding(GO:0001948)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 33.4 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.4 11.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.3 8.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.2 8.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.2 9.1 PID IGF1 PATHWAY IGF1 pathway
0.2 10.3 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.2 10.3 PID BMP PATHWAY BMP receptor signaling
0.2 4.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.2 7.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 4.5 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 3.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 2.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 4.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 11.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
1.3 33.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.9 17.0 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.7 9.8 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.6 9.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.5 15.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.4 9.6 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.3 5.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.3 8.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 5.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 2.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 9.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 3.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 3.1 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 11.5 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 1.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 5.1 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 7.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 3.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 2.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.9 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 4.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 2.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.2 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane