ISMARA results: Hey1_Myc

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hey1_Myc_Mxi1

Z-value: 1.01

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Transcription factors associated with Hey1_Myc_Mxi1

Gene Symbol	Gene ID	Gene Info
Hey1 NCBI RGD Ensembl	ENSRNOG00000011593	hes-related family bHLH transcription factor with YRPW motif 1
Myc NCBI RGD Ensembl	ENSRNOG00000004500	myelocytomatosis oncogene
Mxi1 NCBI RGD Ensembl	ENSRNOG00000034078	MAX interactor 1, dimerization protein

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hey1	rn6_v1_chr2_+_95320283_95320283	-0.48	1.0e-19	Click!
Mxi1	rn6_v1_chr1_+_274030978_274030978	-0.27	6.3e-07	Click!
Myc	rn6_v1_chr7_+_102588369_102588369	-0.09	1.1e-01	Click!

Activity profile of Hey1_Myc_Mxi1 motif

Sorted Z-values of Hey1_Myc_Mxi1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_219759183 Show fit	33.39	ENSRNOT00000026316	Pc NCBI RGD Ensembl Show fit	pyruvate carboxylase
chr20_-_10386663 Show fit	22.39	ENSRNOT00000045275 ENSRNOT00000042432	Cbs NCBI RGD Ensembl Show fit	cystathionine beta synthase
chr3_+_113415774 Show fit	22.25	ENSRNOT00000056151	Serf2 NCBI RGD Ensembl Show fit	small EDRK-rich factor 2
chr8_-_115140080 Show fit	21.45	ENSRNOT00000015851	Acy1 NCBI RGD Ensembl Show fit	aminoacylase 1
chr7_-_73270308 Show fit	21.34	ENSRNOT00000007430	Rida NCBI RGD Ensembl Show fit	reactive intermediate imine deaminase A homolog
chr4_-_157679962 Show fit	21.13	ENSRNOT00000050443	Gapdh NCBI RGD Ensembl Show fit	glyceraldehyde-3-phosphate dehydrogenase
chr9_-_61690956 Show fit	19.01	ENSRNOT00000066589	Hspd1 NCBI RGD Ensembl Show fit	heat shock protein family D member 1
chr5_+_165405168 Show fit	18.06	ENSRNOT00000014934	Srm NCBI RGD Ensembl Show fit	spermidine synthase
chr1_+_247228061 Show fit	16.95	ENSRNOT00000020809	Rcl1 NCBI RGD Ensembl Show fit	RNA terminal phosphate cyclase-like 1
chr8_+_85059051 Show fit	16.47	ENSRNOT00000033196	Gclc NCBI RGD Ensembl Show fit	glutamate-cysteine ligase, catalytic subunit

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hey1_Myc_Mxi1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
12.8	38.4	GO:0019343	cysteine biosynthetic process via cystathionine(GO:0019343)
6.7	33.6	GO:0008295	spermidine biosynthetic process(GO:0008295)
8.3	33.4	GO:0019072	viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
4.3	25.8	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
1.0	22.7	GO:0045475	locomotor rhythm(GO:0045475)
0.5	22.7	GO:1903959	regulation of anion transmembrane transport(GO:1903959)
7.3	21.8	GO:0045041	protein import into mitochondrial intermembrane space(GO:0045041)
2.4	21.4	GO:0070314	G1 to G0 transition(GO:0070314)
7.0	21.1	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
2.6	18.0	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)

Showing 1 to 10 of 513 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	142.1	GO:0005739	mitochondrion(GO:0005739)
0.4	110.2	GO:0005759	mitochondrial matrix(GO:0005759)
0.2	72.1	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.2	34.9	GO:0031966	mitochondrial membrane(GO:0031966)
0.5	34.7	GO:0031901	early endosome membrane(GO:0031901)
0.6	32.3	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
2.9	23.0	GO:0097452	GAIT complex(GO:0097452)
3.8	19.0	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.3	19.0	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.6	18.2	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)

Showing 1 to 10 of 204 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	65.5	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.8	37.9	GO:0016881	acid-amino acid ligase activity(GO:0016881)
11.1	33.4	GO:0004736	pyruvate carboxylase activity(GO:0004736)
0.7	32.4	GO:0070888	E-box binding(GO:0070888)
1.4	28.4	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.4	24.1	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1	23.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	23.4	GO:0004930	G-protein coupled receptor activity(GO:0004930)
3.2	22.4	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
2.2	22.1	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)

Showing 1 to 10 of 341 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	68.7	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.6	34.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.9	21.1	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.5	15.9	PID IFNG PATHWAY	IFN-gamma pathway
0.6	14.5	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.7	14.3	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.3	12.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.6	10.8	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.3	10.8	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.3	9.7	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2

Showing 1 to 10 of 64 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	59.7	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
2.2	47.5	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
1.0	44.7	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
1.9	33.4	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
1.8	27.7	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
2.1	24.9	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.9	24.5	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.7	24.2	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.6	23.4	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.3	23.0	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway

Showing 1 to 10 of 126 entries

Results for Hey1_Myc_Mxi1

Z-value: 1.01

Motif logo

Transcription factors associated with Hey1_Myc_Mxi1

Activity-expression correlation:

Activity profile of Hey1_Myc_Mxi1 motif

Sorted Z-values of Hey1_Myc_Mxi1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hey1_Myc_Mxi1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: