ISMARA results: Hdx

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hdx

Z-value: 0.85

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Transcription factors associated with Hdx

Gene Symbol	Gene ID	Gene Info
Hdx NCBI RGD Ensembl	ENSRNOG00000037799	highly divergent homeobox

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hdx	rn6_v1_chrX_-_82986051_82986051	-0.10	6.7e-02	Click!

Activity profile of Hdx motif

Sorted Z-values of Hdx motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_8489266 Show fit	20.12	ENSRNOT00000016252	Lect2 NCBI RGD Ensembl Show fit	leukocyte cell-derived chemotaxin 2
chr2_-_28799266 Show fit	19.06	ENSRNOT00000089293	Tmem171 NCBI RGD Ensembl Show fit	transmembrane protein 171
chr14_+_13751231 Show fit	18.63	ENSRNOT00000044244	Gk2 NCBI RGD Ensembl Show fit	glycerol kinase 2
chr9_+_23503236 Show fit	17.28	ENSRNOT00000017996	Crisp2 NCBI RGD Ensembl Show fit	cysteine-rich secretory protein 2
chrX_-_32153794 Show fit	17.21	ENSRNOT00000005348	Tmem27 NCBI RGD Ensembl Show fit	transmembrane protein 27
chr9_+_4817854 Show fit	16.60	ENSRNOT00000040879	LOC100910526 NCBI RGD Ensembl Show fit	sulfotransferase 1C2-like
chr2_+_200785507 Show fit	16.11	ENSRNOT00000046942	Hao2 NCBI RGD Ensembl Show fit	hydroxyacid oxidase 2
chr4_-_128266082 Show fit	15.77	ENSRNOT00000039549	Nup50 NCBI RGD Ensembl Show fit	nucleoporin 50
chr1_-_54036068 Show fit	15.12	ENSRNOT00000075019	RGD1560718 NCBI RGD Ensembl Show fit	similar to putative protein kinase
chr16_+_68633720 Show fit	14.83	ENSRNOT00000081838	LOC100911229 NCBI RGD Ensembl Show fit	sperm motility kinase-like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hdx

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	133.4	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
1.8	36.7	GO:0035404	histone-serine phosphorylation(GO:0035404)
1.7	26.4	GO:0051923	sulfation(GO:0051923)
0.1	20.1	GO:0030178	negative regulation of Wnt signaling pathway(GO:0030178)
6.2	18.6	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
1.9	17.2	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
5.4	16.1	GO:0018924	mandelate metabolic process(GO:0018924)
1.1	15.9	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.1	15.7	GO:0001841	neural tube formation(GO:0001841)
4.2	12.7	GO:0061215	mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)

Showing 1 to 10 of 105 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	69.5	GO:0016021	integral component of membrane(GO:0016021)
2.0	36.7	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.2	29.8	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.0	26.7	GO:0005739	mitochondrion(GO:0005739)
0.4	16.9	GO:0043034	costamere(GO:0043034)
1.3	13.9	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.2	13.8	GO:0031526	brush border membrane(GO:0031526)
0.2	12.3	GO:0005643	nuclear pore(GO:0005643)
0.1	8.8	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.6	8.5	GO:0043202	lysosomal lumen(GO:0043202)

Showing 1 to 10 of 62 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	131.2	GO:0004984	olfactory receptor activity(GO:0004984)
2.4	36.7	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
6.2	18.6	GO:0004370	glycerol kinase activity(GO:0004370)
0.3	16.6	GO:0008146	sulfotransferase activity(GO:0008146)
3.3	16.4	GO:0005550	pheromone binding(GO:0005550)
5.4	16.1	GO:0052853	very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.5	15.8	GO:0008536	Ran GTPase binding(GO:0008536)
3.6	14.6	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.3	13.7	GO:0070330	aromatase activity(GO:0070330)
0.2	13.0	GO:0005160	transforming growth factor beta receptor binding(GO:0005160)

Showing 1 to 10 of 90 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	18.8	PID CMYB PATHWAY	C-MYB transcription factor network
0.2	12.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	12.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	9.9	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	7.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	6.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	4.7	PID IGF1 PATHWAY	IGF1 pathway
0.1	4.6	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	4.2	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.1	4.2	PID ATR PATHWAY	ATR signaling pathway

Showing 1 to 10 of 18 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	12.3	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.3	12.3	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
1.1	11.1	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.6	10.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.8	9.8	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
1.1	9.6	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.3	9.3	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.3	9.2	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.5	8.5	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.8	7.6	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism

Showing 1 to 10 of 35 entries

Results for Hdx

Z-value: 0.85

Motif logo

Transcription factors associated with Hdx

Activity-expression correlation:

Activity profile of Hdx motif

Sorted Z-values of Hdx motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hdx

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: