ISMARA results: Hbp1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hbp1

Z-value: 0.89

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Transcription factors associated with Hbp1

Gene Symbol	Gene ID	Gene Info
Hbp1 NCBI RGD Ensembl	ENSRNOG00000008927	HMG-box transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hbp1	rn6_v1_chr6_-_51257625_51257625	-0.50	4.2e-22	Click!

Activity profile of Hbp1 motif

Sorted Z-values of Hbp1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_114423533 Show fit	26.24	ENSRNOT00000091221	Slc2a2 NCBI RGD Ensembl Show fit	solute carrier family 2 member 2
chr2_+_23289374 Show fit	17.66	ENSRNOT00000090666 ENSRNOT00000032783	Dmgdh NCBI RGD Ensembl Show fit	dimethylglycine dehydrogenase
chr9_+_4817854 Show fit	17.00	ENSRNOT00000040879	LOC100910526 NCBI RGD Ensembl Show fit	sulfotransferase 1C2-like
chr4_+_154215250 Show fit	16.16	ENSRNOT00000072465	Mug2 NCBI RGD Ensembl Show fit	murinoglobulin 2
chr1_-_13915594 Show fit	15.67	ENSRNOT00000015927	Arfgef3 NCBI RGD Ensembl Show fit	ARFGEF family member 3
chr4_+_65110746 Show fit	15.44	ENSRNOT00000017675	Akr1d1 NCBI RGD Ensembl Show fit	aldo-keto reductase family 1, member D1
chr9_-_26707571 Show fit	15.27	ENSRNOT00000080948	AABR07067023.1 NCBI RGD Ensembl Show fit
chrX_+_107496072 Show fit	14.66	ENSRNOT00000003283	Plp1 NCBI RGD Ensembl Show fit	proteolipid protein 1
chrX_-_13601069 Show fit	14.61	ENSRNOT00000004686	Otc NCBI RGD Ensembl Show fit	ornithine carbamoyltransferase
chr1_+_83714347 Show fit	13.72	ENSRNOT00000085245	Cyp2a1 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily a, polypeptide 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hbp1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	163.8	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
3.9	46.8	GO:0019627	urea metabolic process(GO:0019627)
1.8	38.5	GO:0019373	epoxygenase P450 pathway(GO:0019373)
1.9	30.4	GO:0051923	sulfation(GO:0051923)
5.2	26.2	GO:0015755	carbohydrate utilization(GO:0009758) fructose transport(GO:0015755)
0.6	22.7	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
3.1	21.4	GO:0009804	coumarin metabolic process(GO:0009804)
0.1	19.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.4	19.1	GO:0006707	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
1.7	18.8	GO:0006957	complement activation, alternative pathway(GO:0006957)

Showing 1 to 10 of 311 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	76.6	GO:0016021	integral component of membrane(GO:0016021)
0.4	46.4	GO:0072562	blood microparticle(GO:0072562)
0.1	39.2	GO:0005759	mitochondrial matrix(GO:0005759)
0.4	34.6	GO:0031526	brush border membrane(GO:0031526)
0.3	30.7	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.0	27.6	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
3.7	25.9	GO:0005579	membrane attack complex(GO:0005579)
0.0	17.9	GO:0005887	integral component of plasma membrane(GO:0005887)
0.4	17.8	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	17.4	GO:0055037	recycling endosome(GO:0055037)

Showing 1 to 10 of 148 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	163.8	GO:0004984	olfactory receptor activity(GO:0004984)
2.7	73.3	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
1.6	48.1	GO:0015020	glucuronosyltransferase activity(GO:0015020)
2.9	26.2	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
3.4	23.6	GO:0004062	aryl sulfotransferase activity(GO:0004062)
1.4	21.7	GO:0005542	folic acid binding(GO:0005542)
0.2	21.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.2	20.9	GO:0005523	tropomyosin binding(GO:0005523)
0.4	20.4	GO:0008146	sulfotransferase activity(GO:0008146)
6.4	19.1	GO:0047787	delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)

Showing 1 to 10 of 218 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	31.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.6	12.3	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.3	12.0	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.6	11.9	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	7.1	PID RAS PATHWAY	Regulation of Ras family activation
0.2	7.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	6.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	4.9	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2	4.7	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1	4.3	PID AURORA A PATHWAY	Aurora A signaling

Showing 1 to 10 of 40 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	35.5	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
1.6	26.8	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.7	25.9	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.4	24.1	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
0.3	22.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	20.4	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.2	19.9	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
1.6	19.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.5	19.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.2	17.6	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides

Showing 1 to 10 of 71 entries

Results for Hbp1

Z-value: 0.89

Motif logo

Transcription factors associated with Hbp1

Activity-expression correlation:

Activity profile of Hbp1 motif

Sorted Z-values of Hbp1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hbp1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: