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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Grhl1
Z-value: 1.15
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Transcription factors associated with Grhl1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Grhl1 | rn6_v1_chr6_+_43743702_43743702 | -0.17 | 3.1e-03 | Click! |
Top targets:  
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_-_28428117 Show fit | 72.38 |
ENSRNOT00000078202
|
solute carrier family 23 member 1 |
|
| chr3_-_10371240 Show fit | 59.99 |
ENSRNOT00000012075
|
argininosuccinate synthase 1 |
|
| chr2_-_187909394 Show fit | 55.05 |
ENSRNOT00000032355
|
RAB25, member RAS oncogene family |
|
| chr1_+_214328071 Show fit | 49.01 |
ENSRNOT00000024725
|
EPS8-like 2 |
|
| chr9_+_95295701 Show fit | 42.34 |
ENSRNOT00000025045
|
UDP glucuronosyltransferase family 1 member A5 |
|
| chr4_-_98342887 Show fit | 38.89 |
ENSRNOT00000010156
|
tumor-associated calcium signal transducer 2 |
|
| chr12_-_23661009 Show fit | 33.56 |
ENSRNOT00000059451
|
uroplakin 3B-like |
|
| chr13_+_52645257 Show fit | 33.34 |
ENSRNOT00000012801
|
ladinin 1 |
|
| chr3_-_120106697 Show fit | 28.00 |
ENSRNOT00000020354
|
prominin 2 |
|
| chr8_+_47674321 Show fit | 26.73 |
ENSRNOT00000026170
ENSRNOT00000078776 |
tripartite motif-containing 29 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Grhl1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.1 | 72.4 | GO:0015882 | L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904) |
| 20.0 | 60.0 | GO:0000053 | argininosuccinate metabolic process(GO:0000053) |
| 2.6 | 55.1 | GO:0031268 | pseudopodium organization(GO:0031268) |
| 4.9 | 49.0 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 4.7 | 42.3 | GO:0052697 | xenobiotic glucuronidation(GO:0052697) |
| 7.8 | 38.9 | GO:0090191 | negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191) |
| 5.6 | 28.0 | GO:0048550 | negative regulation of pinocytosis(GO:0048550) |
| 0.3 | 26.7 | GO:1900181 | negative regulation of protein localization to nucleus(GO:1900181) |
| 0.6 | 26.3 | GO:0048013 | ephrin receptor signaling pathway(GO:0048013) |
| 0.9 | 26.2 | GO:0006706 | steroid catabolic process(GO:0006706) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 136.5 | GO:0016021 | integral component of membrane(GO:0016021) |
| 2.0 | 111.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 3.7 | 60.0 | GO:0070852 | cell body fiber(GO:0070852) |
| 4.2 | 55.1 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.5 | 49.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.3 | 33.3 | GO:0005604 | basement membrane(GO:0005604) |
| 7.0 | 28.0 | GO:0071914 | microspike(GO:0044393) prominosome(GO:0071914) |
| 0.2 | 23.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 1.0 | 22.6 | GO:0030057 | desmosome(GO:0030057) |
| 1.4 | 18.8 | GO:0046581 | intercellular canaliculus(GO:0046581) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.1 | 72.4 | GO:0070890 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 3.2 | 60.0 | GO:0015643 | toxic substance binding(GO:0015643) |
| 2.2 | 55.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 2.2 | 49.0 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 1.4 | 42.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 31.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 28.4 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.6 | 28.0 | GO:0015485 | cholesterol binding(GO:0015485) |
| 1.3 | 26.7 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 8.7 | 26.2 | GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 23.4 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 16.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 9.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 9.2 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.4 | 4.0 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.1 | 2.9 | PID EPHB FWD PATHWAY | EPHB forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 72.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.3 | 60.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 2.2 | 42.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.4 | 18.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.7 | 18.3 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.5 | 16.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 9.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.4 | 9.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.9 | 8.6 | REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.1 | 4.6 | REACTOME AMYLOIDS | Genes involved in Amyloids |