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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Glis2
Z-value: 0.90
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Transcription factors associated with Glis2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Glis2 | rn6_v1_chr10_-_11174861_11174861 | -0.25 | 6.2e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_30791422 Show fit | 31.99 |
ENSRNOT00000047394
ENSRNOT00000000683 |
thymus, brain and testes associated |
|
| chr14_-_78377825 Show fit | 23.71 |
ENSRNOT00000068104
|
|
|
| chr6_-_138250089 Show fit | 19.45 |
ENSRNOT00000048378
|
immunoglobulin heavy constant mu |
|
| chr12_+_9360672 Show fit | 16.93 |
ENSRNOT00000088957
|
fms-related tyrosine kinase 3 |
|
| chr20_-_1980101 Show fit | 16.13 |
ENSRNOT00000084582
ENSRNOT00000085050 ENSRNOT00000082545 ENSRNOT00000088396 |
gamma-aminobutyric acid type B receptor subunit 1 |
|
| chr7_-_119768082 Show fit | 15.82 |
ENSRNOT00000009612
|
somatostatin receptor 3 |
|
| chr12_+_25119355 Show fit | 15.79 |
ENSRNOT00000034629
|
linker for activation of T cells family, member 2 |
|
| chr15_-_54906203 Show fit | 15.62 |
ENSRNOT00000020186
|
cysteinyl leukotriene receptor 2 |
|
| chr17_-_44840131 Show fit | 15.34 |
ENSRNOT00000083417
|
histone cluster 1, H3b |
|
| chr3_+_148579920 Show fit | 15.02 |
ENSRNOT00000012432
|
HCK proto-oncogene, Src family tyrosine kinase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Glis2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 16.9 | GO:0002572 | pro-T cell differentiation(GO:0002572) |
| 2.7 | 16.1 | GO:0014053 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) |
| 2.6 | 15.8 | GO:0038170 | somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170) |
| 2.6 | 15.6 | GO:0061737 | leukotriene signaling pathway(GO:0061737) |
| 0.4 | 15.6 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.7 | 15.0 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 3.6 | 14.3 | GO:0034240 | negative regulation of macrophage fusion(GO:0034240) |
| 0.5 | 13.8 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 0.3 | 12.5 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.4 | 11.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 30.4 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 23.6 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 20.2 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.7 | 19.6 | GO:0042629 | mast cell granule(GO:0042629) |
| 5.4 | 16.1 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.4 | 15.8 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.2 | 15.3 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 14.6 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 1.0 | 14.5 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 55.5 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.5 | 25.2 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 4.0 | 16.1 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 2.6 | 15.8 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.5 | 15.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 3.1 | 15.6 | GO:0004974 | leukotriene receptor activity(GO:0004974) |
| 0.1 | 15.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.2 | 14.3 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.5 | 12.5 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.2 | 12.4 | GO:0030295 | protein kinase activator activity(GO:0030295) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 25.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.4 | 25.3 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.4 | 24.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.3 | 15.6 | PID ENDOTHELIN PATHWAY | Endothelins |
| 1.0 | 14.3 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.4 | 13.0 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.2 | 11.8 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.5 | 10.4 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.3 | 9.2 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.3 | 9.1 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.5 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.7 | 16.1 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 1.1 | 15.6 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.6 | 15.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.7 | 15.0 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 1.1 | 14.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 14.5 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.1 | 14.3 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.3 | 13.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.7 | 12.5 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |