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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Gli3_Zic1

Z-value: 1.24

Motif logo

Transcription factors associated with Gli3_Zic1

Gene Symbol Gene ID Gene Info
ENSRNOG00000014395 GLI family zinc finger 3
ENSRNOG00000014644 Zic family member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zic1rn6_v1_chr8_-_98738446_987384460.677.4e-43Click!
Gli3rn6_v1_chr17_-_52477575_524775750.625.8e-35Click!

Activity profile of Gli3_Zic1 motif

Sorted Z-values of Gli3_Zic1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_170397191 78.31 ENSRNOT00000090181
amyloid beta precursor protein binding family B member 1
chrX_+_71199491 69.92 ENSRNOT00000076168
ENSRNOT00000005077
ENSRNOT00000005102
neuroligin 3
chr10_-_27179254 64.87 ENSRNOT00000004619
gamma-aminobutyric acid type A receptor gamma 2 subunit
chr3_+_154043873 59.06 ENSRNOT00000072502
ENSRNOT00000034166
neuronatin
chr7_-_136853957 58.08 ENSRNOT00000008985
neural EGFL like 2
chr10_+_20320878 45.80 ENSRNOT00000009714
slit guidance ligand 3
chr8_+_55178289 44.60 ENSRNOT00000059127
crystallin, alpha B
chr2_-_29768750 43.57 ENSRNOT00000023460
microtubule-associated protein 1B
chr10_-_14937336 40.03 ENSRNOT00000025494
SRY box 8
chr2_-_172459165 39.00 ENSRNOT00000057473
schwannomin interacting protein 1
chr10_+_89089646 38.14 ENSRNOT00000027505
contactin associated protein 1
chr9_+_118842787 37.44 ENSRNOT00000090512
DLG associated protein 1
chr16_+_54332660 35.12 ENSRNOT00000037685
microtubule associated tumor suppressor 1
chr7_-_93502571 35.05 ENSRNOT00000077033
ENSRNOT00000076080
sterile alpha motif domain containing 12
chr5_-_17061361 33.18 ENSRNOT00000089318
proenkephalin
chr7_-_119441487 33.02 ENSRNOT00000067635
parvalbumin
chr8_-_59239954 32.37 ENSRNOT00000016104
acyl-CoA synthetase bubblegum family member 1
chrX_-_106747303 31.64 ENSRNOT00000073529
transcription elongation factor A like 5
chr4_-_133951264 31.08 ENSRNOT00000090506
PDZ domain containing RING finger 3
chr2_-_115836846 30.58 ENSRNOT00000014359
claudin 11
chr8_-_55177818 30.48 ENSRNOT00000013960
heat shock protein family B (small) member 2
chr1_+_221756286 29.70 ENSRNOT00000028636
glycogen phosphorylase, muscle associated
chr1_+_113034227 29.51 ENSRNOT00000081831
ENSRNOT00000077877
ENSRNOT00000077594
gamma-aminobutyric acid type A receptor beta 3 subunit
chr17_-_18592750 29.49 ENSRNOT00000065742
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr7_-_12326392 29.46 ENSRNOT00000039728
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chrX_+_6791136 29.10 ENSRNOT00000003984
norrin-like
chr10_+_86669233 28.15 ENSRNOT00000012340
thyroid hormone receptor alpha
chr5_+_140923914 27.54 ENSRNOT00000020929
hes-related family bHLH transcription factor with YRPW motif-like
chr4_+_153774486 23.05 ENSRNOT00000074096
tubulin, alpha 8
chr13_+_70379346 23.04 ENSRNOT00000038183
nicotinamide nucleotide adenylyltransferase 2
chr6_-_27190126 22.98 ENSRNOT00000068412
ENSRNOT00000013107
potassium two pore domain channel subfamily K member 3
chr7_-_135630654 22.83 ENSRNOT00000047388
ENSRNOT00000088223
ENSRNOT00000074793
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr16_-_39476384 22.68 ENSRNOT00000092968
glycoprotein m6a
chr5_+_18901039 22.56 ENSRNOT00000012066
family with sequence similarity 110, member B
chrX_+_20216587 22.19 ENSRNOT00000073114
FYVE, RhoGEF and PH domain-containing protein 1
chrX_-_63809861 21.60 ENSRNOT00000009870
MAGE family member D1
chr1_-_215834704 21.29 ENSRNOT00000073850
insulin-like growth factor 2
chr1_-_216080287 21.16 ENSRNOT00000027682
tyrosine hydroxylase
chr11_+_75905443 21.11 ENSRNOT00000002650
fibroblast growth factor 12
chr20_-_1980101 20.84 ENSRNOT00000084582
ENSRNOT00000085050
ENSRNOT00000082545
ENSRNOT00000088396
gamma-aminobutyric acid type B receptor subunit 1
chr1_-_220467159 20.78 ENSRNOT00000075365
transmembrane protein 151A
chr16_-_39476025 20.70 ENSRNOT00000014312
glycoprotein m6a
chr1_-_188097530 20.22 ENSRNOT00000078825
synaptotagmin 17
chr8_+_65686648 19.85 ENSRNOT00000017233
uveal autoantigen with coiled-coil domains and ankyrin repeats
chrX_-_15553720 19.82 ENSRNOT00000012646
GRIP1 associated protein 1
chr10_+_91710495 19.67 ENSRNOT00000033276
reprimo-like
chr8_-_49045154 19.34 ENSRNOT00000088034
pleckstrin homology-like domain, family B, member 1
chr6_+_137997335 19.16 ENSRNOT00000006872
transmembrane protein 121
chr16_+_21288876 18.99 ENSRNOT00000027990
cartilage intermediate layer protein 2
chr8_+_119030875 18.59 ENSRNOT00000028458
myosin light chain 3
chr12_+_43940929 18.44 ENSRNOT00000001486
ring finger protein, transmembrane 2
chr5_+_140870140 18.24 ENSRNOT00000074347
hippocalcin-like 4
chr20_+_3830376 18.20 ENSRNOT00000085547
collagen type XI alpha 2 chain
chr4_-_145487426 17.94 ENSRNOT00000013488
ER membrane protein complex subunit 3
chr8_+_44136496 17.71 ENSRNOT00000087022
sodium voltage-gated channel beta subunit 3
chr5_-_65073012 17.48 ENSRNOT00000007957
glutamate ionotropic receptor NMDA type subunit 3A
chr8_+_119566509 17.28 ENSRNOT00000028633
tetratricopeptide repeat and ankyrin repeat containing 1
chr6_+_27768943 17.00 ENSRNOT00000015820
kinesin family member 3C
chr3_+_14482388 16.58 ENSRNOT00000025857
gelsolin
chr1_-_176607466 16.44 ENSRNOT00000022984
polypeptide N-acetylgalactosaminyltransferase 18
chr9_-_114619711 15.99 ENSRNOT00000050012
microtubule crosslinking factor 1
chr3_+_11593655 15.74 ENSRNOT00000074122
phosphatidylinositol-4-phosphate 5-kinase-like 1
chr5_+_135962911 15.71 ENSRNOT00000087353
patched 2
chr1_-_212548730 15.48 ENSRNOT00000089729
calcyon neuron-specific vesicular protein
chr20_+_25990656 14.95 ENSRNOT00000081254
leucine rich repeat transmembrane neuronal 3
chr12_+_2534212 14.92 ENSRNOT00000001399
cortexin 1
chr5_-_85123829 14.76 ENSRNOT00000007578
BMP/retinoic acid inducible neural specific 1
chr11_+_87435185 14.59 ENSRNOT00000002558
purinergic receptor P2X 6
chr1_-_216971183 14.55 ENSRNOT00000077911
MAS related GPR family member E
chr8_-_116361343 14.34 ENSRNOT00000066296
semaphorin 3B
chr18_+_83471342 14.30 ENSRNOT00000019384
neuropilin and tolloid like 1
chr12_+_28212333 14.12 ENSRNOT00000001182
autism susceptibility candidate 2
chr1_+_101783621 13.99 ENSRNOT00000067679
lemur tyrosine kinase 3
chr3_+_146582752 13.78 ENSRNOT00000010157
glycogen phosphorylase B
chr2_+_27107318 13.76 ENSRNOT00000019553
Rho guanine nucleotide exchange factor 26
chr1_+_97632473 13.59 ENSRNOT00000023671
V-set and transmembrane domain containing 2B
chr10_-_58693754 13.53 ENSRNOT00000071764
PITPNM family member 3
chr1_+_219964429 13.49 ENSRNOT00000088288
spectrin, beta, non-erythrocytic 2
chr10_-_110585376 13.32 ENSRNOT00000054917
Rab40b, member RAS oncogene family
chr1_-_80689171 12.90 ENSRNOT00000045574
basal cell adhesion molecule (Lutheran blood group)
chr9_-_28973246 12.71 ENSRNOT00000091865
ENSRNOT00000015453
regulating synaptic membrane exocytosis 1
chr12_+_18931477 12.39 ENSRNOT00000077087
sprouty RTK signaling antagonist 3
chr6_-_122545899 12.30 ENSRNOT00000005175
potassium two pore domain channel subfamily K member 10
chr18_+_29999290 12.09 ENSRNOT00000027372
protocadherin alpha 4
chr10_+_65448950 12.05 ENSRNOT00000082348
ENSRNOT00000037016
RAB34, member RAS oncogene family
chr18_+_58270410 12.01 ENSRNOT00000067554
APC down-regulated 1
chr6_+_99433550 12.00 ENSRNOT00000079359
ENSRNOT00000008504
heat shock protein family A member 2
chr20_+_25990304 11.95 ENSRNOT00000033980
leucine rich repeat transmembrane neuronal 3
chr11_+_73738433 11.59 ENSRNOT00000002353
transmembrane protein 44
chr20_+_3830164 11.53 ENSRNOT00000045533
ENSRNOT00000084117
collagen type XI alpha 2 chain
chr19_+_25526751 11.24 ENSRNOT00000083448
calcium voltage-gated channel subunit alpha1 A
chr1_+_222519615 11.08 ENSRNOT00000083585
REST corepressor 2
chr13_+_80517536 10.67 ENSRNOT00000004386
myocilin
chr15_+_108608204 10.65 ENSRNOT00000018918
citrate lyase beta like
chr9_+_80118029 10.58 ENSRNOT00000023068
insulin-like growth factor binding protein 2
chr9_+_72052966 10.25 ENSRNOT00000021099
parathyroid hormone 2 receptor
chr5_-_57896475 10.24 ENSRNOT00000017903
similar to testes development-related NYD-SP22 isoform 1
chr8_+_129205931 10.19 ENSRNOT00000082377
ectonucleoside triphosphate diphosphohydrolase 3
chr2_+_195719543 10.17 ENSRNOT00000028324
CUGBP, Elav-like family member 3
chr13_+_52889737 9.73 ENSRNOT00000074366
calcium voltage-gated channel subunit alpha1 S
chr1_-_188097374 9.49 ENSRNOT00000092246
synaptotagmin 17
chr9_-_28972835 9.45 ENSRNOT00000086967
ENSRNOT00000079684
regulating synaptic membrane exocytosis 1
chr11_-_30051103 9.23 ENSRNOT00000046486
T-cell lymphoma invasion and metastasis 1
chr7_-_58286770 9.09 ENSRNOT00000005258
RAB21, member RAS oncogene family
chr2_-_188553289 9.03 ENSRNOT00000088822
tripartite motif-containing 46
chr19_+_22281906 9.01 ENSRNOT00000021711
integrin alpha FG-GAP repeat containing 1
chr1_-_124039196 8.84 ENSRNOT00000051883
cholinergic receptor nicotinic alpha 7 subunit
chr16_-_22561496 8.76 ENSRNOT00000016543
lipoprotein lipase
chr12_+_2046472 8.72 ENSRNOT00000001289
zinc finger protein 358
chr15_+_86243148 8.72 ENSRNOT00000084471
ENSRNOT00000090727
LIM domain 7
chr1_+_144070754 8.69 ENSRNOT00000079989
SH3 domain-containing GRB2-like 3
chr11_-_25078740 8.66 ENSRNOT00000002109
cysteine and tyrosine rich 1
chr9_+_100830250 8.49 ENSRNOT00000024526
BOK, BCL2 family apoptosis regulator
chr12_+_45727112 8.42 ENSRNOT00000001507
serine/arginine repetitive matrix 4
chr1_-_24056373 8.35 ENSRNOT00000015566
solute carrier family 2 member 12
chr11_-_25350974 8.31 ENSRNOT00000002187
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr10_-_105628091 8.29 ENSRNOT00000016067
cytoglobin
chr3_+_173953869 8.12 ENSRNOT00000091212
family with sequence similarity 217, member B
chr3_-_173953684 7.99 ENSRNOT00000090468
protein phosphatase 1, regulatory subunit 3D
chr15_+_40665041 7.91 ENSRNOT00000018300
APC membrane recruitment protein 2
chr3_+_146980923 7.77 ENSRNOT00000011654
NSFL1 cofactor
chr7_+_11769400 7.71 ENSRNOT00000044417
junctional sarcoplasmic reticulum protein 1
chrX_-_112328642 7.58 ENSRNOT00000083150
proteasome 26S subunit, non-ATPase 10
chr1_-_197886759 7.53 ENSRNOT00000074274
SH2B adaptor protein 1
chr15_-_27819376 7.52 ENSRNOT00000067400
RIKEN cDNA A930018M24 gene
chr10_+_69737328 7.31 ENSRNOT00000055999
ENSRNOT00000076773
transmembrane protein 132E
chr17_-_84614228 7.14 ENSRNOT00000043042

chr3_+_172385672 6.98 ENSRNOT00000090989
GNAS complex locus
chr10_+_36741434 6.94 ENSRNOT00000064078
collagen type XXIII alpha 1 chain
chr8_-_36410612 6.91 ENSRNOT00000091308
FAD-dependent oxidoreductase domain containing 1
chr1_-_49844547 6.78 ENSRNOT00000086127
ENSRNOT00000077423
ENSRNOT00000089439
ENSRNOT00000090521

chr6_+_28663602 6.74 ENSRNOT00000005402
peptidyl-tRNA hydrolase domain containing 1
chr1_-_220878059 6.70 ENSRNOT00000036745
sorting nexin 32
chr12_+_13323547 6.69 ENSRNOT00000074138
zinc finger protein 853
chr13_-_42263024 6.52 ENSRNOT00000004741
Ly6/Plaur domain containing 1
chr17_-_10575203 6.47 ENSRNOT00000073186
ADP-ribosylation factor like GTPase 10
chr19_+_60017746 6.34 ENSRNOT00000042623
par-3 family cell polarity regulator
chr12_-_47095438 6.34 ENSRNOT00000001546
coenzyme Q5, methyltransferase
chr12_+_23752844 6.34 ENSRNOT00000001953
scavenger receptor cysteine rich family member with 4 domains
chr18_-_28454756 6.30 ENSRNOT00000040091
spermatogenesis associated 24
chr1_-_84986581 6.21 ENSRNOT00000025819
proteasome 26S subunit, ATPase 4
chr20_+_21316826 6.20 ENSRNOT00000000785
similar to RIKEN cDNA 1700040L02
chrX_-_43592200 6.19 ENSRNOT00000005033
acyl-CoA thioesterase 9
chr20_-_1984737 6.15 ENSRNOT00000040232
ENSRNOT00000051634
ENSRNOT00000079445
gamma-aminobutyric acid type B receptor subunit 1
chr1_+_199664173 6.13 ENSRNOT00000054980
transforming growth factor beta 1 induced transcript 1
chr1_+_79899155 6.03 ENSRNOT00000078503
Myb-related transcription factor, partner of profilin
chr11_-_24641820 5.98 ENSRNOT00000044081
ENSRNOT00000048854
amyloid beta precursor protein
chr12_-_43940798 5.97 ENSRNOT00000001485
similar to hypothetical protein FLJ21415
chrX_+_119030419 5.88 ENSRNOT00000060168
plastin 3
chr4_+_140247313 5.85 ENSRNOT00000040255
ENSRNOT00000064025
ENSRNOT00000041130
ENSRNOT00000043646
inositol 1,4,5-trisphosphate receptor, type 1
chr19_+_37305248 5.83 ENSRNOT00000068299
solute carrier family 9 member A5
chr19_-_22281778 5.77 ENSRNOT00000049624
phosphorylase kinase regulatory subunit beta
chr1_-_31545559 5.77 ENSRNOT00000017779
coiled-coil domain containing 127
chr19_-_32528965 5.74 ENSRNOT00000015929
zinc finger protein 827
chr10_-_13580821 5.66 ENSRNOT00000009735
netrin 3
chr11_-_81379871 5.57 ENSRNOT00000089294
eukaryotic translation initiation factor 4A2
chr14_-_20816588 5.54 ENSRNOT00000033806
solute carrier family 4 member 4
chr4_+_158243086 5.50 ENSRNOT00000032112
anoctamin 2
chr13_+_48607308 5.39 ENSRNOT00000063882
solute carrier family 41 member 1
chrX_-_14642424 5.30 ENSRNOT00000004808
dynein light chain Tctex-type 3
chr3_+_100770975 5.22 ENSRNOT00000089233
brain-derived neurotrophic factor
chr9_-_82699551 5.20 ENSRNOT00000020673
obscurin-like 1
chr8_-_36760742 5.15 ENSRNOT00000017307
DEAD-box helicase 25
chr20_+_12773427 4.98 ENSRNOT00000001695
collagen type VI alpha 2 chain
chr5_-_74190991 4.96 ENSRNOT00000090366
erythrocyte membrane protein band 4.1 like 4B
chr4_+_71588974 4.96 ENSRNOT00000037194
taste receptor, type 2, member 144
chr3_+_79823945 4.90 ENSRNOT00000014484
CUGBP, Elav-like family member 1
chr10_+_67677071 4.84 ENSRNOT00000007312
rhomboid like 3
chr10_+_15099009 4.80 ENSRNOT00000015206
RNA pseudouridylate synthase domain containing 1
chr6_+_44009872 4.73 ENSRNOT00000082657
membrane bound O-acyltransferase domain containing 2
chr19_+_25946979 4.68 ENSRNOT00000004027
GADD45G interacting protein 1
chr13_+_52147555 4.68 ENSRNOT00000084766
leiomodin 1
chr16_-_82439441 4.66 ENSRNOT00000040315

chr7_+_12247498 4.65 ENSRNOT00000022358
proprotein convertase subtilisin/kexin type 4
chr17_-_1093873 4.57 ENSRNOT00000086130
patched 1
chr12_+_19231092 4.56 ENSRNOT00000045379
zinc finger with KRAB and SCAN domains 1
chr8_+_3540361 4.55 ENSRNOT00000050899
vomeronasal 1 receptor 25
chr1_+_221099998 4.48 ENSRNOT00000028262
latent transforming growth factor beta binding protein 3
chr9_-_16643182 4.43 ENSRNOT00000024266
cullin-7
chr9_-_10734073 4.40 ENSRNOT00000071199
lysine demethylase 4B
chr16_+_80826681 4.27 ENSRNOT00000000123
coordinator of PRMT5 and differentiation stimulator
chr9_+_82556573 4.21 ENSRNOT00000026860
desmin
chrX_-_104337203 4.16 ENSRNOT00000050903

chr16_+_22979444 4.11 ENSRNOT00000017822
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr5_-_819326 4.11 ENSRNOT00000023899
peptidase inhibitor 15
chr19_-_56633633 4.10 ENSRNOT00000023911
centriole, cilia and spindle-associated protein
chr19_-_26141111 4.09 ENSRNOT00000067518
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr17_-_10208360 4.08 ENSRNOT00000087397
unc-5 netrin receptor A
chr9_+_94178221 4.07 ENSRNOT00000033487
alkaline phosphatase, placental-like 2
chr17_-_21353134 3.87 ENSRNOT00000067898
small integral membrane protein 13
chr1_-_1767618 3.85 ENSRNOT00000019623
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr8_+_122003916 3.67 ENSRNOT00000091980
cytoplasmic linker associated protein 2
chr5_-_77945016 3.66 ENSRNOT00000076223
zinc finger protein 37
chr5_-_40867023 3.64 ENSRNOT00000011576
mannosidase, endo-alpha
chr3_+_172719432 3.61 ENSRNOT00000033863
zinc finger protein 831
chr19_+_54245950 3.60 ENSRNOT00000024033
cytochrome c oxidase subunit 4i1
chr2_+_12102487 3.55 ENSRNOT00000089209
ENSRNOT00000072155
centrin-3-like
chr12_+_9034308 3.33 ENSRNOT00000001248
FMS-related tyrosine kinase 1
chr7_-_96464049 3.29 ENSRNOT00000006517
hyaluronan synthase 2
chr11_+_61605937 3.26 ENSRNOT00000093455
ENSRNOT00000093242
GRAM domain containing 1C

Network of associatons between targets according to the STRING database.

First level regulatory network of Gli3_Zic1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.5 45.8 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
11.1 33.2 GO:0051867 general adaptation syndrome, behavioral process(GO:0051867)
10.0 40.0 GO:0060221 retinal rod cell differentiation(GO:0060221) renal vesicle induction(GO:0072034)
10.0 69.9 GO:0072553 terminal button organization(GO:0072553)
9.4 28.1 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
7.7 23.0 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
7.6 30.5 GO:0007525 somatic muscle development(GO:0007525)
7.4 22.2 GO:0031632 positive regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031632)
6.7 94.4 GO:0071420 cellular response to histamine(GO:0071420)
6.6 19.8 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
6.5 32.4 GO:0001552 ovarian follicle atresia(GO:0001552)
5.6 44.6 GO:0007021 tubulin complex assembly(GO:0007021)
5.5 16.6 GO:1903921 protein processing in phagocytic vesicle(GO:1900756) regulation of establishment of T cell polarity(GO:1903903) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
5.3 21.2 GO:0052314 phytoalexin metabolic process(GO:0052314)
5.0 29.7 GO:0060023 soft palate development(GO:0060023)
4.8 38.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
4.8 14.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
4.7 14.1 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
4.7 37.4 GO:0070842 aggresome assembly(GO:0070842)
4.5 27.0 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
4.2 21.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
3.7 11.2 GO:0050883 medulla oblongata development(GO:0021550) musculoskeletal movement, spinal reflex action(GO:0050883)
3.5 56.4 GO:0070050 neuron cellular homeostasis(GO:0070050)
3.4 27.5 GO:0072014 proximal tubule development(GO:0072014)
3.4 43.6 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
3.2 16.0 GO:2000574 regulation of microtubule motor activity(GO:2000574)
3.0 21.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
3.0 12.0 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
2.9 25.7 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636)
2.8 8.5 GO:1904700 granulosa cell apoptotic process(GO:1904700) regulation of granulosa cell apoptotic process(GO:1904708)
2.7 32.5 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
2.7 10.7 GO:0038128 ERBB2 signaling pathway(GO:0038128) ERBB3 signaling pathway(GO:0038129)
2.5 17.7 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
2.5 7.6 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
2.3 51.5 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
2.3 7.0 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
2.3 9.2 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
2.2 30.6 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
2.0 21.6 GO:0007258 JUN phosphorylation(GO:0007258)
1.9 5.8 GO:0021997 neural plate axis specification(GO:0021997)
1.8 36.4 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
1.8 39.0 GO:0008210 estrogen metabolic process(GO:0008210)
1.8 23.0 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
1.7 8.3 GO:0044691 tooth eruption(GO:0044691)
1.5 23.0 GO:0071294 cellular response to zinc ion(GO:0071294)
1.5 17.9 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
1.5 4.5 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.4 78.3 GO:0045739 positive regulation of DNA repair(GO:0045739)
1.4 9.7 GO:0002074 extraocular skeletal muscle development(GO:0002074)
1.4 4.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
1.3 12.0 GO:0090385 macropinocytosis(GO:0044351) phagosome-lysosome fusion(GO:0090385)
1.3 8.8 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
1.2 14.8 GO:0007614 short-term memory(GO:0007614)
1.2 13.5 GO:0016081 synaptic vesicle docking(GO:0016081)
1.2 6.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
1.2 35.1 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
1.1 10.2 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
1.1 9.0 GO:0099612 protein localization to axon(GO:0099612)
1.1 11.2 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
1.1 3.3 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
1.1 7.6 GO:0045048 protein insertion into ER membrane(GO:0045048)
1.1 8.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.1 43.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
1.1 13.8 GO:0001886 endothelial cell morphogenesis(GO:0001886)
1.1 6.3 GO:0003383 apical constriction(GO:0003383)
1.0 7.3 GO:0071286 cellular response to magnesium ion(GO:0071286)
1.0 9.1 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
1.0 28.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
1.0 17.5 GO:0060134 prepulse inhibition(GO:0060134)
0.9 2.8 GO:0060974 cell migration involved in heart formation(GO:0060974)
0.9 8.3 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.9 15.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.9 19.8 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.9 4.3 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.8 5.8 GO:0050882 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) voluntary musculoskeletal movement(GO:0050882)
0.8 2.3 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.7 2.2 GO:0097298 regulation of nucleus size(GO:0097298)
0.7 4.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.7 7.3 GO:0043615 astrocyte cell migration(GO:0043615)
0.6 5.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.6 31.1 GO:0007528 neuromuscular junction development(GO:0007528)
0.6 4.4 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.6 1.9 GO:0030091 protein repair(GO:0030091)
0.6 18.6 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.6 4.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.6 45.7 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.6 3.3 GO:0048597 post-embryonic camera-type eye morphogenesis(GO:0048597)
0.6 7.8 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.5 5.8 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.5 2.1 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.5 4.7 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.5 5.9 GO:0051764 actin filament network formation(GO:0051639) actin crosslink formation(GO:0051764)
0.4 10.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.4 5.9 GO:0030575 nuclear body organization(GO:0030575)
0.4 7.7 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.4 2.8 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.4 6.3 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.4 13.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.4 6.2 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.4 19.9 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.4 1.9 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.4 2.5 GO:0070831 basement membrane assembly(GO:0070831)
0.3 3.2 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.3 1.0 GO:0043418 homocysteine catabolic process(GO:0043418)
0.3 3.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 3.8 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.3 4.1 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.3 0.6 GO:1900453 negative regulation of long term synaptic depression(GO:1900453)
0.3 2.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.3 2.1 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.3 8.4 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.3 6.5 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.2 14.8 GO:0072384 organelle transport along microtubule(GO:0072384)
0.2 5.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.2 10.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 4.8 GO:0001522 pseudouridine synthesis(GO:0001522)
0.2 1.8 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.2 2.8 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.2 2.2 GO:0051013 microtubule severing(GO:0051013)
0.2 4.6 GO:0048240 sperm capacitation(GO:0048240)
0.2 6.9 GO:0070207 protein homotrimerization(GO:0070207)
0.2 4.9 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 5.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 3.2 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 2.9 GO:0045109 intermediate filament organization(GO:0045109)
0.1 7.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 10.9 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 1.2 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.1 1.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 5.8 GO:0005977 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.1 2.9 GO:0051412 response to corticosterone(GO:0051412)
0.1 12.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 14.2 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 0.5 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.1 6.2 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 0.5 GO:0033572 transferrin transport(GO:0033572)
0.1 0.6 GO:0021936 regulation of cerebellar granule cell precursor proliferation(GO:0021936)
0.1 10.9 GO:0060070 canonical Wnt signaling pathway(GO:0060070)
0.1 5.5 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 2.9 GO:0043473 pigmentation(GO:0043473)
0.0 5.4 GO:0007605 sensory perception of sound(GO:0007605)
0.0 1.3 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.0 1.8 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 4.7 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.0 0.4 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.3 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.5 GO:0071277 cellular response to calcium ion(GO:0071277)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
21.1 84.3 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
9.9 29.7 GO:0005592 collagen type XI trimer(GO:0005592)
9.0 27.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
6.6 19.8 GO:0098837 postsynaptic recycling endosome(GO:0098837)
5.5 33.2 GO:0032280 symmetric synapse(GO:0032280)
5.4 48.8 GO:0097512 cardiac myofibril(GO:0097512)
4.8 186.5 GO:0060077 inhibitory synapse(GO:0060077)
4.0 16.0 GO:0097427 microtubule bundle(GO:0097427)
4.0 19.8 GO:0043293 apoptosome(GO:0043293)
3.6 10.7 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
3.0 9.1 GO:0010009 cytoplasmic side of endosome membrane(GO:0010009)
2.8 16.6 GO:0030478 actin cap(GO:0030478)
2.6 7.8 GO:1990730 VCP-NSFL1C complex(GO:1990730)
2.4 17.0 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
2.2 13.5 GO:0008091 spectrin(GO:0008091)
2.2 43.6 GO:0043196 varicosity(GO:0043196)
2.1 18.9 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
1.8 9.0 GO:1990769 proximal neuron projection(GO:1990769)
1.7 12.0 GO:0036128 CatSper complex(GO:0036128)
1.6 9.6 GO:1990393 3M complex(GO:1990393)
1.5 23.0 GO:0045180 basal cortex(GO:0045180)
1.5 38.1 GO:0033270 paranode region of axon(GO:0033270)
1.5 64.7 GO:0044295 axonal growth cone(GO:0044295)
1.5 5.8 GO:0031088 platelet dense granule membrane(GO:0031088)
1.4 13.8 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
1.4 15.1 GO:0072546 ER membrane protein complex(GO:0072546)
1.4 4.1 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
1.3 17.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.3 14.3 GO:0098839 postsynaptic density membrane(GO:0098839)
1.0 17.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.9 10.2 GO:0002177 manchette(GO:0002177)
0.9 3.6 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.8 8.0 GO:0042587 glycogen granule(GO:0042587)
0.8 2.3 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) fumarate reductase complex(GO:0045283)
0.8 47.1 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.7 5.8 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.7 36.4 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.7 2.1 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.6 2.5 GO:0005607 laminin-2 complex(GO:0005607)
0.6 15.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.5 2.1 GO:0032021 NELF complex(GO:0032021)
0.5 29.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.5 31.1 GO:0031594 neuromuscular junction(GO:0031594)
0.5 30.6 GO:0045178 basal part of cell(GO:0045178)
0.5 18.6 GO:0031672 A band(GO:0031672)
0.5 6.1 GO:0098984 neuron to neuron synapse(GO:0098984)
0.4 12.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.4 71.2 GO:0043204 perikaryon(GO:0043204)
0.3 52.8 GO:0005802 trans-Golgi network(GO:0005802)
0.3 8.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 24.7 GO:0043195 terminal bouton(GO:0043195)
0.3 4.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.3 5.1 GO:0033391 chromatoid body(GO:0033391)
0.2 3.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 55.7 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2 1.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.2 2.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 4.6 GO:0002080 acrosomal membrane(GO:0002080)
0.2 4.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 15.3 GO:0031225 anchored component of membrane(GO:0031225)
0.2 11.9 GO:0005581 collagen trimer(GO:0005581)
0.1 24.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 5.3 GO:0032420 stereocilium(GO:0032420)
0.1 8.3 GO:0005604 basement membrane(GO:0005604)
0.1 4.2 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 11.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 1.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 2.8 GO:0044306 neuron projection terminus(GO:0044306)
0.1 17.6 GO:0016324 apical plasma membrane(GO:0016324)
0.1 107.4 GO:0005739 mitochondrion(GO:0005739)
0.1 1.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 11.0 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 3.2 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0030891 VCB complex(GO:0030891)
0.0 9.1 GO:0043025 neuronal cell body(GO:0043025)
0.0 2.7 GO:0043209 myelin sheath(GO:0043209)
0.0 13.5 GO:0005768 endosome(GO:0005768)
0.0 10.8 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.2 GO:0000786 nucleosome(GO:0000786)
0.0 1.3 GO:0005884 actin filament(GO:0005884)
0.0 0.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 3.5 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
14.5 43.5 GO:0008184 glycogen phosphorylase activity(GO:0008184)
9.2 27.5 GO:0035939 microsatellite binding(GO:0035939)
7.7 23.0 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
7.4 51.9 GO:0048495 Roundabout binding(GO:0048495)
6.7 27.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
5.5 33.2 GO:0001515 opioid peptide activity(GO:0001515)
5.0 69.9 GO:0042043 neurexin family protein binding(GO:0042043)
4.9 29.5 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
4.6 64.9 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
4.6 23.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
4.1 16.6 GO:0045159 myosin II binding(GO:0045159)
3.2 68.1 GO:0048156 tau protein binding(GO:0048156)
3.0 21.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
2.9 23.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
2.9 37.4 GO:0098879 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
2.8 28.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
2.8 8.3 GO:0004096 catalase activity(GO:0004096)
2.6 15.5 GO:0032051 clathrin light chain binding(GO:0032051)
2.6 28.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
2.5 55.9 GO:0005212 structural constituent of eye lens(GO:0005212)
2.3 2.3 GO:0016635 succinate dehydrogenase (ubiquinone) activity(GO:0008177) oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
2.2 17.7 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
2.2 21.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
2.1 10.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
2.0 15.7 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
1.9 11.6 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
1.9 5.8 GO:0005119 smoothened binding(GO:0005119)
1.8 35.1 GO:0008179 adenylate cyclase binding(GO:0008179)
1.8 10.7 GO:0032027 myosin light chain binding(GO:0032027)
1.7 17.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.7 6.7 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
1.5 6.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
1.5 10.6 GO:0097322 7SK snRNA binding(GO:0097322)
1.5 6.0 GO:0051425 PTB domain binding(GO:0051425)
1.5 5.8 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.4 4.1 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
1.3 28.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
1.3 10.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
1.3 29.5 GO:0048038 quinone binding(GO:0048038)
1.1 21.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.0 6.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
1.0 64.4 GO:0005080 protein kinase C binding(GO:0005080)
1.0 3.8 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.8 4.1 GO:0005042 netrin receptor activity(GO:0005042)
0.7 5.8 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.7 12.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.7 2.8 GO:0051870 methotrexate binding(GO:0051870)
0.7 2.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.7 21.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.7 3.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.7 5.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.6 3.2 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.6 18.6 GO:0003785 actin monomer binding(GO:0003785)
0.6 10.2 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.6 5.8 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.5 8.5 GO:0051400 BH domain binding(GO:0051400)
0.5 8.4 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.5 12.0 GO:0051861 glycolipid binding(GO:0051861)
0.5 5.2 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.5 10.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.5 29.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 3.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.5 29.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544) clathrin binding(GO:0030276)
0.5 1.9 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.5 18.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.5 6.5 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.5 8.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.5 39.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.4 14.3 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.4 9.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.4 5.4 GO:0015491 cation:cation antiporter activity(GO:0015491)
0.4 12.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.4 14.2 GO:0043236 laminin binding(GO:0043236)
0.4 35.4 GO:0005262 calcium channel activity(GO:0005262)
0.4 5.0 GO:0033038 bitter taste receptor activity(GO:0033038)
0.3 3.6 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.3 17.0 GO:0019894 kinesin binding(GO:0019894)
0.3 35.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 4.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.3 4.7 GO:0005523 tropomyosin binding(GO:0005523)
0.3 2.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.3 24.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.3 3.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.3 5.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.2 4.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 3.6 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.2 2.8 GO:0048185 activin binding(GO:0048185)
0.2 1.3 GO:0005047 signal recognition particle binding(GO:0005047)
0.2 4.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.2 3.7 GO:0002162 dystroglycan binding(GO:0002162)
0.2 0.6 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.2 1.9 GO:1990239 steroid hormone binding(GO:1990239)
0.2 7.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2 20.6 GO:0044325 ion channel binding(GO:0044325)
0.2 2.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 10.7 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 32.8 GO:0008017 microtubule binding(GO:0008017)
0.1 30.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 17.1 GO:0008201 heparin binding(GO:0008201)
0.1 6.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 9.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 2.8 GO:0070412 R-SMAD binding(GO:0070412)
0.1 7.9 GO:0051117 ATPase binding(GO:0051117)
0.1 2.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 5.0 GO:0015296 anion:cation symporter activity(GO:0015296)
0.1 7.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.2 GO:0005109 frizzled binding(GO:0005109)
0.1 31.7 GO:0005509 calcium ion binding(GO:0005509)
0.1 5.7 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 3.2 GO:0016209 antioxidant activity(GO:0016209)
0.0 0.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 8.6 GO:0003924 GTPase activity(GO:0003924)
0.0 0.6 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 5.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 6.6 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.0 1.3 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 11.0 GO:0005198 structural molecule activity(GO:0005198)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0017022 myosin binding(GO:0017022)
0.0 4.4 GO:0016887 ATPase activity(GO:0016887)
0.0 1.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 64.2 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
1.1 21.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.9 78.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.9 41.6 NABA COLLAGENS Genes encoding collagen proteins
0.8 9.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.6 132.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.6 16.6 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.5 18.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 26.4 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.3 3.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.3 18.4 PID AP1 PATHWAY AP-1 transcription factor network
0.2 5.8 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 6.3 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 4.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 17.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 2.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 13.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 11.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.0 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.3 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.4 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 94.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
2.7 35.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
2.5 49.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
1.8 25.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
1.6 22.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.5 31.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.3 21.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
1.2 27.0 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.1 36.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.9 31.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.8 44.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.7 29.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.7 41.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.7 16.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6 22.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.6 12.9 REACTOME KINESINS Genes involved in Kinesins
0.5 35.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.5 38.1 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.5 6.0 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.5 8.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.5 9.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.5 7.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.4 24.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.4 5.6 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.4 23.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.4 38.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 3.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.3 2.7 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3 4.7 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.2 5.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.2 16.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 6.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 4.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 5.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 4.7 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.2 11.2 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.2 3.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 9.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 3.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.2 8.1 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.1 22.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 8.2 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.1 4.4 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events