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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Gli1

Z-value: 0.74

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Transcription factors associated with Gli1

Gene Symbol Gene ID Gene Info
Gli1
ENSRNOG00000025120 GLI family zinc finger 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gli1rn6_v1_chr7_-_70630338_706303380.491.3e-20Click!

Activity profile of Gli1 motif

Sorted Z-values of Gli1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_39476384 31.47 ENSRNOT00000092968
Gpm6a
glycoprotein m6a
chr16_-_39476025 28.05 ENSRNOT00000014312
Gpm6a
glycoprotein m6a
chr7_-_136853957 25.77 ENSRNOT00000008985
Nell2
neural EGFL like 2
chr10_-_27179254 23.69 ENSRNOT00000004619
Gabrg2
gamma-aminobutyric acid type A receptor gamma 2 subunit
chr3_+_154043873 22.44 ENSRNOT00000072502
ENSRNOT00000034166
Nnat
neuronatin
chr1_-_170397191 20.33 ENSRNOT00000090181
Apbb1
amyloid beta precursor protein binding family B member 1
chr9_-_75528644 20.26 ENSRNOT00000019283
Erbb4
erb-b2 receptor tyrosine kinase 4
chr11_-_30051103 19.72 ENSRNOT00000046486
Tiam1
T-cell lymphoma invasion and metastasis 1
chr6_+_27768943 19.69 ENSRNOT00000015820
Kif3c
kinesin family member 3C
chr1_-_220467159 18.64 ENSRNOT00000075365
Tmem151a
transmembrane protein 151A
chrX_+_71199491 17.82 ENSRNOT00000076168
ENSRNOT00000005077
ENSRNOT00000005102
Nlgn3
neuroligin 3
chr8_-_59239954 17.66 ENSRNOT00000016104
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr10_+_89089646 17.28 ENSRNOT00000027505
Cntnap1
contactin associated protein 1
chr13_+_70379346 17.25 ENSRNOT00000038183
Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr10_+_20320878 16.79 ENSRNOT00000009714
Slit3
slit guidance ligand 3
chr1_+_113034227 15.92 ENSRNOT00000081831
ENSRNOT00000077877
ENSRNOT00000077594
Gabrb3
gamma-aminobutyric acid type A receptor beta 3 subunit
chr18_+_79406381 14.95 ENSRNOT00000022303
ENSRNOT00000058295
ENSRNOT00000058296
ENSRNOT00000022280
Mbp
myelin basic protein
chr1_-_188097530 14.75 ENSRNOT00000078825
Syt17
synaptotagmin 17
chr10_+_38889370 14.16 ENSRNOT00000091236
Sept8
septin 8
chr16_+_7212488 13.31 ENSRNOT00000024840
Nt5dc2
5'-nucleotidase domain containing 2
chr5_-_17061361 13.26 ENSRNOT00000089318
Penk
proenkephalin
chr20_-_1984737 13.16 ENSRNOT00000040232
ENSRNOT00000051634
ENSRNOT00000079445
Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
chr6_-_4520604 11.86 ENSRNOT00000042230
ENSRNOT00000043870
ENSRNOT00000070918
ENSRNOT00000046246
ENSRNOT00000052367
ENSRNOT00000042251
Slc8a1
solute carrier family 8 member A1
chr10_+_67677071 11.64 ENSRNOT00000007312
Rhbdl3
rhomboid like 3
chr10_-_108321644 11.29 ENSRNOT00000075171
Tbc1d16
TBC1 domain family, member 16
chr7_+_141326950 10.86 ENSRNOT00000084075
Asic1
acid sensing ion channel subunit 1
chr1_-_216080287 10.56 ENSRNOT00000027682
Th
tyrosine hydroxylase
chr4_+_140247313 10.18 ENSRNOT00000040255
ENSRNOT00000064025
ENSRNOT00000041130
ENSRNOT00000043646
Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
chr5_+_131380297 10.14 ENSRNOT00000010548
Agbl4
ATP/GTP binding protein-like 4
chr1_-_84812486 9.84 ENSRNOT00000078369
AABR07002779.1

chr1_+_115975324 9.38 ENSRNOT00000080907
Atp10a
ATPase phospholipid transporting 10A (putative)
chr18_+_58270410 8.96 ENSRNOT00000067554
Apcdd1
APC down-regulated 1
chr15_+_40665041 8.90 ENSRNOT00000018300
Amer2
APC membrane recruitment protein 2
chr6_-_27190126 8.76 ENSRNOT00000068412
ENSRNOT00000013107
Kcnk3
potassium two pore domain channel subfamily K member 3
chr10_+_86669233 7.92 ENSRNOT00000012340
Thra
thyroid hormone receptor alpha
chr5_+_18901039 7.37 ENSRNOT00000012066
Fam110b
family with sequence similarity 110, member B
chr3_-_39596718 7.31 ENSRNOT00000006784
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr17_-_10575203 7.16 ENSRNOT00000073186
Arl10
ADP-ribosylation factor like GTPase 10
chr3_+_152752091 7.09 ENSRNOT00000037177
Dlgap4
DLG associated protein 4
chr4_+_87293871 6.95 ENSRNOT00000090943
AABR07060628.1

chr1_-_188097374 6.85 ENSRNOT00000092246
Syt17
synaptotagmin 17
chrX_-_115426083 6.73 ENSRNOT00000014756
AABR07040947.1

chr5_-_65073012 6.29 ENSRNOT00000007957
Grin3a
glutamate ionotropic receptor NMDA type subunit 3A
chr17_-_1093873 6.19 ENSRNOT00000086130
Ptch1
patched 1
chr19_-_10358695 6.09 ENSRNOT00000019770
Katnb1
katanin regulatory subunit B1
chr6_+_137997335 6.00 ENSRNOT00000006872
Tmem121
transmembrane protein 121
chr7_+_14643704 5.46 ENSRNOT00000044642
AABR07055875.1

chr20_+_4020317 5.42 ENSRNOT00000000526
RT1-DOb
RT1 class II, locus DOb
chr3_+_80676820 5.22 ENSRNOT00000084809
Ambra1
autophagy and beclin 1 regulator 1
chr3_+_79823945 5.19 ENSRNOT00000014484
Celf1
CUGBP, Elav-like family member 1
chr7_-_142300382 5.17 ENSRNOT00000048262
Bin2
bridging integrator 2
chr4_+_24617008 5.03 ENSRNOT00000086607
Ewsr1
EWS RNA-binding protein 1
chr5_+_156618962 4.84 ENSRNOT00000020069
Sh2d5
SH2 domain containing 5
chr10_+_15099009 4.84 ENSRNOT00000015206
Rpusd1
RNA pseudouridylate synthase domain containing 1
chrX_+_28435507 4.76 ENSRNOT00000005615
Prps2
phosphoribosyl pyrophosphate synthetase 2
chr1_+_144070754 4.65 ENSRNOT00000079989
Sh3gl3
SH3 domain-containing GRB2-like 3
chr12_+_47074200 4.53 ENSRNOT00000014910
Dynll1
dynein light chain LC8-type 1
chr6_+_86713803 4.43 ENSRNOT00000005861
Fam179b
family with sequence similarity 179, member B
chr10_+_84986328 4.41 ENSRNOT00000085830
ENSRNOT00000067665
Osbpl7
oxysterol binding protein-like 7
chr2_-_178057157 4.39 ENSRNOT00000091135
Rapgef2
Rap guanine nucleotide exchange factor 2
chr14_+_77322012 4.31 ENSRNOT00000088600
ENSRNOT00000041639
Zbtb49
zinc finger and BTB domain containing 49
chr4_-_145487426 4.23 ENSRNOT00000013488
Emc3
ER membrane protein complex subunit 3
chrX_+_29157470 4.16 ENSRNOT00000081986
LOC100910245
ribose-phosphate pyrophosphokinase 2-like
chr10_+_56824505 4.13 ENSRNOT00000067128
Slc16a11
solute carrier family 16, member 11
chr7_-_12810570 3.97 ENSRNOT00000012578
Fstl3
follistatin like 3
chr16_+_61758917 3.93 ENSRNOT00000084858
Leprotl1
leptin receptor overlapping transcript-like 1
chr6_+_86713604 3.79 ENSRNOT00000059271
Fam179b
family with sequence similarity 179, member B
chr3_-_2573387 3.73 ENSRNOT00000017271
Dpp7
dipeptidylpeptidase 7
chr10_+_56610051 3.62 ENSRNOT00000024348
Dvl2
dishevelled segment polarity protein 2
chr2_+_248715281 3.51 ENSRNOT00000089648
Gtf2b
general transcription factor IIB
chr1_-_210739600 3.50 ENSRNOT00000031734
Tcerg1l
transcription elongation regulator 1-like
chr10_-_90312386 3.34 ENSRNOT00000028445
Slc4a1
solute carrier family 4 member 1
chr5_+_63781801 3.30 ENSRNOT00000008302
Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr3_-_147481073 3.23 ENSRNOT00000084722
Fam110a
family with sequence similarity 110, member A
chr4_+_113935492 3.23 ENSRNOT00000035329
LOC103692170
coiled-coil domain-containing protein 142
chr3_-_138708332 2.99 ENSRNOT00000010678
Rbbp9
RB binding protein 9, serine hydrolase
chr10_+_65448950 2.97 ENSRNOT00000082348
ENSRNOT00000037016
Rab34
RAB34, member RAS oncogene family
chr3_-_148312791 2.84 ENSRNOT00000091419
Bcl2l1
Bcl2-like 1
chrX_-_72370044 2.73 ENSRNOT00000004224
Hdac8
histone deacetylase 8
chr1_-_80689171 2.58 ENSRNOT00000045574
Bcam
basal cell adhesion molecule (Lutheran blood group)
chr19_+_46761570 2.43 ENSRNOT00000058779
Wwox
WW domain-containing oxidoreductase
chr8_-_23084879 2.38 ENSRNOT00000018874
Zfp653
zinc finger protein 653
chr13_-_42263024 2.27 ENSRNOT00000004741
Lypd1
Ly6/Plaur domain containing 1
chrX_-_43592200 2.21 ENSRNOT00000005033
Acot9
acyl-CoA thioesterase 9
chr18_+_60496778 2.21 ENSRNOT00000088624
Nedd4l
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr5_+_172273459 2.20 ENSRNOT00000017957
Mmel1
membrane metallo-endopeptidase-like 1
chr3_+_20641664 2.09 ENSRNOT00000044699
AABR07051741.1

chr18_-_19275273 2.08 ENSRNOT00000041707
LOC102547344
lateral signaling target protein 2 homolog
chr17_+_56935451 2.06 ENSRNOT00000058966
RGD1564129
similar to hypothetical protein 4930474N05
chr9_+_72052966 1.76 ENSRNOT00000021099
Pth2r
parathyroid hormone 2 receptor
chr2_-_206699105 1.68 ENSRNOT00000088095
ENSRNOT00000026952
Magi3
membrane associated guanylate kinase, WW and PDZ domain containing 3
chr2_-_192671059 1.61 ENSRNOT00000012174
Sprr1a
small proline-rich protein 1A
chr2_+_12102487 1.61 ENSRNOT00000089209
ENSRNOT00000072155
LOC100912538
centrin-3-like
chr3_+_8450275 1.57 ENSRNOT00000020073
Odf2
outer dense fiber of sperm tails 2
chr2_-_196527127 1.57 ENSRNOT00000028709
Setdb1
SET domain, bifurcated 1
chr10_-_13580821 1.52 ENSRNOT00000009735
Ntn3
netrin 3
chr3_+_8450612 1.41 ENSRNOT00000040457
Odf2
outer dense fiber of sperm tails 2
chr5_+_135962911 1.34 ENSRNOT00000087353
Ptch2
patched 2
chr2_+_225645568 1.28 ENSRNOT00000017878
Abca4
ATP binding cassette subfamily A member 4
chr1_-_197886759 1.27 ENSRNOT00000074274
Sh2b1
SH2B adaptor protein 1
chr2_+_9683570 1.19 ENSRNOT00000074157
Cetn3
centrin 3
chr5_-_6186329 1.11 ENSRNOT00000012610
Sulf1
sulfatase 1
chr4_+_61924013 1.07 ENSRNOT00000090717
Bpgm
bisphosphoglycerate mutase
chr4_-_170932618 1.04 ENSRNOT00000007779
Arhgdib
Rho GDP dissociation inhibitor beta
chr20_-_10968432 0.99 ENSRNOT00000001593
Cstb
cystatin B
chr6_+_96871625 0.92 ENSRNOT00000012361
Snapc1
small nuclear RNA activating complex, polypeptide 1
chr7_-_2712723 0.91 ENSRNOT00000004363
Il23a
interleukin 23 subunit alpha
chr2_+_27107318 0.91 ENSRNOT00000019553
Arhgef26
Rho guanine nucleotide exchange factor 26
chr9_+_17122284 0.75 ENSRNOT00000077749
Polr1c
RNA polymerase I subunit C
chr9_-_10734073 0.66 ENSRNOT00000071199
Kdm4b
lysine demethylase 4B
chr10_+_4945911 0.46 ENSRNOT00000003420
Prm1
protamine 1
chr2_-_196526886 0.45 ENSRNOT00000077325
Setdb1
SET domain, bifurcated 1
chr2_+_198040536 0.33 ENSRNOT00000028744
Anp32e
acidic nuclear phosphoprotein 32 family member E
chr3_-_20479999 0.30 ENSRNOT00000050573
AABR07051733.2

chr10_+_86860685 0.26 ENSRNOT00000084644
Rara
retinoic acid receptor, alpha
chr7_-_59587382 0.20 ENSRNOT00000091427
ENSRNOT00000066396
Cnot2
CCR4-NOT transcription complex, subunit 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Gli1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.2 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
5.0 14.9 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) positive regulation of metalloendopeptidase activity(GO:1904685)
4.9 19.7 GO:0036135 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
4.4 13.3 GO:0051867 general adaptation syndrome, behavioral process(GO:0051867)
4.2 16.8 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
3.5 17.7 GO:0001552 ovarian follicle atresia(GO:0001552)
2.8 39.6 GO:0071420 cellular response to histamine(GO:0071420)
2.6 7.9 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
2.6 10.6 GO:0052314 phytoalexin metabolic process(GO:0052314)
2.5 17.8 GO:0072553 terminal button organization(GO:0072553)
2.5 20.3 GO:0007262 STAT protein import into nucleus(GO:0007262)
2.2 13.2 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
2.2 17.3 GO:0002175 protein localization to paranode region of axon(GO:0002175)
2.1 25.8 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
2.1 6.2 GO:0021997 neural plate axis specification(GO:0021997)
2.0 6.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
2.0 11.9 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
1.8 5.4 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
1.7 10.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
1.6 10.9 GO:0050915 sensory perception of sour taste(GO:0050915)
1.5 10.2 GO:0050882 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Wnt signaling pathway, calcium modulating pathway(GO:0007223) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) voluntary musculoskeletal movement(GO:0050882)
1.5 59.5 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
1.2 4.8 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
1.1 4.4 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.9 2.8 GO:1905218 cellular response to astaxanthin(GO:1905218)
0.9 2.7 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.8 3.3 GO:0032763 regulation of mast cell cytokine production(GO:0032763)
0.7 9.0 GO:0043615 astrocyte cell migration(GO:0043615)
0.7 23.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.7 3.5 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.7 3.3 GO:0010037 response to carbon dioxide(GO:0010037)
0.6 3.6 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.6 8.8 GO:0071294 cellular response to zinc ion(GO:0071294)
0.6 4.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.6 3.9 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.5 2.0 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.5 4.5 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.4 1.3 GO:0006649 phospholipid transfer to membrane(GO:0006649)
0.4 9.4 GO:0045332 phospholipid translocation(GO:0045332)
0.4 1.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.4 20.3 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.4 4.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.3 1.0 GO:0071461 cellular response to redox state(GO:0071461)
0.3 11.3 GO:0001919 regulation of receptor recycling(GO:0001919)
0.3 6.3 GO:0060134 prepulse inhibition(GO:0060134)
0.3 3.0 GO:0090385 macropinocytosis(GO:0044351) phagosome-lysosome fusion(GO:0090385)
0.3 0.9 GO:2000318 positive regulation of memory T cell differentiation(GO:0043382) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.3 4.4 GO:0071397 cellular response to cholesterol(GO:0071397)
0.3 5.2 GO:0097320 membrane tubulation(GO:0097320)
0.3 5.2 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.3 19.7 GO:0072384 organelle transport along microtubule(GO:0072384)
0.3 22.4 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.2 4.8 GO:0001522 pseudouridine synthesis(GO:0001522)
0.2 5.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 1.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.2 4.0 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.2 0.9 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.2 2.4 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.1 0.7 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.1 2.3 GO:1904376 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.1 1.6 GO:0031424 keratinization(GO:0031424)
0.1 8.9 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1 11.6 GO:0007050 cell cycle arrest(GO:0007050)
0.1 0.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.3 GO:0045630 positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0 4.2 GO:0009156 ribonucleoside monophosphate biosynthetic process(GO:0009156)
0.0 3.0 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 1.7 GO:0043507 positive regulation of JUN kinase activity(GO:0043507)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 2.2 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 10.9 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.3 GO:0043486 histone exchange(GO:0043486)
0.0 1.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.5 GO:0030261 chromosome condensation(GO:0030261)
0.0 2.6 GO:0007160 cell-matrix adhesion(GO:0007160)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 20.3 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
4.4 13.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
2.8 19.7 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
2.5 10.2 GO:0031088 platelet dense granule membrane(GO:0031088)
2.5 14.9 GO:0033269 internode region of axon(GO:0033269)
2.2 13.3 GO:0032280 symmetric synapse(GO:0032280)
2.0 85.4 GO:0044295 axonal growth cone(GO:0044295)
1.7 39.6 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
1.2 10.6 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
1.0 4.8 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.7 17.3 GO:0033270 paranode region of axon(GO:0033270)
0.5 17.8 GO:0060077 inhibitory synapse(GO:0060077)
0.4 2.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.4 4.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.4 6.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.4 3.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 5.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 3.0 GO:0097539 ciliary transition fiber(GO:0097539)
0.2 4.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 15.2 GO:0014704 intercalated disc(GO:0014704)
0.2 5.2 GO:0001891 phagocytic cup(GO:0001891)
0.2 17.9 GO:0005901 caveola(GO:0005901)
0.2 4.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 33.4 GO:0005802 trans-Golgi network(GO:0005802)
0.1 8.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 3.3 GO:0042629 mast cell granule(GO:0042629)
0.1 11.3 GO:0036064 ciliary basal body(GO:0036064)
0.1 5.0 GO:0015030 Cajal body(GO:0015030)
0.1 4.7 GO:0031901 early endosome membrane(GO:0031901)
0.1 3.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 15.5 GO:0043204 perikaryon(GO:0043204)
0.1 4.4 GO:0030139 endocytic vesicle(GO:0030139)
0.1 1.6 GO:0001533 cornified envelope(GO:0001533)
0.1 11.3 GO:0005769 early endosome(GO:0005769)
0.1 0.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 6.1 GO:0000922 spindle pole(GO:0000922)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 6.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.4 GO:0005902 microvillus(GO:0005902)
0.0 6.7 GO:0043209 myelin sheath(GO:0043209)
0.0 4.0 GO:0044306 neuron projection terminus(GO:0044306)
0.0 0.3 GO:0000812 Swr1 complex(GO:0000812)
0.0 2.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.8 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 3.9 GO:0005768 endosome(GO:0005768)
0.0 7.9 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.2 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
3.6 10.9 GO:0044736 acid-sensing ion channel activity(GO:0044736)
3.3 13.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
2.5 10.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
2.4 16.8 GO:0048495 Roundabout binding(GO:0048495)
2.3 20.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
2.2 13.3 GO:0001515 opioid peptide activity(GO:0001515)
2.1 6.2 GO:0005119 smoothened binding(GO:0005119)
2.0 15.9 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
2.0 23.7 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
1.8 17.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.8 8.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
1.7 11.9 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
1.5 10.6 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
1.3 17.8 GO:0042043 neurexin family protein binding(GO:0042043)
1.2 14.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.1 8.9 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
1.0 20.3 GO:0048156 tau protein binding(GO:0048156)
0.9 19.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.8 13.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.7 4.4 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.7 7.9 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.6 6.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.6 4.5 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.6 2.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.5 10.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.5 59.5 GO:0005262 calcium channel activity(GO:0005262)
0.5 2.8 GO:0051434 BH3 domain binding(GO:0051434)
0.4 25.8 GO:0005080 protein kinase C binding(GO:0005080)
0.4 10.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.4 6.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.4 3.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 21.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 19.7 GO:0019894 kinesin binding(GO:0019894)
0.3 4.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.3 9.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.3 2.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.3 5.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.3 1.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 1.1 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.3 7.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 2.2 GO:0019871 potassium channel inhibitor activity(GO:0019870) sodium channel inhibitor activity(GO:0019871)
0.2 3.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.2 8.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2 2.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 5.3 GO:0005109 frizzled binding(GO:0005109)
0.2 3.3 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.1 5.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 4.0 GO:0001968 fibronectin binding(GO:0001968)
0.1 3.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 17.3 GO:0017124 SH3 domain binding(GO:0017124)
0.1 4.4 GO:0015485 cholesterol binding(GO:0015485)
0.1 2.6 GO:0043236 laminin binding(GO:0043236)
0.1 0.2 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224) RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 1.0 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 14.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 0.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 2.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 11.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.2 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 1.3 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 10.6 GO:0005525 GTP binding(GO:0005525)
0.0 5.2 GO:0005543 phospholipid binding(GO:0005543)
0.0 2.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 4.7 GO:0008289 lipid binding(GO:0008289)
0.0 2.8 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.3 GO:0019212 phosphatase inhibitor activity(GO:0019212)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 20.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
1.0 19.7 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.4 10.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.4 10.2 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 7.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.2 20.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 8.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 2.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 3.6 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.2 37.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.3 ST GA12 PATHWAY G alpha 12 Pathway
0.1 9.4 PID AP1 PATHWAY AP-1 transcription factor network
0.1 5.0 PID BARD1 PATHWAY BARD1 signaling events
0.1 2.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 2.0 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 3.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 3.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.7 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.7 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.9 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.0 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 39.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.8 20.3 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.7 8.8 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.7 10.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.6 19.7 REACTOME KINESINS Genes involved in Kinesins
0.6 13.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.4 10.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.3 19.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.3 16.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.3 17.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 4.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 9.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 2.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.2 17.3 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.2 3.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 11.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.7 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 9.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.7 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 10.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 1.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases