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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Gbx2

Z-value: 0.68

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Transcription factors associated with Gbx2

Gene Symbol Gene ID Gene Info
Gbx2
ENSRNOG00000019495 gastrulation brain homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gbx2rn6_v1_chr9_-_97065817_97065817-0.114.3e-02Click!

Activity profile of Gbx2 motif

Sorted Z-values of Gbx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_127632265 52.01 ENSRNOT00000084157
Serpina1
serpin family A member 1
chr3_+_159368273 51.40 ENSRNOT00000041688
Sgk2
serum/glucocorticoid regulated kinase 2
chr1_+_147713892 47.83 ENSRNOT00000092985
ENSRNOT00000054742
ENSRNOT00000074103
Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
chr1_+_250426158 29.25 ENSRNOT00000067643
A1cf
APOBEC1 complementation factor
chr1_+_248428099 27.02 ENSRNOT00000050984
Mbl2
mannose binding lectin 2
chr4_-_169036950 20.54 ENSRNOT00000011295
Gsg1
germ cell associated 1
chr4_-_23718047 17.89 ENSRNOT00000011359
RGD1564345
similar to RIKEN cDNA 4921511H03
chr14_-_21748356 17.54 ENSRNOT00000002670
Cabs1
calcium binding protein, spermatid associated 1
chr10_+_103206014 16.99 ENSRNOT00000004081
Ttyh2
tweety family member 2
chr1_-_174047572 14.20 ENSRNOT00000019597
Stk33
serine/threonine kinase 33
chrY_-_1398030 13.32 ENSRNOT00000088719
Usp9y
ubiquitin specific peptidase 9, Y-linked
chr12_+_47179664 11.74 ENSRNOT00000001551
Cabp1
calcium binding protein 1
chr2_+_54466280 11.00 ENSRNOT00000033112
C6
complement C6
chr5_+_78334284 10.78 ENSRNOT00000020366
Bspry
B-box and SPRY domain containing
chr5_+_28480023 10.48 ENSRNOT00000075067
ENSRNOT00000093754
LOC100912373
uncharacterized LOC100912373
chr7_-_107223047 10.17 ENSRNOT00000007250
ENSRNOT00000084875
Lrrc6
leucine rich repeat containing 6
chrX_-_14783792 8.53 ENSRNOT00000087609
LOC691895
similar to ferritin, heavy polypeptide-like 17
chr2_-_173563273 8.26 ENSRNOT00000081423
Zbbx
zinc finger, B-box domain containing
chr8_+_119083900 7.05 ENSRNOT00000051947
ENSRNOT00000048655
Prss44
protease, serine, 44
chr2_+_220432037 6.72 ENSRNOT00000021988
Frrs1
ferric-chelate reductase 1
chr2_+_72006099 6.66 ENSRNOT00000034044
Cdh12
cadherin 12
chr14_-_43143973 6.11 ENSRNOT00000003248
Uchl1
ubiquitin C-terminal hydrolase L1
chr4_-_11497531 5.83 ENSRNOT00000078799
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr3_+_48106099 5.81 ENSRNOT00000007218
Slc4a10
solute carrier family 4 member 10
chrX_+_84064427 5.51 ENSRNOT00000046364
Zfp711
zinc finger protein 711
chr10_+_11912543 5.44 ENSRNOT00000045192
Zfp597
zinc finger protein 597
chr8_-_45137893 5.16 ENSRNOT00000010743
RGD1309108
similar to hypothetical protein FLJ23554
chr8_+_37557067 4.97 ENSRNOT00000073109
LOC688335
similar to Spleen protein 1 precursor (RSP-1)
chr2_-_122641409 4.76 ENSRNOT00000068334
Dcun1d1
defective in cullin neddylation 1 domain containing 1
chr2_+_208738132 4.73 ENSRNOT00000023972
AABR07012795.1

chr8_+_38396532 4.60 ENSRNOT00000071278
LOC100360143
rCG64164-like
chr8_+_38685415 4.60 ENSRNOT00000073660
LOC688335
similar to Spleen protein 1 precursor (RSP-1)
chr13_-_83457888 4.58 ENSRNOT00000076289
ENSRNOT00000004065
Sft2d2
SFT2 domain containing 2
chr2_-_198706428 4.50 ENSRNOT00000085006
Polr3gl
RNA polymerase III subunit G like
chr17_+_25082056 4.35 ENSRNOT00000037041
AABR07027339.1

chr1_+_220071811 4.28 ENSRNOT00000090642
AC126581.1

chr12_-_46493203 4.07 ENSRNOT00000057036
Cit
citron rho-interacting serine/threonine kinase
chr17_-_62299655 3.41 ENSRNOT00000024855
Gjd4
gap junction protein, delta 4
chr16_+_90613870 3.34 ENSRNOT00000079334
Shcbp1
SHC binding and spindle associated 1
chr4_-_27726943 3.25 ENSRNOT00000068499
LOC500007
similar to EF hand calcium binding domain 1
chr5_-_40867023 3.24 ENSRNOT00000011576
Manea
mannosidase, endo-alpha
chr1_-_78180216 3.24 ENSRNOT00000071576
C5ar2
complement component 5a receptor 2
chr3_+_147952879 3.09 ENSRNOT00000031922
Defb20
defensin beta 20
chr1_-_214414763 2.86 ENSRNOT00000025240
ENSRNOT00000077776
LOC100911440
mitochondrial glutamate carrier 1-like
chr14_+_22597103 2.60 ENSRNOT00000048482
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr6_-_108660063 2.60 ENSRNOT00000006240
Arel1
apoptosis resistant E3 ubiquitin protein ligase 1
chr8_-_41445722 2.57 ENSRNOT00000011381
LOC171573
spleen protein 1 precursor
chr8_+_117117430 2.05 ENSRNOT00000073247
Gpx1
glutathione peroxidase 1
chr8_+_79638696 1.92 ENSRNOT00000085959
Dyx1c1
dyslexia susceptibility 1 candidate 1
chr4_+_143911791 1.90 ENSRNOT00000081511
AABR07061780.1

chr2_-_189333015 1.82 ENSRNOT00000076424
ENSRNOT00000076952
Hax1
HCLS1 associated protein X-1
chr2_-_189333322 1.80 ENSRNOT00000073599
ENSRNOT00000071253
ENSRNOT00000076325
Hax1
HCLS1 associated protein X-1
chr14_-_106248539 1.57 ENSRNOT00000067668
Ugp2
UDP-glucose pyrophosphorylase 2
chrX_-_124252447 1.52 ENSRNOT00000061546
Rhox12
reproductive homeobox 12
chr3_+_138508899 1.44 ENSRNOT00000009437
Kat14
lysine acetyltransferase 14
chr8_+_38240206 1.22 ENSRNOT00000030635
LOC100362690
rCG64164-like
chr5_+_135574172 1.16 ENSRNOT00000023416
Tesk2
testis-specific kinase 2
chr18_+_16146447 0.94 ENSRNOT00000022117
Galnt1
polypeptide N-acetylgalactosaminyltransferase 1
chr18_+_51523758 0.83 ENSRNOT00000078518
Gramd3
GRAM domain containing 3
chr20_+_20519031 0.72 ENSRNOT00000000780
AABR07044783.1

chr9_+_73378057 0.39 ENSRNOT00000043627
ENSRNOT00000045766
ENSRNOT00000092445
ENSRNOT00000037974
Map2
microtubule-associated protein 2
chr8_+_69484174 0.39 ENSRNOT00000077290
ENSRNOT00000056518
RGD1562747
similar to RIKEN cDNA 1110012L19
chr3_-_138683318 0.22 ENSRNOT00000029701
Dzank1
double zinc ribbon and ankyrin repeat domains 1
chr12_-_44520341 0.21 ENSRNOT00000066810
Nos1
nitric oxide synthase 1
chr5_-_9035811 0.03 ENSRNOT00000082023
Mcmdc2
minichromosome maintenance domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Gbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
17.3 52.0 GO:0033986 response to methanol(GO:0033986)
9.6 47.8 GO:0016098 monoterpenoid metabolic process(GO:0016098)
9.5 38.0 GO:2000259 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
7.3 29.3 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) cytidine to uridine editing(GO:0016554)
1.1 10.2 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
1.1 3.2 GO:0090024 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024)
1.0 11.7 GO:0010649 regulation of cell communication by electrical coupling(GO:0010649)
0.7 5.8 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.7 2.0 GO:0009609 response to symbiotic bacterium(GO:0009609)
0.7 3.4 GO:0014717 regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.7 6.1 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.7 8.5 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.5 1.6 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.4 51.4 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.3 5.8 GO:0021860 pyramidal neuron development(GO:0021860)
0.3 3.6 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 4.8 GO:0045116 protein neddylation(GO:0045116)
0.2 2.6 GO:0052695 cellular glucuronidation(GO:0052695)
0.2 2.9 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.2 0.9 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.2 3.8 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.2 4.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.1 17.0 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 14.2 GO:0018210 peptidyl-threonine phosphorylation(GO:0018107) peptidyl-threonine modification(GO:0018210)
0.1 13.3 GO:0016579 protein deubiquitination(GO:0016579)
0.1 4.5 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 0.2 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
0.0 6.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 18.7 GO:0007283 spermatogenesis(GO:0007283)
0.0 3.3 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.0 10.8 GO:0006816 calcium ion transport(GO:0006816)
0.0 1.4 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 2.6 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 29.3 GO:0045293 mRNA editing complex(GO:0045293)
1.6 11.0 GO:0005579 membrane attack complex(GO:0005579)
1.0 5.8 GO:0097441 basilar dendrite(GO:0097441)
0.6 5.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.4 2.0 GO:0097413 Lewy body(GO:0097413)
0.4 27.0 GO:0005581 collagen trimer(GO:0005581)
0.3 17.0 GO:0034707 chloride channel complex(GO:0034707)
0.2 4.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 3.4 GO:0005922 connexon complex(GO:0005922)
0.1 3.6 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 6.1 GO:1904115 axon cytoplasm(GO:1904115)
0.1 17.5 GO:0031514 motile cilium(GO:0031514)
0.1 66.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 0.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 3.2 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 5.0 GO:0031985 Golgi cisterna(GO:0031985)
0.1 11.7 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 43.1 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 10.8 GO:0031252 cell leading edge(GO:0031252)
0.0 10.2 GO:0005929 cilium(GO:0005929)
0.0 3.9 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 38.9 GO:0005654 nucleoplasm(GO:0005654)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 27.0 GO:0005534 galactose binding(GO:0005534)
2.7 51.4 GO:0017081 chloride channel regulator activity(GO:0017081)
1.7 47.8 GO:0008395 steroid hydroxylase activity(GO:0008395)
1.7 6.7 GO:0000293 ferric-chelate reductase activity(GO:0000293)
1.5 6.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
1.5 5.8 GO:0070699 type II activin receptor binding(GO:0070699)
1.1 3.2 GO:0001847 opsonin receptor activity(GO:0001847)
0.9 11.7 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.9 10.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.6 2.9 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.4 52.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 8.5 GO:0008199 ferric iron binding(GO:0008199)
0.4 20.5 GO:0070063 RNA polymerase binding(GO:0070063)
0.4 1.6 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.4 29.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 3.6 GO:0019966 interleukin-1 binding(GO:0019966)
0.3 4.8 GO:0097602 cullin family protein binding(GO:0097602)
0.2 5.8 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 17.0 GO:0005254 chloride channel activity(GO:0005254)
0.2 3.2 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 13.3 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.1 2.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 2.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 3.3 GO:0042169 SH2 domain binding(GO:0042169)
0.1 4.3 GO:0097110 scaffold protein binding(GO:0097110)
0.0 27.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 7.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.4 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 44.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 6.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 21.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.1 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 27.0 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.5 11.0 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.5 52.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 6.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.2 5.8 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.2 4.5 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.2 4.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 2.0 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 3.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 29.3 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.1 3.2 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins