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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Gata6

Z-value: 0.44

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Transcription factors associated with Gata6

Gene Symbol Gene ID Gene Info
Gata6
ENSRNOG00000023433 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gata6rn6_v1_chr18_+_2416552_24165520.018.6e-01Click!

Activity profile of Gata6 motif

Sorted Z-values of Gata6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_114423533 20.36 ENSRNOT00000091221
Slc2a2
solute carrier family 2 member 2
chr4_+_119225040 18.86 ENSRNOT00000012365
Bmp10
bone morphogenetic protein 10
chr8_+_50525091 13.62 ENSRNOT00000074357
Apoa1
apolipoprotein A1
chr19_+_27404712 12.37 ENSRNOT00000023657
Mylk3
myosin light chain kinase 3
chr7_+_11490852 12.05 ENSRNOT00000044484
Creb3l3
cAMP responsive element binding protein 3-like 3
chr2_-_100249811 11.47 ENSRNOT00000086760
Hnf4g
hepatocyte nuclear factor 4, gamma
chr16_+_10267482 9.95 ENSRNOT00000085255
Gdf2
growth differentiation factor 2
chr1_+_279798187 9.56 ENSRNOT00000024065
Pnlip
pancreatic lipase
chr3_+_79940561 9.52 ENSRNOT00000016652
Mybpc3
myosin binding protein C, cardiac
chr6_-_7961207 8.54 ENSRNOT00000007174
Abcg5
ATP binding cassette subfamily G member 5
chr16_-_49820235 6.69 ENSRNOT00000029628
Sorbs2
sorbin and SH3 domain containing 2
chr1_-_207766250 5.36 ENSRNOT00000031397
Clrn3
clarin 3
chr6_+_7961413 5.25 ENSRNOT00000007638
ENSRNOT00000061871
Abcg8
ATP binding cassette subfamily G member 8
chr17_-_84247038 3.91 ENSRNOT00000068553
Nebl
nebulette
chr1_-_207811008 3.12 ENSRNOT00000080506
Clrn3
clarin 3
chr11_-_44049648 2.39 ENSRNOT00000002257
Cpox
coproporphyrinogen oxidase
chr10_+_70262361 2.34 ENSRNOT00000064625
ENSRNOT00000076973
Unc45b
unc-45 myosin chaperone B
chr4_-_50312608 1.99 ENSRNOT00000010019
Fezf1
Fez family zinc finger 1
chr15_+_32817343 1.99 ENSRNOT00000073853
AABR07017902.1

chr2_+_42726809 1.76 ENSRNOT00000036860
AABR07008097.1

chr1_+_199720038 1.67 ENSRNOT00000027297
Ahsp
alpha hemoglobin stabilizing protein
chr2_+_241029693 1.64 ENSRNOT00000033413
Slc39a8
solute carrier family 39 member 8
chr10_-_31493419 1.07 ENSRNOT00000009211
Itk
IL2-inducible T-cell kinase
chr1_+_214664537 0.98 ENSRNOT00000075002
AABR07006030.1

chr13_-_45040593 0.87 ENSRNOT00000004908
Lct
lactase
chr2_-_77784522 0.77 ENSRNOT00000030328
LOC310177
similar to RIKEN cDNA 0610040D20
chr2_-_259382765 0.16 ENSRNOT00000091407
St6galnac3
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr3_+_76842898 0.03 ENSRNOT00000085537
Olr636
olfactory receptor 636

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 31.2 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
4.5 13.6 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
4.1 20.4 GO:0009758 carbohydrate utilization(GO:0009758) fructose transport(GO:0015755)
2.3 13.8 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
1.3 3.9 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
1.0 9.6 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
1.0 9.5 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.8 12.1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.5 2.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 9.9 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.2 1.6 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.2 2.4 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.2 6.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 0.9 GO:0010045 response to nickel cation(GO:0010045)
0.1 1.1 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 11.5 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.0 2.3 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 1.7 GO:0006457 protein folding(GO:0006457)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.8 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
2.7 13.6 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
1.1 9.5 GO:0097512 cardiac myofibril(GO:0097512)
0.2 20.4 GO:0031526 brush border membrane(GO:0031526)
0.1 22.8 GO:0030018 Z disc(GO:0030018)
0.0 2.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 6.7 GO:0030027 lamellipodium(GO:0030027)
0.0 9.9 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 0.9 GO:0005903 brush border(GO:0005903)
0.0 8.5 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.6 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
3.1 12.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
2.7 18.9 GO:0031433 telethonin binding(GO:0031433)
2.3 20.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.9 9.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.8 12.1 GO:0035497 cAMP response element binding(GO:0035497)
0.7 13.8 GO:0017127 cholesterol transporter activity(GO:0017127)
0.5 9.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.3 2.4 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.3 0.9 GO:0017042 glycosylceramidase activity(GO:0017042)
0.2 1.7 GO:0030492 hemoglobin binding(GO:0030492)
0.2 3.9 GO:0005523 tropomyosin binding(GO:0005523)
0.2 9.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.2 11.5 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 2.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 1.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 34.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 9.9 PID ALK1 PATHWAY ALK1 signaling events
0.0 14.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.1 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 27.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
1.2 20.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.5 11.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 9.6 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 0.9 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis