ISMARA results: Gata4

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Gata4

Z-value: 1.07

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Transcription factors associated with Gata4

Gene Symbol	Gene ID	Gene Info
Gata4 NCBI RGD Ensembl	ENSRNOG00000010708	GATA binding protein 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Gata4	rn6_v1_chr15_-_46432965_46432965	0.53	3.4e-24	Click!

Activity profile of Gata4 motif

Sorted Z-values of Gata4 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_279798187 Show fit	82.40	ENSRNOT00000024065	Pnlip NCBI RGD Ensembl Show fit	pancreatic lipase
chrX_-_13601069 Show fit	62.15	ENSRNOT00000004686	Otc NCBI RGD Ensembl Show fit	ornithine carbamoyltransferase
chr8_+_50525091 Show fit	61.50	ENSRNOT00000074357	Apoa1 NCBI RGD Ensembl Show fit	apolipoprotein A1
chr4_+_70689737 Show fit	58.95	ENSRNOT00000018852	Prss2 NCBI RGD Ensembl Show fit	protease, serine, 2
chr5_-_155772040 Show fit	58.46	ENSRNOT00000036788	Cela3b NCBI RGD Ensembl Show fit	chymotrypsin-like elastase family, member 3B
chr4_+_57952982 Show fit	57.82	ENSRNOT00000014465	Cpa1 NCBI RGD Ensembl Show fit	carboxypeptidase A1
chr1_-_85220237 Show fit	56.75	ENSRNOT00000026907	Sycn NCBI RGD Ensembl Show fit	syncollin
chr12_-_46889082 Show fit	53.07	ENSRNOT00000001525	Pla2g1b NCBI RGD Ensembl Show fit	phospholipase A2 group IB
chr6_-_47890033 Show fit	50.07	ENSRNOT00000011290	Colec11 NCBI RGD Ensembl Show fit	collectin sub-family member 11
chr16_+_10267482 Show fit	49.16	ENSRNOT00000085255	Gdf2 NCBI RGD Ensembl Show fit	growth differentiation factor 2

Showing 1 to 10 of 80 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.2	82.4	GO:0061365	positive regulation of triglyceride lipase activity(GO:0061365)
12.4	62.2	GO:0006526	arginine biosynthetic process(GO:0006526)
20.5	61.5	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
2.5	58.9	GO:0030574	collagen catabolic process(GO:0030574)
0.5	58.5	GO:0008203	cholesterol metabolic process(GO:0008203)
0.4	54.4	GO:0017158	regulation of calcium ion-dependent exocytosis(GO:0017158)
17.7	53.1	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
2.5	49.2	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.1	48.6	GO:0051603	proteolysis involved in cellular protein catabolic process(GO:0051603)
0.4	48.5	GO:0031638	zymogen activation(GO:0031638)

Showing 1 to 10 of 56 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	426.9	GO:0005615	extracellular space(GO:0005615)
0.1	62.3	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.2	62.2	GO:0005759	mitochondrial matrix(GO:0005759)
12.3	61.5	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.6	56.7	GO:0030667	secretory granule membrane(GO:0030667)
0.5	37.5	GO:0005581	collagen trimer(GO:0005581)
12.0	35.9	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.2	25.0	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.6	22.7	GO:0008305	integrin complex(GO:0008305)
0.1	22.6	GO:0005667	transcription factor complex(GO:0005667)

Showing 1 to 10 of 27 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	189.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
4.1	82.4	GO:0004806	triglyceride lipase activity(GO:0004806)
4.4	61.7	GO:0042301	phosphate ion binding(GO:0042301)
20.5	61.5	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
5.9	53.1	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.9	49.2	GO:0005160	transforming growth factor beta receptor binding(GO:0005160)
1.7	45.9	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.1	42.9	GO:0030246	carbohydrate binding(GO:0030246)
2.6	42.1	GO:0035497	cAMP response element binding(GO:0035497)
5.6	39.4	GO:0031433	telethonin binding(GO:0031433)

Showing 1 to 10 of 37 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	189.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6	92.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.7	90.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.6	52.4	PID CMYB PATHWAY	C-MYB transcription factor network
1.4	49.2	PID ALK1 PATHWAY	ALK1 signaling events
0.6	43.7	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
1.8	30.5	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.8	22.7	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.2	15.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.5	11.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.1	97.4	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
2.0	83.5	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.3	62.2	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
6.5	58.9	REACTOME DEFENSINS	Genes involved in Defensins
1.4	54.3	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
3.3	53.1	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
1.4	38.0	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.4	30.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
1.7	29.1	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
1.4	25.3	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins

Showing 1 to 10 of 17 entries

Results for Gata4

Z-value: 1.07

Motif logo

Transcription factors associated with Gata4

Activity-expression correlation:

Activity profile of Gata4 motif

Sorted Z-values of Gata4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: