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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Gata4

Z-value: 1.07

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Transcription factors associated with Gata4

Gene Symbol Gene ID Gene Info
ENSRNOG00000010708 GATA binding protein 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gata4rn6_v1_chr15_-_46432965_464329650.533.4e-24Click!

Activity profile of Gata4 motif

Sorted Z-values of Gata4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_279798187 82.40 ENSRNOT00000024065
pancreatic lipase
chrX_-_13601069 62.15 ENSRNOT00000004686
ornithine carbamoyltransferase
chr8_+_50525091 61.50 ENSRNOT00000074357
apolipoprotein A1
chr4_+_70689737 58.95 ENSRNOT00000018852
protease, serine, 2
chr5_-_155772040 58.46 ENSRNOT00000036788
chymotrypsin-like elastase family, member 3B
chr4_+_57952982 57.82 ENSRNOT00000014465
carboxypeptidase A1
chr1_-_85220237 56.75 ENSRNOT00000026907
syncollin
chr12_-_46889082 53.07 ENSRNOT00000001525
phospholipase A2 group IB
chr6_-_47890033 50.07 ENSRNOT00000011290
collectin sub-family member 11
chr16_+_10267482 49.16 ENSRNOT00000085255
growth differentiation factor 2
chr4_+_70614524 48.55 ENSRNOT00000041100
protease, serine 3
chr4_-_70747226 44.74 ENSRNOT00000044960
anionic trypsin-2-like
chr17_+_8489266 44.06 ENSRNOT00000016252
leukocyte cell-derived chemotaxin 2
chr4_+_163162211 42.51 ENSRNOT00000082537
C-type lectin domain family 1, member B
chr7_+_11490852 42.11 ENSRNOT00000044484
cAMP responsive element binding protein 3-like 3
chr4_+_119225040 39.37 ENSRNOT00000012365
bone morphogenetic protein 10
chr6_-_26385761 38.03 ENSRNOT00000073228
glucokinase regulator
chr2_+_147496229 37.90 ENSRNOT00000022105
transmembrane 4 L six family member 4
chr1_-_258877045 32.46 ENSRNOT00000071633
cytochrome P450, family 2, subfamily c, polypeptide 13
chr5_+_151776004 30.54 ENSRNOT00000009683
nuclear receptor subfamily 0, group B, member 2
chr3_+_159936856 29.37 ENSRNOT00000078703
hepatocyte nuclear factor 4, alpha
chr13_-_53870428 24.95 ENSRNOT00000000812
nuclear receptor subfamily 5, group A, member 2
chr11_+_80736576 23.77 ENSRNOT00000047678
mannan-binding lectin serine peptidase 1
chr6_-_7961207 23.57 ENSRNOT00000007174
ATP binding cassette subfamily G member 5
chr10_-_90415070 22.75 ENSRNOT00000055179
integrin subunit alpha 2b
chr9_+_95256627 21.30 ENSRNOT00000025291
UDP glucuronosyltransferase family 1 member A5
chr16_-_49820235 21.13 ENSRNOT00000029628
sorbin and SH3 domain containing 2
chr20_-_5076539 20.06 ENSRNOT00000076253
ENSRNOT00000037613
lymphocyte antigen 6 complex, locus G6F
chr1_+_72882806 19.49 ENSRNOT00000024640
troponin I3, cardiac type
chr1_-_275906686 15.34 ENSRNOT00000092170
glycerol-3-phosphate acyltransferase, mitochondrial
chr7_+_60099120 14.92 ENSRNOT00000007338
leucine-rich repeat-containing protein 10-like
chr11_-_44049648 12.97 ENSRNOT00000002257
coproporphyrinogen oxidase
chr6_+_7961413 12.37 ENSRNOT00000007638
ENSRNOT00000061871
ATP binding cassette subfamily G member 8
chr2_+_227080924 11.76 ENSRNOT00000029871
fatty acid binding protein 2
chr8_+_22047697 11.64 ENSRNOT00000067741
intercellular adhesion molecule 4, Landsteiner-Wiener blood group
chr20_-_2191640 11.22 ENSRNOT00000001016
tripartite motif-containing 10
chr3_+_79940561 10.85 ENSRNOT00000016652
myosin binding protein C, cardiac
chr11_-_60679555 10.04 ENSRNOT00000059735
coiled-coil domain containing 80
chr5_+_133864798 9.85 ENSRNOT00000091977
TAL bHLH transcription factor 1, erythroid differentiation factor
chr8_-_48672732 9.19 ENSRNOT00000079275
hydroxymethylbilane synthase
chr15_+_33632416 8.67 ENSRNOT00000068212

chr3_+_79918969 8.31 ENSRNOT00000016306
Spi-1 proto-oncogene
chr2_-_60657712 8.29 ENSRNOT00000040348
retinoic acid induced 14
chr20_-_5056474 7.60 ENSRNOT00000076375
ENSRNOT00000037191
ENSRNOT00000076863
immunoreceptor tyrosine-based inhibitory motif (ITIM) containing platelet receptor
chr2_+_241029693 7.24 ENSRNOT00000033413
solute carrier family 39 member 8
chr13_-_89654244 6.98 ENSRNOT00000004896
protoporphyrinogen oxidase
chr10_+_86399827 6.87 ENSRNOT00000009299
growth factor receptor bound protein 7
chr6_+_50725085 6.85 ENSRNOT00000009473
solute carrier family 26 member 3
chr9_-_82146874 6.48 ENSRNOT00000024190
FEV, ETS transcription factor
chr3_-_78790691 5.86 ENSRNOT00000008750
olfactory receptor 724
chr1_+_169951913 5.79 ENSRNOT00000040861
olfactory receptor 189
chr1_-_226732736 5.73 ENSRNOT00000072343
pepsin F-like
chr5_+_169898302 5.23 ENSRNOT00000087911

chr10_-_34242985 4.60 ENSRNOT00000046438
similar to novel protein
chr7_-_143408276 4.13 ENSRNOT00000013122
ENSRNOT00000091540
keratin 73
chrX_+_83678339 4.03 ENSRNOT00000005997
apolipoprotein O-like
chr3_+_55910177 4.01 ENSRNOT00000009969
kelch-like family member 41
chr16_+_50022998 3.84 ENSRNOT00000087986
toll-like receptor 3
chr3_-_112985318 3.83 ENSRNOT00000015556
erythrocyte membrane protein band 4.2
chr8_+_40383918 3.67 ENSRNOT00000071422
olfactory receptor 1201
chr10_+_70262361 3.58 ENSRNOT00000064625
ENSRNOT00000076973
unc-45 myosin chaperone B
chr11_-_35749464 3.42 ENSRNOT00000078818
ENSRNOT00000078425
ERG, ETS transcription factor
chr4_+_158088505 2.53 ENSRNOT00000026643
von Willebrand factor
chr5_+_57239086 2.48 ENSRNOT00000060714
serine peptidase inhibitor, Kazal type 4
chr3_+_73335149 2.42 ENSRNOT00000042537
olfactory receptor 470
chr10_+_103874383 2.27 ENSRNOT00000038935
otopetrin 2
chr17_-_21705773 1.95 ENSRNOT00000078010
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr8_-_22974321 1.57 ENSRNOT00000017369
erythropoietin receptor
chr16_+_2634603 1.49 ENSRNOT00000019113
HESX homeobox 1
chr8_-_33661049 1.31 ENSRNOT00000068037
Fli-1 proto-oncogene, ETS transcription factor
chr4_+_102290338 1.24 ENSRNOT00000011067

chr15_-_52399074 1.11 ENSRNOT00000018440
exportin 7
chr5_+_50381244 1.10 ENSRNOT00000012385
glycoprotein hormones, alpha polypeptide
chr15_+_67555835 1.03 ENSRNOT00000045882
protocadherin 17
chr17_+_45670284 0.59 ENSRNOT00000086536
olfactory receptor 1660
chr11_+_31806618 0.52 ENSRNOT00000043410
ENSRNOT00000002769
Son DNA binding protein
chr4_-_163261958 0.35 ENSRNOT00000086390
oxidized low density lipoprotein (lectin-like) receptor 1
chr10_-_56831243 0.23 ENSRNOT00000025403
solute carrier family 16, member 13
chr7_-_3752134 0.03 ENSRNOT00000067319
olfactory receptor 880
chr2_+_204427608 0.02 ENSRNOT00000083374
nescient helix loop helix 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
20.5 61.5 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
17.7 53.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
12.4 62.2 GO:0006526 arginine biosynthetic process(GO:0006526)
9.2 82.4 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
9.0 35.9 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
7.6 38.0 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) negative regulation of glucokinase activity(GO:0033132) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) negative regulation of hexokinase activity(GO:1903300)
7.3 29.4 GO:0010534 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
6.2 31.2 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
6.2 25.0 GO:0061113 pancreas morphogenesis(GO:0061113)
3.3 9.9 GO:0045799 positive regulation of chromatin assembly or disassembly(GO:0045799)
2.8 42.1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
2.5 49.2 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
2.5 58.9 GO:0030574 collagen catabolic process(GO:0030574)
2.4 21.3 GO:0052697 xenobiotic glucuronidation(GO:0052697)
2.1 8.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
2.0 22.2 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
2.0 23.8 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
1.8 42.5 GO:0030220 platelet formation(GO:0030220)
1.7 7.0 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
1.7 15.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
1.2 19.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.2 32.5 GO:0019373 epoxygenase P450 pathway(GO:0019373)
1.1 10.8 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
1.0 7.2 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
1.0 3.8 GO:0045356 microglial cell activation involved in immune response(GO:0002282) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.6 4.0 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.6 3.4 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.5 6.9 GO:0034063 stress granule assembly(GO:0034063)
0.5 58.5 GO:0008203 cholesterol metabolic process(GO:0008203)
0.5 11.2 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.4 2.5 GO:0070417 cellular response to cold(GO:0070417)
0.4 54.4 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)
0.4 37.9 GO:0042246 tissue regeneration(GO:0042246)
0.4 1.6 GO:1904373 response to kainic acid(GO:1904373)
0.4 3.8 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.4 30.5 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.4 22.3 GO:0070527 platelet aggregation(GO:0070527)
0.4 48.5 GO:0031638 zymogen activation(GO:0031638)
0.4 11.3 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.4 6.8 GO:0060081 membrane hyperpolarization(GO:0060081)
0.3 1.5 GO:0030916 otic vesicle formation(GO:0030916)
0.3 7.7 GO:0050892 intestinal absorption(GO:0050892)
0.3 4.0 GO:0042407 cristae formation(GO:0042407)
0.2 6.5 GO:0048665 neuron fate specification(GO:0048665)
0.2 1.0 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.2 4.6 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 1.3 GO:0035855 megakaryocyte development(GO:0035855)
0.1 18.8 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.1 1.1 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.1 10.0 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 48.6 GO:0051603 proteolysis involved in cellular protein catabolic process(GO:0051603)
0.1 3.6 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 5.7 GO:0030163 protein catabolic process(GO:0030163)
0.0 1.1 GO:0006611 protein export from nucleus(GO:0006611)
0.0 15.8 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.5 GO:0000281 mitotic cytokinesis(GO:0000281)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
12.3 61.5 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
12.0 35.9 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
4.9 19.5 GO:1990584 cardiac Troponin complex(GO:1990584)
1.8 10.8 GO:0097512 cardiac myofibril(GO:0097512)
1.2 11.8 GO:0045179 apical cortex(GO:0045179)
0.6 22.7 GO:0008305 integrin complex(GO:0008305)
0.6 56.7 GO:0030667 secretory granule membrane(GO:0030667)
0.6 4.0 GO:0061617 MICOS complex(GO:0061617)
0.5 10.0 GO:0005614 interstitial matrix(GO:0005614)
0.5 37.5 GO:0005581 collagen trimer(GO:0005581)
0.4 4.0 GO:0031143 pseudopodium(GO:0031143)
0.3 7.0 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.3 6.8 GO:0097225 sperm midpiece(GO:0097225)
0.3 426.9 GO:0005615 extracellular space(GO:0005615)
0.2 13.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 62.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 25.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 6.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 9.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 22.6 GO:0005667 transcription factor complex(GO:0005667)
0.1 62.3 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 4.1 GO:0045095 keratin filament(GO:0045095)
0.1 8.3 GO:0001650 fibrillar center(GO:0001650)
0.1 21.1 GO:0005925 focal adhesion(GO:0005925)
0.0 9.2 GO:0000793 condensed chromosome(GO:0000793)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)
0.0 3.8 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
20.5 61.5 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
5.9 53.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
5.6 39.4 GO:0031433 telethonin binding(GO:0031433)
5.4 38.0 GO:0070095 fructose-6-phosphate binding(GO:0070095)
4.9 19.5 GO:0030172 troponin C binding(GO:0030172)
4.4 61.7 GO:0042301 phosphate ion binding(GO:0042301)
4.1 82.4 GO:0004806 triglyceride lipase activity(GO:0004806)
3.8 22.7 GO:0070051 fibrinogen binding(GO:0070051)
3.1 9.2 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
2.8 19.9 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
2.6 42.1 GO:0035497 cAMP response element binding(GO:0035497)
2.6 15.3 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
2.4 29.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
2.0 11.8 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
1.7 35.9 GO:0017127 cholesterol transporter activity(GO:0017127)
1.7 45.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.2 30.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
1.1 32.5 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
1.0 8.3 GO:0051525 NFAT protein binding(GO:0051525)
1.0 10.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.9 49.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.8 189.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.7 21.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.4 36.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.4 10.0 GO:0001968 fibronectin binding(GO:0001968)
0.4 3.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 5.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 1.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 42.9 GO:0030246 carbohydrate binding(GO:0030246)
0.1 14.2 GO:0005178 integrin binding(GO:0005178)
0.1 0.5 GO:0050733 RS domain binding(GO:0050733)
0.1 1.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 3.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 3.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 6.9 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 15.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 30.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
1.7 90.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.4 49.2 PID ALK1 PATHWAY ALK1 signaling events
0.8 189.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.8 22.7 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.6 43.7 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.6 92.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6 52.4 PID CMYB PATHWAY C-MYB transcription factor network
0.5 11.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 6.9 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 3.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 15.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.1 PID EPO PATHWAY EPO signaling pathway
0.0 7.9 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 1.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 2.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 58.9 REACTOME DEFENSINS Genes involved in Defensins
5.1 97.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
3.3 53.1 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
2.2 23.8 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
2.0 83.5 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
1.7 29.1 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
1.4 25.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
1.4 54.3 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
1.4 38.0 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
1.1 21.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.8 15.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.4 30.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 3.8 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.3 6.9 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.3 62.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.3 11.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 11.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell