ISMARA results: Gata3

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Gata3

Z-value: 2.17

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Transcription factors associated with Gata3

Gene Symbol	Gene ID	Gene Info
Gata3 NCBI RGD Ensembl	ENSRNOG00000019336	GATA binding protein 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Gata3	rn6_v1_chr17_+_72429618_72429618	-0.30	2.7e-08	Click!

Activity profile of Gata3 motif

Sorted Z-values of Gata3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_72889270 Show fit	38.16	ENSRNOT00000058843 ENSRNOT00000034957	Tnnt1 NCBI RGD Ensembl Show fit	troponin T1, slow skeletal type
chrX_-_64715823 Show fit	37.38	ENSRNOT00000076297	Asb12 NCBI RGD Ensembl Show fit	ankyrin repeat and SOCS box-containing 12
chr14_-_86047162 Show fit	35.33	ENSRNOT00000018227	Pgam2 NCBI RGD Ensembl Show fit	phosphoglycerate mutase 2
chr4_-_132111079 Show fit	33.86	ENSRNOT00000013719	Eif4e3 NCBI RGD Ensembl Show fit	eukaryotic translation initiation factor 4E family member 3
chr9_-_73948583 Show fit	33.52	ENSRNOT00000018097	Myl1 NCBI RGD Ensembl Show fit	myosin, light chain 1
chrX_+_71342775 Show fit	33.35	ENSRNOT00000004888	Itgb1bp2 NCBI RGD Ensembl Show fit	integrin subunit beta 1 binding protein 2
chr10_+_45289741 Show fit	33.34	ENSRNOT00000066190	Hist3h2ba NCBI RGD Ensembl Show fit	histone cluster 3, H2ba
chr2_+_104416972 Show fit	33.16	ENSRNOT00000017125	Trim55 NCBI RGD Ensembl Show fit	tripartite motif-containing 55
chr1_+_193537137 Show fit	33.09	ENSRNOT00000029967	AABR07005667.1 NCBI RGD Ensembl Show fit
chr16_+_25773602 Show fit	32.08	ENSRNOT00000047750	Gapdh-ps2 NCBI RGD Ensembl Show fit	glyceraldehyde-3-phosphate dehydrogenase, pseudogene 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	352.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
1.2	127.6	GO:0006334	nucleosome assembly(GO:0006334)
0.7	60.7	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
19.5	58.5	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)
1.3	52.0	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
2.8	50.8	GO:0090129	positive regulation of synapse maturation(GO:0090129)
7.5	44.7	GO:1904714	positive regulation of Schwann cell proliferation(GO:0010625) regulation of chaperone-mediated autophagy(GO:1904714)
1.8	36.6	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)
5.0	35.3	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.7	33.3	GO:0036465	synaptic vesicle recycling(GO:0036465)

Showing 1 to 10 of 363 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	116.3	GO:0000786	nucleosome(GO:0000786)
0.7	97.9	GO:0031674	I band(GO:0031674)
1.9	83.9	GO:0031672	A band(GO:0031672)
6.0	71.8	GO:0005861	troponin complex(GO:0005861)
0.3	69.6	GO:0014069	postsynaptic density(GO:0014069)
0.7	61.9	GO:0001750	photoreceptor outer segment(GO:0001750)
0.3	56.0	GO:0005802	trans-Golgi network(GO:0005802)
0.7	54.9	GO:0030016	myofibril(GO:0030016)
2.7	53.9	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
2.0	45.9	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Showing 1 to 10 of 157 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	342.7	GO:0004984	olfactory receptor activity(GO:0004984)
0.2	64.0	GO:0003735	structural constituent of ribosome(GO:0003735)
1.5	57.0	GO:0005246	calcium channel regulator activity(GO:0005246)
2.0	55.0	GO:0031402	sodium ion binding(GO:0031402)
0.7	45.5	GO:0003743	translation initiation factor activity(GO:0003743)
0.4	43.3	GO:0005178	integrin binding(GO:0005178)
2.2	42.5	GO:0008179	adenylate cyclase binding(GO:0008179)
2.6	41.7	GO:0005523	tropomyosin binding(GO:0005523)
1.6	39.6	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
2.8	39.4	GO:0051378	serotonin binding(GO:0051378)

Showing 1 to 10 of 244 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	50.9	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.6	24.6	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.4	21.5	PID TNF PATHWAY	TNF receptor signaling pathway
0.5	20.6	PID IL23 PATHWAY	IL23-mediated signaling events
0.4	20.4	PID FOXO PATHWAY	FoxO family signaling
1.2	19.7	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.4	19.3	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.4	18.9	PID CDC42 PATHWAY	CDC42 signaling events
0.1	18.1	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.5	14.1	PID CXCR3 PATHWAY	CXCR3-mediated signaling events

Showing 1 to 10 of 56 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	105.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.6	62.3	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.5	50.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.9	50.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.8	44.7	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
3.1	43.6	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
2.5	40.1	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.5	36.8	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2	34.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.6	31.0	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi

Showing 1 to 10 of 94 entries

Results for Gata3

Z-value: 2.17

Motif logo

Transcription factors associated with Gata3

Activity-expression correlation:

Activity profile of Gata3 motif

Sorted Z-values of Gata3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: