ISMARA results: Gata2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Gata2_Gata1

Z-value: 1.91

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Transcription factors associated with Gata2_Gata1

Gene Symbol	Gene ID	Gene Info
Gata2 NCBI RGD Ensembl	ENSRNOG00000012347	GATA binding protein 2
Gata1 NCBI RGD Ensembl	ENSRNOG00000025534	GATA binding protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Gata1	rn6_v1_chrX_+_15378789_15378789	0.50	1.1e-21	Click!
Gata2	rn6_v1_chr4_+_120133713_120133713	0.00	9.4e-01	Click!

Activity profile of Gata2_Gata1 motif

Sorted Z-values of Gata2_Gata1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_119225040 Show fit	146.91	ENSRNOT00000012365	Bmp10 NCBI RGD Ensembl Show fit	bone morphogenetic protein 10
chr4_+_57952982 Show fit	135.57	ENSRNOT00000014465	Cpa1 NCBI RGD Ensembl Show fit	carboxypeptidase A1
chr1_+_279798187 Show fit	133.38	ENSRNOT00000024065	Pnlip NCBI RGD Ensembl Show fit	pancreatic lipase
chr12_-_46889082 Show fit	121.41	ENSRNOT00000001525	Pla2g1b NCBI RGD Ensembl Show fit	phospholipase A2 group IB
chr14_+_26662965 Show fit	120.68	ENSRNOT00000002621	Tecrl NCBI RGD Ensembl Show fit	trans-2,3-enoyl-CoA reductase-like
chr5_-_155772040 Show fit	110.46	ENSRNOT00000036788	Cela3b NCBI RGD Ensembl Show fit	chymotrypsin-like elastase family, member 3B
chr4_+_70614524 Show fit	98.01	ENSRNOT00000041100	Prss3 NCBI RGD Ensembl Show fit	protease, serine 3
chr1_+_72882806 Show fit	97.34	ENSRNOT00000024640	Tnni3 NCBI RGD Ensembl Show fit	troponin I3, cardiac type
chr3_+_79940561 Show fit	94.09	ENSRNOT00000016652	Mybpc3 NCBI RGD Ensembl Show fit	myosin binding protein C, cardiac
chr6_-_26385761 Show fit	73.70	ENSRNOT00000073228	Gckr NCBI RGD Ensembl Show fit	glucokinase regulator

Showing 1 to 10 of 156 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata2_Gata1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
35.8	179.0	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
14.8	133.4	GO:0061365	positive regulation of triglyceride lipase activity(GO:0061365)
8.2	130.7	GO:0032780	negative regulation of ATPase activity(GO:0032780)
40.5	121.4	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
7.1	120.7	GO:0042761	very long-chain fatty acid biosynthetic process(GO:0042761)
0.2	111.4	GO:0051603	proteolysis involved in cellular protein catabolic process(GO:0051603)
9.4	94.1	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
0.7	90.8	GO:0031638	zymogen activation(GO:0031638)
7.7	84.5	GO:0006782	protoporphyrinogen IX biosynthetic process(GO:0006782)
0.8	79.8	GO:0008203	cholesterol metabolic process(GO:0008203)

Showing 1 to 10 of 96 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	1006.0	GO:0005615	extracellular space(GO:0005615)
1.2	169.1	GO:0030018	Z disc(GO:0030018)
24.3	97.3	GO:1990584	cardiac Troponin complex(GO:1990584)
15.7	94.1	GO:0097512	cardiac myofibril(GO:0097512)
0.2	61.5	GO:0005759	mitochondrial matrix(GO:0005759)
0.5	61.3	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.7	60.2	GO:0030667	secretory granule membrane(GO:0030667)
11.6	57.9	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.0	56.2	GO:0005739	mitochondrion(GO:0005739)
0.4	51.0	GO:0042383	sarcolemma(GO:0042383)

Showing 1 to 10 of 44 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	319.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
6.5	176.3	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
21.0	146.9	GO:0031433	telethonin binding(GO:0031433)
1.5	134.9	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
6.7	133.4	GO:0004806	triglyceride lipase activity(GO:0004806)
13.5	121.4	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
2.3	120.7	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
24.3	97.3	GO:0030172	troponin C binding(GO:0030172)
8.6	94.1	GO:0032036	myosin heavy chain binding(GO:0032036)
5.6	77.8	GO:0042301	phosphate ion binding(GO:0042301)

Showing 1 to 10 of 74 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	338.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	130.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
1.7	121.4	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
2.8	66.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.4	59.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.1	59.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
1.8	57.6	PID EPO PATHWAY	EPO signaling pathway
0.6	55.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.5	47.0	PID ALK1 PATHWAY	ALK1 signaling events
1.7	44.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions

Showing 1 to 10 of 31 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.4	272.2	REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT	Genes involved in Lipid digestion, mobilization, and transport
7.6	121.4	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
2.9	112.1	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
5.0	84.5	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
2.5	73.7	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
6.8	61.0	REACTOME DEFENSINS	Genes involved in Defensins
3.0	54.8	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
1.4	51.2	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.8	39.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2	37.3	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives

Showing 1 to 10 of 30 entries

Results for Gata2_Gata1

Z-value: 1.91

Motif logo

Transcription factors associated with Gata2_Gata1

Activity-expression correlation:

Activity profile of Gata2_Gata1 motif

Sorted Z-values of Gata2_Gata1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata2_Gata1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: