ISMARA results: Foxp2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxp2_Foxp3

Z-value: 0.86

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Transcription factors associated with Foxp2_Foxp3

Gene Symbol	Gene ID	Gene Info
Foxp2 NCBI RGD Ensembl	ENSRNOG00000054508	forkhead box P2
Foxp3 NCBI RGD Ensembl	ENSRNOG00000011702	forkhead box P3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Foxp3	rn6_v1_chrX_-_15761932_15761932	0.28	4.7e-07	Click!
Foxp2	rn6_v1_chr4_+_41364441_41364441	0.23	4.4e-05	Click!

Activity profile of Foxp2_Foxp3 motif

Sorted Z-values of Foxp2_Foxp3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_103395511 Show fit	26.13	ENSRNOT00000004256	Gprc5c NCBI RGD Ensembl Show fit	G protein-coupled receptor, class C, group 5, member C
chr10_+_96639924 Show fit	21.80	ENSRNOT00000004756	Apoh NCBI RGD Ensembl Show fit	apolipoprotein H
chr4_-_30556814 Show fit	20.82	ENSRNOT00000012760	Pdk4 NCBI RGD Ensembl Show fit	pyruvate dehydrogenase kinase 4
chr4_-_82289672 Show fit	19.96	ENSRNOT00000036394	Hoxa10 NCBI RGD Ensembl Show fit	homeobox A10
chr7_+_58814805 Show fit	19.87	ENSRNOT00000005909	Tspan8 NCBI RGD Ensembl Show fit	tetraspanin 8
chr7_+_74047814 Show fit	19.12	ENSRNOT00000014879	Osr2 NCBI RGD Ensembl Show fit	odd-skipped related transciption factor 2
chr6_+_129399468 Show fit	17.77	ENSRNOT00000071735 ENSRNOT00000074621	Bdkrb2 NCBI RGD Ensembl Show fit	bradykinin receptor B2
chr4_-_82295470 Show fit	17.48	ENSRNOT00000091073	Hoxa10 NCBI RGD Ensembl Show fit	homeobox A10
chr5_+_124300477 Show fit	16.85	ENSRNOT00000010100	C8b NCBI RGD Ensembl Show fit	complement C8 beta chain
chr4_-_82209933 Show fit	16.85	ENSRNOT00000091106	LOC100912608 NCBI RGD Ensembl Show fit	homeobox protein Hox-A10-like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxp2_Foxp3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	48.3	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.0	32.0	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
1.5	27.6	GO:0032060	bleb assembly(GO:0032060)
5.5	21.8	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
5.2	20.8	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.4	19.9	GO:1900047	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
6.4	19.1	GO:0036023	embryonic skeletal limb joint morphogenesis(GO:0036023)
4.4	17.8	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
3.5	17.7	GO:0090131	mesenchyme migration(GO:0090131)
0.0	17.5	GO:0006897	endocytosis(GO:0006897)

Showing 1 to 10 of 262 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	94.0	GO:0070062	extracellular exosome(GO:0070062)
0.1	46.9	GO:0005667	transcription factor complex(GO:0005667)
0.1	37.8	GO:0043235	receptor complex(GO:0043235)
2.5	32.6	GO:0042627	chylomicron(GO:0042627)
1.6	24.3	GO:0032982	myosin filament(GO:0032982)
0.1	24.0	GO:0005759	mitochondrial matrix(GO:0005759)
3.3	23.0	GO:0005579	membrane attack complex(GO:0005579)
0.1	19.8	GO:0016323	basolateral plasma membrane(GO:0016323)
0.7	19.5	GO:0031430	M band(GO:0031430)
0.2	14.1	GO:0045095	keratin filament(GO:0045095)

Showing 1 to 10 of 118 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	35.8	GO:0004930	G-protein coupled receptor activity(GO:0004930)
0.1	34.7	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
9.4	28.3	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.2	27.7	GO:0042826	histone deacetylase binding(GO:0042826)
0.2	23.7	GO:0005178	integrin binding(GO:0005178)
1.7	22.1	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
5.2	20.8	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.9	20.7	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.3	19.5	GO:0017022	myosin binding(GO:0017022)
0.2	18.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)

Showing 1 to 10 of 187 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	38.7	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	33.2	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5	29.7	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	25.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5	24.1	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.4	23.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.8	16.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.2	14.3	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.2	14.0	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.3	13.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton

Showing 1 to 10 of 60 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	28.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.4	25.0	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.7	23.0	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
1.5	20.8	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.7	19.9	REACTOME LIPOPROTEIN METABOLISM	Genes involved in Lipoprotein metabolism
0.2	19.6	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.7	19.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.4	18.5	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	17.8	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.4	17.1	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane

Showing 1 to 10 of 84 entries

Results for Foxp2_Foxp3

Z-value: 0.86

Motif logo

Transcription factors associated with Foxp2_Foxp3

Activity-expression correlation:

Activity profile of Foxp2_Foxp3 motif

Sorted Z-values of Foxp2_Foxp3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxp2_Foxp3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: