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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxm1

Z-value: 0.59

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Transcription factors associated with Foxm1

Gene Symbol Gene ID Gene Info
Foxm1
ENSRNOG00000005936 forkhead box M1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxm1rn6_v1_chr4_+_161685258_161685283-0.196.1e-04Click!

Activity profile of Foxm1 motif

Sorted Z-values of Foxm1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_3677474 20.87 ENSRNOT00000047663
Mt1m
metallothionein 1M
chr3_+_51883559 14.36 ENSRNOT00000007197
Csrnp3
cysteine and serine rich nuclear protein 3
chr17_+_78793336 12.49 ENSRNOT00000057898
Mt1
metallothionein 1
chr18_-_26211445 12.12 ENSRNOT00000027739
Nrep
neuronal regeneration related protein
chr10_+_86399827 9.67 ENSRNOT00000009299
Grb7
growth factor receptor bound protein 7
chr16_+_72388880 9.45 ENSRNOT00000072459
LOC684871
similar to Protein C8orf4 (Thyroid cancer protein 1) (TC-1)
chr16_+_72401887 9.35 ENSRNOT00000074449
LOC100910163
uncharacterized LOC100910163
chr1_+_107262659 8.93 ENSRNOT00000022499
Gas2
growth arrest-specific 2
chr8_-_115981910 7.84 ENSRNOT00000019867
Dock3
dedicator of cyto-kinesis 3
chr10_+_59894340 7.77 ENSRNOT00000080446
Spata22
spermatogenesis associated 22
chr16_+_18736154 7.46 ENSRNOT00000015723
Mbl1
mannose-binding lectin (protein A) 1
chr7_-_101138860 7.40 ENSRNOT00000077137
AABR07058124.4

chr18_-_61788859 7.15 ENSRNOT00000034075
ENSRNOT00000034069
Ccbe1
collagen and calcium binding EGF domains 1
chr2_+_182006242 7.03 ENSRNOT00000064091
Fga
fibrinogen alpha chain
chr14_+_12218553 6.90 ENSRNOT00000003237
Prkg2
protein kinase, cGMP-dependent, type II
chr16_+_74531564 6.58 ENSRNOT00000078971
Slc25a15
solute carrier family 25 member 15
chr9_+_112360419 6.17 ENSRNOT00000086682
Man2a1
mannosidase, alpha, class 2A, member 1
chr7_-_101138373 6.05 ENSRNOT00000043257
LOC500877
Ab1-152
chr8_+_116332796 5.84 ENSRNOT00000021408
Hyal1
hyaluronoglucosaminidase 1
chr7_+_121408829 5.51 ENSRNOT00000023434
Mgat3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr1_-_236900904 5.32 ENSRNOT00000066846
AABR07006480.1

chr11_-_87924816 5.32 ENSRNOT00000031819
Serpind1
serpin family D member 1
chr1_+_258074860 5.10 ENSRNOT00000054729
Cyp2c24
cytochrome P450, family 2, subfamily c, polypeptide 24
chr18_-_58423196 5.02 ENSRNOT00000025556
Piezo2
piezo-type mechanosensitive ion channel component 2
chr1_+_147713892 4.81 ENSRNOT00000092985
ENSRNOT00000054742
ENSRNOT00000074103
Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
chr20_-_54517709 4.52 ENSRNOT00000076234
Grik2
glutamate ionotropic receptor kainate type subunit 2
chr2_+_69415057 4.40 ENSRNOT00000013152
Cdh10
cadherin 10
chr14_-_6201002 4.34 ENSRNOT00000049165
LOC100366030
rCG37858-like
chr17_-_21705773 4.32 ENSRNOT00000078010
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr5_-_14367898 4.26 ENSRNOT00000065402
Atp6v1h
ATPase H+ transporting V1 subunit H
chr20_-_3440769 4.16 ENSRNOT00000084981
Ier3
immediate early response 3
chr14_-_6148830 4.15 ENSRNOT00000075091
ENSRNOT00000092683
LOC100366030
rCG37858-like
chr7_+_141053876 4.12 ENSRNOT00000084674
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr4_+_181103774 4.11 ENSRNOT00000084207
ENSRNOT00000055473
ENSRNOT00000077619
Arntl2
aryl hydrocarbon receptor nuclear translocator-like 2
chr19_-_53754602 3.72 ENSRNOT00000035651
Fam92b
family with sequence similarity 92, member B
chr5_-_78324278 3.53 ENSRNOT00000082642
ENSRNOT00000048904
Wdr31
WD repeat domain 31
chr13_+_78979321 3.45 ENSRNOT00000003857
Ankrd45
ankyrin repeat domain 45
chr1_-_131454689 3.37 ENSRNOT00000014152
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr2_-_28799266 3.36 ENSRNOT00000089293
Tmem171
transmembrane protein 171
chr5_-_14356692 3.35 ENSRNOT00000085654
Atp6v1h
ATPase H+ transporting V1 subunit H
chr3_+_151335292 3.25 ENSRNOT00000073642
Mmp24
matrix metallopeptidase 24
chr2_+_113007549 3.20 ENSRNOT00000017758
Tnfsf10
tumor necrosis factor superfamily member 10
chr7_-_70829815 3.05 ENSRNOT00000011082
Shmt2
serine hydroxymethyltransferase 2
chr1_+_247238798 2.99 ENSRNOT00000083511
Rcl1
RNA terminal phosphate cyclase-like 1
chr1_+_201620642 2.97 ENSRNOT00000093674
Dmbt1
deleted in malignant brain tumors 1
chr4_+_96449351 2.97 ENSRNOT00000091272
Tnip3
TNFAIP3 interacting protein 3
chr10_-_27179900 2.88 ENSRNOT00000082445
Gabrg2
gamma-aminobutyric acid type A receptor gamma 2 subunit
chr7_-_70661891 2.88 ENSRNOT00000010240
Inhbc
inhibin beta C subunit
chr12_-_39697465 2.87 ENSRNOT00000078683
Vps29
VPS29 retromer complex component
chr17_+_43661222 2.86 ENSRNOT00000022881
ENSRNOT00000022809
ENSRNOT00000022810
Hfe
hemochromatosis
chr4_+_138441332 2.81 ENSRNOT00000090847
Cntn4
contactin 4
chr7_-_119071712 2.79 ENSRNOT00000037611
Myh9l1
myosin heavy chain 9-like 1
chr10_-_67478848 2.77 ENSRNOT00000005325
Tefm
transcription elongation factor, mitochondrial
chr2_+_18392142 2.61 ENSRNOT00000043196
Hapln1
hyaluronan and proteoglycan link protein 1
chr2_-_165591110 2.53 ENSRNOT00000091140
Ift80
intraflagellar transport 80
chr10_-_27179254 2.52 ENSRNOT00000004619
Gabrg2
gamma-aminobutyric acid type A receptor gamma 2 subunit
chrX_+_115351114 2.48 ENSRNOT00000047553
Hmg1l1
high-mobility group (nonhistone chromosomal) protein 1-like 1
chr18_-_26656879 2.35 ENSRNOT00000086729
Epb41l4a
erythrocyte membrane protein band 4.1 like 4A
chr6_+_122603269 2.34 ENSRNOT00000005297
Spata7
spermatogenesis associated 7
chr3_-_147819571 2.25 ENSRNOT00000009840
Trib3
tribbles pseudokinase 3
chr7_+_28414350 2.23 ENSRNOT00000085680
Igf1
insulin-like growth factor 1
chr12_+_22449985 2.14 ENSRNOT00000075951
Slc12a9
solute carrier family 12, member 9
chr10_+_53570989 2.13 ENSRNOT00000064764
ENSRNOT00000004516
Tmem220
transmembrane protein 220
chr10_+_47065850 2.05 ENSRNOT00000077868
ENSRNOT00000066250
Dhrs7b
dehydrogenase/reductase 7B
chr3_-_122946289 1.98 ENSRNOT00000055810
Pced1a
PC-esterase domain containing 1A
chr1_+_47032113 1.98 ENSRNOT00000024412
Tulp4
tubby like protein 4
chr15_-_25505691 1.97 ENSRNOT00000074488
LOC100911492
homeobox protein OTX2-like
chr7_-_9711928 1.95 ENSRNOT00000011167
Neurod4
neuronal differentiation 4
chr1_-_169598835 1.90 ENSRNOT00000072996
Olr156
olfactory receptor 156
chr4_+_175729726 1.86 ENSRNOT00000013230
Slco1c1
solute carrier organic anion transporter family, member 1c1
chr5_-_24560063 1.81 ENSRNOT00000037869
Dpy19l4
dpy-19-like 4 (C. elegans)
chr17_-_53713408 1.73 ENSRNOT00000022445
LOC100912163
AT-rich interactive domain-containing protein 4B-like
chr11_-_72814850 1.71 ENSRNOT00000091575
LOC100911374
UBX domain-containing protein 7-like
chr5_-_28164326 1.68 ENSRNOT00000088165
Slc26a7
solute carrier family 26 member 7
chr14_+_8080275 1.66 ENSRNOT00000065965
ENSRNOT00000092542
Mapk10
mitogen activated protein kinase 10
chr2_+_196013799 1.65 ENSRNOT00000084023
Pogz
pogo transposable element with ZNF domain
chr14_-_28536260 1.62 ENSRNOT00000059942
Adgrl3
adhesion G protein-coupled receptor L3
chrX_-_31851715 1.61 ENSRNOT00000068601
Vegfd
vascular endothelial growth factor D
chr7_+_122818975 1.60 ENSRNOT00000000206
Ep300
E1A binding protein p300
chr1_+_61268248 1.59 ENSRNOT00000082730
LOC102552527
zinc finger protein 420-like
chr6_+_26241672 1.53 ENSRNOT00000006543
Supt7l
SPT7-like STAGA complex gamma subunit
chr2_+_257568613 1.52 ENSRNOT00000066125
Usp33
ubiquitin specific peptidase 33
chr5_+_146337491 1.47 ENSRNOT00000029395
LOC100912566
UPF0500 protein C1orf216 homolog
chr10_-_109979712 1.46 ENSRNOT00000086042
Dus1l
dihydrouridine synthase 1-like
chr8_+_117106576 1.25 ENSRNOT00000071664
Rhoa
ras homolog family member A
chr16_+_74076812 1.16 ENSRNOT00000025675
Ap3m2
adaptor-related protein complex 3, mu 2 subunit
chr1_+_60248695 1.13 ENSRNOT00000079558
Vom1r9
vomeronasal 1 receptor 9
chr14_-_33107776 1.06 ENSRNOT00000039252
Polr2b
RNA polymerase II subunit B
chr7_-_120770435 1.03 ENSRNOT00000077000
Ddx17
DEAD-box helicase 17
chr14_+_39663421 1.01 ENSRNOT00000003197
Gabra2
gamma-aminobutyric acid type A receptor alpha2 subunit
chr6_+_107581608 0.98 ENSRNOT00000058101
Acot6
acyl-CoA thioesterase 6
chr1_+_198067066 0.97 ENSRNOT00000084824
Sgf29
SAGA complex associated factor 29
chr17_+_57031766 0.93 ENSRNOT00000092187
ENSRNOT00000068545
Crem
cAMP responsive element modulator
chr10_-_67479077 0.90 ENSRNOT00000090278
Tefm
transcription elongation factor, mitochondrial
chr2_+_39314714 0.85 ENSRNOT00000083786
ENSRNOT00000047282
Smim15
small integral membrane protein 15
chr3_-_74371385 0.83 ENSRNOT00000041668
Olr518
olfactory receptor 518
chr16_+_37500017 0.83 ENSRNOT00000081634
AC135696.1
high mobility group box 1 (Hmgb1), mRNA
chr5_+_145188323 0.78 ENSRNOT00000038888
Tmem35b
transmembrane protein 35B
chr5_-_77316764 0.75 ENSRNOT00000071395
ENSRNOT00000076464
Mup4
major urinary protein 4
chr7_-_123572082 0.73 ENSRNOT00000068020
Naga
N-acetyl galactosaminidase, alpha
chr2_+_44289393 0.67 ENSRNOT00000018877
Il6st
interleukin 6 signal transducer
chr1_-_167992529 0.65 ENSRNOT00000067344
LOC684170
similar to olfactory receptor 566
chr16_+_2379480 0.64 ENSRNOT00000079215
Dnah12
dynein, axonemal, heavy chain 12
chr15_+_61731735 0.60 ENSRNOT00000015517
Kbtbd6
kelch repeat and BTB domain containing 6
chr8_+_18969478 0.56 ENSRNOT00000061325
Olr1130
olfactory receptor 1130
chr3_+_167513759 0.54 ENSRNOT00000072202
AABR07054716.1

chr3_-_78112770 0.52 ENSRNOT00000008396
Olr694
olfactory receptor 694
chr17_+_23661429 0.51 ENSRNOT00000046523
Phactr1
phosphatase and actin regulator 1
chr12_+_38459832 0.51 ENSRNOT00000090343
Vps33a
VPS33A CORVET/HOPS core subunit
chr6_-_10592454 0.48 ENSRNOT00000020600
Pigf
phosphatidylinositol glycan anchor biosynthesis, class F
chr5_+_113592919 0.47 ENSRNOT00000011336
Ift74
intraflagellar transport 74
chr4_+_92431710 0.45 ENSRNOT00000049438
LOC108350839
high mobility group protein B1-like
chr11_+_80358211 0.44 ENSRNOT00000002519
Sst
somatostatin
chr3_+_80670140 0.44 ENSRNOT00000085614
Ambra1
autophagy and beclin 1 regulator 1
chr8_-_17965418 0.43 ENSRNOT00000072508
LOC103693022
olfactory receptor 7G2-like
chr3_-_74448279 0.41 ENSRNOT00000043964
Olr527
olfactory receptor 527
chr1_-_84732242 0.38 ENSRNOT00000025586
LOC102553760
zinc finger protein 59-like
chr12_+_36638457 0.36 ENSRNOT00000085692
Ubc
ubiquitin C
chr13_-_74331214 0.36 ENSRNOT00000006018
Fam20b
FAM20B, glycosaminoglycan xylosylkinase
chr12_-_10973689 0.36 ENSRNOT00000072406
AABR07035357.1

chr16_+_8207223 0.33 ENSRNOT00000026751
Oxnad1
oxidoreductase NAD-binding domain containing 1
chr10_-_60406203 0.32 ENSRNOT00000041318
Olr1505
olfactory receptor 1505
chr11_-_1836897 0.32 ENSRNOT00000050533
Zfp654
zinc finger protein 654
chr1_+_258210344 0.31 ENSRNOT00000001990
LOC100361492
cytochrome P450, family 2, subfamily c, polypeptide 55-like
chr3_-_73668999 0.25 ENSRNOT00000080395
LOC100909940
olfactory receptor 8J3-like
chr6_+_136004214 0.23 ENSRNOT00000013695
NEWGENE_619861
eukaryotic translation initiation factor 5
chr1_+_86429262 0.23 ENSRNOT00000045789
Vom1r3
vomeronasal 1 receptor 3
chr4_-_60548021 0.21 ENSRNOT00000065546
AABR07060165.1

chr1_+_43475589 0.20 ENSRNOT00000092034
ENSRNOT00000024682
Oprm1
opioid receptor, mu 1
chrX_+_156655960 0.19 ENSRNOT00000085723
Mecp2
methyl CpG binding protein 2
chr1_+_168204985 0.17 ENSRNOT00000049036
Olr75
olfactory receptor 75
chr14_+_106153575 0.16 ENSRNOT00000010264
Vps54
VPS54 GARP complex subunit
chr8_+_21271190 0.16 ENSRNOT00000048082
LOC100361194
olfactory receptor Olr1192-like
chr1_-_73732118 0.12 ENSRNOT00000077964
Leng8
leukocyte receptor cluster member 8
chr2_-_96509424 0.12 ENSRNOT00000090866
Zc2hc1a
zinc finger, C2HC-type containing 1A
chr15_-_55277713 0.09 ENSRNOT00000023037
Itm2b
integral membrane protein 2B
chr19_-_38344845 0.06 ENSRNOT00000072666
AABR07043748.1

chr1_+_169153297 0.04 ENSRNOT00000052078
Olr137
olfactory receptor 137
chr8_+_21305250 0.02 ENSRNOT00000050206
Olr1193
olfactory receptor 1193
chr20_+_7330250 0.01 ENSRNOT00000090993
LOC499407
LRRGT00097
chr19_-_27535792 0.00 ENSRNOT00000024040
Olr1666
olfactory receptor 1666
chr16_-_61091169 0.00 ENSRNOT00000016328
Dusp4
dual specificity phosphatase 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxm1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) positive regulation of lymphangiogenesis(GO:1901492)
2.3 6.9 GO:2001226 negative regulation of chloride transport(GO:2001226)
2.1 12.5 GO:0046687 response to chromate(GO:0046687)
1.5 5.8 GO:1900104 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.4 7.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
1.4 4.1 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
1.3 9.3 GO:1900019 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
1.3 6.6 GO:0000066 mitochondrial ornithine transport(GO:0000066)
1.1 3.4 GO:0060849 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
1.1 7.8 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
1.0 4.8 GO:0016098 monoterpenoid metabolic process(GO:0016098)
1.0 2.9 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.7 9.7 GO:0034063 stress granule assembly(GO:0034063)
0.7 4.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.6 1.2 GO:0001998 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998)
0.6 3.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.6 7.5 GO:0051873 disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.6 6.2 GO:0006013 mannose metabolic process(GO:0006013)
0.6 2.2 GO:0001834 trophectodermal cell proliferation(GO:0001834)
0.5 1.6 GO:0018076 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) N-terminal peptidyl-lysine acetylation(GO:0018076)
0.5 3.0 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.5 1.8 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.4 5.4 GO:0071420 cellular response to histamine(GO:0071420)
0.4 7.6 GO:0007035 vacuolar acidification(GO:0007035)
0.3 3.0 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.3 4.2 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.3 5.1 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.3 2.1 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.3 2.3 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.3 5.5 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.3 3.7 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 2.5 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.2 3.2 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.2 1.5 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.2 4.5 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 0.7 GO:0070103 regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.2 0.9 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.2 1.9 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 12.1 GO:0031103 axon regeneration(GO:0031103)
0.2 3.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 2.8 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.2 2.0 GO:0035881 amacrine cell differentiation(GO:0035881)
0.2 14.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 1.7 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 2.3 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.1 1.7 GO:0051382 kinetochore assembly(GO:0051382)
0.1 4.1 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.1 2.9 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.1 3.2 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 1.6 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 1.5 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.1 0.5 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.1 1.7 GO:1902358 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.1 0.2 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.1 0.7 GO:0016139 glycoside catabolic process(GO:0016139)
0.1 0.2 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635) Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356)
0.1 0.5 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 1.2 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 1.5 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 1.0 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.1 2.0 GO:0061512 protein localization to cilium(GO:0061512)
0.1 2.9 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.1 2.0 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 5.0 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.4 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 3.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.2 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.9 GO:0006687 glycosphingolipid metabolic process(GO:0006687) retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 5.3 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.4 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.0 0.4 GO:0010447 response to acidic pH(GO:0010447)
0.0 1.0 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 2.9 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.0 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0036117 hyaluranon cable(GO:0036117)
1.5 7.6 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.9 7.0 GO:0005577 fibrinogen complex(GO:0005577)
0.8 4.5 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.7 2.9 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.6 3.0 GO:0070552 BRISC complex(GO:0070552)
0.5 2.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.4 2.2 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.3 2.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.3 6.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 0.7 GO:0005896 interleukin-6 receptor complex(GO:0005896) ciliary neurotrophic factor receptor complex(GO:0070110)
0.2 8.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 3.0 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 1.5 GO:0030914 STAGA complex(GO:0030914)
0.1 3.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 3.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 7.5 GO:0005581 collagen trimer(GO:0005581)
0.1 3.8 GO:0005801 cis-Golgi network(GO:0005801)
0.1 3.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 2.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 1.0 GO:0070461 SAGA-type complex(GO:0070461)
0.1 0.5 GO:0033263 CORVET complex(GO:0033263)
0.1 1.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0000938 GARP complex(GO:0000938)
0.0 1.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 11.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 9.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.2 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.5 GO:0005776 autophagosome(GO:0005776)
0.0 1.6 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 7.6 GO:0016607 nuclear speck(GO:0016607)
0.0 10.4 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 8.8 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 4.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.6 GO:0030286 dynein complex(GO:0030286)
0.0 0.2 GO:0000930 gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 6.9 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
1.2 3.7 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
1.2 5.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.1 4.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
1.0 4.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
1.0 3.0 GO:0004793 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.8 6.6 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.6 4.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.6 5.0 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.5 6.2 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.4 3.0 GO:0035375 zymogen binding(GO:0035375)
0.4 2.9 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.4 9.3 GO:0005112 Notch binding(GO:0005112)
0.4 5.4 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.4 7.5 GO:0005537 mannose binding(GO:0005537)
0.4 7.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.3 1.0 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.3 9.9 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.3 2.8 GO:0043495 protein anchor(GO:0043495)
0.2 1.5 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.2 1.9 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 1.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 0.7 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.2 3.4 GO:0001972 retinoic acid binding(GO:0001972)
0.2 1.6 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.2 2.1 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 12.5 GO:0005507 copper ion binding(GO:0005507)
0.2 1.7 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.7 GO:0005550 pheromone binding(GO:0005550)
0.1 1.2 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 1.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 5.5 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 2.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 1.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 2.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 2.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 7.1 GO:0005518 collagen binding(GO:0005518)
0.1 4.1 GO:0070888 E-box binding(GO:0070888)
0.1 1.8 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 3.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.7 GO:0015925 galactosidase activity(GO:0015925)
0.1 3.0 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 7.0 GO:0030674 protein binding, bridging(GO:0030674)
0.1 2.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 5.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 11.7 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 1.0 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.2 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 16.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.5 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 3.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.0 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 2.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.8 GO:0099589 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.0 0.6 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 4.9 GO:0008017 microtubule binding(GO:0008017)
0.0 0.5 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 1.4 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.9 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 10.9 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 7.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 8.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 3.2 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 5.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 1.7 PID FAS PATHWAY FAS (CD95) signaling pathway
0.1 2.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 13.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 PID MYC PATHWAY C-MYC pathway
0.0 0.7 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.9 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 9.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.9 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.5 11.7 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.5 9.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.4 5.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.4 7.0 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.4 6.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.4 7.6 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.3 4.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 2.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.3 8.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 2.9 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 3.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 1.9 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 4.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 5.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 3.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.7 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.1 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 1.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 7.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 0.7 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 6.6 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 1.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)