ISMARA results: Foxj3

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxj3_Tbl1xr1

Z-value: 3.21

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Transcription factors associated with Foxj3_Tbl1xr1

Gene Symbol	Gene ID	Gene Info
Foxj3 NCBI RGD Ensembl	ENSRNOG00000061851	forkhead box J3
Tbl1xr1 NCBI RGD Ensembl	ENSRNOG00000011216	transducin (beta)-like 1 X-linked receptor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Foxj3	rn6_v1_chr5_+_138605793_138605793	-0.61	1.8e-34	Click!
Tbl1xr1	rn6_v1_chr2_+_107233054_107233054	0.12	3.8e-02	Click!

Activity profile of Foxj3_Tbl1xr1 motif

Sorted Z-values of Foxj3_Tbl1xr1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_223029559 Show fit	111.67	ENSRNOT00000045584	AABR07013111.1 NCBI RGD Ensembl Show fit
chr4_-_170912629 Show fit	106.61	ENSRNOT00000055691	Erp27 NCBI RGD Ensembl Show fit	endoplasmic reticulum protein 27
chr4_+_69435703 Show fit	104.68	ENSRNOT00000065485	LOC100911271 NCBI RGD Ensembl Show fit	uncharacterized LOC100911271
chr5_-_60191941 Show fit	97.22	ENSRNOT00000033373	Pax5 NCBI RGD Ensembl Show fit	paired box 5
chr4_+_70614524 Show fit	92.97	ENSRNOT00000041100	Prss3 NCBI RGD Ensembl Show fit	protease, serine 3
chr11_+_86094567 Show fit	90.03	ENSRNOT00000086514	LOC100361706 NCBI RGD Ensembl Show fit	lambda-chain C1-region-like
chr13_+_82369493 Show fit	88.57	ENSRNOT00000003733	Sell NCBI RGD Ensembl Show fit	selectin L
chr1_-_259287684 Show fit	88.17	ENSRNOT00000054724	Cyp2c22 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily c, polypeptide 22
chr3_+_17546566 Show fit	87.97	ENSRNOT00000050825	AABR07051583.1 NCBI RGD Ensembl Show fit
chr3_+_16413080 Show fit	86.14	ENSRNOT00000040386	LOC100912707 NCBI RGD Ensembl Show fit	Ig kappa chain V19-17-like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxj3_Tbl1xr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	2757.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
3.4	747.5	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
1.1	514.6	GO:0006412	translation(GO:0006412)
18.9	510.4	GO:0019373	epoxygenase P450 pathway(GO:0019373)
1.0	380.0	GO:0006955	immune response(GO:0006955)
9.6	296.5	GO:0035458	cellular response to interferon-beta(GO:0035458)
9.7	291.6	GO:0006958	complement activation, classical pathway(GO:0006958)
10.5	284.3	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
27.8	222.5	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
6.1	220.2	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)

Showing 1 to 10 of 1,143 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.3	1859.2	GO:0009897	external side of plasma membrane(GO:0009897)
0.9	1151.8	GO:0005615	extracellular space(GO:0005615)
8.8	964.0	GO:0072562	blood microparticle(GO:0072562)
6.4	446.0	GO:0000786	nucleosome(GO:0000786)
4.5	433.6	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
4.7	337.7	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
11.4	320.4	GO:0000788	nuclear nucleosome(GO:0000788)
0.4	292.9	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
1.2	280.3	GO:0005667	transcription factor complex(GO:0005667)
16.0	256.4	GO:0042613	MHC class II protein complex(GO:0042613)

Showing 1 to 10 of 320 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	1738.8	GO:0004984	olfactory receptor activity(GO:0004984)
6.3	1372.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
4.1	1098.8	GO:0030246	carbohydrate binding(GO:0030246)
2.5	1018.4	GO:0005549	odorant binding(GO:0005549)
3.8	959.4	GO:0003735	structural constituent of ribosome(GO:0003735)
6.7	746.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
17.5	525.2	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
2.7	489.2	GO:0042393	histone binding(GO:0042393)
15.6	483.8	GO:0015020	glucuronosyltransferase activity(GO:0015020)
6.2	458.9	GO:0003823	antigen binding(GO:0003823)

Showing 1 to 10 of 616 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	702.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
9.1	598.5	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
11.6	360.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
3.9	260.7	PID CMYB PATHWAY	C-MYB transcription factor network
5.0	248.4	PID BCR 5PATHWAY	BCR signaling pathway
4.3	234.9	PID FANCONI PATHWAY	Fanconi anemia pathway
6.1	194.9	PID IL23 PATHWAY	IL23-mediated signaling events
5.8	193.0	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
4.0	177.2	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
3.3	165.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 106 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
18.8	847.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
10.1	474.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
4.5	443.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
11.4	377.1	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
16.5	313.8	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
4.4	308.3	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
3.7	291.5	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
3.8	234.3	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
1.5	197.7	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
24.0	192.3	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse

Showing 1 to 10 of 170 entries

Results for Foxj3_Tbl1xr1

Z-value: 3.21

Motif logo

Transcription factors associated with Foxj3_Tbl1xr1

Activity-expression correlation:

Activity profile of Foxj3_Tbl1xr1 motif

Sorted Z-values of Foxj3_Tbl1xr1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxj3_Tbl1xr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: