ISMARA results: Foxi1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxi1_Foxo1

Z-value: 0.92

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Transcription factors associated with Foxi1_Foxo1

Gene Symbol	Gene ID	Gene Info
Foxi1 NCBI RGD Ensembl	ENSRNOG00000006293	forkhead box I1
Foxo1 NCBI RGD Ensembl	ENSRNOG00000013397	forkhead box O1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Foxi1	rn6_v1_chr10_-_19164505_19164505	-0.25	6.0e-06	Click!
Foxo1	rn6_v1_chr2_+_141451234_141451234	0.04	5.0e-01	Click!

Activity profile of Foxi1_Foxo1 motif

Sorted Z-values of Foxi1_Foxo1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_14001761 Show fit	38.57	ENSRNOT00000076519	Cd36 NCBI RGD Ensembl Show fit	CD36 molecule
chr13_+_89597138 Show fit	25.07	ENSRNOT00000004662	Apoa2 NCBI RGD Ensembl Show fit	apolipoprotein A2
chr2_-_180914940 Show fit	24.93	ENSRNOT00000015732	Tdo2 NCBI RGD Ensembl Show fit	tryptophan 2,3-dioxygenase
chr1_-_148119857 Show fit	24.13	ENSRNOT00000040325	LOC100361547 NCBI RGD Ensembl Show fit	Cytochrome P450, family 2, subfamily c, polypeptide 7-like
chr16_+_50152008 Show fit	22.14	ENSRNOT00000019237	Klkb1 NCBI RGD Ensembl Show fit	kallikrein B1
chr7_-_119689938 Show fit	20.37	ENSRNOT00000000200	Tmprss6 NCBI RGD Ensembl Show fit	transmembrane protease, serine 6
chr13_-_56763981 Show fit	19.98	ENSRNOT00000087916	LOC100361907 NCBI RGD Ensembl Show fit	complement factor H-related protein B
chr20_-_4863198 Show fit	19.81	ENSRNOT00000001108	Ltb NCBI RGD Ensembl Show fit	lymphotoxin beta
chr20_+_5184515 Show fit	19.00	ENSRNOT00000089411	LOC103694381 NCBI RGD Ensembl Show fit	lymphotoxin-beta
chr1_-_48559162 Show fit	18.67	ENSRNOT00000080352	Plg NCBI RGD Ensembl Show fit	plasminogen

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxi1_Foxo1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	131.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.5	116.8	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
3.2	87.7	GO:0019373	epoxygenase P450 pathway(GO:0019373)
7.2	50.2	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
8.1	48.6	GO:2000332	blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
2.7	29.4	GO:0042730	fibrinolysis(GO:0042730)
4.9	29.3	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
2.0	28.3	GO:0015671	oxygen transport(GO:0015671)
1.6	25.6	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
8.4	25.1	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) diacylglycerol catabolic process(GO:0046340)

Showing 1 to 10 of 624 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	229.8	GO:0005615	extracellular space(GO:0005615)
0.6	189.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	78.8	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.7	73.0	GO:0072562	blood microparticle(GO:0072562)
1.2	34.8	GO:0042588	zymogen granule(GO:0042588)
1.6	32.3	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	30.9	GO:0005739	mitochondrion(GO:0005739)
3.2	29.2	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
2.6	28.3	GO:0005833	hemoglobin complex(GO:0005833)
0.3	27.8	GO:0016605	PML body(GO:0016605)

Showing 1 to 10 of 218 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	96.9	GO:0030246	carbohydrate binding(GO:0030246)
3.0	90.7	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
0.7	83.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	81.3	GO:0004984	olfactory receptor activity(GO:0004984)
0.4	74.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	52.3	GO:0005549	odorant binding(GO:0005549)
0.2	50.7	GO:0003735	structural constituent of ribosome(GO:0003735)
9.7	48.6	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
1.5	46.0	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.2	37.5	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Showing 1 to 10 of 404 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	72.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	62.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.1	48.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.6	45.2	PID CMYB PATHWAY	C-MYB transcription factor network
0.8	39.2	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	39.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
2.5	34.4	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.8	32.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
1.0	31.9	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.6	28.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 100 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	78.4	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.9	45.0	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
2.0	34.3	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
1.6	33.9	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
1.5	32.2	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
1.9	28.4	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
1.7	28.2	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
1.9	26.3	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.3	25.7	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.3	25.4	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation

Showing 1 to 10 of 151 entries

Results for Foxi1_Foxo1

Z-value: 0.92

Motif logo

Transcription factors associated with Foxi1_Foxo1

Activity-expression correlation:

Activity profile of Foxi1_Foxo1 motif

Sorted Z-values of Foxi1_Foxo1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxi1_Foxo1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: