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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxd3

Z-value: 0.62

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Transcription factors associated with Foxd3

Gene Symbol Gene ID Gene Info

Activity profile of Foxd3 motif

Sorted Z-values of Foxd3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_127620296 33.89 ENSRNOT00000012577
Serpina1
serpin family A member 1
chr9_+_95501778 30.02 ENSRNOT00000086805
Spp2
secreted phosphoprotein 2
chr7_-_143523457 26.31 ENSRNOT00000012943
ENSRNOT00000082264
Krt4
keratin 4
chr16_+_50181316 24.41 ENSRNOT00000077662
F11
coagulation factor XI
chr16_+_18736154 22.16 ENSRNOT00000015723
Mbl1
mannose-binding lectin (protein A) 1
chr7_+_34326087 21.52 ENSRNOT00000006971
Hal
histidine ammonia lyase
chr13_+_27465930 20.93 ENSRNOT00000003314
Serpinb10
serpin family B member 10
chr13_+_91080341 19.90 ENSRNOT00000000058
Crp
C-reactive protein
chr1_-_170431073 18.16 ENSRNOT00000024710
Hpx
hemopexin
chr2_+_235264219 17.77 ENSRNOT00000086245
Cfi
complement factor I
chr6_-_127508452 16.77 ENSRNOT00000073709
LOC100909524
protein Z-dependent protease inhibitor-like
chr3_+_149668102 15.12 ENSRNOT00000055342
Bpifb1
BPI fold containing family B, member 1
chr8_-_21901829 15.00 ENSRNOT00000027963
Angptl6
angiopoietin-like 6
chr15_-_44627765 10.23 ENSRNOT00000058887
Dock5
dedicator of cytokinesis 5
chrX_+_40460047 9.04 ENSRNOT00000010970
Phex
phosphate regulating endopeptidase homolog, X-linked
chr4_+_176510696 8.50 ENSRNOT00000016614
Iapp
islet amyloid polypeptide
chr4_-_28437676 6.41 ENSRNOT00000012995
Hepacam2
HEPACAM family member 2
chr8_-_97647072 5.39 ENSRNOT00000030645
Tbc1d2b
TBC1 domain family, member 2B
chr16_-_48692476 5.19 ENSRNOT00000013118
Irf2
interferon regulatory factor 2
chr4_-_163403653 5.04 ENSRNOT00000088151
Klrk1
killer cell lectin like receptor K1
chr4_+_66670618 4.84 ENSRNOT00000010796
Tbxas1
thromboxane A synthase 1
chr10_+_64174931 4.72 ENSRNOT00000035948
RGD1565611
RGD1565611
chr6_-_128434183 4.47 ENSRNOT00000014405
Dicer1
dicer 1 ribonuclease III
chr2_-_186232292 2.56 ENSRNOT00000087088
Dclk2
doublecortin-like kinase 2
chr3_-_12155098 2.55 ENSRNOT00000082696
Garnl3
GTPase activating Rap/RanGAP domain-like 3
chrX_-_71169865 2.00 ENSRNOT00000050415
Il2rg
interleukin 2 receptor subunit gamma
chr1_-_164977633 1.81 ENSRNOT00000029629
Rnf169
ring finger protein 169
chr1_+_265809754 1.70 ENSRNOT00000025221
Pprc1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr5_+_60850852 1.59 ENSRNOT00000016720
Trmt10b
tRNA methyltransferase 10B
chr7_+_51794173 1.28 ENSRNOT00000043774
Otogl
otogelin-like
chr4_-_168517177 1.25 ENSRNOT00000009151
Dusp16
dual specificity phosphatase 16
chr1_-_124803363 1.02 ENSRNOT00000066380
Klf13
Kruppel-like factor 13
chr13_+_53351717 0.91 ENSRNOT00000012038
Kif14
kinesin family member 14
chr15_+_62406873 0.83 ENSRNOT00000047572
Olfm4
olfactomedin 4
chr17_-_34945317 0.74 ENSRNOT00000090457
Vma21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr15_-_32888095 0.73 ENSRNOT00000012233
Dad1
defender against cell death 1
chr1_+_259958310 0.71 ENSRNOT00000019751
LOC103689954
ectonucleoside triphosphate diphosphohydrolase 1
chr10_+_11338306 0.55 ENSRNOT00000033695
LOC100910875
protein FAM100A-like
chr12_-_12782139 0.51 ENSRNOT00000001392
ENSRNOT00000079836
Eif2ak1
eukaryotic translation initiation factor 2 alpha kinase 1
chr10_+_10889488 0.47 ENSRNOT00000071746
Ubald1
UBA-like domain containing 1
chr3_-_73755510 0.40 ENSRNOT00000083628
Olr502
olfactory receptor 502
chr3_-_163847671 0.38 ENSRNOT00000076833
Znfx1
zinc finger, NFX1-type containing 1
chr14_+_46001849 0.31 ENSRNOT00000076611
Rell1
RELT-like 1
chr5_-_136112344 0.30 ENSRNOT00000050195
RGD1563714
RGD1563714
chr5_-_83648044 0.09 ENSRNOT00000046725
RGD1561195
similar to ribosomal protein L31
chr8_-_19527513 0.05 ENSRNOT00000008594
Olr1147
olfactory receptor 1147

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxd3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.3 33.9 GO:0033986 response to methanol(GO:0033986)
7.2 21.5 GO:0019556 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) formamide metabolic process(GO:0043606)
4.5 18.2 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
3.5 24.4 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
3.4 10.2 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
3.3 19.9 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
3.0 9.0 GO:1904383 response to sodium phosphate(GO:1904383)
1.7 22.2 GO:0051873 disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
1.7 5.0 GO:2000502 stimulatory C-type lectin receptor signaling pathway(GO:0002223) negative regulation of natural killer cell chemotaxis(GO:2000502)
1.6 4.7 GO:0016598 protein arginylation(GO:0016598)
1.5 15.1 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
1.5 4.5 GO:0032290 zygote asymmetric cell division(GO:0010070) targeting of mRNA for destruction involved in RNA interference(GO:0030423) peripheral nervous system myelin formation(GO:0032290)
0.6 17.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.5 4.8 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.5 8.5 GO:0045779 negative regulation of bone resorption(GO:0045779)
0.3 0.9 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.3 27.7 GO:0046849 bone remodeling(GO:0046849)
0.2 2.0 GO:0032831 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831)
0.1 23.9 GO:0050680 negative regulation of epithelial cell proliferation(GO:0050680)
0.1 2.6 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 35.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 0.5 GO:0010999 regulation of eIF2 alpha phosphorylation by heme(GO:0010999)
0.1 1.3 GO:0019321 pentose metabolic process(GO:0019321)
0.1 0.8 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.1 1.8 GO:2000780 negative regulation of double-strand break repair(GO:2000780)
0.1 5.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 1.0 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 1.6 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.7 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 1.3 GO:0000188 inactivation of MAPK activity(GO:0000188)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.5 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.4 26.3 GO:0045095 keratin filament(GO:0045095)
0.3 22.2 GO:0005581 collagen trimer(GO:0005581)
0.1 18.2 GO:0072562 blood microparticle(GO:0072562)
0.1 15.7 GO:0030175 filopodium(GO:0030175)
0.1 118.5 GO:0005615 extracellular space(GO:0005615)
0.1 15.0 GO:0030141 secretory granule(GO:0030141)
0.1 1.8 GO:0035861 site of double-strand break(GO:0035861)
0.1 7.3 GO:0030496 midbody(GO:0030496)
0.0 0.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 7.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.7 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 5.2 GO:0005925 focal adhesion(GO:0005925)
0.0 32.1 GO:0070062 extracellular exosome(GO:0070062)
0.0 12.7 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 21.5 GO:0016841 ammonia-lyase activity(GO:0016841)
2.8 19.9 GO:0001849 complement component C1q binding(GO:0001849)
2.0 24.4 GO:0070008 serine-type exopeptidase activity(GO:0070008)
2.0 18.2 GO:0015232 heme transporter activity(GO:0015232)
1.1 4.5 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) pre-miRNA binding(GO:0070883)
1.1 22.2 GO:0005537 mannose binding(GO:0005537)
0.6 69.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 17.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.3 2.0 GO:0019976 interleukin-2 binding(GO:0019976)
0.3 1.6 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.2 5.0 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 4.8 GO:0016860 intramolecular oxidoreductase activity(GO:0016860)
0.1 0.5 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 1.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 9.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.7 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 10.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 5.9 GO:0005179 hormone activity(GO:0005179)
0.0 25.9 GO:0005198 structural molecule activity(GO:0005198)
0.0 7.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 10.9 GO:0008289 lipid binding(GO:0008289)
0.0 1.3 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 4.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 33.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.3 19.9 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 18.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 20.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.0 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 4.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 15.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 19.9 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.3 17.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
1.2 24.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.3 33.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 8.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 5.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 4.5 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.2 4.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 21.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 5.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 10.2 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production