ISMARA results: Foxc2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxc2

Z-value: 1.19

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Transcription factors associated with Foxc2

Gene Symbol	Gene ID	Gene Info
Foxc2 NCBI RGD Ensembl	ENSRNOG00000047446	forkhead box C2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Foxc2	rn6_v1_chr19_+_53044379_53044379	-0.09	1.1e-01	Click!

Activity profile of Foxc2 motif

Sorted Z-values of Foxc2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_225283326 Show fit	133.04	ENSRNOT00000027342	Scgb1a1 NCBI RGD Ensembl Show fit	secretoglobin family 1A member 1
chr3_+_149624712 Show fit	80.19	ENSRNOT00000018581	Bpifa1 NCBI RGD Ensembl Show fit	BPI fold containing family A, member 1
chr20_-_31598118 Show fit	71.24	ENSRNOT00000046537	Col13a1 NCBI RGD Ensembl Show fit	collagen type XIII alpha 1 chain
chr2_+_208749996 Show fit	46.39	ENSRNOT00000086321	Chia NCBI RGD Ensembl Show fit	chitinase, acidic
chr2_+_208750356 Show fit	46.30	ENSRNOT00000041562	Chia NCBI RGD Ensembl Show fit	chitinase, acidic
chr7_-_143523457 Show fit	40.66	ENSRNOT00000012943 ENSRNOT00000082264	Krt4 NCBI RGD Ensembl Show fit	keratin 4
chr4_-_115239723 Show fit	40.17	ENSRNOT00000042699	Actg2 NCBI RGD Ensembl Show fit	actin, gamma 2, smooth muscle, enteric
chr20_-_31597830 Show fit	40.00	ENSRNOT00000085877	Col13a1 NCBI RGD Ensembl Show fit	collagen type XIII alpha 1 chain
chr18_+_68408890 Show fit	31.39	ENSRNOT00000039702	Ccdc68 NCBI RGD Ensembl Show fit	coiled-coil domain containing 68
chr18_+_3887419 Show fit	27.74	ENSRNOT00000093089	Lama3 NCBI RGD Ensembl Show fit	laminin subunit alpha 3

Showing 1 to 10 of 73 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxc2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
33.3	133.0	GO:0032696	negative regulation of interleukin-13 production(GO:0032696)
3.1	111.2	GO:0001958	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
18.5	92.7	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
16.0	80.2	GO:0050828	regulation of liquid surface tension(GO:0050828)
8.0	40.2	GO:0090131	mesenchyme migration(GO:0090131)
0.3	40.0	GO:0050680	negative regulation of epithelial cell proliferation(GO:0050680)
1.5	27.7	GO:0031581	hemidesmosome assembly(GO:0031581)
0.5	24.2	GO:0030195	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
3.3	22.8	GO:1901894	regulation of calcium-transporting ATPase activity(GO:1901894)
3.1	21.6	GO:0051919	positive regulation of fibrinolysis(GO:0051919)

Showing 1 to 10 of 49 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	133.0	GO:0005791	rough endoplasmic reticulum(GO:0005791)
1.4	108.4	GO:0005581	collagen trimer(GO:0005581)
0.1	96.7	GO:0005615	extracellular space(GO:0005615)
0.8	89.7	GO:0005902	microvillus(GO:0005902)
2.7	40.2	GO:0032982	myosin filament(GO:0032982)
0.3	29.7	GO:0005901	caveola(GO:0005901)
0.1	29.1	GO:0009986	cell surface(GO:0009986)
4.6	27.7	GO:0005608	laminin-3 complex(GO:0005608)
0.3	26.6	GO:0031526	brush border membrane(GO:0031526)
0.7	22.8	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)

Showing 1 to 10 of 22 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
26.6	133.0	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.6	110.1	GO:0008201	heparin binding(GO:0008201)
15.4	92.7	GO:0004568	chitinase activity(GO:0004568)
0.1	86.4	GO:0008289	lipid binding(GO:0008289)
0.0	30.7	GO:0005198	structural molecule activity(GO:0005198)
0.5	26.9	GO:0001786	phosphatidylserine binding(GO:0001786)
0.2	24.2	GO:0005178	integrin binding(GO:0005178)
0.0	22.3	GO:0030234	enzyme regulator activity(GO:0030234)
1.8	21.6	GO:0070008	serine-type exopeptidase activity(GO:0070008)
2.6	20.9	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)

Showing 1 to 10 of 40 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	141.9	PID HNF3A PATHWAY	FOXA1 transcription factor network
2.5	122.8	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.8	40.2	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
1.7	27.7	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	9.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	7.6	PID ARF6 PATHWAY	Arf6 signaling events
0.1	2.6	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	2.5	PID LKB1 PATHWAY	LKB1 signaling events
0.1	1.0	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.7	PID MYC PATHWAY	C-MYC pathway

Showing 1 to 10 of 10 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	112.0	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
1.9	51.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	27.7	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
1.0	21.6	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
2.1	20.9	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.5	11.7	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.8	11.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	6.0	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.1	5.7	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.2	2.8	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling

Showing 1 to 10 of 15 entries

Results for Foxc2

Z-value: 1.19

Motif logo

Transcription factors associated with Foxc2

Activity-expression correlation:

Activity profile of Foxc2 motif

Sorted Z-values of Foxc2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxc2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: