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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Foxc1
Z-value: 0.86
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Transcription factors associated with Foxc1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxc1 | rn6_v1_chr17_-_33951484_33951484 | 0.11 | 5.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_215610368 Show fit | 31.41 |
ENSRNOT00000078903
ENSRNOT00000087781 |
troponin I2, fast skeletal type |
|
| chr10_+_53781239 Show fit | 30.28 |
ENSRNOT00000082871
|
myosin heavy chain 2 |
|
| chr1_+_215609645 Show fit | 24.95 |
ENSRNOT00000076140
ENSRNOT00000027487 |
troponin I2, fast skeletal type |
|
| chr10_+_53713938 Show fit | 22.43 |
ENSRNOT00000004236
ENSRNOT00000086599 ENSRNOT00000085582 |
myosin heavy chain 2 |
|
| chr2_+_60131776 Show fit | 21.82 |
ENSRNOT00000080786
|
prolactin receptor |
|
| chr16_+_25773602 Show fit | 18.91 |
ENSRNOT00000047750
|
glyceraldehyde-3-phosphate dehydrogenase, pseudogene 2 |
|
| chr10_+_59725398 Show fit | 18.33 |
ENSRNOT00000026156
|
purinergic receptor P2X 5 |
|
| chr7_-_113937941 Show fit | 17.86 |
ENSRNOT00000012408
|
potassium two pore domain channel subfamily K member 9 |
|
| chr11_-_72109964 Show fit | 17.82 |
ENSRNOT00000058917
|
|
|
| chr5_+_115649046 Show fit | 16.12 |
ENSRNOT00000041328
|
glyceraldehyde-3-phosphate dehydrogenase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Foxc1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 66.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 1.1 | 56.4 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 4.1 | 52.7 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 2.4 | 21.8 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 0.1 | 21.5 | GO:0031668 | cellular response to extracellular stimulus(GO:0031668) |
| 1.7 | 18.3 | GO:0043416 | regulation of skeletal muscle tissue regeneration(GO:0043416) |
| 5.4 | 16.1 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.4 | 14.1 | GO:0072337 | modified amino acid transport(GO:0072337) |
| 2.6 | 13.0 | GO:0030070 | insulin processing(GO:0030070) negative regulation of branching morphogenesis of a nerve(GO:2000173) |
| 1.3 | 11.9 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 66.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 5.4 | 64.6 | GO:0005861 | troponin complex(GO:0005861) |
| 5.9 | 52.7 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.1 | 23.5 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 1.0 | 18.3 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.6 | 16.7 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 2.0 | 16.1 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.1 | 13.9 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.1 | 13.4 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.8 | 13.0 | GO:0031045 | dense core granule(GO:0031045) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 56.4 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.1 | 46.5 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 39.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 27.4 | GO:0005549 | odorant binding(GO:0005549) |
| 7.3 | 21.8 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 0.3 | 21.5 | GO:0038024 | cargo receptor activity(GO:0038024) |
| 2.0 | 18.3 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.2 | 16.7 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 4.0 | 16.1 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.7 | 14.1 | GO:0072349 | modified amino acid transmembrane transporter activity(GO:0072349) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 52.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.4 | 21.8 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 13.0 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.2 | 8.2 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 6.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 4.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.5 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 3.3 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.2 | 3.2 | PID IL3 PATHWAY | IL3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 64.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 1.0 | 21.8 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 1.4 | 17.9 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.5 | 13.0 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.3 | 11.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.7 | 11.8 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 8.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.4 | 7.2 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.2 | 5.5 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 0.1 | 4.5 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |