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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxb1

Z-value: 0.40

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Transcription factors associated with Foxb1

Gene Symbol Gene ID Gene Info
Foxb1
ENSRNOG00000010547 forkhead box B1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxb1rn6_v1_chr8_-_75995371_759953710.651.7e-39Click!

Activity profile of Foxb1 motif

Sorted Z-values of Foxb1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_2190915 11.22 ENSRNOT00000077417
Satb1
SATB homeobox 1
chr11_+_60253608 9.11 ENSRNOT00000090804
LOC685716
similar to OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen)
chr15_-_77736892 6.35 ENSRNOT00000057924
Pcdh9
protocadherin 9
chr4_-_40385349 6.34 ENSRNOT00000039005
Gpr85
G protein-coupled receptor 85
chr11_-_32858830 5.77 ENSRNOT00000002313
Runx1
runt-related transcription factor 1
chr1_-_134870255 5.33 ENSRNOT00000055829
Chd2
chromodomain helicase DNA binding protein 2
chr6_+_42947334 5.21 ENSRNOT00000041376
RGD1563157
similar to 60S ribosomal protein L35
chr5_+_152721940 5.14 ENSRNOT00000039322
Aunip
aurora kinase A and ninein interacting protein
chr15_-_54906203 5.10 ENSRNOT00000020186
Cysltr2
cysteinyl leukotriene receptor 2
chr4_-_81241152 5.04 ENSRNOT00000015325
ENSRNOT00000015152
Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr8_-_80631873 4.95 ENSRNOT00000091661
ENSRNOT00000080662
Unc13c
unc-13 homolog C
chrX_+_159703578 4.74 ENSRNOT00000001162
Cd40lg
CD40 ligand
chr14_+_24129592 4.44 ENSRNOT00000040647
LOC689899
similar to 60S ribosomal protein L23a
chr2_+_198388809 4.18 ENSRNOT00000083087
Hist2h2aa3
histone cluster 2, H2aa3
chr3_+_94549180 4.07 ENSRNOT00000016318
Cstf3
cleavage stimulation factor subunit 3
chr2_-_198382190 3.94 ENSRNOT00000044268
Hist2h2aa2
histone cluster 2, H2aa2
chr6_+_95826546 3.40 ENSRNOT00000043587
AABR07064810.1

chr5_+_164923302 3.20 ENSRNOT00000042285
LOC108349682
60S ribosomal protein L35a
chr13_-_94859390 3.12 ENSRNOT00000005467
ENSRNOT00000079763
AABR07021840.1

chr10_-_85825735 3.12 ENSRNOT00000055379
Fbxo47
F-box protein 47
chr1_+_220325352 3.01 ENSRNOT00000027258
LOC108348098
breast cancer metastasis-suppressor 1 homolog
chr19_-_17045349 2.96 ENSRNOT00000086829
Fto
FTO, alpha-ketoglutarate dependent dioxygenase
chr9_-_15274917 2.95 ENSRNOT00000019650
Pgc
progastricsin
chr13_-_78521911 2.91 ENSRNOT00000087506
Rabgap1l
RAB GTPase activating protein 1-like
chr8_-_33661049 2.89 ENSRNOT00000068037
Fli1
Fli-1 proto-oncogene, ETS transcription factor
chr6_-_108660063 2.76 ENSRNOT00000006240
Arel1
apoptosis resistant E3 ubiquitin protein ligase 1
chr10_+_68588789 2.71 ENSRNOT00000049614
AABR07030122.1

chr2_-_23909016 2.68 ENSRNOT00000084044
Scamp1
secretory carrier membrane protein 1
chr10_-_87351030 2.61 ENSRNOT00000034889
ENSRNOT00000091152
Krt20
keratin 20
chr3_+_65816569 2.55 ENSRNOT00000079672
Ube2e3
ubiquitin-conjugating enzyme E2E 3
chr1_-_44615760 2.47 ENSRNOT00000022148
Nox3
NADPH oxidase 3
chr6_+_108745895 2.42 ENSRNOT00000061786
LOC108348062
eukaryotic translation initiation factor 3 subunit H
chrX_+_78042859 2.29 ENSRNOT00000003286
Lpar4
lysophosphatidic acid receptor 4
chr5_+_103251986 2.27 ENSRNOT00000008757
Cntln
centlein
chr6_-_95061174 2.23 ENSRNOT00000072262
Rtn1
reticulon 1
chr1_+_190671696 2.16 ENSRNOT00000084934
AABR07005633.1

chr3_+_162357356 2.10 ENSRNOT00000030119
Eya2
EYA transcriptional coactivator and phosphatase 2
chr3_+_151691515 2.01 ENSRNOT00000052236
AC118414.1

chr3_-_141411170 1.93 ENSRNOT00000017364
Nkx2-2
NK2 homeobox 2
chr4_+_93959152 1.92 ENSRNOT00000058437
AABR07060795.1

chr14_+_42714315 1.82 ENSRNOT00000084095
ENSRNOT00000091449
Phox2b
paired-like homeobox 2b
chr10_-_16046033 1.79 ENSRNOT00000089460
Cpeb4
cytoplasmic polyadenylation element binding protein 4
chr11_-_11585078 1.66 ENSRNOT00000088878
Robo2
roundabout guidance receptor 2
chr9_-_121713091 1.52 ENSRNOT00000073432
Adcyap1
adenylate cyclase activating polypeptide 1
chr17_-_45746753 1.37 ENSRNOT00000077475
RGD1564243
similar to brain Zn-finger protein
chr6_-_95890325 1.29 ENSRNOT00000050217
LOC690335
similar to 60S ribosomal protein L23a
chr2_+_239415046 1.22 ENSRNOT00000072196
Cxxc4
CXXC finger protein 4
chr3_-_46153371 1.17 ENSRNOT00000085885
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr18_+_16146447 1.16 ENSRNOT00000022117
Galnt1
polypeptide N-acetylgalactosaminyltransferase 1
chr2_+_143475323 1.14 ENSRNOT00000044028
ENSRNOT00000015437
Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr20_+_49319307 1.05 ENSRNOT00000057078
Atg5
autophagy related 5
chr5_+_157165341 0.93 ENSRNOT00000087072
Pla2g2c
phospholipase A2, group IIC
chr4_+_139670092 0.89 ENSRNOT00000008879
Lrrn1
leucine rich repeat neuronal 1
chr9_+_118849302 0.88 ENSRNOT00000087592
Dlgap1
DLG associated protein 1
chr7_-_107391184 0.87 ENSRNOT00000056793
Tmem71
transmembrane protein 71
chrX_-_63203643 0.86 ENSRNOT00000065194
ENSRNOT00000076974
Zfx
zinc finger protein X-linked
chrX_+_78991223 0.76 ENSRNOT00000031200
Fam46d
family with sequence similarity 46, member D
chr10_+_54156649 0.75 ENSRNOT00000074718
Gas7
growth arrest specific 7
chr3_+_73988945 0.73 ENSRNOT00000050404
Olr515
olfactory receptor 515
chr9_-_86103158 0.40 ENSRNOT00000021528
Cul3
cullin 3
chr1_-_89269930 0.37 ENSRNOT00000028532
Ffar2
free fatty acid receptor 2
chr3_-_431933 0.28 ENSRNOT00000033653
Spopl
speckle type BTB/POZ protein like
chr3_-_77525518 0.26 ENSRNOT00000049513
Olr663
olfactory receptor 663
chr14_+_35683442 0.12 ENSRNOT00000003085
Chic2
cysteine-rich hydrophobic domain 2
chr3_+_74058255 0.11 ENSRNOT00000046947
Olr517
olfactory receptor 517
chr1_-_73961432 0.09 ENSRNOT00000035435
Nlrp4b
NLR family, pyrin domain containing 4B
chr3_-_73779982 0.08 ENSRNOT00000079710
Olr505
olfactory receptor 505
chr3_-_74371385 0.08 ENSRNOT00000041668
Olr518
olfactory receptor 518
chr1_+_168830222 0.07 ENSRNOT00000050333
Olr122
olfactory receptor 122
chr6_-_51257625 0.01 ENSRNOT00000012004
Hbp1
HMG-box transcription factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxb1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
1.0 5.0 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
1.0 3.0 GO:0042245 RNA repair(GO:0042245)
0.9 1.8 GO:0021550 medulla oblongata development(GO:0021550)
0.8 5.1 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.8 11.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.6 1.9 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.6 4.7 GO:0033590 response to cobalamin(GO:0033590)
0.6 3.0 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
0.5 1.9 GO:0002877 regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
0.4 4.9 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.4 3.5 GO:0048840 otolith development(GO:0048840)
0.3 3.0 GO:2000210 positive regulation of anoikis(GO:2000210)
0.3 1.7 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.3 5.3 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.2 2.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.2 1.2 GO:0018243 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.2 2.3 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.2 1.8 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.2 4.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 9.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 2.9 GO:0035855 megakaryocyte development(GO:0035855)
0.1 2.4 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.1 0.9 GO:0070842 aggresome assembly(GO:0070842)
0.1 0.4 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.1 2.6 GO:0045109 intermediate filament organization(GO:0045109)
0.1 2.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 8.1 GO:0006342 chromatin silencing(GO:0006342)
0.1 2.3 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 1.1 GO:0006828 manganese ion transport(GO:0006828)
0.0 2.9 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.9 GO:0060746 parental behavior(GO:0060746)
0.0 0.9 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 3.6 GO:0007051 spindle organization(GO:0007051)
0.0 3.0 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.0 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.6 4.9 GO:0044305 calyx of Held(GO:0044305)
0.3 2.4 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282) eukaryotic 48S preinitiation complex(GO:0033290)
0.3 1.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.2 2.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 11.2 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 3.0 GO:0070822 Sin3-type complex(GO:0070822)
0.1 2.7 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 1.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 8.1 GO:0000786 nucleosome(GO:0000786)
0.1 9.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 0.4 GO:0005827 polar microtubule(GO:0005827)
0.1 2.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 1.7 GO:0030673 axolemma(GO:0030673)
0.1 5.8 GO:0005604 basement membrane(GO:0005604)
0.0 4.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 5.1 GO:0000922 spindle pole(GO:0000922)
0.0 6.4 GO:0030426 growth cone(GO:0030426)
0.0 1.1 GO:0034704 calcium channel complex(GO:0034704)
0.0 1.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.2 GO:0005840 ribosome(GO:0005840)
0.0 1.5 GO:0043195 terminal bouton(GO:0043195)
0.0 1.7 GO:0005882 intermediate filament(GO:0005882)
0.0 2.9 GO:0005769 early endosome(GO:0005769)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0001069 regulatory region RNA binding(GO:0001069)
1.0 5.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.7 3.0 GO:0035515 DNA demethylase activity(GO:0035514) oxidative RNA demethylase activity(GO:0035515)
0.6 2.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.5 4.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.3 2.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.3 1.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.2 5.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.4 GO:0031208 POZ domain binding(GO:0031208)
0.1 3.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 1.8 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 4.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.9 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 3.0 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 1.1 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 2.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.9 GO:0098879 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.1 1.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 4.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 3.2 GO:0000049 tRNA binding(GO:0000049)
0.0 5.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 2.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 6.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.9 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.0 4.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.9 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 11.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 4.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 2.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 5.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.1 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.1 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.2 2.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 4.1 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 11.2 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 4.2 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 4.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 5.0 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.5 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 1.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation