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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxa3

Z-value: 1.09

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Transcription factors associated with Foxa3

Gene Symbol Gene ID Gene Info
Foxa3
ENSRNOG00000014256 forkhead box A3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxa3rn6_v1_chr1_-_79930263_799302630.596.5e-32Click!

Activity profile of Foxa3 motif

Sorted Z-values of Foxa3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_50525091 104.84 ENSRNOT00000074357
Apoa1
apolipoprotein A1
chr5_+_124300477 84.70 ENSRNOT00000010100
C8b
complement C8 beta chain
chr18_-_24929091 63.77 ENSRNOT00000019596
Proc
protein C
chr13_-_47377703 62.63 ENSRNOT00000005461
C4bpa
complement component 4 binding protein, alpha
chr1_-_225283326 53.04 ENSRNOT00000027342
Scgb1a1
secretoglobin family 1A member 1
chr11_-_81717521 51.83 ENSRNOT00000058422
Ahsg
alpha-2-HS-glycoprotein
chr11_-_87924816 48.36 ENSRNOT00000031819
Serpind1
serpin family D member 1
chr6_+_33176778 46.75 ENSRNOT00000046811
ENSRNOT00000007371
Apob
apolipoprotein B
chr2_-_182035032 45.34 ENSRNOT00000009813
Fgb
fibrinogen beta chain
chr14_+_20266891 41.98 ENSRNOT00000004174
Gc
group specific component
chr5_-_19368431 39.81 ENSRNOT00000012819
Cyp7a1
cytochrome P450, family 7, subfamily a, polypeptide 1
chr7_+_93975451 38.90 ENSRNOT00000011379
Colec10
collectin subfamily member 10
chr3_-_127500709 38.33 ENSRNOT00000006330
Hao1
hydroxyacid oxidase 1
chr1_+_264741911 37.91 ENSRNOT00000019956
Sema4g
semaphorin 4G
chr3_+_149624712 35.51 ENSRNOT00000018581
Bpifa1
BPI fold containing family A, member 1
chr6_-_104631355 34.66 ENSRNOT00000007825
Slc10a1
solute carrier family 10 member 1
chr7_-_143523457 33.19 ENSRNOT00000012943
ENSRNOT00000082264
Krt4
keratin 4
chr1_+_48273611 31.13 ENSRNOT00000022254
ENSRNOT00000022068
Slc22a1
solute carrier family 22 member 1
chr18_+_59748444 28.12 ENSRNOT00000024752
St8sia3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr10_-_27179900 27.39 ENSRNOT00000082445
Gabrg2
gamma-aminobutyric acid type A receptor gamma 2 subunit
chr2_-_250923744 22.95 ENSRNOT00000084996
Clca1
chloride channel accessory 1
chr2_+_121165137 22.06 ENSRNOT00000016236
Sox2
SRY box 2
chr16_-_18766174 21.46 ENSRNOT00000084813
Sftpd
surfactant protein D
chr12_-_1195591 20.29 ENSRNOT00000001446
Stard13
StAR-related lipid transfer domain containing 13
chr10_+_14240219 20.17 ENSRNOT00000020233
Igfals
insulin-like growth factor binding protein, acid labile subunit
chr4_+_10295122 19.95 ENSRNOT00000017374
Ccdc146
coiled-coil domain containing 146
chr8_-_107952530 19.72 ENSRNOT00000052043
Cldn18
claudin 18
chr7_-_138483612 19.26 ENSRNOT00000085620
Slc38a4
solute carrier family 38, member 4
chr10_-_46404642 18.69 ENSRNOT00000083698
Pemt
phosphatidylethanolamine N-methyltransferase
chr2_+_188543137 17.84 ENSRNOT00000027850
Muc1
mucin 1, cell surface associated
chr10_+_86399827 16.41 ENSRNOT00000009299
Grb7
growth factor receptor bound protein 7
chrX_+_35599258 16.00 ENSRNOT00000072627
ENSRNOT00000005061
Cdkl5
cyclin-dependent kinase-like 5
chr14_+_39964588 15.54 ENSRNOT00000003240
Gabrg1
gamma-aminobutyric acid type A receptor gamma 1 subunit
chr10_-_27179254 15.33 ENSRNOT00000004619
Gabrg2
gamma-aminobutyric acid type A receptor gamma 2 subunit
chr2_+_227080924 14.94 ENSRNOT00000029871
Fabp2
fatty acid binding protein 2
chr2_+_208750356 14.91 ENSRNOT00000041562
Chia
chitinase, acidic
chr8_-_115981910 14.76 ENSRNOT00000019867
Dock3
dedicator of cyto-kinesis 3
chr5_+_165415136 14.48 ENSRNOT00000016317
ENSRNOT00000079407
Masp2
mannan-binding lectin serine peptidase 2
chr7_+_26522314 13.64 ENSRNOT00000011572
Slc41a2
solute carrier family 41 member 2
chr11_-_782954 12.95 ENSRNOT00000040065
Epha3
Eph receptor A3
chr3_+_129018592 12.65 ENSRNOT00000007274
Lamp5
lysosomal-associated membrane protein family, member 5
chr2_+_208749996 12.61 ENSRNOT00000086321
Chia
chitinase, acidic
chr1_+_157646173 12.11 ENSRNOT00000013851
Rab30
RAB30, member RAS oncogene family
chr3_-_71845232 11.83 ENSRNOT00000078645
Calcrl
calcitonin receptor like receptor
chr5_+_120568242 11.82 ENSRNOT00000050597
Lepr
leptin receptor
chr2_-_216348194 11.73 ENSRNOT00000087839
LOC103689940
pancreatic alpha-amylase-like
chr11_+_74984613 11.69 ENSRNOT00000035049
Atp13a5
ATPase 13A5
chr9_+_118849302 11.60 ENSRNOT00000087592
Dlgap1
DLG associated protein 1
chr10_-_88060561 11.48 ENSRNOT00000019133
Krt19
keratin 19
chr5_+_162808646 11.29 ENSRNOT00000021155
Dhrs3
dehydrogenase/reductase 3
chr12_-_30083824 11.20 ENSRNOT00000084968
Tpst1
tyrosylprotein sulfotransferase 1
chr6_-_78549669 10.90 ENSRNOT00000009940
Foxa1
forkhead box A1
chr2_-_111065413 10.71 ENSRNOT00000041111
Nlgn1
neuroligin 1
chr1_+_107262659 10.63 ENSRNOT00000022499
Gas2
growth arrest-specific 2
chr3_+_131351587 10.50 ENSRNOT00000010835
Btbd3
BTB domain containing 3
chr8_-_102149912 10.44 ENSRNOT00000011263
RGD1309079
similar to Ab2-095
chr2_-_147819335 10.12 ENSRNOT00000057909
Ankub1
ankyrin repeat and ubiquitin domain containing 1
chr20_-_38985036 8.32 ENSRNOT00000001066
Serinc1
serine incorporator 1
chr6_-_108167185 8.11 ENSRNOT00000015545
Aldh6a1
aldehyde dehydrogenase 6 family, member A1
chr2_+_69415057 7.84 ENSRNOT00000013152
Cdh10
cadherin 10
chr8_+_91099491 7.49 ENSRNOT00000084852
Sh3bgrl2
SH3 domain binding glutamate-rich protein like 2
chr1_+_234252757 7.33 ENSRNOT00000091814
Rorb
RAR-related orphan receptor B
chrX_+_113510621 7.31 ENSRNOT00000025912
Nxt2
nuclear transport factor 2-like export factor 2
chr3_-_158328881 7.26 ENSRNOT00000044466
Ptprt
protein tyrosine phosphatase, receptor type, T
chr2_-_258997138 7.26 ENSRNOT00000045020
ENSRNOT00000042256
Adgrl2
adhesion G protein-coupled receptor L2
chr3_-_162059524 7.15 ENSRNOT00000033873
Zfp334
zinc finger protein 334
chr14_+_44413636 7.13 ENSRNOT00000003552
Smim14
small integral membrane protein 14
chr4_+_62221011 6.93 ENSRNOT00000041264
Cald1
caldesmon 1
chr8_+_58431407 6.79 ENSRNOT00000011974
Sln
sarcolipin
chr1_-_78521999 6.73 ENSRNOT00000021223
Arhgap35
Rho GTPase activating protein 35
chr3_-_160038078 6.59 ENSRNOT00000013445
Serinc3
serine incorporator 3
chr9_+_27034022 6.52 ENSRNOT00000029696
Paqr8
progestin and adipoQ receptor family member 8
chr12_-_36398206 6.45 ENSRNOT00000090944
ENSRNOT00000058492
Tmem132b
transmembrane protein 132B
chr1_+_168945449 6.43 ENSRNOT00000087661
ENSRNOT00000019913
LOC103694855
hemoglobin subunit beta-2-like
chr10_-_103687425 6.41 ENSRNOT00000039284
Cd300lf
Cd300 molecule-like family member F
chr9_-_81467760 5.97 ENSRNOT00000090868
Cxcr1
C-X-C motif chemokine receptor 1
chr3_+_122836446 5.69 ENSRNOT00000028816
Ebf4
early B-cell factor 4
chr4_+_62220736 5.64 ENSRNOT00000086377
Cald1
caldesmon 1
chr14_+_8080275 5.28 ENSRNOT00000065965
ENSRNOT00000092542
Mapk10
mitogen activated protein kinase 10
chr2_+_144861455 5.14 ENSRNOT00000093284
ENSRNOT00000019748
ENSRNOT00000072110
Dclk1
doublecortin-like kinase 1
chr17_-_21484456 4.91 ENSRNOT00000038180
Sycp2l
synaptonemal complex protein 2-like
chr1_+_72545596 4.67 ENSRNOT00000022698
Shisa7
shisa family member 7
chr14_+_1937041 4.67 ENSRNOT00000000040
Tmed11
transmembrane emp24 protein transport domain containing 11
chr4_+_181103774 4.66 ENSRNOT00000084207
ENSRNOT00000055473
ENSRNOT00000077619
Arntl2
aryl hydrocarbon receptor nuclear translocator-like 2
chr5_+_58359498 4.54 ENSRNOT00000000141
Phf24
PHD finger protein 24
chr7_+_23403891 4.34 ENSRNOT00000037918
Syn3
synapsin III
chr3_+_44806106 4.26 ENSRNOT00000035158
Upp2
uridine phosphorylase 2
chr13_-_91872954 4.24 ENSRNOT00000004613
ENSRNOT00000079263
Cadm3
cell adhesion molecule 3
chr18_+_3887419 4.01 ENSRNOT00000093089
Lama3
laminin subunit alpha 3
chr3_+_148635775 3.99 ENSRNOT00000067261
Tm9sf4
transmembrane 9 superfamily member 4
chr6_-_67084234 3.90 ENSRNOT00000050372
Nova1
NOVA alternative splicing regulator 1
chr2_+_44289393 3.51 ENSRNOT00000018877
Il6st
interleukin 6 signal transducer
chr5_+_49311030 3.44 ENSRNOT00000010850
Cnr1
cannabinoid receptor 1
chr8_+_99568958 3.42 ENSRNOT00000073400
Plscr5
phospholipid scramblase family, member 5
chr9_+_111649631 3.35 ENSRNOT00000056430
Fer
FER tyrosine kinase
chr11_-_69223158 3.34 ENSRNOT00000067060
Mylk
myosin light chain kinase
chr17_-_30661690 3.34 ENSRNOT00000048146
RGD1307537
similar to RIKEN cDNA 4933417A18
chr20_-_9876008 3.10 ENSRNOT00000001537
Tff2
trefoil factor 2
chr8_+_48718329 3.05 ENSRNOT00000089763
Slc37a4
solute carrier family 37 member 4
chr10_-_98469799 2.94 ENSRNOT00000087502
ENSRNOT00000088646
Abca9
ATP binding cassette subfamily A member 9
chr9_+_82345719 2.89 ENSRNOT00000057330
ENSRNOT00000078260
Fam134a
family with sequence similarity 134, member A
chr14_-_21128505 2.88 ENSRNOT00000004776
Rufy3
RUN and FYVE domain containing 3
chr10_-_56276764 2.84 ENSRNOT00000049048
Eif4a1
eukaryotic translation initiation factor 4A1
chr15_+_34216833 2.76 ENSRNOT00000025260
Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr19_-_11669578 2.66 ENSRNOT00000026373
Gnao1
G protein subunit alpha o1
chr6_+_135313008 2.59 ENSRNOT00000030864
Tecpr2
tectonin beta-propeller repeat containing 2
chrX_+_26439197 2.47 ENSRNOT00000078843
ENSRNOT00000052176
ENSRNOT00000087268
Amelx
amelogenin, X-linked
chr10_+_90230711 2.45 ENSRNOT00000055185
Tmub2
transmembrane and ubiquitin-like domain containing 2
chr2_-_256154584 2.43 ENSRNOT00000072487
AABR07013776.1

chr11_-_53731779 2.24 ENSRNOT00000002684
Ift57
intraflagellar transport 57
chr15_-_95514259 2.17 ENSRNOT00000038433
Slitrk6
SLIT and NTRK-like family, member 6
chrX_-_139916883 2.16 ENSRNOT00000090442
Gpc3
glypican 3
chr1_+_70480941 2.15 ENSRNOT00000072404
Olr6
olfactory receptor 6
chr9_+_8054466 2.02 ENSRNOT00000081513
Adgre4
adhesion G protein-coupled receptor E4
chr13_+_78979321 1.93 ENSRNOT00000003857
Ankrd45
ankyrin repeat domain 45
chrX_-_79743117 1.92 ENSRNOT00000044808
LOC103690878
syntaxin-3-like
chr15_-_25505691 1.85 ENSRNOT00000074488
LOC100911492
homeobox protein OTX2-like
chr4_-_84131030 1.77 ENSRNOT00000012196
Cpvl
carboxypeptidase, vitellogenic-like
chr9_+_20951260 1.75 ENSRNOT00000016906
Adgrf4
adhesion G protein-coupled receptor F4
chr11_-_15858281 1.55 ENSRNOT00000090586
AABR07033287.1

chr14_-_21127868 1.55 ENSRNOT00000020608
ENSRNOT00000092172
Rufy3
RUN and FYVE domain containing 3
chr18_+_16146447 1.42 ENSRNOT00000022117
Galnt1
polypeptide N-acetylgalactosaminyltransferase 1
chr2_+_241909832 1.28 ENSRNOT00000047975
Ppp3ca
protein phosphatase 3 catalytic subunit alpha
chr5_-_14367898 1.28 ENSRNOT00000065402
Atp6v1h
ATPase H+ transporting V1 subunit H
chr2_-_244370983 1.14 ENSRNOT00000021458
Rap1gds1
Rap1 GTPase-GDP dissociation stimulator 1
chr3_-_76368909 0.94 ENSRNOT00000043599
Olr614
olfactory receptor 614
chr3_-_78112770 0.92 ENSRNOT00000008396
Olr694
olfactory receptor 694
chr16_-_81980027 0.89 ENSRNOT00000043170
Mcf2l
MCF.2 cell line derived transforming sequence-like
chr2_-_27364906 0.84 ENSRNOT00000078639
Polk
DNA polymerase kappa
chr1_+_214562897 0.83 ENSRNOT00000085125
Ap2a2
adaptor-related protein complex 2, alpha 2 subunit
chr1_-_189182306 0.77 ENSRNOT00000021249
Gp2
glycoprotein 2
chr3_-_78663607 0.77 ENSRNOT00000073134
Olr718
olfactory receptor 718
chr8_+_41350182 0.71 ENSRNOT00000072823
LOC100911758
olfactory receptor 143-like
chr13_+_71305548 0.60 ENSRNOT00000074864
LOC684709
similar to putative membrane protein Re9
chr2_+_166856784 0.60 ENSRNOT00000035765
Otol1
otolin 1
chr7_+_71157664 0.55 ENSRNOT00000005919
Sdr9c7
short chain dehydrogenase/reductase family 9C, member 7
chr1_+_172728264 0.52 ENSRNOT00000075297
Olr267
olfactory receptor 267
chr15_-_28806752 0.47 ENSRNOT00000047436
Olr1640
olfactory receptor 1640
chr17_-_39575720 0.44 ENSRNOT00000022923
Prl8a2
prolactin family 8, subfamily a, member 2
chr11_-_28527890 0.43 ENSRNOT00000002138
Cldn8
claudin 8
chr20_-_27308069 0.35 ENSRNOT00000056047
Slc25a16
solute carrier family 25 member 16
chr1_-_266862842 0.23 ENSRNOT00000027496
LOC103693430
up-regulated during skeletal muscle growth protein 5
chr17_-_78910671 0.15 ENSRNOT00000064609
Acbd7
acyl-CoA binding domain containing 7
chr3_-_78555530 0.14 ENSRNOT00000089672
Olr711
olfactory receptor 711
chr3_-_102432479 0.14 ENSRNOT00000047270
Olr747
olfactory receptor 747
chr16_-_3765917 0.08 ENSRNOT00000088284
Duxbl1
double homeobox B-like 1
chrX_-_136737730 0.06 ENSRNOT00000040754
Olr1765
olfactory receptor 1765
chr7_+_132857628 0.02 ENSRNOT00000005438
Lrrk2
leucine-rich repeat kinase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxa3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
34.9 104.8 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
20.9 62.6 GO:0045959 negative regulation of complement activation, classical pathway(GO:0045959)
13.3 53.0 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
11.4 57.0 GO:0050828 regulation of liquid surface tension(GO:0050828)
10.6 63.8 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
9.6 38.3 GO:0009441 glycolate metabolic process(GO:0009441)
9.4 28.1 GO:1990743 protein sialylation(GO:1990743)
9.1 45.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
8.5 84.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
8.4 50.3 GO:0006642 triglyceride mobilization(GO:0006642)
6.8 20.3 GO:0097498 endothelial tube lumen extension(GO:0097498)
6.6 19.7 GO:2001205 negative regulation of osteoclast development(GO:2001205)
5.5 22.1 GO:0030910 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
5.5 27.5 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
4.3 12.9 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
3.7 11.2 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
3.6 10.9 GO:0061144 alveolar secondary septum development(GO:0061144)
3.3 39.8 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857)
3.1 18.7 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
3.1 31.1 GO:0015697 quaternary ammonium group transport(GO:0015697)
3.1 42.7 GO:0071420 cellular response to histamine(GO:0071420)
3.0 11.8 GO:1904059 negative regulation of eating behavior(GO:1903999) regulation of locomotor rhythm(GO:1904059)
2.8 8.3 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
2.7 8.1 GO:0006574 valine catabolic process(GO:0006574)
2.7 10.7 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
2.6 42.0 GO:0042359 vitamin D metabolic process(GO:0042359)
2.2 17.8 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629) positive regulation of histone H4 acetylation(GO:0090240)
2.2 6.6 GO:0009597 detection of virus(GO:0009597)
2.2 51.8 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
2.1 6.4 GO:1902214 regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of apoptotic cell clearance(GO:2000426)
2.0 6.0 GO:0098759 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
1.4 11.6 GO:0070842 aggresome assembly(GO:0070842)
1.3 34.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
1.3 16.4 GO:0034063 stress granule assembly(GO:0034063)
1.3 11.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.1 3.4 GO:0099553 trans-synaptic signalling, modulating synaptic transmission(GO:0099550) trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
1.1 6.7 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
1.1 3.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
1.0 14.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
1.0 6.8 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.9 2.8 GO:0006116 NADH oxidation(GO:0006116)
0.8 11.8 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.8 3.3 GO:0038109 Kit signaling pathway(GO:0038109) diapedesis(GO:0050904)
0.7 4.3 GO:0044206 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) UMP salvage(GO:0044206)
0.6 7.3 GO:0046549 amacrine cell differentiation(GO:0035881) retinal rod cell development(GO:0046548) retinal cone cell development(GO:0046549)
0.6 20.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.5 2.2 GO:0072138 mesenchymal cell proliferation involved in ureteric bud development(GO:0072138)
0.5 3.1 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.5 3.0 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.5 5.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.4 2.2 GO:0060005 vestibular reflex(GO:0060005)
0.4 6.4 GO:0015671 oxygen transport(GO:0015671)
0.4 14.9 GO:0050892 intestinal absorption(GO:0050892)
0.4 4.0 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.3 1.3 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.3 20.4 GO:0045773 positive regulation of axon extension(GO:0045773)
0.3 10.0 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.3 1.4 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.2 4.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 19.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.2 4.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 38.6 GO:0007596 blood coagulation(GO:0007596)
0.2 0.8 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.2 4.7 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.2 10.4 GO:0060038 cardiac muscle cell proliferation(GO:0060038)
0.1 12.6 GO:0032092 positive regulation of protein binding(GO:0032092)
0.1 5.1 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 1.1 GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration(GO:0032471)
0.1 22.9 GO:0071456 cellular response to hypoxia(GO:0071456)
0.1 2.5 GO:0070166 enamel mineralization(GO:0070166)
0.1 0.8 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.1 1.9 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 7.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 12.1 GO:0007030 Golgi organization(GO:0007030)
0.1 2.2 GO:0060972 left/right pattern formation(GO:0060972)
0.1 0.3 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 10.5 GO:0048813 dendrite morphogenesis(GO:0048813)
0.1 8.9 GO:0050680 negative regulation of epithelial cell proliferation(GO:0050680)
0.1 7.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.3 GO:0007035 vacuolar acidification(GO:0007035)
0.1 2.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 2.7 GO:0014072 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.1 20.2 GO:0007568 aging(GO:0007568)
0.0 0.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 5.4 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.0 4.3 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.0 8.0 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
21.0 104.8 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
15.6 46.7 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
12.5 62.6 GO:0043159 acrosomal matrix(GO:0043159)
12.1 84.7 GO:0005579 membrane attack complex(GO:0005579)
5.7 45.3 GO:0005577 fibrinogen complex(GO:0005577)
3.4 20.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
2.1 12.6 GO:0030478 actin cap(GO:0030478)
1.6 11.5 GO:1990357 terminal web(GO:1990357)
1.6 16.0 GO:0044294 dendritic growth cone(GO:0044294)
1.6 12.7 GO:0032584 growth cone membrane(GO:0032584)
1.5 14.9 GO:0045179 apical cortex(GO:0045179)
1.4 33.0 GO:1902711 GABA-A receptor complex(GO:1902711)
1.2 3.5 GO:0005896 interleukin-6 receptor complex(GO:0005896) ciliary neurotrophic factor receptor complex(GO:0070110)
1.1 20.0 GO:0042589 zymogen granule membrane(GO:0042589)
0.9 6.4 GO:0005833 hemoglobin complex(GO:0005833)
0.9 4.3 GO:0045098 type III intermediate filament(GO:0045098)
0.8 93.8 GO:0072562 blood microparticle(GO:0072562)
0.8 61.0 GO:0005581 collagen trimer(GO:0005581)
0.7 4.0 GO:0005608 laminin-3 complex(GO:0005608)
0.7 10.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.6 10.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146) filopodium tip(GO:0032433)
0.6 28.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.5 15.5 GO:0034707 chloride channel complex(GO:0034707)
0.5 53.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.5 45.1 GO:0005902 microvillus(GO:0005902)
0.3 16.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 2.2 GO:0044292 dendrite terminus(GO:0044292)
0.3 4.4 GO:0071437 invadopodium(GO:0071437)
0.3 1.3 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.2 12.1 GO:0005801 cis-Golgi network(GO:0005801)
0.2 18.7 GO:0031526 brush border membrane(GO:0031526)
0.2 6.0 GO:0042629 mast cell granule(GO:0042629)
0.2 4.9 GO:0000800 lateral element(GO:0000800)
0.2 1.3 GO:0005955 calcineurin complex(GO:0005955)
0.2 6.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 31.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 44.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 19.7 GO:0005923 bicellular tight junction(GO:0005923)
0.2 4.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 10.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 22.1 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 13.8 GO:0005814 centriole(GO:0005814)
0.1 26.3 GO:0014069 postsynaptic density(GO:0014069)
0.1 0.3 GO:0005760 gamma DNA polymerase complex(GO:0005760)
0.1 8.0 GO:0045095 keratin filament(GO:0045095)
0.1 126.1 GO:0005783 endoplasmic reticulum(GO:0005783)
0.1 3.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 3.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.9 GO:0031201 SNARE complex(GO:0031201)
0.1 2.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 10.3 GO:0016324 apical plasma membrane(GO:0016324)
0.1 2.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 4.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.3 GO:0036064 ciliary basal body(GO:0036064)
0.0 2.5 GO:0030139 endocytic vesicle(GO:0030139)
0.0 6.9 GO:0005769 early endosome(GO:0005769)
0.0 7.6 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 5.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.8 GO:0030426 growth cone(GO:0030426)
0.0 13.7 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
34.9 104.8 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
21.3 63.8 GO:0070012 oligopeptidase activity(GO:0070012)
13.0 51.8 GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294)
10.6 53.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
10.4 31.1 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
9.6 38.3 GO:0003973 (S)-2-hydroxy-acid oxidase activity(GO:0003973)
9.4 28.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
7.8 46.7 GO:0035473 lipase binding(GO:0035473)
5.8 34.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
5.0 29.9 GO:0005499 vitamin D binding(GO:0005499)
4.6 27.5 GO:0004568 chitinase activity(GO:0004568)
4.1 77.1 GO:0001848 complement binding(GO:0001848)
3.9 11.8 GO:0001605 adrenomedullin receptor activity(GO:0001605)
3.9 11.7 GO:0004556 alpha-amylase activity(GO:0004556)
3.7 11.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
3.1 42.7 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
2.5 14.9 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
2.0 6.0 GO:0004918 interleukin-8 receptor activity(GO:0004918)
1.9 38.9 GO:0005537 mannose binding(GO:0005537)
1.9 18.7 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
1.6 6.4 GO:0005136 interleukin-4 receptor binding(GO:0005136)
1.5 7.3 GO:0008502 melatonin receptor activity(GO:0008502)
1.4 39.8 GO:0008395 steroid hydroxylase activity(GO:0008395)
1.3 12.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
1.2 14.9 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
1.2 3.5 GO:0004924 oncostatin-M receptor activity(GO:0004924)
1.1 22.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
1.0 16.7 GO:0035198 miRNA binding(GO:0035198)
0.9 15.5 GO:0050811 GABA receptor binding(GO:0050811)
0.9 11.6 GO:0098879 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.9 3.4 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.9 21.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.8 11.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.8 3.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.8 10.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.7 20.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.7 10.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.6 2.5 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.6 16.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.5 11.8 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.5 11.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.5 5.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.5 45.3 GO:0051087 chaperone binding(GO:0051087)
0.5 9.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.4 1.8 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.4 3.0 GO:0015315 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.4 6.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.4 48.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 1.3 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.3 8.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.2 11.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 17.8 GO:0002039 p53 binding(GO:0002039)
0.2 19.3 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 10.3 GO:0017022 myosin binding(GO:0017022)
0.1 1.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 4.7 GO:0070888 E-box binding(GO:0070888)
0.1 0.3 GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base(GO:0016890)
0.1 6.5 GO:0005496 steroid binding(GO:0005496)
0.1 13.6 GO:0072509 divalent inorganic cation transmembrane transporter activity(GO:0072509)
0.1 4.3 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 37.0 GO:0008289 lipid binding(GO:0008289)
0.1 15.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 2.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 1.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 2.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 10.5 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 42.4 GO:0032403 protein complex binding(GO:0032403)
0.0 2.9 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 7.3 GO:0003924 GTPase activity(GO:0003924)
0.0 0.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 16.3 GO:0005198 structural molecule activity(GO:0005198)
0.0 3.9 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.8 GO:0003823 antigen binding(GO:0003823)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 99.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
2.4 130.7 PID HNF3A PATHWAY FOXA1 transcription factor network
2.1 104.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.7 67.9 PID CD40 PATHWAY CD40/CD40L signaling
0.8 44.0 PID BMP PATHWAY BMP receptor signaling
0.6 90.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 6.7 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.4 12.9 PID EPHA FWDPATHWAY EPHA forward signaling
0.4 15.2 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.3 16.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.3 6.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.3 11.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.3 2.7 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 11.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 10.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 4.0 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.2 3.5 PID IL27 PATHWAY IL27-mediated signaling events
0.1 3.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 27.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 1.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
8.9 151.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
6.8 109.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
4.8 62.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
4.7 99.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
3.5 31.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
3.3 39.8 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
2.9 34.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
2.5 42.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
1.3 22.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
1.3 42.0 REACTOME STEROID HORMONES Genes involved in Steroid hormones
1.0 20.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.8 16.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.7 18.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.6 20.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.6 15.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.5 19.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 13.6 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.5 8.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.4 10.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 5.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 4.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.3 2.7 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.3 4.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.3 7.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.3 3.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 38.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 6.7 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 2.9 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 20.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.0 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 2.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 11.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.9 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 2.1 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 7.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.0 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 3.3 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.0 1.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression