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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Foxa3
Z-value: 1.09
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Transcription factors associated with Foxa3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxa3 | rn6_v1_chr1_-_79930263_79930263 | 0.59 | 6.5e-32 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_50525091 Show fit | 104.84 |
ENSRNOT00000074357
|
apolipoprotein A1 |
|
| chr5_+_124300477 Show fit | 84.70 |
ENSRNOT00000010100
|
complement C8 beta chain |
|
| chr18_-_24929091 Show fit | 63.77 |
ENSRNOT00000019596
|
protein C |
|
| chr13_-_47377703 Show fit | 62.63 |
ENSRNOT00000005461
|
complement component 4 binding protein, alpha |
|
| chr1_-_225283326 Show fit | 53.04 |
ENSRNOT00000027342
|
secretoglobin family 1A member 1 |
|
| chr11_-_81717521 Show fit | 51.83 |
ENSRNOT00000058422
|
alpha-2-HS-glycoprotein |
|
| chr11_-_87924816 Show fit | 48.36 |
ENSRNOT00000031819
|
serpin family D member 1 |
|
| chr6_+_33176778 Show fit | 46.75 |
ENSRNOT00000046811
ENSRNOT00000007371 |
apolipoprotein B |
|
| chr2_-_182035032 Show fit | 45.34 |
ENSRNOT00000009813
|
fibrinogen beta chain |
|
| chr14_+_20266891 Show fit | 41.98 |
ENSRNOT00000004174
|
group specific component |
Network of associatons between targets according to the STRING database.
First level regulatory network of Foxa3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 34.9 | 104.8 | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) |
| 8.5 | 84.7 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 10.6 | 63.8 | GO:1903142 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 20.9 | 62.6 | GO:0045959 | negative regulation of complement activation, classical pathway(GO:0045959) |
| 11.4 | 57.0 | GO:0050828 | regulation of liquid surface tension(GO:0050828) |
| 13.3 | 53.0 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) |
| 2.2 | 51.8 | GO:0046852 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 8.4 | 50.3 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 9.1 | 45.3 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 3.1 | 42.7 | GO:0071420 | cellular response to histamine(GO:0071420) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 126.1 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 21.0 | 104.8 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.8 | 93.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 12.1 | 84.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 12.5 | 62.6 | GO:0043159 | acrosomal matrix(GO:0043159) |
| 0.8 | 61.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.5 | 53.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 15.6 | 46.7 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 5.7 | 45.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.5 | 45.1 | GO:0005902 | microvillus(GO:0005902) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 34.9 | 104.8 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 4.1 | 77.1 | GO:0001848 | complement binding(GO:0001848) |
| 21.3 | 63.8 | GO:0070012 | oligopeptidase activity(GO:0070012) |
| 10.6 | 53.0 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 13.0 | 51.8 | GO:0030294 | receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294) |
| 0.4 | 48.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 7.8 | 46.7 | GO:0035473 | lipase binding(GO:0035473) |
| 0.5 | 45.3 | GO:0051087 | chaperone binding(GO:0051087) |
| 3.1 | 42.7 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.0 | 42.4 | GO:0032403 | protein complex binding(GO:0032403) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 130.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 2.1 | 104.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 3.2 | 99.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.6 | 90.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.7 | 67.9 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.8 | 44.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 27.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 16.4 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.4 | 15.2 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.4 | 12.9 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.9 | 151.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 6.8 | 109.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 4.7 | 99.2 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 4.8 | 62.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 2.5 | 42.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 1.3 | 42.0 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 3.3 | 39.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.2 | 38.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 2.9 | 34.7 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 3.5 | 31.1 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |