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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxa2_Foxa1

Z-value: 2.04

Motif logo

Transcription factors associated with Foxa2_Foxa1

Gene Symbol Gene ID Gene Info
ENSRNOG00000013133 forkhead box A2
ENSRNOG00000009284 forkhead box A1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxa2rn6_v1_chr3_+_142383278_1423832780.812.8e-77Click!
Foxa1rn6_v1_chr6_-_78549669_785496690.735.6e-54Click!

Activity profile of Foxa2_Foxa1 motif

Sorted Z-values of Foxa2_Foxa1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_124300477 300.99 ENSRNOT00000010100
complement C8 beta chain
chr7_-_138483612 234.88 ENSRNOT00000085620
solute carrier family 38, member 4
chr11_-_81717521 198.30 ENSRNOT00000058422
alpha-2-HS-glycoprotein
chr6_-_127534247 167.27 ENSRNOT00000012500
serpin family A member 6
chr14_+_20266891 160.56 ENSRNOT00000004174
group specific component
chr1_-_48563776 155.42 ENSRNOT00000023368
plasminogen
chr6_+_33176778 155.39 ENSRNOT00000046811
ENSRNOT00000007371
apolipoprotein B
chr11_-_87924816 155.13 ENSRNOT00000031819
serpin family D member 1
chr7_+_2689501 143.60 ENSRNOT00000041341
apolipoprotein F
chr5_-_19368431 142.02 ENSRNOT00000012819
cytochrome P450, family 7, subfamily a, polypeptide 1
chr2_-_216348194 137.23 ENSRNOT00000087839
pancreatic alpha-amylase-like
chr3_-_127500709 128.68 ENSRNOT00000006330
hydroxyacid oxidase 1
chr6_-_104631355 117.04 ENSRNOT00000007825
solute carrier family 10 member 1
chr7_+_93975451 114.56 ENSRNOT00000011379
collectin subfamily member 10
chr10_+_14240219 105.14 ENSRNOT00000020233
insulin-like growth factor binding protein, acid labile subunit
chr8_+_50559126 94.87 ENSRNOT00000024918
apolipoprotein A5
chr2_-_216382244 93.98 ENSRNOT00000086695
ENSRNOT00000087259
pancreatic alpha-amylase-like
chr16_+_50152008 93.02 ENSRNOT00000019237
kallikrein B1
chr1_-_225283326 92.09 ENSRNOT00000027342
secretoglobin family 1A member 1
chr2_+_104744461 90.04 ENSRNOT00000016083
ENSRNOT00000082627
ceruloplasmin
chr8_+_50525091 84.88 ENSRNOT00000074357
apolipoprotein A1
chr1_-_198486157 83.71 ENSRNOT00000022758
zymogen granule protein 16
chr2_-_182035032 82.19 ENSRNOT00000009813
fibrinogen beta chain
chr5_+_152290084 78.84 ENSRNOT00000089849
absent in melanoma 1-like
chr7_-_143523457 77.50 ENSRNOT00000012943
ENSRNOT00000082264
keratin 4
chr9_+_74124016 72.32 ENSRNOT00000019023
carbamoyl-phosphate synthase 1
chr3_-_55587946 71.99 ENSRNOT00000075107
ATP binding cassette subfamily B member 11
chr3_+_5519990 71.78 ENSRNOT00000070873
ENSRNOT00000007640
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr11_+_61605937 67.06 ENSRNOT00000093455
ENSRNOT00000093242
GRAM domain containing 1C
chr20_-_9876008 65.89 ENSRNOT00000001537
trefoil factor 2
chr16_+_50181316 65.83 ENSRNOT00000077662
coagulation factor XI
chr8_-_107952530 63.34 ENSRNOT00000052043
claudin 18
chr16_-_7026540 53.08 ENSRNOT00000051751
inter-alpha trypsin inhibitor, heavy chain 1
chr1_-_170431073 53.07 ENSRNOT00000024710
hemopexin
chr10_-_103687425 47.57 ENSRNOT00000039284
Cd300 molecule-like family member F
chr1_-_189182306 47.42 ENSRNOT00000021249
glycoprotein 2
chr3_+_149624712 46.22 ENSRNOT00000018581
BPI fold containing family A, member 1
chr4_+_57855416 46.12 ENSRNOT00000029608
carboxypeptidase A2
chr1_+_148240504 45.13 ENSRNOT00000085373
Cytochrome P450, family 2, subfamily c, polypeptide 7-like
chr7_+_41475163 44.18 ENSRNOT00000037844
dual specificity phosphatase 6
chr18_-_24929091 44.12 ENSRNOT00000019596
protein C
chr4_+_62220736 43.91 ENSRNOT00000086377
caldesmon 1
chr6_-_77421286 43.55 ENSRNOT00000011453
NK2 homeobox 1
chr8_-_49109981 43.40 ENSRNOT00000019933
tetratricopeptide repeat domain 36
chr4_+_62221011 42.71 ENSRNOT00000041264
caldesmon 1
chr4_-_15505362 40.44 ENSRNOT00000009763
hepatocyte growth factor
chr20_-_31598118 39.14 ENSRNOT00000046537
collagen type XIII alpha 1 chain
chr10_-_46404642 36.14 ENSRNOT00000083698
phosphatidylethanolamine N-methyltransferase
chr1_+_166428761 35.96 ENSRNOT00000085555
StAR-related lipid transfer domain containing 10
chr10_+_56710464 35.70 ENSRNOT00000065370
ENSRNOT00000064064
asialoglycoprotein receptor 2
chr13_+_83073866 31.25 ENSRNOT00000075996
dermatopontin
chr7_+_28414350 30.82 ENSRNOT00000085680
insulin-like growth factor 1
chr1_+_48273611 30.36 ENSRNOT00000022254
ENSRNOT00000022068
solute carrier family 22 member 1
chr12_+_47407811 29.97 ENSRNOT00000001565
HNF1 homeobox A
chr16_+_18716019 29.42 ENSRNOT00000047870
surfactant protein A1
chr10_-_88060561 28.31 ENSRNOT00000019133
keratin 19
chr6_-_78549669 26.95 ENSRNOT00000009940
forkhead box A1
chr13_-_53870428 26.11 ENSRNOT00000000812
nuclear receptor subfamily 5, group A, member 2
chr11_+_65022100 26.06 ENSRNOT00000003934
nuclear receptor subfamily 1, group I, member 2
chr7_-_28040510 24.62 ENSRNOT00000005674
achaete-scute family bHLH transcription factor 1
chr1_+_264741911 24.16 ENSRNOT00000019956
semaphorin 4G
chr5_+_165415136 23.76 ENSRNOT00000016317
ENSRNOT00000079407
mannan-binding lectin serine peptidase 2
chr2_+_53109684 22.97 ENSRNOT00000086590
selenoprotein P
chr4_-_119188251 21.31 ENSRNOT00000057350
gastrokine 3
chr3_-_48451650 21.21 ENSRNOT00000007356
glucagon
chr1_-_131460473 20.72 ENSRNOT00000084336
nuclear receptor subfamily 2, group F, member 2
chr5_+_162808646 19.88 ENSRNOT00000021155
dehydrogenase/reductase 3
chr10_+_86399827 19.71 ENSRNOT00000009299
growth factor receptor bound protein 7
chr2_-_250923744 18.90 ENSRNOT00000084996
chloride channel accessory 1
chr3_+_140024043 17.91 ENSRNOT00000086409
Ras and Rab interactor 2
chr14_+_18983853 17.30 ENSRNOT00000003836
Ras association domain family member 6
chr20_-_31597830 17.15 ENSRNOT00000085877
collagen type XIII alpha 1 chain
chr5_-_88629491 16.52 ENSRNOT00000058906
transducin like enhancer of split 1
chr2_+_208749996 16.35 ENSRNOT00000086321
chitinase, acidic
chr18_+_68408890 16.05 ENSRNOT00000039702
coiled-coil domain containing 68
chr2_+_24546536 15.54 ENSRNOT00000014036
orthopedia homeobox
chr2_-_100249811 15.42 ENSRNOT00000086760
hepatocyte nuclear factor 4, gamma
chr8_+_82878941 15.13 ENSRNOT00000014846
bone morphogenetic protein 5
chr8_+_57886168 14.55 ENSRNOT00000039336
exophilin 5
chrX_-_111102464 14.24 ENSRNOT00000084176
ripply transcriptional repressor 1
chr6_-_77508585 14.03 ENSRNOT00000011562
NK2 homeobox 8
chr2_+_208750356 13.97 ENSRNOT00000041562
chitinase, acidic
chr4_+_62380914 13.95 ENSRNOT00000029845
transmembrane protein 140
chr6_-_51257625 13.79 ENSRNOT00000012004
HMG-box transcription factor 1
chr15_+_55126953 12.93 ENSRNOT00000021430
lysophosphatidic acid receptor 6
chr2_-_234296145 12.88 ENSRNOT00000014155
ELOVL fatty acid elongase 6
chr2_-_158133861 12.77 ENSRNOT00000090700
ventricular zone expressed PH domain-containing 1
chr1_+_107262659 12.25 ENSRNOT00000022499
growth arrest-specific 2
chrX_+_40460047 12.03 ENSRNOT00000010970
phosphate regulating endopeptidase homolog, X-linked
chr6_+_137243185 11.41 ENSRNOT00000030879
zinc finger and BTB domain containing 42
chr4_-_82127051 11.25 ENSRNOT00000083658
ENSRNOT00000007807
homeo box A1
chr16_-_23156962 11.18 ENSRNOT00000018543
SH2 domain containing 4A
chr9_-_81467760 11.12 ENSRNOT00000090868
C-X-C motif chemokine receptor 1
chr8_+_40009691 10.85 ENSRNOT00000042679
V-set and immunoglobulin domain containing 2
chr10_+_56411028 10.68 ENSRNOT00000085772

chr14_+_44413636 10.33 ENSRNOT00000003552
small integral membrane protein 14
chr13_-_51201331 10.20 ENSRNOT00000005272
ENSRNOT00000078990
transmembrane protein 183A
chr1_+_72810545 10.01 ENSRNOT00000092117
protein tyrosine phosphatase, receptor type, H
chr2_-_258997138 9.94 ENSRNOT00000045020
ENSRNOT00000042256
adhesion G protein-coupled receptor L2
chr2_-_54823917 9.86 ENSRNOT00000039057
ENSRNOT00000079333
caspase recruitment domain family, member 6
chr2_+_44289393 9.46 ENSRNOT00000018877
interleukin 6 signal transducer
chr4_+_14001761 9.10 ENSRNOT00000076519
CD36 molecule
chr3_+_44806106 9.10 ENSRNOT00000035158
uridine phosphorylase 2
chr5_-_115387377 9.02 ENSRNOT00000036030
ENSRNOT00000077492
similar to hypothetical protein MGC34837
chr1_+_214778496 9.00 ENSRNOT00000028967
mucin 5B, oligomeric mucus/gel-forming
chr2_-_204254699 8.84 ENSRNOT00000021487
mab-21 like 3
chr9_-_20195566 8.76 ENSRNOT00000015223
adhesion G protein-coupled receptor F5
chr2_-_193136520 8.54 ENSRNOT00000042142
keratinocyte proline-rich protein
chrX_+_26439197 8.48 ENSRNOT00000078843
ENSRNOT00000052176
ENSRNOT00000087268
amelogenin, X-linked
chr11_-_67756799 8.28 ENSRNOT00000030975
poly (ADP-ribose) polymerase family, member 9
chr17_-_1093873 7.92 ENSRNOT00000086130
patched 1
chr1_+_256955652 7.70 ENSRNOT00000020411
leucine-rich, glioma inactivated 1
chr15_+_33074441 7.65 ENSRNOT00000075610
matrix metallopeptidase 14
chr12_-_30083824 7.60 ENSRNOT00000084968
tyrosylprotein sulfotransferase 1
chr7_+_13938302 7.30 ENSRNOT00000009643
caspase 14
chr20_-_27757149 7.19 ENSRNOT00000088287
dermatan sulfate epimerase
chr10_+_82292110 7.10 ENSRNOT00000004435
chondroadherin
chr10_+_108340240 6.88 ENSRNOT00000077535
coiled-coil domain containing 40
chr17_+_42133076 6.82 ENSRNOT00000031384
aldehyde dehydrogenase 5 family, member A1
chr4_+_163293724 6.72 ENSRNOT00000077356
GABA type A receptor associated protein like 1
chr10_-_95212111 6.70 ENSRNOT00000020795
karyopherin subunit alpha 2
chr2_+_121165137 6.41 ENSRNOT00000016236
SRY box 2
chr10_+_70884531 6.12 ENSRNOT00000015199
C-C motif chemokine ligand 4
chr5_+_173237642 6.11 ENSRNOT00000068770
ankyrin repeat domain 65
chrX_-_79743117 5.99 ENSRNOT00000044808
syntaxin-3-like
chr12_+_22665112 5.63 ENSRNOT00000001918
adaptor-related protein complex 1, sigma 1 subunit
chr2_-_192671059 5.54 ENSRNOT00000012174
small proline-rich protein 1A
chr2_+_234375315 5.48 ENSRNOT00000071270
elongation of very long chain fatty acids protein 6-like
chr2_+_110306363 5.45 ENSRNOT00000040463
LRRGT00202
chrX_+_35599258 5.33 ENSRNOT00000072627
ENSRNOT00000005061
cyclin-dependent kinase-like 5
chr2_-_236480502 5.33 ENSRNOT00000015020
sphingomyelin synthase 2
chr11_-_782954 5.28 ENSRNOT00000040065
Eph receptor A3
chr8_-_115981910 5.04 ENSRNOT00000019867
dedicator of cyto-kinesis 3
chr9_-_78607307 4.86 ENSRNOT00000057672
ATP binding cassette subfamily A member 12
chr17_-_84830185 4.69 ENSRNOT00000040697
SKI/DACH domain containing 1
chr19_+_53055745 4.67 ENSRNOT00000074430
forkhead box L1
chr9_+_77834091 4.62 ENSRNOT00000033459
von Willebrand factor C domain-containing protein 2-like
chr2_-_198706428 4.58 ENSRNOT00000085006
RNA polymerase III subunit G like
chr5_+_116420690 4.49 ENSRNOT00000087089
nuclear factor I/A
chr13_-_48927483 4.44 ENSRNOT00000010976
cyclin-dependent kinase 18
chr4_-_168297373 4.43 ENSRNOT00000066575
LDL receptor related protein 6
chr1_+_215460226 4.43 ENSRNOT00000027270
hypothetical protein LOC685544
chr8_-_102149912 4.23 ENSRNOT00000011263
similar to Ab2-095
chr7_+_91833297 4.22 ENSRNOT00000079792
solute carrier family 30 member 8
chr7_+_99954492 4.20 ENSRNOT00000005885
tribbles pseudokinase 1
chr20_-_27308069 4.17 ENSRNOT00000056047
solute carrier family 25 member 16
chr8_+_81863619 4.09 ENSRNOT00000080608
family with sequence similarity 214, member A
chr4_-_148362278 3.92 ENSRNOT00000051510
similar to 60S ribosomal protein L23a
chr4_+_66670618 3.82 ENSRNOT00000010796
thromboxane A synthase 1
chr4_-_28437676 3.62 ENSRNOT00000012995
HEPACAM family member 2
chr1_+_244615821 3.58 ENSRNOT00000080124
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr20_+_49319307 3.32 ENSRNOT00000057078
autophagy related 5
chr17_-_13393243 2.97 ENSRNOT00000018252
growth arrest and DNA-damage-inducible, gamma
chr15_-_95514259 2.81 ENSRNOT00000038433
SLIT and NTRK-like family, member 6
chr2_-_78283473 2.67 ENSRNOT00000087246

chr5_+_50381244 2.67 ENSRNOT00000012385
glycoprotein hormones, alpha polypeptide
chr17_-_55346279 2.58 ENSRNOT00000025037
supervillin
chr3_-_160038078 2.57 ENSRNOT00000013445
serine incorporator 3
chr1_-_24191908 2.53 ENSRNOT00000061157
serum/glucocorticoid regulated kinase 1
chr3_-_141411170 2.49 ENSRNOT00000017364
NK2 homeobox 2
chr3_-_60795951 2.47 ENSRNOT00000002174
activating transcription factor 2
chr4_+_119171245 2.45 ENSRNOT00000067651
gastrokine 2
chr1_+_168519499 2.40 ENSRNOT00000045286
olfactory receptor 98
chrX_-_15504165 2.38 ENSRNOT00000006233
OTU deubiquitinase 5
chr6_+_129438158 2.33 ENSRNOT00000005953
bradykinin receptor B1
chr3_-_64543100 2.23 ENSRNOT00000025803
zinc finger protein 385B
chr1_+_201620642 2.19 ENSRNOT00000093674
deleted in malignant brain tumors 1
chr15_+_24942218 2.19 ENSRNOT00000016629
pellino E3 ubiquitin protein ligase family member 2
chr8_-_61595032 2.10 ENSRNOT00000023428
sorting nexin 33
chr2_-_183128932 2.10 ENSRNOT00000031179
meiotic nuclear divisions 1
chr1_-_90149991 1.92 ENSRNOT00000076987
similar to RIKEN cDNA 4931406P16
chr9_-_55256340 1.90 ENSRNOT00000028907
serum deprivation response
chr14_+_42714315 1.88 ENSRNOT00000084095
ENSRNOT00000091449
paired-like homeobox 2b
chr6_-_26497328 1.86 ENSRNOT00000074938
nuclear receptor binding protein 1
chr10_+_87846947 1.81 ENSRNOT00000077436
keratin associated protein 9-5
chrX_-_63203643 1.79 ENSRNOT00000065194
ENSRNOT00000076974
zinc finger protein X-linked
chr17_-_42818258 1.76 ENSRNOT00000088978
Prolactin family 3, subfamily c, member 1
chr9_+_45605552 1.59 ENSRNOT00000059587
neuromedin S
chr4_+_179481263 1.57 ENSRNOT00000021284
electron transfer flavoprotein regulatory factor 1
chr5_-_12172009 1.49 ENSRNOT00000061903
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
chr16_-_75415555 1.45 ENSRNOT00000029297
defensin alpha 7
chr10_+_58860940 1.39 ENSRNOT00000056551
ENSRNOT00000074523
XIAP associated factor-1
chr10_-_84789832 1.27 ENSRNOT00000071719
CDK5 regulatory subunit associated protein 3
chr16_-_75107931 1.15 ENSRNOT00000058066
defensin beta 15
chr11_+_74984613 1.15 ENSRNOT00000035049
ATPase 13A5
chr9_+_111220858 1.12 ENSRNOT00000076669
diphosphoinositol pentakisphosphate kinase 2
chr8_-_58120045 1.07 ENSRNOT00000086812
ATM serine/threonine kinase
chr3_-_176781040 0.96 ENSRNOT00000044026
glucocorticoid modulatory element binding protein 2
chr20_+_33527932 0.95 ENSRNOT00000066492
nephrocan
chr1_-_40972826 0.93 ENSRNOT00000060757
required for meiotic nuclear division 1 homolog
chr9_-_15274917 0.84 ENSRNOT00000019650
progastricsin
chr10_+_57040267 0.82 ENSRNOT00000026207
arrestin, beta 2
chr4_+_72589565 0.77 ENSRNOT00000079349
olfactory receptor 437
chrX_+_26440584 0.74 ENSRNOT00000087293
ENSRNOT00000005328
amelogenin, X-linked
chr5_+_113725717 0.69 ENSRNOT00000032248
TEK receptor tyrosine kinase
chr5_-_7874909 0.64 ENSRNOT00000064774
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr10_-_87351030 0.61 ENSRNOT00000034889
ENSRNOT00000091152
keratin 20
chr8_-_37026142 0.61 ENSRNOT00000060446
rCG22807-like
chr1_-_151106802 0.60 ENSRNOT00000021971
tyrosinase
chr8_+_85951191 0.59 ENSRNOT00000037665
CD109 molecule

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
51.8 155.4 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
44.9 179.7 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
32.2 128.7 GO:0009441 glycolate metabolic process(GO:0009441)
31.8 158.8 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
27.5 164.8 GO:0006642 triglyceride mobilization(GO:0006642)
27.4 301.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
21.1 63.3 GO:2001205 negative regulation of osteoclast development(GO:2001205)
20.4 81.5 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
16.4 82.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
15.9 47.6 GO:2000426 regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of apoptotic cell clearance(GO:2000426)
14.7 44.2 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
14.5 72.3 GO:0071400 cellular response to oleic acid(GO:0071400)
13.3 53.1 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
11.9 47.4 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
11.8 142.0 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857)
11.6 57.8 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
11.3 90.0 GO:0015679 plasma membrane copper ion transport(GO:0015679)
10.9 98.1 GO:0046618 drug export(GO:0046618)
10.4 20.7 GO:0060849 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
10.1 40.4 GO:1902947 regulation of tau-protein kinase activity(GO:1902947)
9.4 65.9 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
9.2 46.2 GO:0050828 regulation of liquid surface tension(GO:0050828)
9.0 27.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
8.9 160.6 GO:0042359 vitamin D metabolic process(GO:0042359)
8.6 198.3 GO:0030502 negative regulation of bone mineralization(GO:0030502)
7.6 15.1 GO:0021502 neural fold elevation formation(GO:0021502)
7.5 30.0 GO:0035565 regulation of pronephros size(GO:0035565)
7.4 44.1 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
7.3 43.5 GO:0021759 globus pallidus development(GO:0021759)
7.0 167.3 GO:0008211 glucocorticoid metabolic process(GO:0008211)
6.5 26.1 GO:0061113 pancreas morphogenesis(GO:0061113)
6.4 153.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
6.1 30.3 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
6.0 36.1 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
6.0 12.0 GO:1904383 response to sodium phosphate(GO:1904383)
5.9 29.4 GO:0008228 opsonization(GO:0008228)
5.3 21.2 GO:1903576 response to L-arginine(GO:1903576)
3.8 11.3 GO:0021569 rhombomere 3 development(GO:0021569) rhombomere 4 development(GO:0021570)
3.7 11.1 GO:0098758 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
3.6 156.4 GO:0033344 cholesterol efflux(GO:0033344)
3.0 30.4 GO:0015697 quaternary ammonium group transport(GO:0015697)
2.8 234.9 GO:0003333 amino acid transmembrane transport(GO:0003333)
2.8 71.8 GO:0035864 response to potassium ion(GO:0035864)
2.6 18.4 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
2.5 7.6 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
2.5 19.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.4 7.3 GO:0070268 cornification(GO:0070268)
2.4 7.2 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
2.3 6.8 GO:0006083 acetate metabolic process(GO:0006083)
1.9 15.5 GO:0021979 hypothalamus cell differentiation(GO:0021979)
1.8 53.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
1.8 5.3 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
1.7 23.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
1.7 45.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
1.6 6.4 GO:0071698 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.6 4.7 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
1.5 19.7 GO:0034063 stress granule assembly(GO:0034063)
1.5 9.1 GO:0044206 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) UMP salvage(GO:0044206)
1.5 4.4 GO:0061348 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) Wnt signaling pathway involved in forebrain neuroblast division(GO:0021874) external genitalia morphogenesis(GO:0035261) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) regulation of cardiac chamber morphogenesis(GO:1901219) negative regulation of cardiac chamber morphogenesis(GO:1901220) regulation of cardiac ventricle development(GO:1904412)
1.5 14.5 GO:0071985 multivesicular body sorting pathway(GO:0071985)
1.4 23.0 GO:0001887 selenium compound metabolic process(GO:0001887)
1.4 51.5 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
1.3 6.5 GO:2000334 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
1.3 8.8 GO:0043031 negative regulation of macrophage activation(GO:0043031)
1.2 6.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
1.1 4.2 GO:0045658 regulation of neutrophil differentiation(GO:0045658)
1.0 4.2 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
1.0 8.3 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
1.0 14.1 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
1.0 86.6 GO:0032092 positive regulation of protein binding(GO:0032092)
1.0 6.9 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
1.0 28.3 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
1.0 16.5 GO:2000811 negative regulation of anoikis(GO:2000811)
1.0 6.7 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.9 1.9 GO:0021550 medulla oblongata development(GO:0021550)
0.9 3.6 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.9 5.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.9 13.8 GO:0032369 negative regulation of lipid transport(GO:0032369)
0.8 3.3 GO:2000619 negative regulation of histone H4-K16 acetylation(GO:2000619)
0.8 2.5 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.8 2.4 GO:1905077 regulation of interleukin-17 secretion(GO:1905076) negative regulation of interleukin-17 secretion(GO:1905077)
0.8 7.1 GO:0060346 bone trabecula formation(GO:0060346)
0.8 3.8 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.7 31.2 GO:0030199 collagen fibril organization(GO:0030199)
0.6 2.6 GO:0009597 detection of virus(GO:0009597)
0.6 4.5 GO:0072189 ureter development(GO:0072189)
0.6 2.8 GO:0060005 vestibular reflex(GO:0060005)
0.6 75.9 GO:0050680 negative regulation of epithelial cell proliferation(GO:0050680)
0.5 139.3 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.5 9.2 GO:0070166 enamel mineralization(GO:0070166)
0.4 35.7 GO:0055088 lipid homeostasis(GO:0055088)
0.4 4.2 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.4 5.5 GO:0031424 keratinization(GO:0031424)
0.4 2.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.4 1.1 GO:1904868 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.3 6.0 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.2 2.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 2.1 GO:0036089 cleavage furrow formation(GO:0036089) macropinocytosis(GO:0044351)
0.2 1.3 GO:0071569 protein ufmylation(GO:0071569)
0.2 2.7 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.2 147.3 GO:0005975 carbohydrate metabolic process(GO:0005975)
0.2 3.0 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.2 74.7 GO:0007568 aging(GO:0007568)
0.2 0.8 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778) regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786) positive regulation of antibacterial peptide production(GO:0002803)
0.2 1.8 GO:0060746 parental behavior(GO:0060746)
0.1 9.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 4.2 GO:0060038 cardiac muscle cell proliferation(GO:0060038)
0.1 4.6 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 5.3 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 1.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.9 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 2.3 GO:0045776 negative regulation of blood pressure(GO:0045776)
0.1 5.2 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 1.0 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.6 GO:0045109 intermediate filament organization(GO:0045109)
0.0 2.2 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 1.6 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.6 GO:0033280 response to vitamin D(GO:0033280)
0.0 1.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 4.0 GO:0042742 defense response to bacterium(GO:0042742)
0.0 1.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 2.5 GO:0030522 intracellular receptor signaling pathway(GO:0030522)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
84.9 84.9 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
51.7 155.2 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
43.0 301.0 GO:0005579 membrane attack complex(GO:0005579)
32.8 393.9 GO:0034362 low-density lipoprotein particle(GO:0034362)
22.7 136.0 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
14.4 86.6 GO:0030478 actin cap(GO:0030478)
12.0 83.7 GO:0060205 cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
10.3 82.2 GO:0005577 fibrinogen complex(GO:0005577)
8.1 105.0 GO:0046581 intercellular canaliculus(GO:0046581)
4.7 543.8 GO:0072562 blood microparticle(GO:0072562)
4.0 28.3 GO:1990357 terminal web(GO:1990357)
3.2 9.5 GO:0005896 interleukin-6 receptor complex(GO:0005896) ciliary neurotrophic factor receptor complex(GO:0070110)
2.7 200.3 GO:0005581 collagen trimer(GO:0005581)
1.8 9.1 GO:0045098 type III intermediate filament(GO:0045098)
1.8 5.3 GO:0045203 intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
1.4 72.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
1.3 13.3 GO:0044294 dendritic growth cone(GO:0044294)
1.2 21.1 GO:0042589 zymogen granule membrane(GO:0042589)
1.2 30.0 GO:0045120 pronucleus(GO:0045120)
1.1 4.4 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.9 68.8 GO:0045095 keratin filament(GO:0045095)
0.8 3.3 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.8 4.9 GO:0097209 epidermal lamellar body(GO:0097209)
0.8 89.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.8 7.6 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.6 11.1 GO:0042629 mast cell granule(GO:0042629)
0.6 762.2 GO:0005615 extracellular space(GO:0005615)
0.5 26.7 GO:0005902 microvillus(GO:0005902)
0.5 87.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.5 41.4 GO:0031225 anchored component of membrane(GO:0031225)
0.4 19.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.4 28.6 GO:0031526 brush border membrane(GO:0031526)
0.3 3.6 GO:0071564 npBAF complex(GO:0071564)
0.3 26.4 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.3 4.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 5.5 GO:0001533 cornified envelope(GO:0001533)
0.2 51.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 9.2 GO:0005604 basement membrane(GO:0005604)
0.2 28.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 6.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.2 142.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.2 6.0 GO:0031201 SNARE complex(GO:0031201)
0.1 2.6 GO:0043034 costamere(GO:0043034)
0.1 6.7 GO:0005643 nuclear pore(GO:0005643)
0.1 10.4 GO:0005923 bicellular tight junction(GO:0005923)
0.1 6.7 GO:0005776 autophagosome(GO:0005776)
0.1 16.9 GO:0005667 transcription factor complex(GO:0005667)
0.1 5.6 GO:0048475 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.1 1.9 GO:0035861 site of double-strand break(GO:0035861)
0.0 4.2 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 1.9 GO:0005901 caveola(GO:0005901)
0.0 1.1 GO:1990391 DNA repair complex(GO:1990391)
0.0 20.7 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
77.1 231.2 GO:0004556 alpha-amylase activity(GO:0004556)
49.6 198.3 GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294)
41.7 250.3 GO:0035473 lipase binding(GO:0035473)
32.2 128.7 GO:0003973 (S)-2-hydroxy-acid oxidase activity(GO:0003973)
28.3 84.9 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
22.0 132.1 GO:0005499 vitamin D binding(GO:0005499)
19.5 117.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
18.4 92.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
15.0 90.0 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
14.7 44.1 GO:0070012 oligopeptidase activity(GO:0070012)
12.0 155.4 GO:1990405 protein antigen binding(GO:1990405)
11.9 47.6 GO:0005136 interleukin-4 receptor binding(GO:0005136)
10.1 30.4 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
7.2 72.0 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
6.0 72.3 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
5.9 53.1 GO:0015232 heme transporter activity(GO:0015232)
5.7 114.6 GO:0005537 mannose binding(GO:0005537)
5.4 64.6 GO:0070008 serine-type exopeptidase activity(GO:0070008)
5.1 142.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
5.1 30.3 GO:0004568 chitinase activity(GO:0004568)
4.6 64.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
3.8 105.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
3.7 11.1 GO:0004918 interleukin-8 receptor activity(GO:0004918)
3.6 43.5 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
3.6 36.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
3.2 375.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
3.2 9.5 GO:0004924 oncostatin-M receptor activity(GO:0004924)
2.9 23.0 GO:0008430 selenium binding(GO:0008430)
2.8 44.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
2.6 7.9 GO:0005119 smoothened binding(GO:0005119)
2.5 7.6 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
2.4 23.8 GO:0001846 opsonin binding(GO:0001846)
2.3 9.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
2.3 9.2 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
2.1 237.5 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
2.0 45.1 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
1.8 18.4 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
1.7 46.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.5 6.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
1.5 15.1 GO:0070700 BMP receptor binding(GO:0070700)
1.5 40.3 GO:0042056 chemoattractant activity(GO:0042056)
1.5 30.8 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
1.4 20.7 GO:0001972 retinoic acid binding(GO:0001972)
1.3 6.5 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
1.2 92.6 GO:0017022 myosin binding(GO:0017022)
1.1 10.0 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
1.1 4.4 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
1.1 5.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
1.0 4.2 GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base(GO:0016890)
1.0 4.9 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
1.0 62.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.9 19.9 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.9 18.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.9 78.0 GO:0051087 chaperone binding(GO:0051087)
0.8 6.7 GO:0030957 Tat protein binding(GO:0030957)
0.8 3.3 GO:0019776 Atg8 ligase activity(GO:0019776)
0.7 28.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.6 77.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.6 30.0 GO:0001221 transcription cofactor binding(GO:0001221)
0.6 47.4 GO:0003823 antigen binding(GO:0003823)
0.6 7.3 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153) cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.5 16.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.5 5.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.5 24.6 GO:0070888 E-box binding(GO:0070888)
0.5 143.4 GO:0030246 carbohydrate binding(GO:0030246)
0.4 52.7 GO:0008201 heparin binding(GO:0008201)
0.4 2.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.4 0.8 GO:0031762 follicle-stimulating hormone receptor binding(GO:0031762)
0.4 2.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.4 74.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 1.5 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.4 8.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 9.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.3 2.2 GO:0035375 zymogen binding(GO:0035375)
0.3 1.1 GO:0000829 inositol heptakisphosphate kinase activity(GO:0000829)
0.3 2.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 1.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.2 9.1 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 4.2 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.2 6.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 6.8 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 0.4 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 1.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 0.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.4 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 7.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 3.8 GO:0016860 intramolecular oxidoreductase activity(GO:0016860)
0.1 53.1 GO:0005198 structural molecule activity(GO:0005198)
0.1 2.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.6 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 7.0 GO:0005179 hormone activity(GO:0005179)
0.0 50.3 GO:0032403 protein complex binding(GO:0032403)
0.0 1.9 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 2.0 GO:0002039 p53 binding(GO:0002039)
0.0 1.7 GO:0008565 protein transporter activity(GO:0008565)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 350.3 PID HNF3A PATHWAY FOXA1 transcription factor network
5.7 275.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
3.4 181.1 PID BMP PATHWAY BMP receptor signaling
3.2 158.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.9 437.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.5 90.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
1.3 56.3 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
1.3 191.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.2 44.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
1.1 30.8 PID IGF1 PATHWAY IGF1 pathway
0.9 19.7 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.9 36.7 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.9 18.1 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.7 6.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.5 20.9 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.5 106.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.5 8.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.4 11.1 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.3 9.5 PID IL27 PATHWAY IL27-mediated signaling events
0.3 15.1 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.2 12.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 5.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 6.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.5 PID INSULIN PATHWAY Insulin Pathway
0.1 2.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 2.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 1.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.7 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
19.7 335.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
15.8 189.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
12.4 260.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
11.8 142.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
9.3 324.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
9.0 126.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
8.4 158.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
6.0 234.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
4.9 163.2 REACTOME STEROID HORMONES Genes involved in Steroid hormones
3.4 30.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
3.2 44.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
2.8 74.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
2.7 40.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
2.6 74.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
1.9 63.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
1.9 74.0 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
1.5 21.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
1.1 28.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
1.1 20.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
1.0 201.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.9 51.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.8 9.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.8 9.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.8 9.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.7 12.9 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.7 5.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.6 9.0 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.4 16.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.4 12.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 23.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 4.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.3 6.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 4.9 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 6.5 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.2 4.6 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.2 2.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 1.1 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.2 4.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 3.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.2 5.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 5.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 7.2 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.1 6.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 6.7 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 7.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 5.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 0.8 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 2.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport