ISMARA results: Foxa2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Foxa2_Foxa1

Z-value: 2.04

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Transcription factors associated with Foxa2_Foxa1

Gene Symbol	Gene ID	Gene Info
Foxa2 NCBI RGD Ensembl	ENSRNOG00000013133	forkhead box A2
Foxa1 NCBI RGD Ensembl	ENSRNOG00000009284	forkhead box A1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Foxa2	rn6_v1_chr3_+_142383278_142383278	0.81	2.8e-77	Click!
Foxa1	rn6_v1_chr6_-_78549669_78549669	0.73	5.6e-54	Click!

Activity profile of Foxa2_Foxa1 motif

Sorted Z-values of Foxa2_Foxa1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_124300477 Show fit	300.99	ENSRNOT00000010100	C8b NCBI RGD Ensembl Show fit	complement C8 beta chain
chr7_-_138483612 Show fit	234.88	ENSRNOT00000085620	Slc38a4 NCBI RGD Ensembl Show fit	solute carrier family 38, member 4
chr11_-_81717521 Show fit	198.30	ENSRNOT00000058422	Ahsg NCBI RGD Ensembl Show fit	alpha-2-HS-glycoprotein
chr6_-_127534247 Show fit	167.27	ENSRNOT00000012500	Serpina6 NCBI RGD Ensembl Show fit	serpin family A member 6
chr14_+_20266891 Show fit	160.56	ENSRNOT00000004174	Gc NCBI RGD Ensembl Show fit	group specific component
chr1_-_48563776 Show fit	155.42	ENSRNOT00000023368	Plg NCBI RGD Ensembl Show fit	plasminogen
chr6_+_33176778 Show fit	155.39	ENSRNOT00000046811 ENSRNOT00000007371	Apob NCBI RGD Ensembl Show fit	apolipoprotein B
chr11_-_87924816 Show fit	155.13	ENSRNOT00000031819	Serpind1 NCBI RGD Ensembl Show fit	serpin family D member 1
chr7_+_2689501 Show fit	143.60	ENSRNOT00000041341	Apof NCBI RGD Ensembl Show fit	apolipoprotein F
chr5_-_19368431 Show fit	142.02	ENSRNOT00000012819	Cyp7a1 NCBI RGD Ensembl Show fit	cytochrome P450, family 7, subfamily a, polypeptide 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxa2_Foxa1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
27.4	301.0	GO:0006957	complement activation, alternative pathway(GO:0006957)
2.8	234.9	GO:0003333	amino acid transmembrane transport(GO:0003333)
8.6	198.3	GO:0030502	negative regulation of bone mineralization(GO:0030502)
44.9	179.7	GO:0010901	regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
7.0	167.3	GO:0008211	glucocorticoid metabolic process(GO:0008211)
27.5	164.8	GO:0006642	triglyceride mobilization(GO:0006642)
8.9	160.6	GO:0042359	vitamin D metabolic process(GO:0042359)
31.8	158.8	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
3.6	156.4	GO:0033344	cholesterol efflux(GO:0033344)
51.8	155.4	GO:0052047	interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)

Showing 1 to 10 of 122 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	762.2	GO:0005615	extracellular space(GO:0005615)
4.7	543.8	GO:0072562	blood microparticle(GO:0072562)
32.8	393.9	GO:0034362	low-density lipoprotein particle(GO:0034362)
43.0	301.0	GO:0005579	membrane attack complex(GO:0005579)
2.7	200.3	GO:0005581	collagen trimer(GO:0005581)
51.7	155.2	GO:0044279	other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.2	142.6	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
22.7	136.0	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
8.1	105.0	GO:0046581	intercellular canaliculus(GO:0046581)
0.8	89.5	GO:0005791	rough endoplasmic reticulum(GO:0005791)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	375.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
41.7	250.3	GO:0035473	lipase binding(GO:0035473)
2.1	237.5	GO:0015171	amino acid transmembrane transporter activity(GO:0015171)
77.1	231.2	GO:0004556	alpha-amylase activity(GO:0004556)
49.6	198.3	GO:0030294	receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294)
12.0	155.4	GO:1990405	protein antigen binding(GO:1990405)
0.5	143.4	GO:0030246	carbohydrate binding(GO:0030246)
5.1	142.0	GO:0008395	steroid hydroxylase activity(GO:0008395)
22.0	132.1	GO:0005499	vitamin D binding(GO:0005499)
32.2	128.7	GO:0003973	(S)-2-hydroxy-acid oxidase activity(GO:0003973)

Showing 1 to 10 of 98 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	437.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
6.4	350.3	PID HNF3A PATHWAY	FOXA1 transcription factor network
5.7	275.1	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
1.3	191.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
3.4	181.1	PID BMP PATHWAY	BMP receptor signaling
3.2	158.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.5	106.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
1.5	90.0	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
1.3	56.3	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
1.2	44.2	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway

Showing 1 to 10 of 29 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
19.7	335.1	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
9.3	324.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
12.4	260.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
6.0	234.9	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
1.0	201.0	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
15.8	189.0	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
4.9	163.2	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
8.4	158.8	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
11.8	142.0	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
9.0	126.3	REACTOME COMMON PATHWAY	Genes involved in Common Pathway

Showing 1 to 10 of 50 entries

Results for Foxa2_Foxa1

Z-value: 2.04

Motif logo

Transcription factors associated with Foxa2_Foxa1

Activity-expression correlation:

Activity profile of Foxa2_Foxa1 motif

Sorted Z-values of Foxa2_Foxa1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxa2_Foxa1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: