ISMARA results: Figla

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Figla

Z-value: 0.89

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Transcription factors associated with Figla

Gene Symbol	Gene ID	Gene Info
Figla NCBI RGD Ensembl	ENSRNOG00000015877	folliculogenesis specific bHLH transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Figla	rn6_v1_chr4_+_117679342_117679342	0.06	2.9e-01	Click!

Activity profile of Figla motif

Sorted Z-values of Figla motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_87774552 Show fit	98.63	ENSRNOT00000044342	Krtap9-1 NCBI RGD Ensembl Show fit	keratin associated protein 9-1
chr10_+_87782376 Show fit	44.61	ENSRNOT00000017415	LOC680396 NCBI RGD Ensembl Show fit	hypothetical protein LOC680396
chr10_-_87564327 Show fit	41.32	ENSRNOT00000064760 ENSRNOT00000068237	LOC680160 NCBI RGD Ensembl Show fit	similar to keratin associated protein 4-7
chr2_-_105089659 Show fit	35.89	ENSRNOT00000043381	Cpb1 NCBI RGD Ensembl Show fit	carboxypeptidase B1
chr10_+_87759769 Show fit	35.18	ENSRNOT00000017378 ENSRNOT00000046526	Krtap9-1 NCBI RGD Ensembl Show fit	keratin associated protein 9-1
chr5_-_155772040 Show fit	29.26	ENSRNOT00000036788	Cela3b NCBI RGD Ensembl Show fit	chymotrypsin-like elastase family, member 3B
chr4_-_28437676 Show fit	23.27	ENSRNOT00000012995	Hepacam2 NCBI RGD Ensembl Show fit	HEPACAM family member 2
chr10_+_87788458 Show fit	19.74	ENSRNOT00000042020	LOC100910814 NCBI RGD Ensembl Show fit	keratin-associated protein 9-1-like
chr10_-_87529599 Show fit	19.32	ENSRNOT00000074099	Krtap2-1 NCBI RGD Ensembl Show fit	keratin associated protein 2-1
chr7_-_143016040 Show fit	18.60	ENSRNOT00000029697	Krt80 NCBI RGD Ensembl Show fit	keratin 80

Showing 1 to 10 of 114 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Figla

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	34.6	GO:0016125	sterol metabolic process(GO:0016125)
1.3	16.8	GO:0016264	gap junction assembly(GO:0016264) cellular response to glucagon stimulus(GO:0071377)
4.2	16.7	GO:0016332	establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
2.5	14.9	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	14.4	GO:0051604	protein maturation(GO:0051604)
4.6	13.9	GO:0042939	glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.4	13.8	GO:0060445	branching involved in salivary gland morphogenesis(GO:0060445)
0.1	11.2	GO:0007586	digestion(GO:0007586)
0.2	10.9	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.2	10.7	GO:0016925	protein sumoylation(GO:0016925)

Showing 1 to 10 of 55 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	129.9	GO:0045095	keratin filament(GO:0045095)
0.0	32.5	GO:0005615	extracellular space(GO:0005615)
0.1	23.3	GO:0030496	midbody(GO:0030496)
0.0	23.3	GO:0016604	nuclear body(GO:0016604)
2.2	17.6	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.8	16.8	GO:0097449	connexon complex(GO:0005922) astrocyte projection(GO:0097449)
0.0	14.7	GO:0005667	transcription factor complex(GO:0005667)
1.0	13.9	GO:0032426	stereocilium tip(GO:0032426)
0.1	11.6	GO:0031594	neuromuscular junction(GO:0031594)
0.6	10.9	GO:0032433	filopodium tip(GO:0032433)

Showing 1 to 10 of 37 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	94.8	GO:0042802	identical protein binding(GO:0042802)
0.2	40.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.3	35.9	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.2	30.2	GO:0030165	PDZ domain binding(GO:0030165)
0.1	22.4	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1	17.4	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
1.2	16.8	GO:0005243	gap junction channel activity(GO:0005243)
0.1	14.9	GO:0001047	core promoter binding(GO:0001047)
3.5	13.9	GO:0045159	myosin II binding(GO:0045159)
0.0	12.2	GO:0043565	sequence-specific DNA binding(GO:0043565)

Showing 1 to 10 of 44 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	27.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.9	14.9	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	13.9	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.2	10.9	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.2	10.7	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.1	8.6	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	7.8	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.2	7.6	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	6.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	6.0	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	16.8	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.9	14.9	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.2	10.9	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.4	9.4	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1	7.8	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.7	7.6	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.1	7.6	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.4	7.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2	7.0	REACTOME KINESINS	Genes involved in Kinesins
0.1	6.8	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

Showing 1 to 10 of 23 entries

Results for Figla

Z-value: 0.89

Motif logo

Transcription factors associated with Figla

Activity-expression correlation:

Activity profile of Figla motif

Sorted Z-values of Figla motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Figla

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: