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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Figla

Z-value: 0.89

Motif logo

Transcription factors associated with Figla

Gene Symbol Gene ID Gene Info
ENSRNOG00000015877 folliculogenesis specific bHLH transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Figlarn6_v1_chr4_+_117679342_1176793420.062.9e-01Click!

Activity profile of Figla motif

Sorted Z-values of Figla motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_87774552 98.63 ENSRNOT00000044342
keratin associated protein 9-1
chr10_+_87782376 44.61 ENSRNOT00000017415
hypothetical protein LOC680396
chr10_-_87564327 41.32 ENSRNOT00000064760
ENSRNOT00000068237
similar to keratin associated protein 4-7
chr2_-_105089659 35.89 ENSRNOT00000043381
carboxypeptidase B1
chr10_+_87759769 35.18 ENSRNOT00000017378
ENSRNOT00000046526
keratin associated protein 9-1
chr5_-_155772040 29.26 ENSRNOT00000036788
chymotrypsin-like elastase family, member 3B
chr4_-_28437676 23.27 ENSRNOT00000012995
HEPACAM family member 2
chr10_+_87788458 19.74 ENSRNOT00000042020
keratin-associated protein 9-1-like
chr10_-_87529599 19.32 ENSRNOT00000074099
keratin associated protein 2-1
chr7_-_143016040 18.60 ENSRNOT00000029697
keratin 80
chr4_+_56981283 17.57 ENSRNOT00000010989
tetraspanin 33
chr5_-_24631679 17.44 ENSRNOT00000010846
ENSRNOT00000067129
epithelial splicing regulatory protein 1
chr15_-_37383277 16.77 ENSRNOT00000011711
gap junction protein, beta 2
chr10_+_104368247 16.73 ENSRNOT00000006519
LLGL2, scribble cell polarity complex component
chr7_-_71226150 14.98 ENSRNOT00000005875
similar to Retinol dehydrogenase type II (RODH II) (29 k-protein)
chr5_+_154522119 14.85 ENSRNOT00000072618
E2F transcription factor 2
chr10_+_103713045 13.93 ENSRNOT00000004351
SLC9A3 regulator 1
chr3_+_112531703 12.23 ENSRNOT00000041727
protein CASC5-like
chr10_+_106812739 11.58 ENSRNOT00000074225
synaptogyrin 2
chr4_-_69196430 11.20 ENSRNOT00000017673
Trypsin V-A
chr18_+_61377051 11.00 ENSRNOT00000066659
O-acyltransferase like
chr2_+_77868412 10.86 ENSRNOT00000065897
ENSRNOT00000014022
myosin X
chr10_-_108196217 10.75 ENSRNOT00000075440
chromobox 4
chr1_+_80000165 10.60 ENSRNOT00000084912
SIX homeobox 5
chr12_+_9728486 10.36 ENSRNOT00000001263
ligand of numb-protein X 2
chr4_-_82271893 10.16 ENSRNOT00000075005
homeobox A7
chrX_-_154918095 10.09 ENSRNOT00000085224
elongation factor 1-alpha 1-like
chr7_-_101140308 9.82 ENSRNOT00000006279
family with sequence similarity 84, member B
chr5_-_169212170 9.42 ENSRNOT00000013385
taste 1 receptor member 1
chr8_+_62341613 9.26 ENSRNOT00000066923
secretory carrier membrane protein 2
chr1_+_100470722 9.19 ENSRNOT00000086917
aspartate dehydrogenase domain containing
chr11_-_90406797 8.63 ENSRNOT00000073049
snail family transcriptional repressor 2
chr3_+_141927400 8.26 ENSRNOT00000066588

chr4_-_82202096 7.87 ENSRNOT00000081824
homeobox protein Hox-A10-like
chr1_-_89269930 7.84 ENSRNOT00000028532
free fatty acid receptor 2
chr9_-_18371856 7.78 ENSRNOT00000027293
SPT3 homolog, SAGA and STAGA complex component
chr10_-_87541851 7.67 ENSRNOT00000089610
similar to keratin associated protein 2-4
chr1_+_224824799 7.61 ENSRNOT00000024757
solute carrier family 22 member 6
chr1_+_41325462 7.60 ENSRNOT00000081017
ENSRNOT00000078494
ENSRNOT00000088168
estrogen receptor 1
chr2_-_43068677 7.47 ENSRNOT00000036658
GC-rich promoter binding protein 1
chr15_+_32355565 7.19 ENSRNOT00000072382

chr3_+_161236898 7.01 ENSRNOT00000082303
ENSRNOT00000020323
ubiquitin-conjugating enzyme E2C
chr1_-_80311043 7.01 ENSRNOT00000068092
kinesin light chain 3
chr9_+_66335492 6.53 ENSRNOT00000037555
similar to KIAA2012 protein
chr6_+_26051396 6.27 ENSRNOT00000006452
ribokinase
chr1_+_7252349 5.84 ENSRNOT00000030329
PLAG1 like zinc finger 1
chr3_+_125503638 5.52 ENSRNOT00000028900
cardiolipin synthase 1
chr10_-_87578854 5.43 ENSRNOT00000065619
similar to keratin associated protein 4-7
chr1_-_221431713 5.31 ENSRNOT00000028485
transmembrane 7 superfamily member 2
chr16_-_39970532 5.26 ENSRNOT00000071331
spermatogenesis associated 4
chr1_+_78739930 5.18 ENSRNOT00000021976
striatin 4
chr17_-_8619737 5.12 ENSRNOT00000065217
RGD1562024
chr10_-_89088993 5.09 ENSRNOT00000027458
C-C motif chemokine receptor 10
chr10_-_70220558 4.97 ENSRNOT00000041389
ENSRNOT00000076398
ENSRNOT00000076596
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr13_-_110642754 4.92 ENSRNOT00000029039
hydroxysteroid 17-beta dehydrogenase 6-like
chr10_-_87521514 4.82 ENSRNOT00000084668
ENSRNOT00000071705
keratin associated protein 2-4-like
chr10_-_87535438 4.75 ENSRNOT00000086873
keratin associated protein 2-4
chr3_+_148386189 4.67 ENSRNOT00000011255
myosin light chain kinase 2
chr9_+_88357556 4.53 ENSRNOT00000020669
collagen type IV alpha 3 chain
chr4_-_82186190 4.35 ENSRNOT00000071729
homeobox protein Hox-A7-like
chr8_+_116754178 4.32 ENSRNOT00000068295
ENSRNOT00000084429
ubiquitin-like modifier activating enzyme 7
chr10_-_87753668 4.29 ENSRNOT00000066758
ENSRNOT00000047104
keratin associated protein 4-3
chr15_+_4475051 4.23 ENSRNOT00000008461
potassium two pore domain channel subfamily K member 16
chr1_+_277355619 4.07 ENSRNOT00000022788
NHL repeat containing 2
chr20_-_2701637 3.95 ENSRNOT00000049667
heat shock protein family A (Hsp70) member 1A
chr20_-_2210033 3.78 ENSRNOT00000084596
tripartite motif-containing 26
chr20_-_4879779 3.51 ENSRNOT00000081924
heat shock protein family A (Hsp70) member 1B
chr12_-_46414434 3.50 ENSRNOT00000041281
citron rho-interacting serine/threonine kinase
chr18_+_48132414 3.33 ENSRNOT00000050631
sorting nexin 2
chr10_-_56289882 3.30 ENSRNOT00000090762
ENSRNOT00000056903
tumor necrosis factor superfamily member 13
chr17_-_42267079 3.29 ENSRNOT00000059564
uncharacterized LOC100911664
chr20_-_5865775 3.20 ENSRNOT00000000612
ENSRNOT00000092641
SRSF protein kinase 1
chr10_+_87832743 3.19 ENSRNOT00000055286
keratin associated protein 31-1
chr3_-_152179193 3.17 ENSRNOT00000026700
RNA binding motif protein 12
chr10_-_54467956 3.12 ENSRNOT00000065383
ubiquitin specific peptidase 43
chr3_+_7686503 3.11 ENSRNOT00000017984
senataxin
chr1_+_192025710 3.08 ENSRNOT00000077457
ubiquitin family domain containing 1
chr1_-_192025350 2.98 ENSRNOT00000071946
glutamyl-tRNA synthetase 2, mitochondrial
chr11_+_50781127 2.95 ENSRNOT00000002738
activated leukocyte cell adhesion molecule
chr12_-_47360507 2.77 ENSRNOT00000001562
signal peptide peptidase like 3
chr3_+_103753238 2.63 ENSRNOT00000007144
solute carrier family 12, member 6
chr8_-_22874637 2.50 ENSRNOT00000064551
ENSRNOT00000090424
dedicator of cytokinesis 6
chr13_-_73558912 2.47 ENSRNOT00000093655
centrosomal protein 350
chr10_+_87846947 2.45 ENSRNOT00000077436
keratin associated protein 9-5
chr4_-_129846642 2.45 ENSRNOT00000010717
FERM domain containing 4B
chr2_+_95008477 2.44 ENSRNOT00000015327
tumor protein D52
chr4_+_127164453 2.40 ENSRNOT00000017889
kelch repeat and BTB domain containing 8
chr1_-_215423099 2.35 ENSRNOT00000027259

chr20_+_14101659 2.35 ENSRNOT00000072696
guanylyl cyclase domain containing 1
chr10_+_16542882 2.31 ENSRNOT00000028146
stanniocalcin 2
chrX_-_111942749 2.20 ENSRNOT00000087583

chr8_+_111210811 2.12 ENSRNOT00000011347
angiomotin like 2
chr2_+_95008311 2.03 ENSRNOT00000077270
tumor protein D52
chr10_+_65772443 1.96 ENSRNOT00000013296
SEBOX homeobox
chr10_+_87808493 1.92 ENSRNOT00000065405
hypothetical protein LOC680428
chr2_+_197720259 1.80 ENSRNOT00000070919
golgi phosphoprotein 3-like
chr1_+_82151669 1.77 ENSRNOT00000091357
capicua transcriptional repressor
chr11_-_35749464 1.60 ENSRNOT00000078818
ENSRNOT00000078425
ERG, ETS transcription factor
chr7_-_2912491 1.56 ENSRNOT00000048453

chr6_+_75996643 1.56 ENSRNOT00000052076
signal recognition particle 54A
chr9_+_51009116 1.55 ENSRNOT00000039313
methyltransferase like 21C-like 1
chr19_-_55434252 1.51 ENSRNOT00000045052
poly(A)binding protein nuclear 1-like
chr7_-_143552588 1.48 ENSRNOT00000086317
ENSRNOT00000092619
ENSRNOT00000092138
keratin 78
chr6_+_50528823 1.37 ENSRNOT00000008321
laminin subunit beta 1
chr8_-_50126413 1.22 ENSRNOT00000072712
ENSRNOT00000022583
centrosomal protein 164
chr3_+_11476883 1.04 ENSRNOT00000072241
nuclear apoptosis inducing factor 1
chr3_+_73089269 0.93 ENSRNOT00000084321
olfactory receptor 453
chr19_+_22699808 0.78 ENSRNOT00000023169
similar to RIKEN cDNA 4921524J17
chr4_+_88048267 0.77 ENSRNOT00000044913
vomeronasal 1 receptor 81
chr4_-_68597586 0.59 ENSRNOT00000015921
similar to RIKEN cDNA E330009J07 gene
chr18_+_3887419 0.50 ENSRNOT00000093089
laminin subunit alpha 3
chr3_+_140024043 0.42 ENSRNOT00000086409
Ras and Rab interactor 2
chr10_-_43895376 0.12 ENSRNOT00000031811
olfactory receptor 1413
chr3_-_60460724 0.04 ENSRNOT00000024706
cholinergic receptor nicotinic alpha 1 subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of Figla

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.9 GO:0042939 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
4.2 16.7 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
3.1 9.2 GO:0006742 NADP catabolic process(GO:0006742)
2.9 8.6 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
2.5 7.5 GO:1902380 positive regulation of mRNA cleavage(GO:0031439) positive regulation of endoribonuclease activity(GO:1902380) positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904722)
2.5 14.9 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
2.1 6.3 GO:0019303 D-ribose catabolic process(GO:0019303)
2.0 7.8 GO:0002752 leukocyte chemotaxis involved in inflammatory response(GO:0002232) cell surface pattern recognition receptor signaling pathway(GO:0002752) regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
1.9 7.6 GO:1990375 baculum development(GO:1990375)
1.8 7.0 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
1.6 9.4 GO:0050917 sensory perception of umami taste(GO:0050917)
1.6 4.7 GO:0031448 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
1.5 7.6 GO:0031427 response to methotrexate(GO:0031427)
1.3 16.8 GO:0016264 gap junction assembly(GO:0016264) cellular response to glucagon stimulus(GO:0071377)
1.1 10.2 GO:0045656 negative regulation of monocyte differentiation(GO:0045656)
1.1 3.3 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.9 10.6 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.9 2.6 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.9 4.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.8 5.0 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.8 5.5 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.8 3.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.6 3.0 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.5 1.4 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.4 13.8 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.4 7.8 GO:0016578 histone deubiquitination(GO:0016578)
0.3 4.5 GO:0032836 glomerular basement membrane development(GO:0032836)
0.3 1.6 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.3 2.8 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.3 34.6 GO:0016125 sterol metabolic process(GO:0016125)
0.2 2.4 GO:0014029 neural crest formation(GO:0014029)
0.2 3.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.2 1.8 GO:0048194 Golgi vesicle budding(GO:0048194)
0.2 10.7 GO:0016925 protein sumoylation(GO:0016925)
0.2 3.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.2 10.9 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 3.5 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.1 2.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 9.0 GO:0006414 translational elongation(GO:0006414)
0.1 1.6 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 2.9 GO:1902284 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.1 2.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 2.5 GO:0034453 microtubule anchoring(GO:0034453)
0.1 3.2 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.1 5.1 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.1 11.2 GO:0007586 digestion(GO:0007586)
0.1 4.1 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 14.4 GO:0051604 protein maturation(GO:0051604)
0.0 4.3 GO:0042633 molting cycle(GO:0042303) hair cycle(GO:0042633)
0.0 4.5 GO:0030183 B cell differentiation(GO:0030183)
0.0 1.0 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 3.1 GO:0016579 protein deubiquitination(GO:0016579)
0.0 10.4 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 2.0 GO:0048477 oogenesis(GO:0048477)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 17.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
1.7 129.9 GO:0045095 keratin filament(GO:0045095)
1.2 5.0 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
1.0 13.9 GO:0032426 stereocilium tip(GO:0032426)
0.8 16.8 GO:0097449 connexon complex(GO:0005922) astrocyte projection(GO:0097449)
0.8 7.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.7 10.7 GO:0035102 PRC1 complex(GO:0035102)
0.6 10.9 GO:0032433 filopodium tip(GO:0032433)
0.6 7.8 GO:0030914 STAGA complex(GO:0030914)
0.6 4.5 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.5 7.0 GO:0035253 ciliary rootlet(GO:0035253)
0.4 2.8 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.4 7.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 1.4 GO:0005606 laminin-1 complex(GO:0005606) laminin-2 complex(GO:0005607) laminin-10 complex(GO:0043259)
0.3 9.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 3.5 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.2 1.6 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.2 5.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 2.9 GO:0042101 T cell receptor complex(GO:0042101)
0.1 23.3 GO:0030496 midbody(GO:0030496)
0.1 11.6 GO:0031594 neuromuscular junction(GO:0031594)
0.1 3.3 GO:0030904 retromer complex(GO:0030904)
0.1 1.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 0.5 GO:0005608 laminin-3 complex(GO:0005608) laminin-5 complex(GO:0005610)
0.1 5.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 3.9 GO:0016235 aggresome(GO:0016235)
0.1 7.6 GO:0005901 caveola(GO:0005901)
0.1 3.1 GO:0045171 intercellular bridge(GO:0045171)
0.1 5.3 GO:0031985 Golgi cisterna(GO:0031985)
0.0 10.2 GO:0031965 nuclear membrane(GO:0031965)
0.0 14.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 23.3 GO:0016604 nuclear body(GO:0016604)
0.0 8.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 4.7 GO:0008021 synaptic vesicle(GO:0008021)
0.0 32.5 GO:0005615 extracellular space(GO:0005615)
0.0 4.3 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.9 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
3.5 13.9 GO:0045159 myosin II binding(GO:0045159)
2.5 7.5 GO:0031249 denatured protein binding(GO:0031249)
1.5 7.6 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
1.3 35.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.2 16.8 GO:0005243 gap junction channel activity(GO:0005243)
1.2 4.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
1.1 3.3 GO:1990460 leptin receptor binding(GO:1990460)
1.0 7.6 GO:0031404 chloride ion binding(GO:0031404)
0.7 2.6 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.6 10.7 GO:0019789 SUMO transferase activity(GO:0019789)
0.5 5.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.5 2.8 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.4 9.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 4.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.4 1.6 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.3 5.1 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.3 9.4 GO:0008527 taste receptor activity(GO:0008527)
0.3 9.2 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.3 5.5 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.2 7.0 GO:0061650 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.2 5.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 30.2 GO:0030165 PDZ domain binding(GO:0030165)
0.2 6.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.2 40.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 1.4 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 7.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 7.0 GO:0019894 kinesin binding(GO:0019894)
0.1 5.0 GO:0002039 p53 binding(GO:0002039)
0.1 9.3 GO:0008565 protein transporter activity(GO:0008565)
0.1 22.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 14.9 GO:0001047 core promoter binding(GO:0001047)
0.1 1.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 4.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 17.4 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 8.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 3.0 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 2.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 5.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 94.8 GO:0042802 identical protein binding(GO:0042802)
0.0 3.1 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 12.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 3.2 GO:0000287 magnesium ion binding(GO:0000287)
0.0 3.6 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 14.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 3.3 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.2 10.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.2 7.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.2 10.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 13.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 8.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 6.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 27.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.0 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 7.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 5.0 PID TNF PATHWAY TNF receptor signaling pathway
0.1 3.5 PID RHOA PATHWAY RhoA signaling pathway
0.1 2.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.2 PID ATR PATHWAY ATR signaling pathway
0.0 0.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 3.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 16.8 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.9 14.9 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.7 7.6 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.4 7.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.4 9.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 5.5 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.3 4.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 5.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 7.0 REACTOME KINESINS Genes involved in Kinesins
0.2 10.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 3.0 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 7.6 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 7.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 4.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 4.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 5.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 6.8 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 4.3 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 2.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 4.9 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 2.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes