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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Ezh2_Atf2_Ikzf1
Z-value: 1.77
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Transcription factors associated with Ezh2_Atf2_Ikzf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Atf2 | rn6_v1_chr3_-_60765645_60765645 | 0.51 | 3.7e-22 | Click! |
| Ikzf1 | rn6_v1_chr14_+_91783514_91783514 | -0.44 | 1.7e-16 | Click! |
| Ezh2 | rn6_v1_chr4_-_77347011_77347011 | -0.21 | 1.3e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_110046687 Show fit | 98.23 |
ENSRNOT00000057404
ENSRNOT00000006624 ENSRNOT00000089695 |
sodium leak channel, non-selective |
|
| chr7_+_123510804 Show fit | 88.84 |
ENSRNOT00000010491
|
septin 3 |
|
| chr15_+_33600102 Show fit | 85.70 |
ENSRNOT00000022664
|
CKLF-like MARVEL transmembrane domain containing 5 |
|
| chr17_-_10766253 Show fit | 74.98 |
ENSRNOT00000000117
|
complexin 2 |
|
| chr4_+_175729726 Show fit | 70.82 |
ENSRNOT00000013230
|
solute carrier organic anion transporter family, member 1c1 |
|
| chr3_-_44086006 Show fit | 69.53 |
ENSRNOT00000034449
ENSRNOT00000082604 |
ermin |
|
| chr3_+_113318563 Show fit | 69.08 |
ENSRNOT00000089230
|
creatine kinase, mitochondrial 1 |
|
| chr7_-_136853154 Show fit | 67.72 |
ENSRNOT00000087376
|
neural EGFL like 2 |
|
| chr7_-_136853957 Show fit | 66.84 |
ENSRNOT00000008985
|
neural EGFL like 2 |
|
| chr11_-_35098883 Show fit | 66.39 |
ENSRNOT00000079955
|
potassium voltage-gated channel subfamily J member 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ezh2_Atf2_Ikzf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 168.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 24.0 | 168.2 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 11.2 | 134.6 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 18.1 | 108.3 | GO:0099526 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 3.1 | 98.5 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114) |
| 8.4 | 92.3 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 12.7 | 89.2 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 2.9 | 87.9 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 7.2 | 86.2 | GO:0046548 | retinal rod cell development(GO:0046548) |
| 7.7 | 84.2 | GO:0007258 | JUN phosphorylation(GO:0007258) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 371.3 | GO:0043204 | perikaryon(GO:0043204) |
| 39.4 | 197.2 | GO:0099569 | presynaptic cytoskeleton(GO:0099569) |
| 0.7 | 194.4 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.6 | 178.3 | GO:0030424 | axon(GO:0030424) |
| 23.5 | 141.0 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 19.3 | 115.7 | GO:0044308 | axonal spine(GO:0044308) |
| 5.0 | 115.7 | GO:1902711 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 10.9 | 109.3 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 12.5 | 99.8 | GO:0032584 | growth cone membrane(GO:0032584) |
| 4.8 | 96.6 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 181.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 2.7 | 172.6 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 42.0 | 168.2 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
| 0.4 | 131.0 | GO:0015631 | tubulin binding(GO:0015631) |
| 3.9 | 110.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 12.3 | 98.2 | GO:0022842 | leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842) |
| 3.6 | 96.6 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.6 | 90.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 5.0 | 89.7 | GO:0005522 | profilin binding(GO:0005522) |
| 3.6 | 86.7 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 163.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 2.2 | 116.5 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 2.6 | 112.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 2.3 | 79.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 2.4 | 60.7 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 1.0 | 49.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.8 | 47.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 1.5 | 44.8 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.2 | 40.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 2.6 | 33.2 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.4 | 223.2 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 9.2 | 128.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 3.4 | 119.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 6.8 | 114.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 3.6 | 106.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 5.3 | 84.2 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 3.4 | 71.6 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 3.1 | 70.8 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.8 | 62.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 5.4 | 53.9 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |