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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Etv6
Z-value: 0.82
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Transcription factors associated with Etv6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Etv6 | rn6_v1_chr4_+_167754525_167754525 | -0.09 | 1.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_-_105355716 Show fit | 11.15 |
ENSRNOT00000015043
|
translocase of inner mitochondrial membrane 8 homolog A1 (yeast) |
|
| chr8_-_87213627 Show fit | 10.52 |
ENSRNOT00000066084
|
cytochrome c oxidase subunit 7A2 |
|
| chr3_-_79728879 Show fit | 8.73 |
ENSRNOT00000012425
|
NADH dehydrogenase (ubiquinone) Fe-S protein 3 |
|
| chr19_+_52032886 Show fit | 6.78 |
ENSRNOT00000019923
|
malonyl-CoA decarboxylase |
|
| chr10_-_20658100 Show fit | 6.54 |
ENSRNOT00000010252
|
arginyl-tRNA synthetase |
|
| chr1_-_199395363 Show fit | 6.24 |
ENSRNOT00000090368
ENSRNOT00000026587 |
protease, serine, 36 |
|
| chr4_-_153373649 Show fit | 6.11 |
ENSRNOT00000016495
|
ATPase H+ transporting V1 subunit E1 |
|
| chr9_-_17254949 Show fit | 6.07 |
ENSRNOT00000026499
|
mitochondrial ribosomal protein S18A |
|
| chr1_-_216953999 Show fit | 5.94 |
ENSRNOT00000028126
|
MAS related GPR family member G |
|
| chr10_+_55924938 Show fit | 5.87 |
ENSRNOT00000087003
ENSRNOT00000057079 |
trafficking protein particle complex 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Etv6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.0 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.2 | 9.3 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.2 | 8.7 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.1 | 8.5 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
| 0.6 | 7.6 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 1.2 | 7.4 | GO:0015074 | DNA integration(GO:0015074) |
| 2.3 | 6.8 | GO:0036115 | coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) fatty-acyl-CoA catabolic process(GO:0036115) |
| 0.4 | 6.7 | GO:0043248 | proteasome assembly(GO:0043248) |
| 1.6 | 6.5 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.2 | 6.5 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.4 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.5 | 13.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.3 | 13.0 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 11.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.4 | 10.4 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.2 | 8.5 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.2 | 7.6 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.3 | 6.8 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.5 | 6.5 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 6.5 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 9.8 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.0 | 8.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 8.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 8.5 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.2 | 7.3 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 6.7 | GO:0042623 | ATPase activity, coupled(GO:0042623) |
| 1.6 | 6.5 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) arginine binding(GO:0034618) |
| 0.7 | 6.1 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.1 | 5.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 4.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 4.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 3.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 3.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 3.1 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 2.6 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 2.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 2.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 2.1 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 8.3 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 7.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 6.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 6.5 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.2 | 6.3 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.4 | 5.5 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 1.0 | 5.2 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 5.1 | REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| 0.3 | 4.7 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |