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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Etv4

Z-value: 0.65

Motif logo

Transcription factors associated with Etv4

Gene Symbol Gene ID Gene Info
ENSRNOG00000020792 ets variant 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Etv4rn6_v1_chr10_-_89700283_897002830.474.3e-19Click!

Activity profile of Etv4 motif

Sorted Z-values of Etv4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_158088505 18.96 ENSRNOT00000026643
von Willebrand factor
chr4_+_163162211 15.88 ENSRNOT00000082537
C-type lectin domain family 1, member B
chr5_+_82587420 14.50 ENSRNOT00000014020
toll-like receptor 4
chr16_+_18716019 14.24 ENSRNOT00000047870
surfactant protein A1
chr10_+_83655460 12.38 ENSRNOT00000008011
G protein subunit gamma transducin 2
chr10_+_47765432 12.35 ENSRNOT00000078231
microfibril-associated glycoprotein 4-like
chr2_-_190100276 11.72 ENSRNOT00000015351
S100 calcium binding protein A9
chr11_+_64601029 11.13 ENSRNOT00000004138
Rho GTPase activating protein 31
chr10_+_89167146 10.02 ENSRNOT00000043953
receptor activity modifying protein 2
chr10_+_89166890 9.98 ENSRNOT00000088331
receptor activity modifying protein 2
chr20_+_30915213 9.01 ENSRNOT00000000681
perforin 1
chr10_+_35133252 8.74 ENSRNOT00000051916
secretoglobin, family 3A, member 1
chr2_-_21698937 8.70 ENSRNOT00000080165

chr7_-_107392972 8.68 ENSRNOT00000093425
transmembrane protein 71
chr3_+_55369214 8.65 ENSRNOT00000067161
nitric oxide synthase trafficking
chr13_+_47602692 8.58 ENSRNOT00000038822
Fc fragment of IgM receptor
chr1_-_98493978 8.44 ENSRNOT00000023942
natural killer cell granule protein 7
chr13_-_55173692 8.22 ENSRNOT00000064785
ENSRNOT00000029878
ENSRNOT00000029865
ENSRNOT00000060292
ENSRNOT00000000814
protein tyrosine phosphatase, receptor type, C
chr7_+_142776252 7.87 ENSRNOT00000008673
activin A receptor like type 1
chr2_-_113616766 7.76 ENSRNOT00000016858
ENSRNOT00000074723
transmembrane protein 212
chr16_-_19918644 7.38 ENSRNOT00000083345
ENSRNOT00000023926
plasmalemma vesicle associated protein
chr7_+_142776580 7.36 ENSRNOT00000081047
activin A receptor like type 1
chr8_-_133002201 7.31 ENSRNOT00000008772
C-C motif chemokine receptor 1
chr15_+_57221292 7.28 ENSRNOT00000014502
lymphocyte cytosolic protein 1
chr2_-_197860699 7.02 ENSRNOT00000028740
extracellular matrix protein 1
chr3_-_160730360 6.81 ENSRNOT00000075864
similar to secretory leukocyte protease inhibitor
chr2_-_172459165 6.76 ENSRNOT00000057473
schwannomin interacting protein 1
chr10_-_70646495 6.54 ENSRNOT00000071218
growth arrest-specific 2 like 2
chr3_+_122114108 6.40 ENSRNOT00000091935
signal-regulatory protein alpha
chr18_+_51492196 6.14 ENSRNOT00000020570
GRAM domain containing 3
chr5_-_141242131 5.74 ENSRNOT00000081482
microtubule-actin crosslinking factor 1
chr17_-_46794845 5.70 ENSRNOT00000077910
ENSRNOT00000090663
ENSRNOT00000078331
engulfment and cell motility 1
chr1_+_88875375 5.69 ENSRNOT00000028284
Tyro protein tyrosine kinase binding protein
chr13_+_89774764 5.67 ENSRNOT00000005619
Rho GTPase activating protein 30
chr5_-_101138427 5.48 ENSRNOT00000058615
Fras1 related extracellular matrix 1
chr1_+_219403970 5.35 ENSRNOT00000029607
protein tyrosine phosphatase, receptor type, C-associated protein
chr9_-_85986208 5.30 ENSRNOT00000073128
family with sequence similarity 124 member B
chr10_+_12046541 5.20 ENSRNOT00000081191
MEFV, pyrin innate immunity regulator
chr5_-_137321121 5.18 ENSRNOT00000027414
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr15_-_54906203 5.04 ENSRNOT00000020186
cysteinyl leukotriene receptor 2
chr3_-_110517163 5.01 ENSRNOT00000078037
phospholipase C, beta 2
chr18_-_24735349 4.94 ENSRNOT00000036537
G protein-coupled receptor 17
chr9_-_90806126 4.88 ENSRNOT00000072054
family with sequence similarity 124B
chr5_-_160158386 4.74 ENSRNOT00000089345
filamin binding LIM protein 1
chr13_+_50164563 4.71 ENSRNOT00000029533
lymphocyte transmembrane adaptor 1
chr7_+_143707237 4.67 ENSRNOT00000074212
tensin 2
chr1_+_198744050 4.65 ENSRNOT00000024404
integrin subunit alpha L
chr8_-_72204730 4.62 ENSRNOT00000023810
F-box and leucine-rich repeat protein 22
chrX_-_32355296 4.59 ENSRNOT00000081652
ENSRNOT00000065075
adaptor-related protein complex 1, sigma 2 subunit
chr4_-_119327822 4.54 ENSRNOT00000012645
Rho GTPase activating protein 25
chr5_-_147303346 4.52 ENSRNOT00000009153
hippocalcin
chr7_-_71048383 4.47 ENSRNOT00000005693
G protein-coupled receptor 182
chr7_+_132857628 4.44 ENSRNOT00000005438
leucine-rich repeat kinase 2
chr1_+_215628785 4.31 ENSRNOT00000054864
lymphocyte-specific protein 1
chr10_+_14094754 4.27 ENSRNOT00000019660
ribosomal protein L3-like
chr10_+_12046701 4.26 ENSRNOT00000011073
ENSRNOT00000084004
MEFV, pyrin innate immunity regulator
chr13_+_51958834 4.25 ENSRNOT00000007833
protein tyrosine phosphatase, non-receptor type 7
chr1_-_227441442 4.23 ENSRNOT00000028433
membrane spanning 4-domains A1
chr10_-_30118873 4.19 ENSRNOT00000006063
ubiquitin-like domain containing CTD phosphatase 1
chr10_+_91254058 4.14 ENSRNOT00000087218
ENSRNOT00000065373
formin-like 1
chr2_+_112868707 4.13 ENSRNOT00000017805
neutral cholesterol ester hydrolase 1
chr3_+_80555196 4.11 ENSRNOT00000067318
Rho GTPase activating protein 1
chr15_+_34352914 4.11 ENSRNOT00000067150
guanosine monophosphate reductase 2
chr4_-_10329241 4.08 ENSRNOT00000017232
fibrinogen-like 2
chrX_+_134979646 4.07 ENSRNOT00000006035
SAM and SH3 domain containing 3
chr9_+_94745217 4.03 ENSRNOT00000051338
inositol polyphosphate-5-phosphatase D
chr10_-_83655182 4.02 ENSRNOT00000007897
ABI family, member 3
chr7_+_119482272 4.00 ENSRNOT00000009544
neutrophil cytosolic factor 4
chr10_-_103685844 3.98 ENSRNOT00000064284
Cd300 molecule-like family member F
chr7_+_12782491 3.97 ENSRNOT00000065093
calponin 2
chr10_-_64657089 3.90 ENSRNOT00000080703
active BCR-related
chr11_-_66759402 3.90 ENSRNOT00000003326
hematopoietic cell specific Lyn substrate 1
chr3_+_79918969 3.77 ENSRNOT00000016306
Spi-1 proto-oncogene
chr9_+_42871950 3.76 ENSRNOT00000089673
AT-rich interaction domain 5A
chr1_+_88078350 3.72 ENSRNOT00000048677
RAS guanyl releasing protein 4
chr2_-_243224883 3.70 ENSRNOT00000014139
dual adaptor of phosphotyrosine and 3-phosphoinositides 1
chr8_-_116465801 3.70 ENSRNOT00000085915
semaphorin 3F
chr10_+_63662986 3.69 ENSRNOT00000088722
scavenger receptor class F, member 1
chr1_-_126211439 3.65 ENSRNOT00000014988
tight junction protein 1
chr1_+_197999037 3.58 ENSRNOT00000091065
apolipoprotein B receptor
chr10_-_64642292 3.55 ENSRNOT00000084670
active BCR-related
chr16_-_9430743 3.53 ENSRNOT00000043811
WDFY family member 4
chr18_+_30550877 3.47 ENSRNOT00000027164
protocadherin beta-7-like
chr14_+_91783514 3.44 ENSRNOT00000080753
IKAROS family zinc finger 1
chr8_-_65587658 3.43 ENSRNOT00000091982
leucine rich repeat containing 49
chr3_+_11679530 3.41 ENSRNOT00000074562
ENSRNOT00000071801
endoglin
chr1_-_199823386 3.40 ENSRNOT00000027375
regulator of G-protein signaling 10
chr10_-_13892997 3.40 ENSRNOT00000004192
TNF receptor associated factor 7
chr8_-_65587427 3.34 ENSRNOT00000016491
leucine rich repeat containing 49
chr1_+_60717386 3.30 ENSRNOT00000015019
protein phosphatase 2 scaffold subunit A alpha
chr1_-_47502952 3.25 ENSRNOT00000025580
T-cell activation RhoGTPase activating protein
chr14_-_83062302 3.15 ENSRNOT00000086769
ENSRNOT00000085735
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr7_+_145068286 3.14 ENSRNOT00000088956
ENSRNOT00000065753
NCK associated protein 1 like
chr6_-_125317593 3.05 ENSRNOT00000074142
ovarian cancer G-protein coupled receptor 1-like
chr14_-_86739335 3.02 ENSRNOT00000078282
purine rich element binding protein B
chr3_+_58965552 2.88 ENSRNOT00000002068
mitogen-activated protein kinase kinase kinase 20
chr6_+_109939345 2.84 ENSRNOT00000013560
intraflagellar transport 43
chr12_-_39667849 2.79 ENSRNOT00000011499
actin related protein 2/3 complex, subunit 3
chrX_-_77700269 2.77 ENSRNOT00000092418
cysteinyl leukotriene receptor 1
chr1_+_256786124 2.75 ENSRNOT00000034563
free fatty acid receptor 4
chr10_-_56270640 2.70 ENSRNOT00000056918
Cd68 molecule
chr6_+_98284170 2.67 ENSRNOT00000031979
ras homolog family member J
chr5_-_59063592 2.60 ENSRNOT00000022400
talin 1
chrX_-_71616997 2.58 ENSRNOT00000004406
C-X-C motif chemokine receptor 3
chr20_+_27954433 2.52 ENSRNOT00000064288
LIM zinc finger domain containing 1
chr1_+_198528635 2.51 ENSRNOT00000022765
hypothetical protein LOC308990
chr20_-_5441706 2.41 ENSRNOT00000000549
VPS52 GARP complex subunit
chr15_-_34469350 2.41 ENSRNOT00000067536
adenylate cyclase 4
chr20_-_4818568 2.41 ENSRNOT00000001115
DExD-box helicase 39B
chr8_-_118893702 2.40 ENSRNOT00000028416
neurotrophin receptor associated death domain
chr9_+_94879745 2.39 ENSRNOT00000080482
autophagy related 16-like 1
chr2_+_243160917 2.38 ENSRNOT00000014027
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
chr5_+_144031402 2.34 ENSRNOT00000011694
colony stimulating factor 3 receptor
chr10_-_90995982 2.33 ENSRNOT00000093266
glial fibrillary acidic protein
chr8_-_82641536 2.32 ENSRNOT00000014491
secretogranin III
chr15_-_50425900 2.31 ENSRNOT00000058715
ADAM metallopeptidase domain 28
chr3_-_164239250 2.28 ENSRNOT00000012604
spermatogenesis associated 2
chr3_+_28627084 2.27 ENSRNOT00000049884
Rho GTPase activating protein 15
chr14_-_86333424 2.25 ENSRNOT00000083191
NudC domain containing 3
chr20_+_4355175 2.24 ENSRNOT00000000510
G-protein signaling modulator 3
chr6_+_43001948 2.21 ENSRNOT00000007374
hippocalcin-like 1
chr15_-_57805184 2.20 ENSRNOT00000000168
component of oligomeric golgi complex 3
chr11_-_60882379 2.17 ENSRNOT00000002799
CD200 receptor 1
chr5_-_140585408 2.12 ENSRNOT00000018711
adenylate cyclase associated protein 1
chr3_+_161272385 2.12 ENSRNOT00000021052
zinc finger, SWIM-type containing 3
chr8_+_117062884 2.10 ENSRNOT00000082452
ENSRNOT00000071540
nicolin 1
chr20_+_5455974 2.09 ENSRNOT00000000553
ENSRNOT00000092676
prefoldin subunit 6
chr10_-_14299167 2.06 ENSRNOT00000042066
mitogen-activated protein kinase 8 interacting protein 3
chr3_-_80875817 2.06 ENSRNOT00000091265
diacylglycerol kinase zeta
chr1_+_142050458 2.02 ENSRNOT00000018107
neugrin, neurite outgrowth associated
chr13_-_88536728 2.00 ENSRNOT00000003950
U2AF homology motif kinase 1
chr18_+_29629184 1.98 ENSRNOT00000021797
histidyl-tRNA synthetase 2
chr16_-_7588841 1.98 ENSRNOT00000084645
methyltransferase like 6
chr1_+_197999336 1.95 ENSRNOT00000023555
apolipoprotein B receptor
chr18_+_56379890 1.95 ENSRNOT00000078764
platelet derived growth factor receptor beta
chr1_-_221015929 1.94 ENSRNOT00000028137
signal-induced proliferation-associated 1
chr8_-_122604787 1.92 ENSRNOT00000047198
tripartite motif containing 71
chr5_+_144160108 1.91 ENSRNOT00000064972
eva-1 homolog B
chr1_+_8310577 1.90 ENSRNOT00000015131
human immunodeficiency virus type I enhancer binding protein 2
chr7_-_11223649 1.87 ENSRNOT00000061191
major facilitator superfamily domain containing 12
chr1_+_142060955 1.83 ENSRNOT00000017862
VPS33B, late endosome and lysosome associated
chr12_+_43940929 1.81 ENSRNOT00000001486
ring finger protein, transmembrane 2
chr18_+_51523758 1.79 ENSRNOT00000078518
GRAM domain containing 3
chr5_+_153507093 1.79 ENSRNOT00000086650
ENSRNOT00000083645
runt-related transcription factor 3
chr11_-_65845418 1.76 ENSRNOT00000091057
follistatin-like 1
chrX_-_78911601 1.75 ENSRNOT00000003188
similar to RIKEN cDNA 2610002M06
chr1_-_77844189 1.66 ENSRNOT00000017555
glioma tumor suppressor candidate region gene 2
chr1_-_198662610 1.65 ENSRNOT00000055012
septin 1
chr3_-_111037166 1.64 ENSRNOT00000017070
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr16_-_19308842 1.63 ENSRNOT00000019556
family with sequence similarity 32, member A
chr5_+_64294321 1.62 ENSRNOT00000083796
Myb/SANT DNA binding domain containing 3
chr4_+_6559545 1.61 ENSRNOT00000067183
protein kinase AMP-activated non-catalytic subunit gamma 2
chr2_+_202470487 1.58 ENSRNOT00000026953
ganglioside-induced differentiation-associated-protein 2
chr14_+_106008086 1.58 ENSRNOT00000009319
pellino E3 ubiquitin protein ligase 1
chr1_+_101055622 1.58 ENSRNOT00000079189
nitric oxide synthase interacting protein
chr20_+_11168298 1.57 ENSRNOT00000032240
trafficking protein particle complex 10
chr11_-_14304603 1.55 ENSRNOT00000040202
ENSRNOT00000082143
SAM domain, SH3 domain and nuclear localization signals, 1
chr13_+_89797800 1.55 ENSRNOT00000005811
upstream transcription factor 1
chr2_-_187133993 1.52 ENSRNOT00000019502
platelet endothelial aggregation receptor 1
chr13_-_95250235 1.47 ENSRNOT00000085648
AKT serine/threonine kinase 3
chr3_-_162581610 1.45 ENSRNOT00000079324
zinc finger, MYND-type containing 8
chr3_+_67849966 1.44 ENSRNOT00000057826
dual specificity phosphatase 19
chrX_-_15627235 1.42 ENSRNOT00000013369
WD repeat domain 45
chr17_+_9837402 1.41 ENSRNOT00000076436
RAB24, member RAS oncogene family
chr15_-_34479741 1.41 ENSRNOT00000027759
receptor-interacting serine-threonine kinase 3
chr3_+_122544788 1.40 ENSRNOT00000063828
transglutaminase 3
chr8_-_127782070 1.40 ENSRNOT00000045493
phospholipase C, delta 1
chr5_-_137238354 1.40 ENSRNOT00000039235
seizure threshold 2 homolog (mouse)
chr3_+_171037957 1.40 ENSRNOT00000008764
RNA binding motif protein 38
chr13_+_90467265 1.39 ENSRNOT00000008518
coatomer protein complex subunit alpha
chr1_-_20155960 1.38 ENSRNOT00000061389
sterile alpha motif domain containing 3
chr3_+_160467552 1.38 ENSRNOT00000066657
serine/threonine kinase 4
chrY_+_914045 1.36 ENSRNOT00000088593
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr15_-_33766438 1.36 ENSRNOT00000033977
adaptor-related protein complex 1, gamma 2 subunit
chr18_-_58423196 1.36 ENSRNOT00000025556
piezo-type mechanosensitive ion channel component 2
chr10_+_55492404 1.33 ENSRNOT00000005588
ENSRNOT00000078038
ribosomal protein L26
chr6_-_76552559 1.33 ENSRNOT00000065230
Ral GTPase activating protein catalytic alpha subunit 1
chr1_+_31576183 1.31 ENSRNOT00000019735
programmed cell death 6
chrX_+_15155230 1.31 ENSRNOT00000073289
ENSRNOT00000051439
Wiskott-Aldrich syndrome
chr7_+_127964752 1.31 ENSRNOT00000038168
hypothetical gene supported by NM_053561; AF062594
chr8_-_103298927 1.30 ENSRNOT00000046873
ENSRNOT00000011609
U2 snRNP-associated SURP domain containing
chr1_+_87019975 1.28 ENSRNOT00000041205
galectin 4
chr13_+_90943255 1.28 ENSRNOT00000011539
V-set and immunoglobulin domain containing 8
chr8_-_21968415 1.27 ENSRNOT00000067325
ENSRNOT00000064932
DNA methyltransferase 1
chr10_-_84976170 1.25 ENSRNOT00000013542
leucine rich repeat containing 46
chr18_+_22964210 1.25 ENSRNOT00000066816
phosphatidylinositol 3-kinase, catalytic subunit type 3
chr3_+_72080630 1.23 ENSRNOT00000008911
mediator complex subunit 19
chr3_-_113423473 1.22 ENSRNOT00000064982
serine incorporator 4
chr10_-_94988461 1.19 ENSRNOT00000048490
DEAD-box helicase 5
chr5_-_60658521 1.18 ENSRNOT00000092866
ENSRNOT00000093024
ENSRNOT00000016875
translocase of outer mitochondrial membrane 5
F-box protein 10
chr15_+_34270648 1.17 ENSRNOT00000026333
ring finger protein 31
chr15_-_19575914 1.15 ENSRNOT00000043897

chr7_-_93826665 1.14 ENSRNOT00000011344
TNF receptor superfamily member 11B
chr13_-_90467235 1.13 ENSRNOT00000081534
ENSRNOT00000008150
nicastrin
chr1_-_198316882 1.11 ENSRNOT00000085304
ENSRNOT00000064985
TAO kinase 2
chr3_-_111037425 1.09 ENSRNOT00000085628
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr17_-_21705773 1.09 ENSRNOT00000078010
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr5_-_154319629 1.09 ENSRNOT00000014415
lysophospholipase II
chr4_-_27473150 1.07 ENSRNOT00000032505
KRIT1, ankyrin repeat containing
chr1_+_234749568 1.07 ENSRNOT00000016871
osteoclast stimulating factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Etv4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.7 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
3.6 14.5 GO:0070428 detection of lipopolysaccharide(GO:0032497) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
2.7 8.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
2.5 7.4 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
2.4 9.5 GO:0071640 regulation of macrophage inflammatory protein 1 alpha production(GO:0071640)
2.3 23.4 GO:0097084 vascular smooth muscle cell development(GO:0097084)
2.1 19.0 GO:0070417 cellular response to cold(GO:0070417)
2.0 4.0 GO:2000426 negative regulation of apoptotic cell clearance(GO:2000426)
1.9 15.2 GO:0090500 dorsal aorta morphogenesis(GO:0035912) endocardial cushion to mesenchymal transition(GO:0090500)
1.9 7.5 GO:0045658 regulation of neutrophil differentiation(GO:0045658)
1.8 1.8 GO:0070889 platelet alpha granule organization(GO:0070889)
1.6 14.2 GO:0008228 opsonization(GO:0008228)
1.5 4.5 GO:0030824 negative regulation of cGMP metabolic process(GO:0030824)
1.5 4.4 GO:1902499 positive regulation of protein autoubiquitination(GO:1902499) regulation of peroxidase activity(GO:2000468)
1.3 1.3 GO:1902164 positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
1.3 7.8 GO:0061737 leukotriene signaling pathway(GO:0061737)
1.0 3.1 GO:0006713 glucocorticoid catabolic process(GO:0006713)
1.0 3.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
1.0 3.9 GO:0042509 regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.9 3.8 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.8 8.6 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.7 5.7 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.7 4.1 GO:0032439 endosome localization(GO:0032439)
0.7 3.3 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.7 1.3 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.7 2.0 GO:0038091 VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.6 1.9 GO:0042631 cellular response to water deprivation(GO:0042631)
0.6 15.9 GO:0030220 platelet formation(GO:0030220)
0.6 5.7 GO:2001204 regulation of osteoclast development(GO:2001204)
0.6 14.3 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.6 3.7 GO:0097491 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.6 7.4 GO:0051764 actin crosslink formation(GO:0051764)
0.6 10.0 GO:0002418 immune response to tumor cell(GO:0002418)
0.6 1.7 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.5 1.5 GO:0019086 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) late viral transcription(GO:0019086) positive regulation of transcription by glucose(GO:0046016)
0.5 1.4 GO:2000449 CD8-positive, alpha-beta T cell extravasation(GO:0035697) positive regulation of necroptotic process(GO:0060545) regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449)
0.5 4.7 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.5 2.3 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.5 8.7 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.5 3.6 GO:0071000 response to magnetism(GO:0071000)
0.4 2.4 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.4 1.1 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.4 4.7 GO:0033623 regulation of integrin activation(GO:0033623)
0.4 2.9 GO:0033622 integrin activation(GO:0033622)
0.4 2.5 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.4 1.4 GO:0034696 response to prostaglandin F(GO:0034696)
0.3 1.4 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.3 6.8 GO:0008210 estrogen metabolic process(GO:0008210)
0.3 1.3 GO:0010424 DNA methylation on cytosine within a CG sequence(GO:0010424) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.3 5.1 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.3 7.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.3 5.8 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.3 4.1 GO:0051014 actin filament severing(GO:0051014)
0.3 1.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.3 4.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.3 2.8 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.3 3.7 GO:0048680 positive regulation of axon regeneration(GO:0048680)
0.3 4.2 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.3 1.1 GO:0002084 protein depalmitoylation(GO:0002084)
0.3 2.4 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.3 2.4 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.3 2.7 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.3 1.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.3 1.6 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
0.3 1.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 5.6 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.2 3.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 6.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.2 1.0 GO:0006014 D-ribose metabolic process(GO:0006014)
0.2 1.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.2 2.6 GO:0010818 T cell chemotaxis(GO:0010818)
0.2 1.4 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.2 2.0 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.2 3.4 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.2 5.0 GO:0046037 GMP metabolic process(GO:0046037)
0.2 0.4 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.2 0.6 GO:0045990 carbon catabolite regulation of transcription(GO:0045990)
0.2 0.8 GO:1904378 maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.2 1.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 0.7 GO:2000830 vacuolar phosphate transport(GO:0007037) positive regulation of parathyroid hormone secretion(GO:2000830)
0.2 1.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.2 4.7 GO:0014850 response to muscle activity(GO:0014850)
0.2 5.7 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.2 1.0 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.2 1.0 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.2 1.9 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.2 6.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 2.2 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.2 3.5 GO:0061157 mRNA destabilization(GO:0061157)
0.2 0.5 GO:1990166 protein localization to site of double-strand break(GO:1990166)
0.2 6.6 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.2 4.1 GO:0007567 parturition(GO:0007567)
0.2 0.5 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 0.7 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 4.9 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.1 5.2 GO:0045026 plasma membrane fusion(GO:0045026)
0.1 2.1 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 0.4 GO:0006407 rRNA export from nucleus(GO:0006407)
0.1 1.6 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.1 0.9 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 5.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 1.1 GO:0007220 Notch receptor processing(GO:0007220)
0.1 0.5 GO:1904959 regulation of cytochrome-c oxidase activity(GO:1904959)
0.1 2.1 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 1.7 GO:1901673 cell separation after cytokinesis(GO:0000920) regulation of mitotic spindle assembly(GO:1901673)
0.1 2.0 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 0.9 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.1 3.8 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.1 1.2 GO:0015825 L-serine transport(GO:0015825)
0.1 0.9 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.1 1.8 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 1.6 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 0.3 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.1 4.6 GO:0060612 adipose tissue development(GO:0060612)
0.1 0.6 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.1 0.5 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 0.4 GO:0031508 pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623)
0.1 0.2 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635)
0.1 4.1 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.1 0.3 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 4.3 GO:0051057 positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.1 0.7 GO:0051934 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934)
0.1 0.6 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.1 0.6 GO:0008215 spermine metabolic process(GO:0008215)
0.1 1.6 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 0.7 GO:0002467 germinal center formation(GO:0002467)
0.1 5.5 GO:0006641 triglyceride metabolic process(GO:0006641)
0.1 0.6 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 2.4 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 1.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.4 GO:0060539 diaphragm development(GO:0060539)
0.0 0.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 1.5 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732)
0.0 1.2 GO:2000758 positive regulation of histone acetylation(GO:0035066) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.4 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.6 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 19.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 2.1 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.0 0.5 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.2 GO:0010728 regulation of hydrogen peroxide biosynthetic process(GO:0010728)
0.0 1.7 GO:0030593 neutrophil chemotaxis(GO:0030593)
0.0 0.4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 1.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.4 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.3 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 2.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.4 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 0.3 GO:0006265 DNA topological change(GO:0006265)
0.0 0.7 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 1.3 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.0 GO:0097325 melanocyte proliferation(GO:0097325)
0.0 1.1 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.7 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 2.1 GO:0017148 negative regulation of translation(GO:0017148)
0.0 0.5 GO:0002687 positive regulation of leukocyte migration(GO:0002687)
0.0 0.6 GO:0006611 protein export from nucleus(GO:0006611)
0.0 2.6 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 1.8 GO:0051607 defense response to virus(GO:0051607)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 19.0 GO:0033093 Weibel-Palade body(GO:0033093)
2.9 14.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
2.2 4.4 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.7 5.0 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
1.7 5.0 GO:1902560 GMP reductase complex(GO:1902560)
1.5 9.0 GO:0031904 endosome lumen(GO:0031904)
0.6 2.4 GO:1990745 GARP complex(GO:0000938) EARP complex(GO:1990745)
0.6 2.3 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.5 4.1 GO:0097443 sorting endosome(GO:0097443)
0.4 6.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.4 2.8 GO:0030991 intraciliary transport particle A(GO:0030991)
0.4 4.0 GO:0043020 NADPH oxidase complex(GO:0043020)
0.4 14.2 GO:0005771 multivesicular body(GO:0005771)
0.4 4.5 GO:0044327 dendritic spine head(GO:0044327)
0.3 3.1 GO:0031209 SCAR complex(GO:0031209)
0.3 2.4 GO:0071986 Ragulator complex(GO:0071986)
0.3 1.0 GO:0032807 DNA ligase IV complex(GO:0032807)
0.3 2.0 GO:0089701 U2AF(GO:0089701)
0.3 8.8 GO:0001891 phagocytic cup(GO:0001891)
0.3 2.4 GO:0000815 ESCRT III complex(GO:0000815)
0.3 3.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.3 2.8 GO:0071439 clathrin complex(GO:0071439)
0.3 2.4 GO:0005688 U6 snRNP(GO:0005688)
0.3 2.1 GO:0016272 prefoldin complex(GO:0016272)
0.2 2.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 9.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.4 GO:0097342 ripoptosome(GO:0097342)
0.2 1.2 GO:0071797 LUBAC complex(GO:0071797)
0.2 3.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.2 1.5 GO:0016589 NURF complex(GO:0016589)
0.2 0.8 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2 1.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.2 15.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 1.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.2 1.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 13.5 GO:0005776 autophagosome(GO:0005776)
0.1 3.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.6 GO:0032059 bleb(GO:0032059)
0.1 1.2 GO:0071141 SMAD protein complex(GO:0071141)
0.1 2.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 7.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.4 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 1.2 GO:0043202 lysosomal lumen(GO:0043202)
0.1 1.0 GO:0005915 zonula adherens(GO:0005915)
0.1 0.9 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.7 GO:0072687 meiotic spindle(GO:0072687)
0.1 18.8 GO:0030027 lamellipodium(GO:0030027)
0.1 35.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.9 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.6 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 6.3 GO:0030863 cortical cytoskeleton(GO:0030863)
0.1 7.4 GO:0005901 caveola(GO:0005901)
0.1 1.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 1.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 2.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.4 GO:0097361 CIA complex(GO:0097361)
0.1 1.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 2.1 GO:0030673 axolemma(GO:0030673)
0.1 0.3 GO:0036398 TCR signalosome(GO:0036398)
0.1 1.3 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.9 GO:0017119 Golgi transport complex(GO:0017119)
0.1 0.6 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 1.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.4 GO:0001740 Barr body(GO:0001740)
0.1 0.5 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 5.7 GO:0001726 ruffle(GO:0001726)
0.1 30.9 GO:0009986 cell surface(GO:0009986)
0.1 3.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.1 GO:0030118 clathrin coat(GO:0030118)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.5 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 2.9 GO:0030139 endocytic vesicle(GO:0030139)
0.0 6.0 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 5.0 GO:0043679 axon terminus(GO:0043679)
0.0 3.1 GO:0005604 basement membrane(GO:0005604)
0.0 2.5 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 2.4 GO:0012506 vesicle membrane(GO:0012506)
0.0 6.2 GO:0005925 focal adhesion(GO:0005925)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 19.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.5 GO:0048475 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 1.5 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 2.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.2 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 6.4 GO:0030054 cell junction(GO:0030054)
0.0 1.3 GO:0030133 transport vesicle(GO:0030133)
0.0 1.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.9 GO:0016605 PML body(GO:0016605)
0.0 0.4 GO:0005637 nuclear inner membrane(GO:0005637)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 14.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
2.5 15.2 GO:0098821 activin receptor activity, type I(GO:0016361) BMP receptor activity(GO:0098821)
2.4 7.3 GO:0071791 chemokine (C-C motif) ligand 5 binding(GO:0071791)
2.0 11.7 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
1.7 5.0 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
1.6 7.8 GO:0004974 leukotriene receptor activity(GO:0004974)
1.5 4.5 GO:0001605 adrenomedullin receptor activity(GO:0001605)
1.5 4.4 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
1.4 7.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)
1.3 6.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.1 20.0 GO:0015026 coreceptor activity(GO:0015026)
1.1 5.5 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
1.0 4.0 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312) PTB domain binding(GO:0051425)
1.0 3.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
1.0 4.0 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.9 8.2 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.8 2.3 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.7 19.0 GO:0019865 immunoglobulin binding(GO:0019865)
0.7 3.4 GO:0005534 galactose binding(GO:0005534)
0.7 2.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.5 1.6 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.5 1.5 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.5 3.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.5 1.4 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.5 3.6 GO:0071253 connexin binding(GO:0071253)
0.4 4.7 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.4 2.6 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.4 4.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.4 1.8 GO:0030348 syntaxin-3 binding(GO:0030348)
0.3 4.1 GO:0042301 phosphate ion binding(GO:0042301)
0.3 2.6 GO:0030274 LIM domain binding(GO:0030274)
0.3 6.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 2.4 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.3 2.1 GO:0017070 U6 snRNA binding(GO:0017070) U4 snRNA binding(GO:0030621)
0.3 3.7 GO:0045499 chemorepellent activity(GO:0045499)
0.3 1.0 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.3 1.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.3 9.0 GO:0022829 wide pore channel activity(GO:0022829)
0.2 4.1 GO:0005522 profilin binding(GO:0005522)
0.2 5.4 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.2 29.9 GO:0017124 SH3 domain binding(GO:0017124)
0.2 4.2 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 3.7 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.2 0.6 GO:0019961 interferon binding(GO:0019961)
0.2 0.6 GO:0031177 phosphopantetheine binding(GO:0031177)
0.2 0.9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 0.7 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
0.2 2.1 GO:0001727 lipid kinase activity(GO:0001727)
0.2 3.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 1.3 GO:0043495 protein anchor(GO:0043495)
0.2 1.3 GO:0016936 galactoside binding(GO:0016936)
0.2 1.9 GO:0035198 miRNA binding(GO:0035198)
0.2 1.1 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 4.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 1.4 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 1.2 GO:0051525 NFAT protein binding(GO:0051525)
0.1 4.0 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.2 GO:0070878 primary miRNA binding(GO:0070878)
0.1 2.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 34.3 GO:0030695 GTPase regulator activity(GO:0030695)
0.1 7.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.0 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 0.4 GO:0004967 glucagon receptor activity(GO:0004967)
0.1 2.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 1.2 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 2.7 GO:0008527 taste receptor activity(GO:0008527)
0.1 1.2 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.1 1.0 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.5 GO:0070051 fibrinogen binding(GO:0070051)
0.1 2.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 27.1 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 1.0 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 1.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.8 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 0.6 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 0.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 23.4 GO:0003779 actin binding(GO:0003779)
0.1 0.5 GO:0016531 copper chaperone activity(GO:0016531)
0.1 0.3 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 1.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.6 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.2 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 1.0 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.6 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 2.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.4 GO:0019209 kinase activator activity(GO:0019209)
0.0 4.5 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.4 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 2.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 7.1 GO:0003924 GTPase activity(GO:0003924)
0.0 2.4 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.4 GO:0005521 lamin binding(GO:0005521)
0.0 0.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 2.3 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 1.3 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.4 GO:0043236 laminin binding(GO:0043236)
0.0 1.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.3 GO:0005484 SNAP receptor activity(GO:0005484)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 40.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.5 18.6 PID ALK1 PATHWAY ALK1 signaling events
0.4 12.4 PID CONE PATHWAY Visual signal transduction: Cones
0.4 9.0 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.4 14.0 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.4 4.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 4.0 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.3 7.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 3.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.3 11.3 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.3 7.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.2 11.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 4.5 PID NECTIN PATHWAY Nectin adhesion pathway
0.2 8.9 PID ENDOTHELIN PATHWAY Endothelins
0.2 3.7 PID RAS PATHWAY Regulation of Ras family activation
0.2 25.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 3.8 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.2 2.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 4.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 22.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.9 PID ARF 3PATHWAY Arf1 pathway
0.1 1.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 2.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 2.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 4.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 3.8 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 0.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.6 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.7 PID AURORA B PATHWAY Aurora B signaling
0.0 1.1 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID FGF PATHWAY FGF signaling pathway
0.0 0.5 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 14.5 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
1.3 19.0 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.9 12.7 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.8 9.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.8 17.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.8 12.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.7 7.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.6 4.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.5 10.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.5 7.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 5.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 5.5 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3 3.3 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.3 3.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3 3.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.3 20.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 36.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 1.6 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 1.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.2 9.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 1.6 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 6.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 2.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.1 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 1.4 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 1.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 1.4 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 1.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 1.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 1.0 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 0.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 2.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 0.9 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 1.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 0.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 0.7 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 1.3 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 2.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.6 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.2 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling