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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Ets2

Z-value: 0.60

Motif logo

Transcription factors associated with Ets2

Gene Symbol Gene ID Gene Info
ENSRNOG00000001647 ETS proto-oncogene 2, transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ets2rn6_v1_chr11_+_36075709_360757090.342.9e-10Click!

Activity profile of Ets2 motif

Sorted Z-values of Ets2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_68360664 17.81 ENSRNOT00000030971
hemicentin 1
chr16_+_18716019 15.36 ENSRNOT00000047870
surfactant protein A1
chr6_-_79306443 13.39 ENSRNOT00000030706
C-type lectin domain family 14, member A
chr10_-_40764185 12.58 ENSRNOT00000017486
secreted protein acidic and cysteine rich
chr1_+_81763614 11.78 ENSRNOT00000027254
CD79a molecule
chr7_+_142776252 11.35 ENSRNOT00000008673
activin A receptor like type 1
chr7_+_142776580 11.05 ENSRNOT00000081047
activin A receptor like type 1
chr2_-_190100276 10.97 ENSRNOT00000015351
S100 calcium binding protein A9
chr7_-_107392972 10.95 ENSRNOT00000093425
transmembrane protein 71
chr7_+_14037620 10.81 ENSRNOT00000009606
synapse defective Rho GTPase homolog 1
chr9_-_16795887 10.63 ENSRNOT00000071609
Cd79a molecule-like
chr4_+_78320190 10.61 ENSRNOT00000032742
ENSRNOT00000091359
GTPase, IMAP family member 4
chr1_-_227441442 9.23 ENSRNOT00000028433
membrane spanning 4-domains A1
chr3_+_11679530 9.18 ENSRNOT00000074562
ENSRNOT00000071801
endoglin
chr4_+_158088505 9.14 ENSRNOT00000026643
von Willebrand factor
chr2_+_188745503 8.89 ENSRNOT00000056652
SHC adaptor protein 1
chr14_+_80195715 8.67 ENSRNOT00000010784
SH3 domain and tetratricopeptide repeats 1
chr10_+_35133252 8.53 ENSRNOT00000051916
secretoglobin, family 3A, member 1
chr3_+_93909156 8.42 ENSRNOT00000090365
LIM domain only 2
chr4_+_28989115 8.31 ENSRNOT00000075326
G protein subunit gamma 11
chr7_-_64251110 8.25 ENSRNOT00000006180
SLIT-ROBO Rho GTPase activating protein 1
chr2_-_187133993 8.24 ENSRNOT00000019502
platelet endothelial aggregation receptor 1
chr1_-_221015929 8.21 ENSRNOT00000028137
signal-induced proliferation-associated 1
chr1_-_175796040 8.15 ENSRNOT00000024060
murine retrovirus integration site 1 homolog
chr4_-_78342863 7.96 ENSRNOT00000049038
GTPase, IMAP family member 6
chr4_+_31387420 7.79 ENSRNOT00000074048
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like
chr14_+_34727915 7.77 ENSRNOT00000085089
kinase insert domain receptor
chr5_-_59063592 7.72 ENSRNOT00000022400
talin 1
chr14_+_70780623 7.65 ENSRNOT00000083871
ENSRNOT00000058803
LIM domain binding 2
chr7_-_118108864 7.55 ENSRNOT00000006184
myoglobin
chr9_-_27192135 7.54 ENSRNOT00000017592
translocation associated membrane protein 2
chr5_+_16526058 7.51 ENSRNOT00000011130
LYN proto-oncogene, Src family tyrosine kinase
chr14_-_86796378 7.50 ENSRNOT00000092021
myosin IG
chr3_+_16610086 7.40 ENSRNOT00000046231
rCG64257-like
chr10_-_70802782 7.35 ENSRNOT00000045867
chemokine (C-C motif) ligand 6
chr15_+_57221292 7.34 ENSRNOT00000014502
lymphocyte cytosolic protein 1
chr1_-_199624783 7.02 ENSRNOT00000026908
cytochrome c oxidase subunit 6A2
chr4_-_170080456 7.01 ENSRNOT00000070936
uncharacterized LOC100912527
chr8_-_116465801 6.94 ENSRNOT00000085915
semaphorin 3F
chr2_-_62634785 6.91 ENSRNOT00000017937
PDZ domain containing 2
chr16_+_10727571 6.87 ENSRNOT00000084422
multimerin 2
chr5_+_82587420 6.85 ENSRNOT00000014020
toll-like receptor 4
chr10_+_94566928 6.82 ENSRNOT00000078446
proline rich 29
chr17_-_10001901 6.80 ENSRNOT00000082836
fibroblast growth factor receptor 4
chr1_-_216918969 6.74 ENSRNOT00000079454
oxysterol binding protein-like 5
chr13_-_52514875 6.73 ENSRNOT00000064758
neuron navigator 1
chr9_-_119332967 6.73 ENSRNOT00000021048
myosin light chain 12A
chr1_+_88875375 6.64 ENSRNOT00000028284
Tyro protein tyrosine kinase binding protein
chr1_-_89509343 6.43 ENSRNOT00000028637
FXYD domain-containing ion transport regulator 3
chr8_+_39878955 6.43 ENSRNOT00000060300
roundabout homolog 4-like
chr16_-_9430743 6.37 ENSRNOT00000043811
WDFY family member 4
chr5_-_145377221 6.23 ENSRNOT00000019246
gap junction protein, alpha 4
chr9_+_10952374 6.18 ENSRNOT00000074993
leucine-rich alpha-2-glycoprotein 1
chr1_-_260254600 5.87 ENSRNOT00000019014
B-cell linker
chr8_-_39093277 5.85 ENSRNOT00000043344
roundabout homolog 4-like
chr6_+_98284170 5.84 ENSRNOT00000031979
ras homolog family member J
chr10_+_63662986 5.77 ENSRNOT00000088722
scavenger receptor class F, member 1
chr20_+_30915213 5.70 ENSRNOT00000000681
perforin 1
chr2_-_113616766 5.58 ENSRNOT00000016858
ENSRNOT00000074723
transmembrane protein 212
chr3_+_122544788 5.54 ENSRNOT00000063828
transglutaminase 3
chr4_-_170129407 5.52 ENSRNOT00000075717
uncharacterized LOC100912609
chr3_+_80555196 5.37 ENSRNOT00000067318
Rho GTPase activating protein 1
chr6_+_96479430 5.24 ENSRNOT00000006729
protein kinase C, eta
chr10_+_56764927 5.08 ENSRNOT00000025308
C-type lectin domain family 10, member A
chr1_+_215610368 5.07 ENSRNOT00000078903
ENSRNOT00000087781
troponin I2, fast skeletal type
chrX_+_68752597 5.02 ENSRNOT00000077039
StAR-related lipid transfer domain containing 8
chr3_-_110517163 4.95 ENSRNOT00000078037
phospholipase C, beta 2
chr10_+_59529785 4.93 ENSRNOT00000064840
ENSRNOT00000065181
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr15_-_34469350 4.89 ENSRNOT00000067536
adenylate cyclase 4
chr8_+_116324040 4.87 ENSRNOT00000081353
hyaluronoglucosaminidase 2
chr8_+_107882219 4.80 ENSRNOT00000019902
DAZ interacting zinc finger protein 1-like
chr3_+_58965552 4.72 ENSRNOT00000002068
mitogen-activated protein kinase kinase kinase 20
chr1_+_81779380 4.72 ENSRNOT00000065865
ENSRNOT00000080143
ENSRNOT00000089592
ENSRNOT00000080840
Rho guanine nucleotide exchange factor 1
chr1_+_175586097 4.70 ENSRNOT00000024933
adenosine monophosphate deaminase 3
chr5_-_159119171 4.68 ENSRNOT00000074074
ENSRNOT00000075382
ENSRNOT00000074378
Rho guanine nucleotide exchange factor 10 like
chr1_-_242083484 4.57 ENSRNOT00000065921
tight junction protein 2
chr18_-_56115593 4.44 ENSRNOT00000045041
treacle ribosome biogenesis factor 1
chr9_+_42871950 4.41 ENSRNOT00000089673
AT-rich interaction domain 5A
chr1_-_89473904 4.41 ENSRNOT00000089474
FXYD domain-containing ion transport regulator 5
chr7_+_12471824 4.33 ENSRNOT00000068197
strawberry notch homolog 2
chr16_+_4469468 4.32 ENSRNOT00000021164
wingless-type MMTV integration site family, member 5A
chr6_-_43448280 4.27 ENSRNOT00000081110
ADAM metallopeptidase domain 17
chr13_-_67206688 4.25 ENSRNOT00000003630
ENSRNOT00000090693
phospholipase A2 group IVA
chr20_+_46199981 4.22 ENSRNOT00000000337
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr13_-_88642011 4.21 ENSRNOT00000067037
hypothetical LOC100361087
chr14_+_1463359 4.20 ENSRNOT00000070834
colony stimulating factor 2 receptor alpha subunit
chr19_+_49016891 4.19 ENSRNOT00000016713
dynein light chain roadblock-type 2
chr4_+_56625561 4.10 ENSRNOT00000008356
ENSRNOT00000090808
ENSRNOT00000008972
calumenin
chr1_-_219438779 4.06 ENSRNOT00000029237
TBC1 domain family, member 10C
chr14_-_81023682 4.01 ENSRNOT00000081570
regulator of G-protein signaling 12
chr1_+_23409408 3.98 ENSRNOT00000022362
EYA transcriptional coactivator and phosphatase 4
chr1_+_256786124 3.92 ENSRNOT00000034563
free fatty acid receptor 4
chr10_-_13892997 3.88 ENSRNOT00000004192
TNF receptor associated factor 7
chr1_+_122981755 3.83 ENSRNOT00000013468
necdin, MAGE family member
chr13_+_89774764 3.80 ENSRNOT00000005619
Rho GTPase activating protein 30
chr15_+_52451161 3.79 ENSRNOT00000018725
docking protein 2
chr1_-_89474252 3.75 ENSRNOT00000028597
FXYD domain-containing ion transport regulator 5
chr5_-_160158386 3.73 ENSRNOT00000089345
filamin binding LIM protein 1
chr20_+_13662867 3.71 ENSRNOT00000032257
similar to Homo sapiens fetal lung specific expression unknown
chrX_-_32355296 3.65 ENSRNOT00000081652
ENSRNOT00000065075
adaptor-related protein complex 1, sigma 2 subunit
chr11_-_14304603 3.62 ENSRNOT00000040202
ENSRNOT00000082143
SAM domain, SH3 domain and nuclear localization signals, 1
chr2_+_187447501 3.57 ENSRNOT00000038589
IQ motif containing GTPase activating protein 3
chr1_-_169456098 3.57 ENSRNOT00000030827
tripartite motif-containing 30C
chr10_-_30118873 3.54 ENSRNOT00000006063
ubiquitin-like domain containing CTD phosphatase 1
chr19_+_19395655 3.49 ENSRNOT00000019130
sorting nexin 20
chr8_-_72204730 3.46 ENSRNOT00000023810
F-box and leucine-rich repeat protein 22
chr5_-_137238354 3.45 ENSRNOT00000039235
seizure threshold 2 homolog (mouse)
chr5_+_58661049 3.44 ENSRNOT00000078274
unc-13 homolog B
chr20_+_6973398 3.35 ENSRNOT00000041665
FYVE, RhoGEF and PH domain containing 2
chr5_-_152458023 3.34 ENSRNOT00000031225
connector enhancer of kinase suppressor of Ras 1
chr11_+_82680253 3.33 ENSRNOT00000077119
ENSRNOT00000075512
lipase H
chr10_-_62483342 3.32 ENSRNOT00000079956
hypermethylated in cancer 1 protein-like
chr10_-_85084850 3.32 ENSRNOT00000012462
TBK1 binding protein 1
chr1_+_87938042 3.30 ENSRNOT00000027837
mitogen activated protein kinase kinase kinase kinase 1
chrX_-_157474219 3.29 ENSRNOT00000079860
zinc finger protein 275
chr16_+_23317953 3.22 ENSRNOT00000075287

chr13_+_52645257 3.22 ENSRNOT00000012801
ladinin 1
chr15_+_8730871 3.22 ENSRNOT00000081845
nuclear receptor subfamily 1, group D, member 2
chr8_-_65587658 3.21 ENSRNOT00000091982
leucine rich repeat containing 49
chr5_-_33182147 3.20 ENSRNOT00000080358
MAGE family member D2
chr2_-_189573280 3.19 ENSRNOT00000022897
ribosomal protein S27
chr7_-_73450262 3.15 ENSRNOT00000006943
NIPA-like domain containing 2
chr10_+_74002151 3.10 ENSRNOT00000005661
peptidyl-tRNA hydrolase 2
chr9_-_113598477 3.05 ENSRNOT00000035606
ENSRNOT00000084884
ralA binding protein 1
chr9_+_14551758 2.99 ENSRNOT00000017157
nuclear transcription factor Y subunit alpha
chr10_-_59112788 2.95 ENSRNOT00000041886
SPNS sphingolipid transporter 3
chr12_+_12374790 2.84 ENSRNOT00000001347
tectonin beta-propeller repeat containing 1
chr4_-_155051429 2.82 ENSRNOT00000020094
killer cell lectin like receptor G1
chr8_-_65587427 2.80 ENSRNOT00000016491
leucine rich repeat containing 49
chr2_+_4942775 2.69 ENSRNOT00000093548
ENSRNOT00000093741
family with sequence similarity 172, member A
chr2_+_212435728 2.69 ENSRNOT00000046960

chr7_-_119716238 2.66 ENSRNOT00000075678
interleukin 2 receptor subunit beta
chr16_-_85305782 2.66 ENSRNOT00000067511
ENSRNOT00000076737
tumor necrosis factor superfamily member 13b
chr20_+_27954433 2.61 ENSRNOT00000064288
LIM zinc finger domain containing 1
chr4_-_119327822 2.61 ENSRNOT00000012645
Rho GTPase activating protein 25
chr17_-_46794845 2.58 ENSRNOT00000077910
ENSRNOT00000090663
ENSRNOT00000078331
engulfment and cell motility 1
chr15_-_57805184 2.57 ENSRNOT00000000168
component of oligomeric golgi complex 3
chr14_+_78939903 2.56 ENSRNOT00000078562
ENSRNOT00000088221
mannosidase, alpha, class 2B, member 2
Morf4 family associated protein 1
chr11_+_24263281 2.54 ENSRNOT00000086946
GA binding protein transcription factor, alpha subunit
chr8_+_77107536 2.53 ENSRNOT00000083255
ADAM metallopeptidase domain 10
chr7_+_118895405 2.52 ENSRNOT00000092095
similar to apolipoprotein L2; apolipoprotein L-II
chr8_-_28075514 2.48 ENSRNOT00000072851
VPS26 retromer complex component B
chr9_+_65614142 2.47 ENSRNOT00000016613
caspase 8
chr8_+_45797315 2.42 ENSRNOT00000059997

chr1_+_215609645 2.40 ENSRNOT00000076140
ENSRNOT00000027487
troponin I2, fast skeletal type
chr11_-_51202703 2.36 ENSRNOT00000002719
ENSRNOT00000077220
Cbl proto-oncogene B
chr20_+_28815039 2.34 ENSRNOT00000075800
sosondowah ankyrin repeat domain family member C
chr10_+_57268375 2.28 ENSRNOT00000005242
ring finger protein 167
chr13_-_47979797 2.26 ENSRNOT00000080035
Ras association domain family member 5
chr3_+_28627084 2.26 ENSRNOT00000049884
Rho GTPase activating protein 15
chr5_-_79222687 2.24 ENSRNOT00000010516
AT-hook transcription factor
chr11_+_84745904 2.23 ENSRNOT00000002617
kelch-like family member 6
chr3_-_5976244 2.23 ENSRNOT00000009893
vav guanine nucleotide exchange factor 2
chr19_+_43392085 2.21 ENSRNOT00000023854
splicing factor 3b, subunit 3
chrX_+_15155230 2.12 ENSRNOT00000073289
ENSRNOT00000051439
Wiskott-Aldrich syndrome
chr6_+_136358057 2.09 ENSRNOT00000092741
kinesin light chain 1
chr9_-_116222374 2.07 ENSRNOT00000090111
ENSRNOT00000067900
Rho GTPase activating protein 28
chr3_-_3476215 2.07 ENSRNOT00000024352
UBA domain containing 1
chr1_-_265798167 2.04 ENSRNOT00000079483
LIM domain binding 1
chr15_-_33766438 2.01 ENSRNOT00000033977
adaptor-related protein complex 1, gamma 2 subunit
chr5_+_60250546 2.01 ENSRNOT00000017707
zinc finger CCHC-type containing 7
chr1_+_222250995 2.01 ENSRNOT00000031458
tRNA phosphotransferase 1
chr1_-_175420106 2.01 ENSRNOT00000013126
ENSRNOT00000077125
SET binding factor 2
chr9_+_81880177 2.00 ENSRNOT00000022839
serine/threonine kinase 36
chr5_+_156668712 1.99 ENSRNOT00000067228
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
chr10_-_47164596 1.93 ENSRNOT00000075751
protein GTLF3B-like
chr16_+_20824864 1.90 ENSRNOT00000092293
ENSRNOT00000092446
UPF1, RNA helicase and ATPase
chr10_+_55492404 1.89 ENSRNOT00000005588
ENSRNOT00000078038
ribosomal protein L26
chr8_+_116307141 1.88 ENSRNOT00000037375
Ras association domain family member 1
chr1_+_197999037 1.88 ENSRNOT00000091065
apolipoprotein B receptor
chr4_-_100099517 1.86 ENSRNOT00000014277
atonal bHLH transcription factor 8
chr15_+_34352914 1.85 ENSRNOT00000067150
guanosine monophosphate reductase 2
chr1_+_201256910 1.83 ENSRNOT00000090143
transforming, acidic coiled-coil containing protein 2
chr4_+_140247313 1.82 ENSRNOT00000040255
ENSRNOT00000064025
ENSRNOT00000041130
ENSRNOT00000043646
inositol 1,4,5-trisphosphate receptor, type 1
chr10_+_17421075 1.81 ENSRNOT00000047011
serine/threonine kinase 10
chr20_-_4818568 1.79 ENSRNOT00000001115
DExD-box helicase 39B
chr12_+_13716596 1.79 ENSRNOT00000080216
actin, beta
chr2_+_187993758 1.77 ENSRNOT00000027182
Rho/Rac guanine nucleotide exchange factor 2
chr16_+_20825044 1.75 ENSRNOT00000027268
UPF1, RNA helicase and ATPase
chr7_-_120027026 1.74 ENSRNOT00000011215
caspase recruitment domain family, member 10
chr9_+_46840992 1.73 ENSRNOT00000019415
interleukin 1 receptor type 2
chr15_+_57340579 1.73 ENSRNOT00000015467
zinc finger CCCH type containing 13
chr20_+_5125349 1.71 ENSRNOT00000085598
ENSRNOT00000001129
BCL2-associated athanogene 6
chr10_-_103481153 1.70 ENSRNOT00000035639
CD300 molecule-like family member b
chr15_+_33108671 1.69 ENSRNOT00000015468
LDL receptor related protein 10
chr12_+_11179329 1.62 ENSRNOT00000001302
zinc finger protein 394
chr8_+_61080103 1.58 ENSRNOT00000022976
high mobility group 20A
chr19_+_37568113 1.57 ENSRNOT00000023710
family with sequence similarity 65, member A
chr16_+_74177215 1.57 ENSRNOT00000025851
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr8_-_6076598 1.56 ENSRNOT00000090774
baculoviral IAP repeat-containing 3
chr2_-_33025271 1.55 ENSRNOT00000074941
microtubule associated serine/threonine kinase family member 4
chr1_+_198199622 1.53 ENSRNOT00000026688
glycerophosphodiester phosphodiesterase domain containing 3
chr1_-_101118825 1.52 ENSRNOT00000066328
ribosomal protein S11
chr10_-_105795958 1.50 ENSRNOT00000067739
serine and arginine rich splicing factor 2
chr3_-_111037166 1.50 ENSRNOT00000017070
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr5_+_104941066 1.47 ENSRNOT00000009225
Ras-related GTP binding A
chr9_+_94880053 1.47 ENSRNOT00000024445
autophagy related 16-like 1
chr20_+_9948908 1.46 ENSRNOT00000001541
ubiquitin associated and SH3 domain containing, A
chr4_+_157523320 1.46 ENSRNOT00000023192
zinc finger protein 384
chr9_+_94879745 1.46 ENSRNOT00000080482
autophagy related 16-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Ets2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
3.2 31.6 GO:0090500 dorsal aorta morphogenesis(GO:0035912) endocardial cushion to mesenchymal transition(GO:0090500)
2.7 8.2 GO:0042631 cellular response to water deprivation(GO:0042631)
2.5 7.5 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
2.5 7.5 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
2.3 6.8 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
1.9 9.5 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
1.7 15.4 GO:0008228 opsonization(GO:0008228)
1.7 6.8 GO:2000830 vacuolar phosphate transport(GO:0007037) positive regulation of parathyroid hormone secretion(GO:2000830)
1.5 10.7 GO:0045048 protein insertion into ER membrane(GO:0045048)
1.5 4.6 GO:2001205 negative regulation of osteoclast development(GO:2001205)
1.4 4.3 GO:0071348 cellular response to interleukin-11(GO:0071348)
1.4 4.3 GO:0048850 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) melanocyte proliferation(GO:0097325)
1.4 8.5 GO:0048597 post-embryonic camera-type eye morphogenesis(GO:0048597)
1.4 4.2 GO:0019417 sulfur oxidation(GO:0019417)
1.3 9.3 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
1.2 3.7 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294)
1.2 14.2 GO:0016081 synaptic vesicle docking(GO:0016081)
1.2 8.2 GO:0043654 recognition of apoptotic cell(GO:0043654)
1.2 6.9 GO:0036484 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
1.1 21.7 GO:0033591 response to L-ascorbic acid(GO:0033591)
1.1 6.6 GO:2001204 regulation of osteoclast development(GO:2001204)
1.1 5.4 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
1.0 4.2 GO:0038158 granulocyte colony-stimulating factor signaling pathway(GO:0038158)
1.0 4.9 GO:0042117 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) monocyte activation(GO:0042117) multi-organism membrane fusion(GO:0044800)
0.9 5.2 GO:0034351 negative regulation of glial cell apoptotic process(GO:0034351)
0.8 8.2 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.8 4.7 GO:0032264 IMP salvage(GO:0032264)
0.8 6.9 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.7 10.5 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.7 5.1 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248)
0.7 4.3 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.7 7.7 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.7 3.4 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.7 4.0 GO:0023021 termination of signal transduction(GO:0023021)
0.6 1.9 GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
0.6 8.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.6 1.7 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.5 2.7 GO:0031296 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
0.5 2.0 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.5 4.4 GO:0014029 neural crest formation(GO:0014029)
0.5 7.3 GO:0051639 actin filament network formation(GO:0051639) actin crosslink formation(GO:0051764)
0.5 2.9 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.5 1.4 GO:0002332 transitional stage B cell differentiation(GO:0002332) transitional one stage B cell differentiation(GO:0002333) positive regulation of actin filament binding(GO:1904531) positive regulation of actin binding(GO:1904618) activation of protein kinase C activity(GO:1990051)
0.5 5.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 4.1 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.4 5.8 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.4 8.5 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.4 5.8 GO:0048680 positive regulation of axon regeneration(GO:0048680)
0.4 1.8 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.4 4.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.4 4.7 GO:0006991 response to sterol depletion(GO:0006991)
0.4 2.1 GO:0035617 stress granule disassembly(GO:0035617)
0.4 1.2 GO:1902544 positive regulation of endodeoxyribonuclease activity(GO:0032079) regulation of DNA N-glycosylase activity(GO:1902544)
0.4 1.2 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.4 3.2 GO:0070294 renal sodium ion absorption(GO:0070294)
0.4 2.6 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.4 2.6 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.4 1.5 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.4 13.4 GO:0002042 cell migration involved in sprouting angiogenesis(GO:0002042)
0.4 5.7 GO:0002418 immune response to tumor cell(GO:0002418)
0.3 1.4 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.3 3.1 GO:2000210 positive regulation of anoikis(GO:2000210)
0.3 5.1 GO:0060546 negative regulation of necroptotic process(GO:0060546)
0.3 6.0 GO:0010669 epithelial structure maintenance(GO:0010669)
0.3 0.9 GO:0009249 protein lipoylation(GO:0009249)
0.3 3.6 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.3 5.5 GO:0031424 keratinization(GO:0031424)
0.3 3.7 GO:0033623 regulation of integrin activation(GO:0033623)
0.3 12.3 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.3 0.8 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.3 1.8 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.3 1.3 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.3 1.6 GO:1903347 negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347)
0.3 4.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.2 6.2 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.2 0.9 GO:0010424 DNA methylation on cytosine within a CG sequence(GO:0010424) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.2 2.4 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.2 14.6 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.2 2.6 GO:0006013 mannose metabolic process(GO:0006013)
0.2 0.7 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.2 0.2 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.2 7.4 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.2 0.6 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of neutrophil activation(GO:1902564)
0.2 3.6 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.2 6.7 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.2 8.9 GO:0045907 positive regulation of vasoconstriction(GO:0045907)
0.2 3.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.2 2.9 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.2 0.4 GO:0070889 platelet alpha granule organization(GO:0070889)
0.2 2.0 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.2 7.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.2 1.0 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.2 2.1 GO:1904424 regulation of GTP binding(GO:1904424)
0.2 4.8 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.2 0.7 GO:0044211 CTP salvage(GO:0044211)
0.2 2.5 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 3.3 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.2 3.8 GO:0007413 axonal fasciculation(GO:0007413)
0.2 1.4 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.2 5.6 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 0.7 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.1 1.8 GO:0030953 astral microtubule organization(GO:0030953)
0.1 3.2 GO:2000505 regulation of energy homeostasis(GO:2000505)
0.1 0.7 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 3.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 2.6 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 0.7 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 0.4 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
0.1 18.9 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 1.7 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 1.9 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 1.8 GO:2000401 regulation of lymphocyte migration(GO:2000401)
0.1 4.9 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 2.8 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.3 GO:0035811 negative regulation of urine volume(GO:0035811) regulation of histone H3-K79 methylation(GO:2001160)
0.1 1.7 GO:0033005 positive regulation of mast cell activation(GO:0033005)
0.1 1.8 GO:0046037 GMP metabolic process(GO:0046037)
0.1 3.9 GO:0050710 negative regulation of cytokine secretion(GO:0050710)
0.1 0.3 GO:0019086 late viral transcription(GO:0019086)
0.1 0.8 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 1.9 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.1 4.1 GO:0048265 response to pain(GO:0048265)
0.1 1.5 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.1 0.5 GO:0046070 dGTP metabolic process(GO:0046070)
0.1 1.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 1.5 GO:0033197 response to vitamin E(GO:0033197)
0.1 0.4 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.1 0.9 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 0.8 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.9 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.2 GO:0043248 proteasome assembly(GO:0043248)
0.1 3.7 GO:0060612 adipose tissue development(GO:0060612)
0.1 0.3 GO:0060687 regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.1 3.0 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.1 0.1 GO:0071454 cellular response to anoxia(GO:0071454)
0.1 0.9 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.1 0.2 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.1 3.1 GO:0015914 phospholipid transport(GO:0015914)
0.1 0.7 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.1 2.5 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.1 5.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 1.5 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.1 1.0 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.4 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.9 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 1.8 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.6 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.8 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 1.1 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.0 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.0 1.1 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.6 GO:0051307 meiotic chromosome separation(GO:0051307)
0.0 1.2 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 4.6 GO:0006869 lipid transport(GO:0006869)
0.0 0.5 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.4 GO:0005513 detection of calcium ion(GO:0005513)
0.0 1.4 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 0.1 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.4 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 2.5 GO:0042113 B cell activation(GO:0042113)
0.0 1.2 GO:0032091 negative regulation of protein binding(GO:0032091)
0.0 0.8 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 3.3 GO:0016042 lipid catabolic process(GO:0016042)
0.0 0.1 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.0 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 4.2 GO:0045087 innate immune response(GO:0045087)
0.0 0.2 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.4 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.2 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
2.9 11.8 GO:0019815 B cell receptor complex(GO:0019815)
2.5 7.5 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
1.7 5.0 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
1.6 13.1 GO:0097443 sorting endosome(GO:0097443)
1.5 9.1 GO:0033093 Weibel-Palade body(GO:0033093)
1.4 6.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
1.1 10.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.0 4.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.0 5.7 GO:0031904 endosome lumen(GO:0031904)
0.9 25.8 GO:0001891 phagocytic cup(GO:0001891)
0.8 2.5 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.8 3.1 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.7 3.7 GO:0044530 supraspliceosomal complex(GO:0044530)
0.6 7.5 GO:0005861 troponin complex(GO:0005861)
0.6 1.8 GO:1902560 GMP reductase complex(GO:1902560)
0.6 1.8 GO:0061574 ASAP complex(GO:0061574)
0.5 1.8 GO:0031088 platelet dense granule membrane(GO:0031088)
0.4 3.4 GO:0044305 calyx of Held(GO:0044305)
0.4 15.4 GO:0005771 multivesicular body(GO:0005771)
0.4 5.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 13.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 6.7 GO:0016460 myosin II complex(GO:0016460)
0.3 2.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.3 6.2 GO:0005922 connexon complex(GO:0005922)
0.3 4.3 GO:0017119 Golgi transport complex(GO:0017119)
0.3 1.5 GO:0035061 interchromatin granule(GO:0035061)
0.3 1.5 GO:1990130 Iml1 complex(GO:1990130)
0.3 4.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.3 6.7 GO:0043194 axon initial segment(GO:0043194)
0.3 1.3 GO:1990393 3M complex(GO:1990393)
0.2 1.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 27.9 GO:0005604 basement membrane(GO:0005604)
0.2 1.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 2.7 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 1.2 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.2 1.8 GO:0005688 U6 snRNP(GO:0005688)
0.2 1.0 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.2 4.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 4.1 GO:0031527 filopodium membrane(GO:0031527)
0.2 1.8 GO:0097433 dense body(GO:0097433)
0.2 1.7 GO:0071439 clathrin complex(GO:0071439)
0.2 2.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 4.8 GO:0097440 apical dendrite(GO:0097440)
0.2 3.7 GO:0045120 pronucleus(GO:0045120)
0.2 0.6 GO:0042585 germinal vesicle(GO:0042585)
0.2 4.3 GO:0042588 zymogen granule(GO:0042588)
0.1 4.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 2.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 17.6 GO:0072562 blood microparticle(GO:0072562)
0.1 3.7 GO:0000421 autophagosome membrane(GO:0000421)
0.1 0.6 GO:0072487 MSL complex(GO:0072487)
0.1 1.0 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 1.4 GO:0005686 U2 snRNP(GO:0005686)
0.1 1.8 GO:0035253 ciliary rootlet(GO:0035253)
0.1 0.9 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 0.7 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 2.5 GO:0030904 retromer complex(GO:0030904)
0.1 2.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 23.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 0.4 GO:0043219 lateral loop(GO:0043219)
0.1 5.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 0.5 GO:0044294 SCAR complex(GO:0031209) dendritic growth cone(GO:0044294)
0.1 3.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 11.7 GO:0001726 ruffle(GO:0001726)
0.1 0.4 GO:0000125 PCAF complex(GO:0000125)
0.1 0.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 21.0 GO:0005911 cell-cell junction(GO:0005911)
0.1 7.2 GO:0001650 fibrillar center(GO:0001650)
0.0 0.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 3.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 5.3 GO:0043195 terminal bouton(GO:0043195)
0.0 21.5 GO:0009986 cell surface(GO:0009986)
0.0 9.4 GO:0010008 endosome membrane(GO:0010008)
0.0 4.5 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.0 2.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.4 GO:0000940 condensed nuclear chromosome kinetochore(GO:0000778) condensed chromosome outer kinetochore(GO:0000940)
0.0 2.0 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.1 GO:0045171 intercellular bridge(GO:0045171)
0.0 9.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.3 GO:0030673 axolemma(GO:0030673)
0.0 3.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.4 GO:0031941 filamentous actin(GO:0031941)
0.0 19.3 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 22.4 GO:0016361 activin receptor activity, type I(GO:0016361) BMP receptor activity(GO:0098821)
2.2 8.9 GO:0048408 epidermal growth factor binding(GO:0048408)
2.2 17.4 GO:0030274 LIM domain binding(GO:0030274)
1.8 9.2 GO:0005534 galactose binding(GO:0005534)
1.8 11.0 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
1.7 6.8 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
1.7 13.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
1.6 4.9 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
1.4 4.3 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
1.4 4.2 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
1.3 5.2 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
1.2 9.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
1.2 4.7 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.1 7.5 GO:0031014 troponin T binding(GO:0031014)
1.0 7.8 GO:0038085 vascular endothelial growth factor-activated receptor activity(GO:0005021) vascular endothelial growth factor binding(GO:0038085)
0.9 4.4 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.9 6.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.8 7.5 GO:0043208 glycosphingolipid binding(GO:0043208)
0.8 5.0 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.7 4.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.6 3.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.6 2.5 GO:0035877 death effector domain binding(GO:0035877)
0.6 1.8 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.6 4.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.6 2.3 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.6 3.3 GO:0032027 myosin light chain binding(GO:0032027)
0.6 5.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.5 4.9 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.5 1.6 GO:0008384 IkappaB kinase activity(GO:0008384)
0.5 7.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.5 6.9 GO:0045499 chemorepellent activity(GO:0045499)
0.5 2.9 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.5 1.8 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.4 9.2 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.4 4.2 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.4 1.2 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.4 3.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.4 1.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.4 8.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 3.7 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.3 9.1 GO:0019865 immunoglobulin binding(GO:0019865)
0.3 1.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.3 2.7 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.3 5.8 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.3 14.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 6.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 15.7 GO:0048365 Rac GTPase binding(GO:0048365)
0.3 6.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.3 3.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.2 4.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 1.2 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.2 2.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 5.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 8.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 5.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 1.8 GO:0030621 U6 snRNA binding(GO:0017070) U4 snRNA binding(GO:0030621)
0.2 1.7 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.2 12.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 3.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.2 1.8 GO:0030957 Tat protein binding(GO:0030957)
0.2 1.0 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.2 4.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 5.8 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.5 GO:0019961 interferon binding(GO:0019961)
0.2 48.5 GO:0005096 GTPase activator activity(GO:0005096)
0.2 1.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.2 1.2 GO:0004111 creatine kinase activity(GO:0004111)
0.2 1.3 GO:0016936 galactoside binding(GO:0016936)
0.2 0.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 4.2 GO:0071949 FAD binding(GO:0071949)
0.2 0.8 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.1 0.3 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 3.9 GO:0008527 taste receptor activity(GO:0008527)
0.1 0.7 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.5 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 0.4 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.1 2.6 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 0.8 GO:0051434 BH3 domain binding(GO:0051434)
0.1 1.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 4.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.8 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 6.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 1.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.8 GO:0034046 poly(G) binding(GO:0034046)
0.1 1.5 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 3.7 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 3.2 GO:0022829 wide pore channel activity(GO:0022829)
0.1 9.8 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.1 6.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.9 GO:0051400 BH domain binding(GO:0051400)
0.1 0.4 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 1.9 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 2.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.2 GO:0097677 STAT family protein binding(GO:0097677)
0.1 3.3 GO:0004620 phospholipase activity(GO:0004620)
0.1 1.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.2 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 22.6 GO:0005525 GTP binding(GO:0005525)
0.1 1.9 GO:0070888 E-box binding(GO:0070888)
0.1 1.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 2.5 GO:0005080 protein kinase C binding(GO:0005080)
0.1 0.7 GO:0003796 lysozyme activity(GO:0003796)
0.1 6.3 GO:0017124 SH3 domain binding(GO:0017124)
0.1 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 3.0 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.2 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 2.2 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 5.6 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.2 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.0 7.1 GO:0051020 GTPase binding(GO:0051020)
0.0 10.3 GO:0030246 carbohydrate binding(GO:0030246)
0.0 3.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.0 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.0 0.9 GO:0019894 kinesin binding(GO:0019894)
0.0 1.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.9 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 4.2 GO:0045296 cadherin binding(GO:0045296)
0.0 1.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.8 GO:0008146 sulfotransferase activity(GO:0008146)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 34.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
1.0 27.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.9 31.6 PID ALK1 PATHWAY ALK1 signaling events
0.7 7.8 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.4 9.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.4 17.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.4 7.7 PID NECTIN PATHWAY Nectin adhesion pathway
0.3 20.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.3 8.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.3 16.3 PID BCR 5PATHWAY BCR signaling pathway
0.3 20.2 PID ENDOTHELIN PATHWAY Endothelins
0.2 4.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.2 35.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 27.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 1.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.2 3.3 PID IL3 PATHWAY IL3-mediated signaling events
0.2 4.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 2.8 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.6 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 0.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.7 PID IL2 1PATHWAY IL2-mediated signaling events
0.1 5.4 PID FGF PATHWAY FGF signaling pathway
0.1 4.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 2.4 PID CD40 PATHWAY CD40/CD40L signaling
0.1 1.8 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 1.7 PID IL1 PATHWAY IL1-mediated signaling events
0.1 1.9 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 1.3 PID ARF 3PATHWAY Arf1 pathway
0.1 0.5 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 0.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 1.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.7 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.3 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.7 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.2 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 1.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.4 PID MYC PATHWAY C-MYC pathway
0.0 0.3 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 16.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.9 8.4 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.8 28.9 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.8 7.8 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.7 10.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.6 13.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.6 6.8 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.5 4.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.5 7.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.5 4.3 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.5 6.8 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.5 8.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.4 7.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.4 6.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.4 4.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.4 52.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.4 2.5 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.3 6.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.3 4.9 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.3 4.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3 4.9 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.3 3.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.3 3.0 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 5.3 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 5.2 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.2 2.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 17.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 7.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 1.9 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.2 1.3 REACTOME GAP JUNCTION TRAFFICKING Genes involved in Gap junction trafficking
0.1 3.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 3.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 4.1 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 0.4 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 2.1 REACTOME KINESINS Genes involved in Kinesins
0.1 1.7 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.8 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 2.3 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 4.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.6 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 1.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 4.9 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.0 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.9 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 3.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.4 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.6 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.1 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 0.7 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 4.0 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.8 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions