ISMARA results: Ets1

Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Ets1

Z-value: 2.58

Motif logo

Transcription factors associated with Ets1

Gene Symbol	Gene ID	Gene Info
Ets1 NCBI RGD Ensembl	ENSRNOG00000008941	ETS proto-oncogene 1, transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Ets1	rn6_v1_chr8_+_33816386_33816386	0.81	8.5e-76	Click!

Activity profile of Ets1 motif

Sorted Z-values of Ets1 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_198662610 Show fit	212.60	ENSRNOT00000055012	Sept1 NCBI RGD Ensembl Show fit	septin 1
chr13_+_89774764 Show fit	165.17	ENSRNOT00000005619	Arhgap30 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 30
chr1_+_198744050 Show fit	149.82	ENSRNOT00000024404	Itgal NCBI RGD Ensembl Show fit	integrin subunit alpha L
chr1_+_219403970 Show fit	114.23	ENSRNOT00000029607	Ptprcap NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, receptor type, C-associated protein
chr1_-_198577226 Show fit	113.22	ENSRNOT00000055013	Spn NCBI RGD Ensembl Show fit	sialophorin
chr15_+_57221292 Show fit	110.12	ENSRNOT00000014502	Lcp1 NCBI RGD Ensembl Show fit	lymphocyte cytosolic protein 1
chr13_+_50164563 Show fit	106.05	ENSRNOT00000029533	Lax1 NCBI RGD Ensembl Show fit	lymphocyte transmembrane adaptor 1
chr1_+_201620642 Show fit	97.48	ENSRNOT00000093674	Dmbt1 NCBI RGD Ensembl Show fit	deleted in malignant brain tumors 1
chr5_-_147761983 Show fit	97.43	ENSRNOT00000012936	Lck NCBI RGD Ensembl Show fit	LCK proto-oncogene, Src family tyrosine kinase
chr10_+_11810926 Show fit	96.78	ENSRNOT00000036205 ENSRNOT00000036189	Nlrc3 NCBI RGD Ensembl Show fit	NLR family, CARD domain containing 3
chr5_-_79222687 Show fit	95.59	ENSRNOT00000010516	Akna NCBI RGD Ensembl Show fit	AT-hook transcription factor
chr1_+_81779380 Show fit	93.26	ENSRNOT00000065865 ENSRNOT00000080143 ENSRNOT00000089592 ENSRNOT00000080840	Arhgef1 NCBI RGD Ensembl Show fit	Rho guanine nucleotide exchange factor 1
chr1_-_219438779 Show fit	92.33	ENSRNOT00000029237	Tbc1d10c NCBI RGD Ensembl Show fit	TBC1 domain family, member 10C
chr8_-_49308806 Show fit	90.91	ENSRNOT00000047291	Cd3e NCBI RGD Ensembl Show fit	CD3e molecule
chr11_+_84745904 Show fit	84.46	ENSRNOT00000002617	Klhl6 NCBI RGD Ensembl Show fit	kelch-like family member 6
chr20_+_4355175 Show fit	83.85	ENSRNOT00000000510	Gpsm3 NCBI RGD Ensembl Show fit	G-protein signaling modulator 3
chr1_+_81763614 Show fit	82.65	ENSRNOT00000027254	Cd79a NCBI RGD Ensembl Show fit	CD79a molecule
chr8_+_55603968 Show fit	82.46	ENSRNOT00000066848	Pou2af1 NCBI RGD Ensembl Show fit	POU class 2 associating factor 1
chr13_+_83996080 Show fit	81.59	ENSRNOT00000004403 ENSRNOT00000070958	Cd247 NCBI RGD Ensembl Show fit	Cd247 molecule
chr16_-_9430743 Show fit	80.56	ENSRNOT00000043811	Wdfy4 NCBI RGD Ensembl Show fit	WDFY family member 4
chr3_+_159995064 Show fit	78.02	ENSRNOT00000012606	Ttpal NCBI RGD Ensembl Show fit	alpha tocopherol transfer protein like
chr1_-_197770669 Show fit	77.11	ENSRNOT00000023563	Lat NCBI RGD Ensembl Show fit	linker for activation of T cells
chr10_-_87067456 Show fit	77.00	ENSRNOT00000014163	Ccr7 NCBI RGD Ensembl Show fit	C-C motif chemokine receptor 7
chr14_-_23604834 Show fit	74.53	ENSRNOT00000002760	Stap1 NCBI RGD Ensembl Show fit	signal transducing adaptor family member 1
chr20_+_30915213 Show fit	74.34	ENSRNOT00000000681	Prf1 NCBI RGD Ensembl Show fit	perforin 1
chr9_-_9675110 Show fit	74.30	ENSRNOT00000073294	Vav1 NCBI RGD Ensembl Show fit	vav guanine nucleotide exchange factor 1
chr13_-_55173692 Show fit	74.16	ENSRNOT00000064785 ENSRNOT00000029878 ENSRNOT00000029865 ENSRNOT00000060292 ENSRNOT00000000814	Ptprc NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, receptor type, C
chr14_+_44889287 Show fit	73.80	ENSRNOT00000091312 ENSRNOT00000032273	Tmem156 NCBI RGD Ensembl Show fit	transmembrane protein 156
chr9_-_16795887 Show fit	71.63	ENSRNOT00000071609	Cd79al NCBI RGD Ensembl Show fit	Cd79a molecule-like
chr5_+_154522119 Show fit	71.25	ENSRNOT00000072618	E2f2 NCBI RGD Ensembl Show fit	E2F transcription factor 2
chr1_-_199823386 Show fit	70.83	ENSRNOT00000027375	Rgs10 NCBI RGD Ensembl Show fit	regulator of G-protein signaling 10
chr11_+_54619129 Show fit	70.38	ENSRNOT00000059924	Trat1 NCBI RGD Ensembl Show fit	T cell receptor associated transmembrane adaptor 1
chr10_-_59112788 Show fit	70.02	ENSRNOT00000041886	Spns3 NCBI RGD Ensembl Show fit	SPNS sphingolipid transporter 3
chr2_-_190100276 Show fit	68.24	ENSRNOT00000015351	S100a9 NCBI RGD Ensembl Show fit	S100 calcium binding protein A9
chr20_+_9948908 Show fit	67.92	ENSRNOT00000001541	Ubash3a NCBI RGD Ensembl Show fit	ubiquitin associated and SH3 domain containing, A
chr1_-_227441442 Show fit	67.77	ENSRNOT00000028433	Ms4a1 NCBI RGD Ensembl Show fit	membrane spanning 4-domains A1
chr7_-_107616038 Show fit	67.64	ENSRNOT00000088752	Sla NCBI RGD Ensembl Show fit	src-like adaptor
chr20_+_5509059 Show fit	66.43	ENSRNOT00000065349	Kifc1 NCBI RGD Ensembl Show fit	kinesin family member C1
chr7_+_125288081 Show fit	66.05	ENSRNOT00000085216	Parvg NCBI RGD Ensembl Show fit	parvin, gamma
chr1_-_85317968 Show fit	65.70	ENSRNOT00000026891	Gmfg NCBI RGD Ensembl Show fit	glia maturation factor, gamma
chr3_+_28627084 Show fit	65.15	ENSRNOT00000049884	Arhgap15 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 15
chr9_+_67763897 Show fit	64.75	ENSRNOT00000071226	Icos NCBI RGD Ensembl Show fit	inducible T-cell co-stimulator
chr2_+_187218851 Show fit	64.66	ENSRNOT00000017798	Sh2d2a NCBI RGD Ensembl Show fit	SH2 domain containing 2A
chr15_+_60084918 Show fit	64.55	ENSRNOT00000012632	Epsti1 NCBI RGD Ensembl Show fit	epithelial stromal interaction 1
chr17_-_78812111 Show fit	62.26	ENSRNOT00000021506	Dclre1c NCBI RGD Ensembl Show fit	DNA cross-link repair 1C
chr13_+_48426820 Show fit	61.24	ENSRNOT00000048391	Ctse NCBI RGD Ensembl Show fit	cathepsin E
chr7_-_143837780 Show fit	60.15	ENSRNOT00000016642	Itgb7 NCBI RGD Ensembl Show fit	integrin subunit beta 7
chr1_+_198528635 Show fit	59.28	ENSRNOT00000022765	LOC308990 NCBI RGD Ensembl Show fit	hypothetical protein LOC308990
chr13_+_48427038 Show fit	58.59	ENSRNOT00000009241	Ctse NCBI RGD Ensembl Show fit	cathepsin E
chrX_+_15155230 Show fit	58.36	ENSRNOT00000073289 ENSRNOT00000051439	Was NCBI RGD Ensembl Show fit	Wiskott-Aldrich syndrome
chr7_+_70614617 Show fit	58.29	ENSRNOT00000035382	Arhgap9 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 9
chr3_-_160802433 Show fit	58.02	ENSRNOT00000076191	Slpi NCBI RGD Ensembl Show fit	secretory leukocyte peptidase inhibitor
chr1_-_101236065 Show fit	56.92	ENSRNOT00000066834	Cd37 NCBI RGD Ensembl Show fit	CD37 molecule
chr8_-_23148396 Show fit	56.55	ENSRNOT00000075237	Acp5 NCBI RGD Ensembl Show fit	acid phosphatase 5, tartrate resistant
chr13_-_47979797 Show fit	56.43	ENSRNOT00000080035	Rassf5 NCBI RGD Ensembl Show fit	Ras association domain family member 5
chr1_+_260289589 Show fit	55.64	ENSRNOT00000051058	Dntt NCBI RGD Ensembl Show fit	DNA nucleotidylexotransferase
chr7_-_107392972 Show fit	55.57	ENSRNOT00000093425	Tmem71 NCBI RGD Ensembl Show fit	transmembrane protein 71
chr2_+_183674522 Show fit	55.12	ENSRNOT00000014433	Tmem154 NCBI RGD Ensembl Show fit	transmembrane protein 154
chr1_-_167347490 Show fit	53.82	ENSRNOT00000076499	Rhog NCBI RGD Ensembl Show fit	ras homolog family member G
chr1_-_222272285 Show fit	53.60	ENSRNOT00000028737	Fermt3 NCBI RGD Ensembl Show fit	fermitin family member 3
chr1_-_227932603 Show fit	52.85	ENSRNOT00000033795	Ms4a6a NCBI RGD Ensembl Show fit	membrane spanning 4-domains A6A
chr8_-_21968415 Show fit	52.45	ENSRNOT00000067325 ENSRNOT00000064932	Dnmt1 NCBI RGD Ensembl Show fit	DNA methyltransferase 1
chr7_-_119716238 Show fit	52.44	ENSRNOT00000075678	Il2rb NCBI RGD Ensembl Show fit	interleukin 2 receptor subunit beta
chr15_-_29246222 Show fit	52.13	ENSRNOT00000081806	AABR07017617.1 NCBI RGD Ensembl Show fit
chr10_+_84309430 Show fit	51.93	ENSRNOT00000030159	Skap1 NCBI RGD Ensembl Show fit	src kinase associated phosphoprotein 1
chr10_+_91254058 Show fit	51.75	ENSRNOT00000087218 ENSRNOT00000065373	Fmnl1 NCBI RGD Ensembl Show fit	formin-like 1
chr5_-_169630340 Show fit	51.58	ENSRNOT00000087043	Kcnab2 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily A regulatory beta subunit 2
chr10_+_94566928 Show fit	51.46	ENSRNOT00000078446	Prr29 NCBI RGD Ensembl Show fit	proline rich 29
chr12_+_13716596 Show fit	51.27	ENSRNOT00000080216	Actb NCBI RGD Ensembl Show fit	actin, beta
chr5_-_159602251 Show fit	51.26	ENSRNOT00000011394	Necap2 NCBI RGD Ensembl Show fit	NECAP endocytosis associated 2
chr10_+_106785077 Show fit	51.07	ENSRNOT00000075047	Tmc8 NCBI RGD Ensembl Show fit	transmembrane channel-like 8
chr8_+_60760078 Show fit	50.06	ENSRNOT00000063930	Pstpip1 NCBI RGD Ensembl Show fit	proline-serine-threonine phosphatase-interacting protein 1
chr1_+_229642412 Show fit	50.06	ENSRNOT00000017109	Lpxn NCBI RGD Ensembl Show fit	leupaxin
chr14_+_3058993 Show fit	49.83	ENSRNOT00000002807	Gfi1 NCBI RGD Ensembl Show fit	growth factor independent 1 transcriptional repressor
chr1_-_88881460 Show fit	49.27	ENSRNOT00000028287	Hcst NCBI RGD Ensembl Show fit	hematopoietic cell signal transducer
chr2_+_212257225 Show fit	48.77	ENSRNOT00000077883	Vav3 NCBI RGD Ensembl Show fit	vav guanine nucleotide exchange factor 3
chr5_+_153507093 Show fit	48.73	ENSRNOT00000086650 ENSRNOT00000083645	Runx3 NCBI RGD Ensembl Show fit	runt-related transcription factor 3
chr4_-_78342863 Show fit	48.59	ENSRNOT00000049038	Gimap6 NCBI RGD Ensembl Show fit	GTPase, IMAP family member 6
chr5_+_149047681 Show fit	48.08	ENSRNOT00000015198	Laptm5 NCBI RGD Ensembl Show fit	lysosomal protein transmembrane 5
chr11_-_66759402 Show fit	47.54	ENSRNOT00000003326	Hcls1 NCBI RGD Ensembl Show fit	hematopoietic cell specific Lyn substrate 1
chr12_-_39667849 Show fit	47.06	ENSRNOT00000011499	Arpc3 NCBI RGD Ensembl Show fit	actin related protein 2/3 complex, subunit 3
chr3_-_118959850 Show fit	47.01	ENSRNOT00000092750	Atp8b4 NCBI RGD Ensembl Show fit	ATPase phospholipid transporting 8B4 (putative)
chr9_+_65620658 Show fit	46.19	ENSRNOT00000084498	Casp8 NCBI RGD Ensembl Show fit	caspase 8
chr8_-_62424303 Show fit	46.16	ENSRNOT00000091223	Csk NCBI RGD Ensembl Show fit	c-src tyrosine kinase
chr7_+_118895405 Show fit	45.82	ENSRNOT00000092095	RGD1309808 NCBI RGD Ensembl Show fit	similar to apolipoprotein L2; apolipoprotein L-II
chrX_+_70461718 Show fit	45.78	ENSRNOT00000078233 ENSRNOT00000003789	Kif4a NCBI RGD Ensembl Show fit	kinesin family member 4A
chrX_-_71616997 Show fit	45.65	ENSRNOT00000004406	Cxcr3 NCBI RGD Ensembl Show fit	C-X-C motif chemokine receptor 3
chr3_-_110517163 Show fit	45.50	ENSRNOT00000078037	Plcb2 NCBI RGD Ensembl Show fit	phospholipase C, beta 2
chr10_+_18996523 Show fit	45.39	ENSRNOT00000046135	Lcp2 NCBI RGD Ensembl Show fit	lymphocyte cytosolic protein 2
chr1_-_226791773 Show fit	45.20	ENSRNOT00000082482 ENSRNOT00000065376 ENSRNOT00000054812 ENSRNOT00000086669	LOC100911215 NCBI RGD Ensembl Show fit	T-cell surface glycoprotein CD5-like
chr1_-_198225580 Show fit	45.18	ENSRNOT00000026909	Ppp4c NCBI RGD Ensembl Show fit	protein phosphatase 4, catalytic subunit
chr9_-_9985358 Show fit	44.60	ENSRNOT00000080856	Crb3 NCBI RGD Ensembl Show fit	crumbs 3, cell polarity complex component
chr1_+_87938042 Show fit	44.25	ENSRNOT00000027837	Map4k1 NCBI RGD Ensembl Show fit	mitogen activated protein kinase kinase kinase kinase 1
chr1_+_88875375 Show fit	44.11	ENSRNOT00000028284	Tyrobp NCBI RGD Ensembl Show fit	Tyro protein tyrosine kinase binding protein
chr20_+_5441876 Show fit	43.96	ENSRNOT00000092476	Rps18 NCBI RGD Ensembl Show fit	ribosomal protein S18
chr2_+_186776644 Show fit	43.92	ENSRNOT00000046778	Fcrl3 NCBI RGD Ensembl Show fit	Fc receptor-like 3
chr2_+_236233239 Show fit	43.89	ENSRNOT00000013694	Lef1 NCBI RGD Ensembl Show fit	lymphoid enhancer binding factor 1
chr20_+_6973398 Show fit	43.61	ENSRNOT00000041665	Fgd2 NCBI RGD Ensembl Show fit	FYVE, RhoGEF and PH domain containing 2
chr7_+_37812831 Show fit	43.49	ENSRNOT00000005910	Btg1 NCBI RGD Ensembl Show fit	BTG anti-proliferation factor 1
chr11_-_60180031 Show fit	43.28	ENSRNOT00000043020 ENSRNOT00000093731	Gcsam NCBI RGD Ensembl Show fit	germinal center-associated, signaling and motility
chr3_-_160738927 Show fit	43.11	ENSRNOT00000043470	Slpil2 NCBI RGD Ensembl Show fit	antileukoproteinase-like 2
chr4_-_163227242 Show fit	42.61	ENSRNOT00000091552 ENSRNOT00000077793	Clec7a NCBI RGD Ensembl Show fit	C-type lectin domain family 7, member A
chr4_-_162189994 Show fit	42.40	ENSRNOT00000045501	LOC689757 NCBI RGD Ensembl Show fit	similar to osteoclast inhibitory lectin
chr1_-_222118459 Show fit	42.28	ENSRNOT00000067217	Ccdc88b NCBI RGD Ensembl Show fit	coiled-coil domain containing 88B
chr3_-_2853272 Show fit	42.22	ENSRNOT00000023022	Fcna NCBI RGD Ensembl Show fit	ficolin A
chr1_-_167347662 Show fit	41.94	ENSRNOT00000027641 ENSRNOT00000076592	Rhog NCBI RGD Ensembl Show fit	ras homolog family member G
chr3_-_160739137 Show fit	41.35	ENSRNOT00000075836	Slpil2 NCBI RGD Ensembl Show fit	antileukoproteinase-like 2
chr10_-_31419235 Show fit	39.90	ENSRNOT00000059496	Cyfip2 NCBI RGD Ensembl Show fit	cytoplasmic FMR1 interacting protein 2
chr8_+_96551245 Show fit	39.58	ENSRNOT00000039850	Bcl2a1 NCBI RGD Ensembl Show fit	BCL2-related protein A1
chr15_-_42898150 Show fit	39.54	ENSRNOT00000030036	Ptk2b NCBI RGD Ensembl Show fit	protein tyrosine kinase 2 beta
chr8_+_102304095 Show fit	38.98	ENSRNOT00000011358	Slc9a9 NCBI RGD Ensembl Show fit	solute carrier family 9 member A9
chr4_+_78320190 Show fit	38.47	ENSRNOT00000032742 ENSRNOT00000091359	Gimap4 NCBI RGD Ensembl Show fit	GTPase, IMAP family member 4
chr4_-_157263890 Show fit	38.33	ENSRNOT00000065416	Ptpn6 NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, non-receptor type 6
chr10_+_59529785 Show fit	38.04	ENSRNOT00000064840 ENSRNOT00000065181	Atp2a3 NCBI RGD Ensembl Show fit	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr7_+_11077411 Show fit	37.92	ENSRNOT00000007117	S1pr4 NCBI RGD Ensembl Show fit	sphingosine-1-phosphate receptor 4
chr5_-_140585408 Show fit	37.86	ENSRNOT00000018711	Cap1 NCBI RGD Ensembl Show fit	adenylate cyclase associated protein 1
chr4_+_78378144 Show fit	37.67	ENSRNOT00000059156	Gimap5 NCBI RGD Ensembl Show fit	GTPase, IMAP family member 5
chr1_+_86938138 Show fit	37.60	ENSRNOT00000075601	Ccer2 NCBI RGD Ensembl Show fit	coiled-coil glutamate-rich protein 2
chr20_-_3397039 Show fit	37.37	ENSRNOT00000001084 ENSRNOT00000085259	Ppp1r18 NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory subunit 18
chr16_-_19918644 Show fit	37.18	ENSRNOT00000083345 ENSRNOT00000023926	Plvap NCBI RGD Ensembl Show fit	plasmalemma vesicle associated protein
chr4_+_78371121 Show fit	37.17	ENSRNOT00000059157	Gimap1 NCBI RGD Ensembl Show fit	GTPase, IMAP family member 1
chr2_+_55835151 Show fit	37.02	ENSRNOT00000018634	Fyb NCBI RGD Ensembl Show fit	FYN binding protein
chr2_-_187909394 Show fit	36.63	ENSRNOT00000032355	Rab25 NCBI RGD Ensembl Show fit	RAB25, member RAS oncogene family
chr9_-_61528882 Show fit	36.52	ENSRNOT00000015432	Ankrd44 NCBI RGD Ensembl Show fit	ankyrin repeat domain 44
chr20_+_46199981 Show fit	36.24	ENSRNOT00000000337	Mical1 NCBI RGD Ensembl Show fit	microtubule associated monooxygenase, calponin and LIM domain containing 1
chr1_-_206282575 Show fit	36.23	ENSRNOT00000024974	Adam12 NCBI RGD Ensembl Show fit	ADAM metallopeptidase domain 12
chr3_+_79918969 Show fit	36.18	ENSRNOT00000016306	Spi1 NCBI RGD Ensembl Show fit	Spi-1 proto-oncogene
chr13_+_47602692 Show fit	36.16	ENSRNOT00000038822	Fcmr NCBI RGD Ensembl Show fit	Fc fragment of IgM receptor
chr16_-_7588841 Show fit	36.13	ENSRNOT00000084645	Mettl6 NCBI RGD Ensembl Show fit	methyltransferase like 6
chr4_+_78378313 Show fit	36.01	ENSRNOT00000083891	Gimap5 NCBI RGD Ensembl Show fit	GTPase, IMAP family member 5
chr14_-_100184192 Show fit	35.56	ENSRNOT00000007044	Plek NCBI RGD Ensembl Show fit	pleckstrin
chr10_+_31324512 Show fit	35.55	ENSRNOT00000008559	Fndc9 NCBI RGD Ensembl Show fit	fibronectin type III domain containing 9
chr2_+_32820322 Show fit	35.44	ENSRNOT00000013768	Cd180 NCBI RGD Ensembl Show fit	CD180 molecule
chr1_-_47502952 Show fit	35.40	ENSRNOT00000025580	Tagap NCBI RGD Ensembl Show fit	T-cell activation RhoGTPase activating protein
chr10_+_17421075 Show fit	35.01	ENSRNOT00000047011	Stk10 NCBI RGD Ensembl Show fit	serine/threonine kinase 10
chr9_+_65614142 Show fit	34.92	ENSRNOT00000016613	Casp8 NCBI RGD Ensembl Show fit	caspase 8
chr10_-_57275708 Show fit	34.83	ENSRNOT00000005370	Pfn1 NCBI RGD Ensembl Show fit	profilin 1
chr17_-_21591203 Show fit	34.59	ENSRNOT00000036195	Pak1ip1 NCBI RGD Ensembl Show fit	PAK1 interacting protein 1
chr1_-_89269930 Show fit	34.49	ENSRNOT00000028532	Ffar2 NCBI RGD Ensembl Show fit	free fatty acid receptor 2
chr3_+_20641664 Show fit	34.45	ENSRNOT00000044699	AABR07051741.1 NCBI RGD Ensembl Show fit
chr3_+_146365092 Show fit	34.37	ENSRNOT00000008865	Cst7 NCBI RGD Ensembl Show fit	cystatin F
chr9_+_81518584 Show fit	34.27	ENSRNOT00000084309	Arpc2 NCBI RGD Ensembl Show fit	actin related protein 2/3 complex, subunit 2
chr11_-_14304603 Show fit	34.21	ENSRNOT00000040202 ENSRNOT00000082143	Samsn1 NCBI RGD Ensembl Show fit	SAM domain, SH3 domain and nuclear localization signals, 1
chr1_-_89474252 Show fit	34.13	ENSRNOT00000028597	Fxyd5 NCBI RGD Ensembl Show fit	FXYD domain-containing ion transport regulator 5
chr7_+_18440742 Show fit	34.07	ENSRNOT00000011513	Myo1f NCBI RGD Ensembl Show fit	myosin IF
chrX_+_1311121 Show fit	33.86	ENSRNOT00000038909	Cfp NCBI RGD Ensembl Show fit	complement factor properdin
chr7_-_12640232 Show fit	33.79	ENSRNOT00000014981	Elane NCBI RGD Ensembl Show fit	elastase, neutrophil expressed
chr10_-_70341837 Show fit	33.54	ENSRNOT00000077261	Slfn13 NCBI RGD Ensembl Show fit	schlafen family member 13
chr10_+_43067299 Show fit	33.23	ENSRNOT00000003447	Galnt10 NCBI RGD Ensembl Show fit	polypeptide N-acetylgalactosaminyltransferase 10
chr18_+_44716226 Show fit	33.22	ENSRNOT00000086431	Tnfaip8 NCBI RGD Ensembl Show fit	TNF alpha induced protein 8
chr13_+_88606894 Show fit	32.94	ENSRNOT00000048692	Sh2d1b NCBI RGD Ensembl Show fit	SH2 domain containing 1B
chr3_+_110618298 Show fit	32.85	ENSRNOT00000012454	Knstrn NCBI RGD Ensembl Show fit	kinetochore-localized astrin/SPAG5 binding protein
chr6_+_126170911 Show fit	32.84	ENSRNOT00000077477	Rin3 NCBI RGD Ensembl Show fit	Ras and Rab interactor 3
chr17_-_9791781 Show fit	32.67	ENSRNOT00000090536	Rgs14 NCBI RGD Ensembl Show fit	regulator of G-protein signaling 14
chr5_-_147953093 Show fit	32.65	ENSRNOT00000075270	Khdrbs1 NCBI RGD Ensembl Show fit	KH RNA binding domain containing, signal transduction associated 1
chr9_+_8052210 Show fit	32.19	ENSRNOT00000073659	Adgre4 NCBI RGD Ensembl Show fit	adhesion G protein-coupled receptor E4
chr13_-_83202864 Show fit	32.18	ENSRNOT00000003976	Xcl1 NCBI RGD Ensembl Show fit	X-C motif chemokine ligand 1
chr5_+_25042710 Show fit	32.13	ENSRNOT00000061385	RGD1559904 NCBI RGD Ensembl Show fit	similar to mKIAA1429 protein
chr14_-_69927938 Show fit	32.13	ENSRNOT00000058838	Ncapg NCBI RGD Ensembl Show fit	non-SMC condensin I complex, subunit G
chr4_-_119327822 Show fit	32.09	ENSRNOT00000012645	Arhgap25 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 25
chr10_+_55013703 Show fit	31.82	ENSRNOT00000032785	Pik3r5 NCBI RGD Ensembl Show fit	phosphoinositide-3-kinase, regulatory subunit 5
chr4_+_157523320 Show fit	31.82	ENSRNOT00000023192	Zfp384 NCBI RGD Ensembl Show fit	zinc finger protein 384
chr13_+_90759260 Show fit	31.64	ENSRNOT00000010551	Pigm NCBI RGD Ensembl Show fit	phosphatidylinositol glycan anchor biosynthesis, class M
chr3_+_148327965 Show fit	31.62	ENSRNOT00000010851 ENSRNOT00000088481	Tpx2 NCBI RGD Ensembl Show fit	TPX2, microtubule nucleation factor
chr6_+_126170720 Show fit	31.53	ENSRNOT00000065246	Rin3 NCBI RGD Ensembl Show fit	Ras and Rab interactor 3
chr15_-_29465807 Show fit	31.36	ENSRNOT00000075046	AABR07017635.1 NCBI RGD Ensembl Show fit
chr20_-_11815647 Show fit	31.02	ENSRNOT00000001639	Itgb2 NCBI RGD Ensembl Show fit	integrin subunit beta 2
chr3_-_172537877 Show fit	30.99	ENSRNOT00000072069	Ctsz NCBI RGD Ensembl Show fit	cathepsin Z
chr10_-_70802782 Show fit	30.85	ENSRNOT00000045867	Ccl6 NCBI RGD Ensembl Show fit	chemokine (C-C motif) ligand 6
chr14_-_34115273 Show fit	30.76	ENSRNOT00000032156	Cep135 NCBI RGD Ensembl Show fit	centrosomal protein 135
chr15_+_31989041 Show fit	30.69	ENSRNOT00000073686	AABR07017868.2 NCBI RGD Ensembl Show fit
chr2_-_243224883 Show fit	30.56	ENSRNOT00000014139	Dapp1 NCBI RGD Ensembl Show fit	dual adaptor of phosphotyrosine and 3-phosphoinositides 1
chr3_-_79390956 Show fit	30.39	ENSRNOT00000077943	Ptprj NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, receptor type, J
chr16_+_61758917 Show fit	30.35	ENSRNOT00000084858	Leprotl1 NCBI RGD Ensembl Show fit	leptin receptor overlapping transcript-like 1
chr16_+_20293229 Show fit	30.33	ENSRNOT00000025421	Rpl18a NCBI RGD Ensembl Show fit	ribosomal protein L18A
chr5_-_76756140 Show fit	30.24	ENSRNOT00000022107 ENSRNOT00000089251	Ptbp3 NCBI RGD Ensembl Show fit	polypyrimidine tract binding protein 3
chr1_+_78767911 Show fit	30.16	ENSRNOT00000022360	Prkd2 NCBI RGD Ensembl Show fit	protein kinase D2
chr10_+_94988362 Show fit	30.05	ENSRNOT00000066525	Cep95 NCBI RGD Ensembl Show fit	centrosomal protein 95
chr4_+_34282625 Show fit	29.97	ENSRNOT00000011138 ENSRNOT00000086735	Glcci1 NCBI RGD Ensembl Show fit	glucocorticoid induced 1
chr8_+_28075551 Show fit	29.86	ENSRNOT00000012078	Ncapd3 NCBI RGD Ensembl Show fit	non-SMC condensin II complex, subunit D3
chr8_+_133029625 Show fit	29.82	ENSRNOT00000008809	Ccr3 NCBI RGD Ensembl Show fit	C-C motif chemokine receptor 3
chr3_-_151625644 Show fit	29.59	ENSRNOT00000026657	Rbm12 NCBI RGD Ensembl Show fit	RNA binding motif protein 12
chr1_-_89473904 Show fit	29.39	ENSRNOT00000089474	Fxyd5 NCBI RGD Ensembl Show fit	FXYD domain-containing ion transport regulator 5
chr14_+_85230648 Show fit	29.30	ENSRNOT00000089866	Ap1b1 NCBI RGD Ensembl Show fit	adaptor-related protein complex 1, beta 1 subunit
chr2_-_58534211 Show fit	29.28	ENSRNOT00000089178	Skp2 NCBI RGD Ensembl Show fit	S-phase kinase associated protein 2
chr10_+_75088422 Show fit	29.09	ENSRNOT00000081951	Mpo NCBI RGD Ensembl Show fit	myeloperoxidase
chr7_+_12471824 Show fit	28.99	ENSRNOT00000068197	Sbno2 NCBI RGD Ensembl Show fit	strawberry notch homolog 2
chr7_+_145068286 Show fit	28.94	ENSRNOT00000088956 ENSRNOT00000065753	Nckap1l NCBI RGD Ensembl Show fit	NCK associated protein 1 like
chr10_+_29123273 Show fit	28.68	ENSRNOT00000005171	Ccnjl NCBI RGD Ensembl Show fit	cyclin J-like
chr7_+_119482272 Show fit	28.67	ENSRNOT00000009544	Ncf4 NCBI RGD Ensembl Show fit	neutrophil cytosolic factor 4
chr1_-_198476476 Show fit	28.59	ENSRNOT00000027525	Kif22 NCBI RGD Ensembl Show fit	kinesin family member 22
chr1_-_134871167 Show fit	28.40	ENSRNOT00000076300	Chd2 NCBI RGD Ensembl Show fit	chromodomain helicase DNA binding protein 2
chr16_-_19303824 Show fit	28.33	ENSRNOT00000019350	Ap1m1 NCBI RGD Ensembl Show fit	adaptor-related protein complex 1, mu 1 subunit
chr5_+_142845114 Show fit	28.15	ENSRNOT00000039870	Yrdc NCBI RGD Ensembl Show fit	yrdC N(6)-threonylcarbamoyltransferase domain containing
chr17_-_9792007 Show fit	27.92	ENSRNOT00000021596	Rgs14 NCBI RGD Ensembl Show fit	regulator of G-protein signaling 14
chr8_+_22559098 Show fit	27.78	ENSRNOT00000041091	LOC691141 NCBI RGD Ensembl Show fit	hypothetical protein LOC691141
chr8_+_133195288 Show fit	27.49	ENSRNOT00000078529	Ccr2 NCBI RGD Ensembl Show fit	C-C motif chemokine receptor 2
chr10_+_56576428 Show fit	27.33	ENSRNOT00000079237 ENSRNOT00000023291	Cldn7 NCBI RGD Ensembl Show fit	claudin 7
chr15_-_30323833 Show fit	27.31	ENSRNOT00000071631	AABR07017714.1 NCBI RGD Ensembl Show fit
chr1_-_260254600 Show fit	27.29	ENSRNOT00000019014	Blnk NCBI RGD Ensembl Show fit	B-cell linker

Network of associatons between targets according to the STRING database.

First level regulatory network of Ets1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
70.9	212.6	GO:0007056	spindle assembly involved in female meiosis(GO:0007056)
37.7	113.2	GO:0001807	regulation of type IV hypersensitivity(GO:0001807)
31.5	94.5	GO:1902226	regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
28.3	141.3	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
27.5	27.5	GO:1902567	negative regulation of eosinophil activation(GO:1902567)
27.4	274.2	GO:0046645	positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645)
24.9	49.8	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
23.9	71.7	GO:2000538	regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
20.2	60.6	GO:0010070	zygote asymmetric cell division(GO:0010070)
19.2	77.0	GO:2000525	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
19.2	76.7	GO:0002752	cell surface pattern recognition receptor signaling pathway(GO:0002752)
19.0	114.2	GO:0002669	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
17.7	53.2	GO:0002148	hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
16.6	49.7	GO:0061152	trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
16.5	132.3	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
15.1	75.4	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
15.0	60.0	GO:2000814	positive regulation of barbed-end actin filament capping(GO:2000814)
15.0	149.8	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
14.2	56.9	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
14.2	42.6	GO:0071226	cellular response to molecule of fungal origin(GO:0071226)
13.1	52.4	GO:0090309	DNA methylation on cytosine within a CG sequence(GO:0010424) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
13.1	52.4	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)
12.2	36.5	GO:1901726	negative regulation of histone deacetylase activity(GO:1901726)
12.1	36.2	GO:0019417	sulfur oxidation(GO:0019417)
11.9	47.5	GO:0042509	regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
11.9	71.2	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
11.7	58.4	GO:0002457	T cell antigen processing and presentation(GO:0002457)
11.4	68.2	GO:0045113	regulation of integrin biosynthetic process(GO:0045113)
11.3	33.8	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
11.1	99.9	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
10.9	32.6	GO:0046833	positive regulation of RNA export from nucleus(GO:0046833)
10.8	21.6	GO:0002084	protein depalmitoylation(GO:0002084)
10.6	105.7	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
10.0	30.1	GO:1904383	response to sodium phosphate(GO:1904383)
9.8	39.2	GO:0044027	hypermethylation of CpG island(GO:0044027)
9.7	29.0	GO:0071348	cellular response to interleukin-11(GO:0071348)
9.6	28.9	GO:0002322	B cell proliferation involved in immune response(GO:0002322)
9.4	28.2	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
9.4	56.2	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
8.9	35.6	GO:0070560	protein secretion by platelet(GO:0070560)
8.6	34.4	GO:2001168	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
8.6	154.5	GO:0001833	inner cell mass cell proliferation(GO:0001833)
8.6	25.7	GO:0002232	leukocyte chemotaxis involved in inflammatory response(GO:0002232)
8.2	24.6	GO:0042631	cellular response to water deprivation(GO:0042631)
8.2	24.5	GO:0038158	granulocyte colony-stimulating factor signaling pathway(GO:0038158)
8.1	24.2	GO:1901227	negative regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901227)
8.0	24.1	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
8.0	119.8	GO:0016540	protein autoprocessing(GO:0016540)
7.9	31.5	GO:0070475	rRNA base methylation(GO:0070475)
7.8	62.3	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
7.7	46.2	GO:0042997	negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
7.5	82.8	GO:0002517	T cell tolerance induction(GO:0002517)
7.5	52.7	GO:2000402	negative regulation of lymphocyte migration(GO:2000402)
7.5	22.5	GO:1904845	response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
7.3	110.1	GO:0051764	actin filament network formation(GO:0051639) actin crosslink formation(GO:0051764)
7.3	139.4	GO:0097284	hepatocyte apoptotic process(GO:0097284)
7.3	43.9	GO:0002281	macrophage activation involved in immune response(GO:0002281)
7.2	14.5	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
7.2	107.9	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
7.1	21.4	GO:0048210	Golgi vesicle fusion to target membrane(GO:0048210)
7.1	120.6	GO:0002418	immune response to tumor cell(GO:0002418)
6.9	20.7	GO:0000432	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
6.9	96.5	GO:0002467	germinal center formation(GO:0002467)
6.9	20.7	GO:1904211	membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
6.7	53.6	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
6.5	45.8	GO:0000022	mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
6.4	38.6	GO:1904747	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
6.4	44.7	GO:0022614	membrane to membrane docking(GO:0022614)
6.2	18.5	GO:0097029	mature conventional dendritic cell differentiation(GO:0097029)
6.1	79.7	GO:1900017	positive regulation of cytokine production involved in inflammatory response(GO:1900017)
6.1	30.3	GO:0000454	snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
6.0	18.0	GO:0072697	protein localization to cell cortex(GO:0072697)
5.9	29.3	GO:1902916	positive regulation of protein polyubiquitination(GO:1902916)
5.8	34.8	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
5.8	80.7	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
5.7	17.2	GO:1902564	negative regulation of neutrophil degranulation(GO:0043314) negative regulation of neutrophil activation(GO:1902564)
5.7	39.9	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
5.5	98.3	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
5.4	16.2	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)
5.3	10.6	GO:0009826	unidimensional cell growth(GO:0009826)
5.3	58.3	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
5.3	448.0	GO:0050851	antigen receptor-mediated signaling pathway(GO:0050851)
5.2	31.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
5.1	15.4	GO:0021997	neural plate axis specification(GO:0021997)
5.1	15.2	GO:0072434	signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
5.0	14.9	GO:0071169	establishment of protein localization to chromatin(GO:0071169)
4.9	9.9	GO:0043380	regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382)
4.9	24.3	GO:0044806	G-quadruplex DNA unwinding(GO:0044806)
4.9	14.6	GO:0061092	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
4.8	24.2	GO:1904044	response to aldosterone(GO:1904044)
4.8	4.8	GO:0006408	snRNA export from nucleus(GO:0006408)
4.8	24.1	GO:0042256	mature ribosome assembly(GO:0042256)
4.8	14.4	GO:0014739	positive regulation of muscle hyperplasia(GO:0014739)
4.8	95.8	GO:1900027	regulation of ruffle assembly(GO:1900027)
4.8	62.0	GO:0007076	mitotic chromosome condensation(GO:0007076)
4.6	27.7	GO:0006361	transcription initiation from RNA polymerase I promoter(GO:0006361)
4.6	78.4	GO:0032460	negative regulation of protein oligomerization(GO:0032460)
4.6	9.2	GO:0006407	rRNA export from nucleus(GO:0006407)
4.6	54.9	GO:0051014	actin filament severing(GO:0051014)
4.6	50.2	GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
4.5	13.6	GO:2000158	positive regulation of ubiquitin-specific protease activity(GO:2000158)
4.5	17.9	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
4.4	8.7	GO:1902566	regulation of eosinophil degranulation(GO:0043309) regulation of eosinophil activation(GO:1902566)
4.3	43.5	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
4.3	12.9	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
4.3	124.4	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
4.3	17.2	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347)
4.2	12.7	GO:1901097	negative regulation of autophagosome maturation(GO:1901097)
4.1	45.6	GO:1900118	negative regulation of execution phase of apoptosis(GO:1900118)
4.0	11.9	GO:0036066	protein O-linked fucosylation(GO:0036066)
4.0	11.9	GO:0034635	glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
3.9	66.8	GO:0000185	activation of MAPKKK activity(GO:0000185)
3.8	30.3	GO:0097327	response to antineoplastic agent(GO:0097327)
3.7	26.0	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
3.6	40.0	GO:0048245	eosinophil chemotaxis(GO:0048245)
3.6	36.3	GO:1901978	positive regulation of cell cycle checkpoint(GO:1901978)
3.6	14.5	GO:0051684	maintenance of Golgi location(GO:0051684) double-strand break repair via classical nonhomologous end joining(GO:0097680)
3.6	14.4	GO:0030242	pexophagy(GO:0030242)
3.6	10.7	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
3.6	28.6	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
3.5	39.0	GO:0098719	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
3.5	14.2	GO:0072429	response to intra-S DNA damage checkpoint signaling(GO:0072429)
3.5	35.4	GO:2000234	positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
3.4	6.8	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
3.3	10.0	GO:0006713	glucocorticoid catabolic process(GO:0006713)
3.3	33.2	GO:0016266	O-glycan processing(GO:0016266)
3.3	13.1	GO:0032707	negative regulation of interleukin-23 production(GO:0032707)
3.3	45.8	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
3.1	43.5	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
3.1	31.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
3.1	34.1	GO:0043312	neutrophil degranulation(GO:0043312)
3.1	21.6	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
3.1	9.2	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
3.1	36.6	GO:0031268	pseudopodium organization(GO:0031268)
3.0	42.3	GO:0042832	defense response to protozoan(GO:0042832)
3.0	12.1	GO:0045359	positive regulation of interferon-beta biosynthetic process(GO:0045359)
3.0	36.1	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
3.0	15.0	GO:1900246	positive regulation of RIG-I signaling pathway(GO:1900246)
3.0	11.9	GO:0038096	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
3.0	23.8	GO:0051533	positive regulation of NFAT protein import into nucleus(GO:0051533)
3.0	17.8	GO:0046836	glycolipid transport(GO:0046836)
2.9	20.5	GO:0090650	response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
2.9	14.6	GO:0045048	protein insertion into ER membrane(GO:0045048)
2.9	126.0	GO:0072676	lymphocyte migration(GO:0072676)
2.9	5.7	GO:0090669	telomerase RNA stabilization(GO:0090669)
2.8	28.3	GO:0043482	endosome to melanosome transport(GO:0035646) pigment accumulation(GO:0043476) cellular pigment accumulation(GO:0043482) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
2.8	25.4	GO:0080009	mRNA methylation(GO:0080009)
2.7	87.6	GO:0007080	mitotic metaphase plate congression(GO:0007080)
2.6	26.3	GO:0070995	NADPH oxidation(GO:0070995)
2.6	13.1	GO:1904668	positive regulation of ubiquitin protein ligase activity(GO:1904668)
2.6	7.7	GO:0071630	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
2.6	7.7	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
2.6	51.3	GO:0071257	cellular response to electrical stimulus(GO:0071257)
2.5	7.6	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
2.5	5.0	GO:0032066	nucleolus to nucleoplasm transport(GO:0032066)
2.5	15.0	GO:1900244	positive regulation of synaptic vesicle endocytosis(GO:1900244)
2.5	20.0	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
2.5	19.7	GO:1903715	regulation of aerobic respiration(GO:1903715)
2.5	14.8	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
2.4	7.2	GO:0002143	tRNA wobble position uridine thiolation(GO:0002143)
2.4	9.6	GO:0090187	positive regulation of pancreatic juice secretion(GO:0090187)
2.4	4.8	GO:0060266	regulation of respiratory burst involved in inflammatory response(GO:0060264) negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
2.4	14.2	GO:0051415	interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
2.3	9.3	GO:0051542	negative regulation of iron ion transmembrane transport(GO:0034760) elastin biosynthetic process(GO:0051542)
2.3	25.0	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
2.3	6.8	GO:1902299	pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
2.2	6.7	GO:0071461	cellular response to redox state(GO:0071461)
2.2	17.7	GO:1900264	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
2.2	11.0	GO:2000002	negative regulation of DNA damage checkpoint(GO:2000002)
2.1	55.2	GO:0009299	mRNA transcription(GO:0009299)
2.1	14.6	GO:1901098	positive regulation of autophagosome maturation(GO:1901098)
2.1	16.6	GO:0006265	DNA topological change(GO:0006265)
2.1	4.1	GO:1902214	negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125) regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of apoptotic cell clearance(GO:2000426)
2.0	18.4	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
2.0	8.1	GO:0071802	negative regulation of podosome assembly(GO:0071802)
2.0	22.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
2.0	5.9	GO:0036334	epidermal stem cell homeostasis(GO:0036334)
2.0	45.2	GO:0010569	regulation of double-strand break repair via homologous recombination(GO:0010569)
1.9	13.4	GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
1.9	116.1	GO:0045576	mast cell activation(GO:0045576)
1.9	34.2	GO:0050869	negative regulation of B cell activation(GO:0050869)
1.9	41.7	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
1.9	33.8	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
1.9	3.7	GO:0010847	regulation of chromatin assembly(GO:0010847)
1.8	9.2	GO:1901668	regulation of superoxide dismutase activity(GO:1901668)
1.8	11.0	GO:0032494	response to peptidoglycan(GO:0032494)
1.8	7.3	GO:0006011	UDP-glucose metabolic process(GO:0006011)
1.8	5.4	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) endoplasmic reticulum mannose trimming(GO:1904380)
1.8	5.4	GO:0042350	GDP-L-fucose biosynthetic process(GO:0042350)
1.8	73.2	GO:0050912	detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
1.8	8.9	GO:0016259	selenocysteine metabolic process(GO:0016259)
1.8	21.4	GO:0031468	nuclear envelope reassembly(GO:0031468)
1.8	7.1	GO:0032824	natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
1.8	58.0	GO:0019731	antibacterial humoral response(GO:0019731)
1.7	47.2	GO:0000028	ribosomal small subunit assembly(GO:0000028)
1.7	7.0	GO:0009212	dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
1.7	3.5	GO:1903003	positive regulation of protein deubiquitination(GO:1903003)
1.7	5.2	GO:1903896	positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
1.7	5.1	GO:0048102	autophagic cell death(GO:0048102)
1.7	18.7	GO:0033601	positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
1.7	8.5	GO:0097338	response to clozapine(GO:0097338)
1.7	11.8	GO:0036260	7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260)
1.7	6.6	GO:0000492	box C/D snoRNP assembly(GO:0000492)
1.6	55.9	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
1.6	26.1	GO:0046339	diacylglycerol metabolic process(GO:0046339)
1.6	11.2	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
1.6	11.2	GO:0006477	protein sulfation(GO:0006477)
1.6	15.9	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
1.6	12.6	GO:0040016	embryonic cleavage(GO:0040016)
1.6	17.3	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
1.6	12.6	GO:2001138	positive regulation of cellular respiration(GO:1901857) regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140)
1.6	39.0	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
1.6	4.7	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
1.5	60.9	GO:0010501	RNA secondary structure unwinding(GO:0010501)
1.5	12.0	GO:0072673	lamellipodium morphogenesis(GO:0072673)
1.5	13.4	GO:0043983	histone H4-K12 acetylation(GO:0043983)
1.5	2.9	GO:0006701	progesterone biosynthetic process(GO:0006701)
1.4	11.5	GO:0090435	protein localization to nuclear envelope(GO:0090435)
1.4	5.7	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
1.4	15.6	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
1.4	23.8	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
1.3	8.0	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
1.3	5.3	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
1.3	2.6	GO:0030382	sperm mitochondrion organization(GO:0030382)
1.3	34.1	GO:0046329	negative regulation of JNK cascade(GO:0046329)
1.3	5.2	GO:0033183	negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
1.3	11.7	GO:0042790	transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
1.3	10.4	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
1.3	6.5	GO:0031394	positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
1.3	7.7	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
1.3	7.7	GO:0015860	purine nucleoside transmembrane transport(GO:0015860)
1.3	6.3	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
1.3	17.7	GO:0042274	ribosomal small subunit biogenesis(GO:0042274)
1.3	3.8	GO:0039689	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
1.3	8.8	GO:0015866	ADP transport(GO:0015866)
1.2	33.2	GO:0050830	defense response to Gram-positive bacterium(GO:0050830)
1.2	28.1	GO:0000470	maturation of LSU-rRNA(GO:0000470)
1.2	9.8	GO:1903140	regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
1.2	3.6	GO:0006436	tryptophanyl-tRNA aminoacylation(GO:0006436)
1.2	8.5	GO:2000210	positive regulation of anoikis(GO:2000210)
1.2	44.6	GO:0006505	GPI anchor metabolic process(GO:0006505)
1.2	1.2	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
1.2	9.3	GO:0006348	chromatin silencing at telomere(GO:0006348)
1.2	22.1	GO:0002115	store-operated calcium entry(GO:0002115)
1.2	10.4	GO:0001973	adenosine receptor signaling pathway(GO:0001973)
1.2	8.1	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
1.1	37.1	GO:0033198	response to ATP(GO:0033198)
1.1	2.2	GO:1901423	response to benzene(GO:1901423)
1.1	5.6	GO:0046477	glycosylceramide catabolic process(GO:0046477)
1.1	50.2	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
1.1	33.4	GO:0006911	phagocytosis, engulfment(GO:0006911)
1.1	3.3	GO:0010993	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
1.1	19.8	GO:0060216	definitive hemopoiesis(GO:0060216)
1.1	7.7	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
1.1	8.7	GO:0070417	cellular response to cold(GO:0070417)
1.1	37.6	GO:0070527	platelet aggregation(GO:0070527)
1.1	9.6	GO:0034472	snRNA 3'-end processing(GO:0034472)
1.0	6.3	GO:0045974	miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
1.0	5.1	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
1.0	11.2	GO:0045023	G0 to G1 transition(GO:0045023)
1.0	8.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
1.0	8.1	GO:0000012	single strand break repair(GO:0000012)
1.0	4.0	GO:1904798	regulation of core promoter binding(GO:1904796) positive regulation of core promoter binding(GO:1904798)
1.0	4.0	GO:0009597	detection of virus(GO:0009597)
1.0	44.4	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
1.0	8.8	GO:0060837	blood vessel endothelial cell differentiation(GO:0060837)
1.0	15.6	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
1.0	5.8	GO:0032878	regulation of establishment or maintenance of cell polarity(GO:0032878)
1.0	2.9	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
1.0	4.8	GO:0001555	oocyte growth(GO:0001555)
0.9	6.6	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
0.9	9.4	GO:0043970	histone H3-K9 acetylation(GO:0043970)
0.9	15.7	GO:0048268	clathrin coat assembly(GO:0048268)
0.9	7.4	GO:0001842	neural fold formation(GO:0001842)
0.9	24.8	GO:0043551	regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.9	1.8	GO:0046604	positive regulation of mitotic centrosome separation(GO:0046604)
0.9	39.5	GO:0030520	intracellular estrogen receptor signaling pathway(GO:0030520)
0.9	14.3	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
0.9	4.5	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.9	7.1	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.9	13.3	GO:0045793	positive regulation of cell size(GO:0045793)
0.9	8.9	GO:0035562	negative regulation of chromatin binding(GO:0035562)
0.9	4.4	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.9	410.0	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.9	6.1	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
0.9	9.6	GO:0032506	cytokinetic process(GO:0032506)
0.9	3.5	GO:0033602	negative regulation of dopamine secretion(GO:0033602)
0.8	13.6	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.8	0.8	GO:0000350	generation of catalytic spliceosome for second transesterification step(GO:0000350) spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.8	4.2	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.8	5.8	GO:0010668	ectodermal cell differentiation(GO:0010668)
0.8	5.7	GO:0006517	mannose metabolic process(GO:0006013) protein deglycosylation(GO:0006517)
0.8	7.2	GO:0035330	regulation of hippo signaling(GO:0035330)
0.8	18.0	GO:0030488	tRNA methylation(GO:0030488)
0.8	21.0	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.8	30.4	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.8	26.3	GO:2000036	regulation of stem cell population maintenance(GO:2000036)
0.8	0.8	GO:0070370	cellular heat acclimation(GO:0070370)
0.8	55.3	GO:0030183	B cell differentiation(GO:0030183)
0.8	3.8	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.8	13.5	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.7	14.2	GO:0009642	response to light intensity(GO:0009642)
0.7	2.2	GO:0021649	vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835) dorsal root ganglion development(GO:1990791)
0.7	7.4	GO:2000010	positive regulation of protein localization to cell surface(GO:2000010)
0.7	37.9	GO:0045761	regulation of adenylate cyclase activity(GO:0045761)
0.7	10.3	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.7	2.2	GO:0021764	amygdala development(GO:0021764)
0.7	11.7	GO:1900037	regulation of cellular response to hypoxia(GO:1900037)
0.7	45.4	GO:0031398	positive regulation of protein ubiquitination(GO:0031398)
0.7	38.2	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.7	8.6	GO:0043388	positive regulation of DNA binding(GO:0043388)
0.7	27.9	GO:0045773	positive regulation of axon extension(GO:0045773)
0.7	22.4	GO:0030521	androgen receptor signaling pathway(GO:0030521)
0.7	2.0	GO:0006433	prolyl-tRNA aminoacylation(GO:0006433)
0.7	13.9	GO:0034508	centromere complex assembly(GO:0034508)
0.7	11.7	GO:0006491	N-glycan processing(GO:0006491)
0.7	5.9	GO:0070933	histone H4 deacetylation(GO:0070933)
0.6	6.8	GO:0030259	lipid glycosylation(GO:0030259)
0.6	4.3	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.6	3.6	GO:0032757	positive regulation of interleukin-8 production(GO:0032757)
0.6	12.3	GO:0034724	DNA replication-independent nucleosome organization(GO:0034724)
0.6	12.2	GO:0006298	mismatch repair(GO:0006298)
0.6	4.0	GO:0033210	leptin-mediated signaling pathway(GO:0033210)
0.6	3.9	GO:0035372	protein localization to microtubule(GO:0035372)
0.5	2.7	GO:0070234	positive regulation of T cell apoptotic process(GO:0070234)
0.5	5.9	GO:0034643	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.5	4.8	GO:0001675	acrosome assembly(GO:0001675)
0.5	1.6	GO:0090164	asymmetric Golgi ribbon formation(GO:0090164)
0.5	2.1	GO:1903758	regulation of postsynaptic density protein 95 clustering(GO:1902897) positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.5	6.7	GO:0035066	positive regulation of histone acetylation(GO:0035066)
0.5	4.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.5	16.7	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.5	38.9	GO:0042157	lipoprotein metabolic process(GO:0042157)
0.5	13.3	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.5	4.7	GO:0046325	negative regulation of glucose import(GO:0046325)
0.5	1.4	GO:0009249	protein lipoylation(GO:0009249)
0.5	0.5	GO:1903608	protein localization to cytoplasmic stress granule(GO:1903608)
0.5	15.7	GO:0045907	positive regulation of vasoconstriction(GO:0045907)
0.4	19.1	GO:0006406	mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.4	4.4	GO:0021683	cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4	8.7	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.4	8.5	GO:2000279	negative regulation of DNA biosynthetic process(GO:2000279)
0.4	61.5	GO:0050714	positive regulation of protein secretion(GO:0050714)
0.4	12.7	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.4	5.5	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.4	5.1	GO:0035196	production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.4	5.0	GO:0051084	'de novo' posttranslational protein folding(GO:0051084)
0.4	5.2	GO:0035518	histone H2A monoubiquitination(GO:0035518)
0.4	33.2	GO:0051607	defense response to virus(GO:0051607)
0.4	16.7	GO:0071549	cellular response to dexamethasone stimulus(GO:0071549)
0.4	18.1	GO:0050863	regulation of T cell activation(GO:0050863)
0.4	2.9	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.3	5.2	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.3	5.1	GO:0006271	DNA strand elongation involved in DNA replication(GO:0006271)
0.3	5.1	GO:0006376	mRNA splice site selection(GO:0006376)
0.3	2.7	GO:0070197	meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.3	1.3	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.3	1.3	GO:0046855	phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.3	4.8	GO:0046415	urate metabolic process(GO:0046415)
0.3	2.1	GO:1901741	positive regulation of myoblast fusion(GO:1901741)
0.3	53.1	GO:0008380	RNA splicing(GO:0008380)
0.3	0.6	GO:0010481	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.3	7.9	GO:1990090	cellular response to nerve growth factor stimulus(GO:1990090)
0.3	1.5	GO:0075522	IRES-dependent viral translational initiation(GO:0075522)
0.3	2.6	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.3	3.2	GO:0051457	maintenance of protein location in nucleus(GO:0051457)
0.3	9.7	GO:0043966	histone H3 acetylation(GO:0043966)
0.3	4.7	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.3	9.7	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.3	6.6	GO:0034067	protein localization to Golgi apparatus(GO:0034067)
0.3	8.9	GO:0002224	toll-like receptor signaling pathway(GO:0002224)
0.3	1.8	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.3	2.3	GO:0002002	regulation of angiotensin levels in blood(GO:0002002) regulation of angiotensin metabolic process(GO:0060177)
0.3	1.8	GO:2000480	regulation of cAMP-dependent protein kinase activity(GO:2000479) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3	3.3	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.3	3.5	GO:0006895	Golgi to endosome transport(GO:0006895)
0.2	75.5	GO:0006897	endocytosis(GO:0006897)
0.2	6.6	GO:0032465	regulation of cytokinesis(GO:0032465)
0.2	5.0	GO:1903146	regulation of mitophagy(GO:1903146)
0.2	10.4	GO:0031532	actin cytoskeleton reorganization(GO:0031532)
0.2	1.4	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.2	4.7	GO:0045879	negative regulation of smoothened signaling pathway(GO:0045879)
0.2	1.5	GO:0090141	positive regulation of mitochondrial fission(GO:0090141)
0.2	4.7	GO:0031047	gene silencing by RNA(GO:0031047)
0.2	14.5	GO:0030307	positive regulation of cell growth(GO:0030307)
0.2	5.6	GO:0006400	tRNA modification(GO:0006400)
0.2	1.7	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.2	2.6	GO:0010165	response to X-ray(GO:0010165)
0.2	2.3	GO:0016180	snRNA processing(GO:0016180)
0.2	1.0	GO:0015074	DNA integration(GO:0015074)
0.2	2.2	GO:0007257	activation of JUN kinase activity(GO:0007257)
0.2	3.8	GO:0006801	superoxide metabolic process(GO:0006801)
0.2	3.2	GO:0043967	histone H4 acetylation(GO:0043967)
0.2	3.7	GO:0042113	B cell activation(GO:0042113)
0.2	0.3	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.2	11.8	GO:0030217	T cell differentiation(GO:0030217)
0.1	0.4	GO:0034628	nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1	2.5	GO:0071539	protein localization to centrosome(GO:0071539)
0.1	3.6	GO:0000186	activation of MAPKK activity(GO:0000186)
0.1	1.9	GO:0043248	proteasome assembly(GO:0043248)
0.1	2.2	GO:0032456	endocytic recycling(GO:0032456)
0.1	3.2	GO:0045739	positive regulation of DNA repair(GO:0045739)
0.1	1.5	GO:0032508	DNA duplex unwinding(GO:0032508)
0.1	2.3	GO:0006270	DNA replication initiation(GO:0006270)
0.1	0.4	GO:0030576	Cajal body organization(GO:0030576)
0.1	3.0	GO:0051057	positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.1	2.3	GO:0016573	histone acetylation(GO:0016573)
0.1	9.3	GO:0000209	protein polyubiquitination(GO:0000209)
0.1	0.6	GO:0097428	protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1	2.6	GO:0008299	isoprenoid biosynthetic process(GO:0008299)
0.1	10.9	GO:0090305	nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.1	3.2	GO:0031023	microtubule organizing center organization(GO:0031023)
0.1	0.8	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.1	1.8	GO:0009615	response to virus(GO:0009615)
0.1	2.9	GO:0010212	response to ionizing radiation(GO:0010212)
0.1	0.2	GO:0006172	ADP biosynthetic process(GO:0006172) dATP metabolic process(GO:0046060)
0.0	0.7	GO:0000731	DNA synthesis involved in DNA repair(GO:0000731)
0.0	0.6	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0	1.5	GO:0050776	regulation of immune response(GO:0050776)
0.0	2.3	GO:0070588	calcium ion transmembrane transport(GO:0070588)
0.0	0.0	GO:0033234	negative regulation of protein sumoylation(GO:0033234)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
28.7	86.2	GO:0030690	Noc1p-Noc2p complex(GO:0030690)
26.4	210.8	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
25.2	100.8	GO:0019815	B cell receptor complex(GO:0019815)
22.7	45.4	GO:0036398	TCR signalosome(GO:0036398)
15.2	136.9	GO:0042101	T cell receptor complex(GO:0042101)
15.2	45.5	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
14.6	43.9	GO:1990907	beta-catenin-TCF complex(GO:1990907)
14.2	212.6	GO:0072687	meiotic spindle(GO:0072687)
12.4	74.3	GO:0031904	endosome lumen(GO:0031904)
12.1	422.4	GO:0001772	immunological synapse(GO:0001772)
12.0	132.0	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
10.7	64.2	GO:0036195	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
10.6	31.8	GO:0005944	phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
10.0	29.9	GO:0042585	germinal vesicle(GO:0042585)
8.5	50.8	GO:0030289	protein phosphatase 4 complex(GO:0030289)
7.5	37.3	GO:0034455	t-UTP complex(GO:0034455)
6.9	61.9	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
6.4	51.2	GO:0043020	NADPH oxidase complex(GO:0043020)
6.3	50.1	GO:0005826	actomyosin contractile ring(GO:0005826)
6.1	30.3	GO:0090661	box H/ACA telomerase RNP complex(GO:0090661)
5.8	40.8	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
5.8	17.5	GO:0044609	DBIRD complex(GO:0044609)
5.8	46.3	GO:0005885	Arp2/3 protein complex(GO:0005885)
5.7	5.7	GO:0000814	ESCRT II complex(GO:0000814)
5.6	276.4	GO:0002102	podosome(GO:0002102)
5.4	27.2	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)
5.1	97.5	GO:0042589	zymogen granule membrane(GO:0042589)
4.8	90.3	GO:0031527	filopodium membrane(GO:0031527)
4.7	55.9	GO:0005687	U4 snRNP(GO:0005687)
4.6	32.1	GO:0000796	condensin complex(GO:0000796)
4.6	41.0	GO:0031209	SCAR complex(GO:0031209)
4.5	40.8	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
4.5	31.6	GO:0043203	axon hillock(GO:0043203)
4.3	38.7	GO:0070419	nonhomologous end joining complex(GO:0070419)
4.3	12.8	GO:0071001	U4/U6 snRNP(GO:0071001)
4.2	25.4	GO:0036396	MIS complex(GO:0036396)
3.9	30.9	GO:0016589	NURF complex(GO:0016589)
3.8	53.2	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
3.8	11.3	GO:0035101	FACT complex(GO:0035101)
3.7	51.6	GO:0044224	juxtaparanode region of axon(GO:0044224)
3.7	18.4	GO:0044530	supraspliceosomal complex(GO:0044530)
3.7	36.6	GO:0031143	pseudopodium(GO:0031143)
3.6	10.7	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
3.5	42.2	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
3.5	10.5	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
3.4	13.6	GO:0072487	MSL complex(GO:0072487)
3.3	9.8	GO:0031515	tRNA (m1A) methyltransferase complex(GO:0031515)
3.3	91.2	GO:0008305	integrin complex(GO:0008305)
3.1	21.5	GO:0032584	growth cone membrane(GO:0032584)
3.1	21.4	GO:0098553	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
3.0	24.2	GO:0032059	bleb(GO:0032059)
3.0	18.0	GO:0070847	core mediator complex(GO:0070847)
3.0	14.9	GO:0031933	telomeric heterochromatin(GO:0031933)
3.0	14.9	GO:0061689	tricellular tight junction(GO:0061689)
2.9	2.9	GO:0031467	Cul7-RING ubiquitin ligase complex(GO:0031467)
2.9	20.0	GO:0097136	Bcl-2 family protein complex(GO:0097136)
2.8	33.2	GO:0030125	clathrin vesicle coat(GO:0030125)
2.6	33.8	GO:0005686	U2 snRNP(GO:0005686)
2.5	7.4	GO:0044611	nuclear pore inner ring(GO:0044611)
2.4	14.6	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
2.4	7.2	GO:0071006	U2-type catalytic step 1 spliceosome(GO:0071006)
2.4	7.2	GO:0097543	ciliary inversin compartment(GO:0097543)
2.4	14.2	GO:0000923	equatorial microtubule organizing center(GO:0000923)
2.3	9.4	GO:0044299	C-fiber(GO:0044299)
2.3	76.9	GO:0030131	clathrin adaptor complex(GO:0030131)
2.3	20.5	GO:0016600	flotillin complex(GO:0016600)
2.3	6.8	GO:0036387	nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
2.2	22.0	GO:0042588	zymogen granule(GO:0042588)
2.2	24.1	GO:0031080	nuclear pore outer ring(GO:0031080)
2.1	14.5	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
2.0	16.0	GO:0071141	SMAD protein complex(GO:0071141)
2.0	8.0	GO:1990745	GARP complex(GO:0000938) EARP complex(GO:1990745)
2.0	6.0	GO:0061574	ASAP complex(GO:0061574)
2.0	11.9	GO:0032426	stereocilium tip(GO:0032426)
2.0	23.7	GO:0035631	CD40 receptor complex(GO:0035631)
2.0	17.7	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
1.9	61.8	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
1.9	126.9	GO:0005871	kinesin complex(GO:0005871)
1.9	9.6	GO:0070938	contractile ring(GO:0070938)
1.9	15.3	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
1.9	140.4	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
1.9	48.3	GO:0030687	preribosome, large subunit precursor(GO:0030687)
1.8	49.8	GO:0005721	pericentric heterochromatin(GO:0005721)
1.8	11.0	GO:0005672	transcription factor TFIIA complex(GO:0005672)
1.8	19.8	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
1.8	532.0	GO:0009897	external side of plasma membrane(GO:0009897)
1.7	19.1	GO:0005662	DNA replication factor A complex(GO:0005662)
1.7	5.2	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
1.7	30.7	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
1.7	6.6	GO:0005726	perichromatin fibrils(GO:0005726)
1.6	24.7	GO:0071011	precatalytic spliceosome(GO:0071011)
1.6	121.8	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
1.6	146.3	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
1.5	58.6	GO:0000791	euchromatin(GO:0000791)
1.5	21.1	GO:0060091	kinocilium(GO:0060091)
1.5	32.9	GO:0035371	microtubule plus-end(GO:0035371)
1.4	21.4	GO:0030119	AP-type membrane coat adaptor complex(GO:0030119)
1.4	7.0	GO:0000120	RNA polymerase I transcription factor complex(GO:0000120)
1.4	5.5	GO:0097422	tubular endosome(GO:0097422)
1.4	21.6	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
1.3	41.2	GO:0034451	centriolar satellite(GO:0034451)
1.3	130.0	GO:0005884	actin filament(GO:0005884)
1.3	13.1	GO:0044613	nuclear pore central transport channel(GO:0044613)
1.3	13.1	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
1.3	10.4	GO:0000798	nuclear cohesin complex(GO:0000798)
1.3	16.3	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
1.2	8.7	GO:0043219	lateral loop(GO:0043219)
1.2	4.9	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
1.2	9.9	GO:0071004	U2-type prespliceosome(GO:0071004)
1.2	9.5	GO:0032593	insulin-responsive compartment(GO:0032593)
1.2	5.8	GO:0043625	delta DNA polymerase complex(GO:0043625)
1.2	3.5	GO:0038039	G-protein coupled receptor heterodimeric complex(GO:0038039)
1.1	6.7	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
1.1	7.7	GO:0097504	Gemini of coiled bodies(GO:0097504)
1.1	12.0	GO:0071564	npBAF complex(GO:0071564)
1.1	53.4	GO:0045335	phagocytic vesicle(GO:0045335)
1.1	8.5	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
1.1	20.0	GO:0016460	myosin II complex(GO:0016460)
1.0	12.5	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
1.0	5.1	GO:0061700	GATOR2 complex(GO:0061700)
1.0	6.0	GO:0030914	STAGA complex(GO:0030914)
1.0	31.0	GO:0099738	cell cortex region(GO:0099738)
1.0	13.5	GO:0017119	Golgi transport complex(GO:0017119)
1.0	122.7	GO:0001726	ruffle(GO:0001726)
1.0	88.0	GO:0016605	PML body(GO:0016605)
0.9	11.3	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.9	27.1	GO:0032040	small-subunit processome(GO:0032040)
0.9	112.0	GO:0001650	fibrillar center(GO:0001650)
0.9	6.1	GO:0035068	micro-ribonucleoprotein complex(GO:0035068)
0.9	5.1	GO:0043202	lysosomal lumen(GO:0043202)
0.8	16.0	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.8	27.1	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.8	4.1	GO:1903767	sweet taste receptor complex(GO:1903767) taste receptor complex(GO:1903768)
0.8	83.6	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.8	47.8	GO:0030139	endocytic vesicle(GO:0030139)
0.8	68.8	GO:0017053	transcriptional repressor complex(GO:0017053)
0.8	4.7	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.8	3.8	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.8	35.7	GO:0016328	lateral plasma membrane(GO:0016328)
0.8	29.3	GO:0005657	replication fork(GO:0005657)
0.7	72.4	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.7	51.8	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.7	51.7	GO:0000922	spindle pole(GO:0000922)
0.7	4.7	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.7	9.3	GO:0035145	exon-exon junction complex(GO:0035145)
0.6	15.2	GO:1990391	DNA repair complex(GO:1990391)
0.6	12.0	GO:0005640	nuclear outer membrane(GO:0005640)
0.6	8.2	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.6	8.9	GO:0000346	transcription export complex(GO:0000346)
0.6	8.8	GO:0044665	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.6	22.8	GO:0016235	aggresome(GO:0016235)
0.6	9.5	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.6	10.5	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.5	4.4	GO:0008290	F-actin capping protein complex(GO:0008290)
0.5	2.5	GO:0001652	granular component(GO:0001652)
0.5	1.5	GO:0098835	presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.5	5.9	GO:0030008	TRAPP complex(GO:0030008)
0.5	4.8	GO:0044666	MLL3/4 complex(GO:0044666)
0.5	15.3	GO:0045171	intercellular bridge(GO:0045171)
0.5	117.3	GO:0005925	focal adhesion(GO:0005925)
0.5	2.3	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.4	10.8	GO:0032153	cell division site(GO:0032153) cell division site part(GO:0032155)
0.4	5.4	GO:0090544	BAF-type complex(GO:0090544)
0.4	21.2	GO:0031594	neuromuscular junction(GO:0031594)
0.4	80.5	GO:0005765	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4	0.8	GO:0005682	U5 snRNP(GO:0005682)
0.4	83.4	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.4	5.4	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.4	37.0	GO:0005814	centriole(GO:0005814)
0.4	87.5	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.4	83.6	GO:0005667	transcription factor complex(GO:0005667)
0.4	7.7	GO:0005776	autophagosome(GO:0005776)
0.4	13.4	GO:0000123	histone acetyltransferase complex(GO:0000123)
0.4	5.1	GO:0000421	autophagosome membrane(GO:0000421)
0.3	86.6	GO:0016607	nuclear speck(GO:0016607)
0.3	20.4	GO:0000776	kinetochore(GO:0000776)
0.3	2.1	GO:0042788	polysomal ribosome(GO:0042788)
0.3	16.0	GO:0030426	growth cone(GO:0030426)
0.3	20.4	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.3	6.5	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.3	4.7	GO:0030014	CCR4-NOT complex(GO:0030014)
0.2	5.0	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.2	5.0	GO:0015030	Cajal body(GO:0015030)
0.2	2.6	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.2	4.6	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.2	29.7	GO:0044306	neuron projection terminus(GO:0044306)
0.2	71.6	GO:0005768	endosome(GO:0005768)
0.2	14.9	GO:0032993	protein-DNA complex(GO:0032993)
0.1	53.0	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.1	9.5	GO:0000784	nuclear chromosome, telomeric region(GO:0000784)
0.1	1.5	GO:0098799	outer mitochondrial membrane protein complex(GO:0098799)
0.1	7.4	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	1.8	GO:1904115	axon cytoplasm(GO:1904115)
0.1	4.0	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.1	1.1	GO:0032039	integrator complex(GO:0032039)
0.0	0.6	GO:0060077	inhibitory synapse(GO:0060077)
0.0	5.8	GO:0043235	receptor complex(GO:0043235)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
24.8	74.5	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
24.4	97.4	GO:0042610	CD8 receptor binding(GO:0042610)
20.3	81.1	GO:0035877	death effector domain binding(GO:0035877)
17.5	52.4	GO:0004911	interleukin-2 receptor activity(GO:0004911)
13.9	97.5	GO:0035375	zymogen binding(GO:0035375)
13.8	41.5	GO:0034211	GTP-dependent protein kinase activity(GO:0034211)
13.8	55.2	GO:0045159	myosin II binding(GO:0045159)
13.4	134.3	GO:0019957	C-C chemokine binding(GO:0019957)
11.7	35.2	GO:0051916	granulocyte colony-stimulating factor binding(GO:0051916)
11.7	70.0	GO:0046624	sphingolipid transporter activity(GO:0046624)
11.5	103.9	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
11.4	68.2	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
11.1	55.4	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
10.6	31.8	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
10.1	70.4	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
10.0	60.0	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
8.8	229.3	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
8.2	49.2	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
8.0	24.0	GO:0001069	regulatory region RNA binding(GO:0001069)
7.5	37.4	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
7.3	43.9	GO:0030284	estrogen receptor activity(GO:0030284)
7.2	21.5	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
7.1	121.3	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
6.7	20.0	GO:0097677	STAT family protein binding(GO:0097677)
6.6	59.0	GO:0030957	Tat protein binding(GO:0030957)
6.4	19.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
6.3	31.6	GO:0061676	importin-alpha family protein binding(GO:0061676)
6.3	75.4	GO:0071933	Arp2/3 complex binding(GO:0071933)
6.1	36.5	GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
5.9	17.8	GO:0017089	glycolipid transporter activity(GO:0017089)
5.7	17.2	GO:0008384	IkappaB kinase activity(GO:0008384)
5.7	45.6	GO:0019958	C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
5.6	39.5	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
5.6	44.9	GO:0051525	NFAT protein binding(GO:0051525)
5.5	121.7	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
5.4	16.2	GO:0002114	interleukin-33 receptor activity(GO:0002114)
5.4	139.6	GO:0004190	aspartic-type endopeptidase activity(GO:0004190)
5.3	85.4	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
5.3	106.5	GO:0032794	GTPase activating protein binding(GO:0032794)
5.3	47.3	GO:1990948	ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
5.0	14.9	GO:0070506	high-density lipoprotein particle receptor activity(GO:0070506)
4.5	13.6	GO:0035800	deubiquitinase activator activity(GO:0035800)
4.5	9.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
4.4	26.3	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
4.3	34.2	GO:0001784	phosphotyrosine binding(GO:0001784)
4.2	12.6	GO:1990050	phosphatidic acid transporter activity(GO:1990050)
4.1	28.7	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
3.9	15.7	GO:0048408	epidermal growth factor binding(GO:0048408)
3.9	39.0	GO:0015386	potassium:proton antiporter activity(GO:0015386)
3.9	31.1	GO:0017070	U6 snRNA binding(GO:0017070)
3.8	15.2	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
3.8	37.9	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
3.8	30.3	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
3.8	112.5	GO:0042169	SH2 domain binding(GO:0042169)
3.7	59.6	GO:0051400	BH domain binding(GO:0051400)
3.7	18.6	GO:0001042	RNA polymerase I core binding(GO:0001042)
3.6	28.7	GO:0016936	galactoside binding(GO:0016936)
3.5	67.0	GO:0003993	acid phosphatase activity(GO:0003993)
3.5	34.8	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
3.4	17.2	GO:0070180	large ribosomal subunit rRNA binding(GO:0070180) 5.8S rRNA binding(GO:1990932)
3.3	20.0	GO:0016361	activin receptor activity, type I(GO:0016361)
3.3	13.3	GO:0050815	phosphoserine binding(GO:0050815)
3.3	9.8	GO:0016429	tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
3.2	12.6	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
3.1	9.4	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
3.1	21.6	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
3.1	61.6	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
3.1	45.8	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
3.0	30.4	GO:0070097	delta-catenin binding(GO:0070097)
3.0	33.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
3.0	12.0	GO:0043533	inositol hexakisphosphate binding(GO:0000822) inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
2.9	20.4	GO:0097322	7SK snRNA binding(GO:0097322)
2.9	26.1	GO:0001727	lipid kinase activity(GO:0001727)
2.9	8.7	GO:0016230	sphingomyelin phosphodiesterase activator activity(GO:0016230)
2.9	409.7	GO:0017124	SH3 domain binding(GO:0017124)
2.8	14.2	GO:0015616	DNA translocase activity(GO:0015616)
2.8	8.5	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
2.8	8.4	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
2.7	57.7	GO:0023026	MHC class II protein complex binding(GO:0023026)
2.7	8.0	GO:0032564	dATP binding(GO:0032564)
2.6	30.9	GO:0017166	vinculin binding(GO:0017166)
2.6	46.2	GO:0070064	proline-rich region binding(GO:0070064)
2.5	22.5	GO:0008409	5'-3' exonuclease activity(GO:0008409)
2.5	175.5	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
2.4	17.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
2.4	9.8	GO:0043120	tumor necrosis factor binding(GO:0043120)
2.4	29.1	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
2.4	12.1	GO:0001032	RNA polymerase III type 3 promoter DNA binding(GO:0001032)
2.3	51.6	GO:0004033	aldo-keto reductase (NADP) activity(GO:0004033)
2.3	9.4	GO:0008140	cAMP response element binding protein binding(GO:0008140)
2.3	49.1	GO:0005521	lamin binding(GO:0005521)
2.3	58.0	GO:0031489	myosin V binding(GO:0031489)
2.3	16.0	GO:1901612	cardiolipin binding(GO:1901612)
2.3	45.5	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
2.2	81.7	GO:0022829	wide pore channel activity(GO:0022829)
2.2	13.1	GO:0051022	Rho GDP-dissociation inhibitor binding(GO:0051022)
2.2	21.6	GO:0102336	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
2.1	12.8	GO:0034191	apolipoprotein A-I receptor binding(GO:0034191)
2.1	10.5	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
1.9	526.6	GO:0030695	GTPase regulator activity(GO:0030695)
1.9	53.2	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
1.9	11.2	GO:0004340	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
1.9	9.3	GO:0032767	copper-exporting ATPase activity(GO:0004008) copper-dependent protein binding(GO:0032767) copper-transporting ATPase activity(GO:0043682)
1.9	11.2	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
1.9	63.0	GO:0008009	chemokine activity(GO:0008009)
1.8	9.2	GO:0046966	thyroid hormone receptor binding(GO:0046966)
1.8	81.7	GO:0017080	sodium channel regulator activity(GO:0017080)
1.8	21.6	GO:0050897	cobalt ion binding(GO:0050897)
1.8	16.0	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
1.8	17.7	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.8	56.7	GO:1990841	promoter-specific chromatin binding(GO:1990841)
1.8	35.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
1.7	30.2	GO:0004697	protein kinase C activity(GO:0004697)
1.7	59.9	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.7	8.3	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.6	13.2	GO:0017049	GTP-Rho binding(GO:0017049)
1.6	8.2	GO:0030348	syntaxin-3 binding(GO:0030348)
1.6	39.0	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
1.6	17.8	GO:0008641	small protein activating enzyme activity(GO:0008641)
1.6	75.2	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
1.6	64.8	GO:0030544	Hsp70 protein binding(GO:0030544)
1.6	11.0	GO:0050700	CARD domain binding(GO:0050700)
1.6	4.7	GO:0008169	C-methyltransferase activity(GO:0008169)
1.6	12.4	GO:0032036	myosin heavy chain binding(GO:0032036)
1.5	16.5	GO:0000295	adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346)
1.5	6.0	GO:0009019	tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
1.5	17.7	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
1.5	14.5	GO:0070300	phosphatidic acid binding(GO:0070300)
1.4	8.6	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
1.4	14.3	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.4	12.9	GO:1990825	sequence-specific mRNA binding(GO:1990825)
1.4	5.6	GO:0070568	guanylyltransferase activity(GO:0070568)
1.4	15.4	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
1.4	28.9	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
1.3	68.2	GO:0019843	rRNA binding(GO:0019843)
1.3	13.3	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
1.3	21.2	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
1.3	27.4	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
1.3	14.2	GO:0051011	microtubule minus-end binding(GO:0051011)
1.3	53.8	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
1.3	7.7	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
1.3	81.8	GO:0004004	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
1.3	2.5	GO:0055100	adiponectin binding(GO:0055100)
1.2	53.2	GO:0016684	peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
1.2	8.6	GO:0043024	ribosomal small subunit binding(GO:0043024)
1.2	22.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
1.2	3.6	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)
1.2	33.8	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
1.2	24.0	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
1.2	178.8	GO:0051015	actin filament binding(GO:0051015)
1.2	3.5	GO:0019961	interferon binding(GO:0019961)
1.2	419.5	GO:0005525	GTP binding(GO:0005525)
1.2	47.3	GO:1990782	protein tyrosine kinase binding(GO:1990782)
1.2	8.1	GO:1990446	U1 snRNP binding(GO:1990446)
1.2	12.7	GO:0042577	lipid phosphatase activity(GO:0042577)
1.1	12.6	GO:0017160	Ral GTPase binding(GO:0017160)
1.1	4.5	GO:0004082	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
1.1	6.7	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
1.1	65.2	GO:0035064	methylated histone binding(GO:0035064)
1.1	38.5	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
1.1	7.4	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
1.0	7.3	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
1.0	4.1	GO:0097001	interleukin-4 receptor binding(GO:0005136) ceramide binding(GO:0097001)
1.0	4.1	GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
1.0	5.1	GO:0050733	RS domain binding(GO:0050733)
1.0	4.0	GO:0001093	TFIIB-class transcription factor binding(GO:0001093)
1.0	41.0	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
1.0	6.9	GO:0034452	dynactin binding(GO:0034452)
1.0	26.7	GO:0003697	single-stranded DNA binding(GO:0003697)
1.0	3.9	GO:0005522	profilin binding(GO:0005522)
1.0	23.6	GO:0008527	taste receptor activity(GO:0008527)
1.0	53.2	GO:0004386	helicase activity(GO:0004386)
1.0	35.5	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.9	7.5	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
0.9	3.7	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.9	2.8	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.9	9.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.9	53.4	GO:0004527	exonuclease activity(GO:0004527)
0.9	19.8	GO:0030515	snoRNA binding(GO:0030515)
0.9	36.9	GO:0005044	scavenger receptor activity(GO:0005044)
0.9	3.5	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.8	6.8	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.8	33.3	GO:0004180	carboxypeptidase activity(GO:0004180)
0.8	1.6	GO:0004629	phospholipase C activity(GO:0004629)
0.8	23.6	GO:0001221	transcription cofactor binding(GO:0001221)
0.7	2.2	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.7	3.7	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.7	12.9	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.7	33.9	GO:0031491	nucleosome binding(GO:0031491)
0.7	13.3	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.7	14.6	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.7	2.0	GO:0004827	proline-tRNA ligase activity(GO:0004827)
0.7	32.5	GO:0000049	tRNA binding(GO:0000049)
0.6	20.7	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.6	243.8	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.6	19.7	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.6	15.5	GO:0042162	telomeric DNA binding(GO:0042162)
0.6	3.1	GO:0008318	protein prenyltransferase activity(GO:0008318)
0.6	22.5	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.6	1.8	GO:0016882	cyclo-ligase activity(GO:0016882)
0.6	2.3	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.6	11.1	GO:0004559	alpha-mannosidase activity(GO:0004559)
0.5	2.2	GO:0019003	GDP binding(GO:0019003)
0.5	9.0	GO:0005537	mannose binding(GO:0005537)
0.5	2.1	GO:0002046	opsin binding(GO:0002046)
0.5	52.7	GO:0004702	receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.5	5.5	GO:0008242	omega peptidase activity(GO:0008242)
0.5	14.3	GO:0005080	protein kinase C binding(GO:0005080)
0.5	132.2	GO:0003712	transcription cofactor activity(GO:0003712)
0.5	16.9	GO:0019894	kinesin binding(GO:0019894)
0.5	22.7	GO:0005057	receptor signaling protein activity(GO:0005057)
0.4	2.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.4	11.8	GO:0031369	translation initiation factor binding(GO:0031369)
0.4	45.8	GO:0017016	Ras GTPase binding(GO:0017016)
0.4	8.2	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.4	9.2	GO:0043236	laminin binding(GO:0043236)
0.4	6.4	GO:0008094	DNA-dependent ATPase activity(GO:0008094)
0.4	3.4	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.4	4.8	GO:0015643	toxic substance binding(GO:0015643)
0.4	5.2	GO:0002162	dystroglycan binding(GO:0002162)
0.4	9.1	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.4	12.0	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.4	2.5	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.4	12.2	GO:0003684	damaged DNA binding(GO:0003684)
0.4	7.2	GO:0050699	WW domain binding(GO:0050699)
0.4	6.0	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.4	8.4	GO:0000030	mannosyltransferase activity(GO:0000030)
0.3	30.3	GO:0008565	protein transporter activity(GO:0008565)
0.3	9.0	GO:0051219	phosphoprotein binding(GO:0051219)
0.3	2.1	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.3	1.4	GO:0016303	1-phosphatidylinositol-3-kinase activity(GO:0016303) phosphatidylinositol 3-kinase activity(GO:0035004)
0.3	7.6	GO:0030145	manganese ion binding(GO:0030145)
0.3	2.7	GO:0031490	chromatin DNA binding(GO:0031490)
0.3	20.3	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.3	18.0	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.3	0.8	GO:0000386	second spliceosomal transesterification activity(GO:0000386)
0.3	33.8	GO:0019902	phosphatase binding(GO:0019902)
0.3	8.6	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3	26.6	GO:0008022	protein C-terminus binding(GO:0008022)
0.3	13.9	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.3	5.8	GO:0035254	glutamate receptor binding(GO:0035254)
0.3	2.1	GO:0008494	translation activator activity(GO:0008494)
0.3	1.8	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.3	18.6	GO:0005262	calcium channel activity(GO:0005262)
0.2	33.1	GO:0008168	methyltransferase activity(GO:0008168)
0.2	30.8	GO:0004866	endopeptidase inhibitor activity(GO:0004866)
0.2	233.0	GO:0003723	RNA binding(GO:0003723)
0.2	123.5	GO:0044212	transcription regulatory region DNA binding(GO:0044212)
0.2	1.3	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832)
0.2	1.0	GO:0097602	cullin family protein binding(GO:0097602)
0.2	2.9	GO:0017127	cholesterol transporter activity(GO:0017127)
0.2	2.4	GO:0046875	ephrin receptor binding(GO:0046875)
0.1	1.7	GO:0008179	adenylate cyclase binding(GO:0008179)
0.1	0.4	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1	2.9	GO:0008013	beta-catenin binding(GO:0008013)
0.1	1.7	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1	19.5	GO:0005126	cytokine receptor binding(GO:0005126)
0.1	1.6	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1	5.6	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.0	0.4	GO:0032183	SUMO binding(GO:0032183)
0.0	3.4	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0	8.7	GO:0046982	protein heterodimerization activity(GO:0046982)
0.0	0.9	GO:0005507	copper ion binding(GO:0005507)
0.0	0.2	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
12.4	819.1	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
7.9	230.2	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
7.4	81.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
6.8	123.0	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
6.6	124.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
5.6	96.0	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
5.6	50.4	PID S1P S1P4 PATHWAY	S1P4 pathway
5.1	242.0	PID AURORA B PATHWAY	Aurora B signaling
5.0	69.7	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
4.8	116.3	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
4.8	52.9	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
4.5	99.9	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
4.0	76.7	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
3.6	72.8	PID GMCSF PATHWAY	GMCSF-mediated signaling events
3.6	64.6	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
3.6	131.7	PID BCR 5PATHWAY	BCR signaling pathway
3.5	187.4	PID RAC1 PATHWAY	RAC1 signaling pathway
3.5	62.3	PID IL23 PATHWAY	IL23-mediated signaling events
3.3	71.7	PID CD40 PATHWAY	CD40/CD40L signaling
3.2	22.1	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
3.1	74.5	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
3.1	61.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
3.0	90.8	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
3.0	66.5	PID IL2 1PATHWAY	IL2-mediated signaling events
3.0	111.6	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
3.0	62.9	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
2.8	110.7	PID ILK PATHWAY	Integrin-linked kinase signaling
2.6	37.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
2.3	51.1	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
2.2	123.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein
2.1	36.2	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
2.0	12.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
2.0	40.5	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
2.0	72.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
1.8	20.1	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
1.8	8.8	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
1.6	74.9	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
1.5	85.2	PID CMYB PATHWAY	C-MYB transcription factor network
1.5	55.4	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
1.5	96.2	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
1.3	17.1	PID MYC PATHWAY	C-MYC pathway
1.3	52.1	PID P53 REGULATION PATHWAY	p53 pathway
1.3	53.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
1.1	7.8	PID TRAIL PATHWAY	TRAIL signaling pathway
1.0	24.3	PID RHOA PATHWAY	RhoA signaling pathway
1.0	4.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.9	15.1	PID ATM PATHWAY	ATM pathway
0.8	6.6	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.8	9.0	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.7	33.0	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.7	26.2	PID E2F PATHWAY	E2F transcription factor network
0.7	24.3	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.7	14.0	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.6	3.8	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.6	8.7	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.6	8.7	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.5	15.5	PID FANCONI PATHWAY	Fanconi anemia pathway
0.4	101.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	1.6	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.4	2.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.3	23.4	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.3	13.5	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.3	5.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.3	9.5	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.3	8.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.3	3.7	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.3	11.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.3	6.8	PID IL4 2PATHWAY	IL4-mediated signaling events
0.3	4.0	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.2	5.9	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.2	17.7	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	5.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	8.2	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.2	4.0	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	4.5	PID LKB1 PATHWAY	LKB1 signaling events
0.1	28.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	1.8	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	2.3	PID PLK1 PATHWAY	PLK1 signaling events
0.1	1.4	PID ARF6 PATHWAY	Arf6 signaling events
0.1	2.1	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
35.5	390.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
11.0	176.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
10.8	421.7	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
8.9	98.3	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
7.9	94.6	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
7.5	330.0	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
6.9	27.5	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
6.8	47.8	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
6.4	172.6	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
5.9	76.9	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
5.4	16.3	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
4.8	82.0	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
4.6	45.5	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
4.4	136.9	REACTOME KINESINS	Genes involved in Kinesins
4.2	58.4	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
4.1	116.0	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
4.1	94.4	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
4.0	193.8	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
3.9	15.6	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
3.0	9.0	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
2.8	290.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
2.8	30.8	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
2.5	80.9	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
2.4	46.5	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
2.4	14.5	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
2.4	40.8	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
2.4	177.4	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
2.4	25.9	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
2.2	22.0	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
2.2	15.2	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
2.0	177.0	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
2.0	21.5	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1.9	64.2	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
1.8	91.3	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
1.7	58.8	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
1.7	29.4	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
1.7	25.4	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
1.7	45.1	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
1.7	31.6	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
1.6	11.5	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
1.6	6.5	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
1.5	37.0	REACTOME G1 PHASE	Genes involved in G1 Phase
1.5	20.0	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
1.4	14.0	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
1.3	20.5	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
1.3	8.8	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
1.2	72.1	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
1.2	9.6	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
1.2	14.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
1.2	42.7	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
1.1	16.9	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
1.1	20.0	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
1.1	19.3	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
1.0	35.1	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
1.0	22.1	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
1.0	51.6	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
1.0	9.8	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.9	21.1	REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.9	15.5	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.8	10.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.8	12.4	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.8	11.2	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.8	5.6	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.8	20.3	REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	Genes involved in 3' -UTR-mediated translational regulation
0.7	13.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.7	6.3	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.7	27.1	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.7	21.6	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.7	15.0	REACTOME RNA POL I TRANSCRIPTION INITIATION	Genes involved in RNA Polymerase I Transcription Initiation
0.6	10.3	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.6	13.1	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.6	8.6	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.6	14.8	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.5	13.0	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.5	35.5	REACTOME TOLL RECEPTOR CASCADES	Genes involved in Toll Receptor Cascades
0.5	8.8	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.5	14.7	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.5	30.3	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.4	26.4	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.4	9.4	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.4	8.5	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.3	7.5	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3	6.9	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.3	3.7	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.3	6.1	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.2	4.6	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2	2.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.2	8.6	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.2	8.7	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.2	2.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	9.9	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	1.8	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.1	10.6	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	1.9	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.1	2.7	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.1	13.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.1	1.4	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.1	1.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	0.8	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0	1.4	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.0	2.7	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.0	0.3	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS

Results for Ets1

Z-value: 2.58

Motif logo

Transcription factors associated with Ets1

Activity-expression correlation:

Activity profile of Ets1 motif

Sorted Z-values of Ets1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Ets1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: