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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Ets1
Z-value: 2.58
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Transcription factors associated with Ets1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ets1 | rn6_v1_chr8_+_33816386_33816386 | 0.81 | 8.5e-76 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_198662610 Show fit | 212.60 |
ENSRNOT00000055012
|
septin 1 |
|
| chr13_+_89774764 Show fit | 165.17 |
ENSRNOT00000005619
|
Rho GTPase activating protein 30 |
|
| chr1_+_198744050 Show fit | 149.82 |
ENSRNOT00000024404
|
integrin subunit alpha L |
|
| chr1_+_219403970 Show fit | 114.23 |
ENSRNOT00000029607
|
protein tyrosine phosphatase, receptor type, C-associated protein |
|
| chr1_-_198577226 Show fit | 113.22 |
ENSRNOT00000055013
|
sialophorin |
|
| chr15_+_57221292 Show fit | 110.12 |
ENSRNOT00000014502
|
lymphocyte cytosolic protein 1 |
|
| chr13_+_50164563 Show fit | 106.05 |
ENSRNOT00000029533
|
lymphocyte transmembrane adaptor 1 |
|
| chr1_+_201620642 Show fit | 97.48 |
ENSRNOT00000093674
|
deleted in malignant brain tumors 1 |
|
| chr5_-_147761983 Show fit | 97.43 |
ENSRNOT00000012936
|
LCK proto-oncogene, Src family tyrosine kinase |
|
| chr10_+_11810926 Show fit | 96.78 |
ENSRNOT00000036205
ENSRNOT00000036189 |
NLR family, CARD domain containing 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ets1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 448.0 | GO:0050851 | antigen receptor-mediated signaling pathway(GO:0050851) |
| 0.9 | 410.0 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 27.4 | 274.2 | GO:0046645 | positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) |
| 70.9 | 212.6 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
| 8.6 | 154.5 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 15.0 | 149.8 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 28.3 | 141.3 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 7.3 | 139.4 | GO:0097284 | hepatocyte apoptotic process(GO:0097284) |
| 16.5 | 132.3 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 2.9 | 126.0 | GO:0072676 | lymphocyte migration(GO:0072676) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 532.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 12.1 | 422.4 | GO:0001772 | immunological synapse(GO:0001772) |
| 5.6 | 276.4 | GO:0002102 | podosome(GO:0002102) |
| 14.2 | 212.6 | GO:0072687 | meiotic spindle(GO:0072687) |
| 26.4 | 210.8 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 1.6 | 146.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.9 | 140.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 15.2 | 136.9 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 12.0 | 132.0 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 1.3 | 130.0 | GO:0005884 | actin filament(GO:0005884) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 526.6 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 1.2 | 419.5 | GO:0005525 | GTP binding(GO:0005525) |
| 2.9 | 409.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.6 | 243.8 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.2 | 233.0 | GO:0003723 | RNA binding(GO:0003723) |
| 8.8 | 229.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 1.2 | 178.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 2.5 | 175.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 5.4 | 139.6 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) |
| 13.4 | 134.3 | GO:0019957 | C-C chemokine binding(GO:0019957) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.4 | 819.1 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 5.1 | 242.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 7.9 | 230.2 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 3.5 | 187.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 3.6 | 131.7 | PID BCR 5PATHWAY | BCR signaling pathway |
| 6.6 | 124.5 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 2.2 | 123.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 6.8 | 123.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 4.8 | 116.3 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 3.0 | 111.6 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.8 | 421.7 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 35.5 | 390.2 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 7.5 | 330.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 2.8 | 290.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 4.0 | 193.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 2.4 | 177.4 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 2.0 | 177.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 11.0 | 176.1 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 6.4 | 172.6 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 4.4 | 136.9 | REACTOME KINESINS | Genes involved in Kinesins |