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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Esr2
Z-value: 1.57
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Transcription factors associated with Esr2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Esr2 | rn6_v1_chr6_-_99214251_99214251 | -0.54 | 1.1e-25 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_28066635 Show fit | 34.22 |
ENSRNOT00000005844
|
phenylalanine hydroxylase |
|
| chr20_-_12820466 Show fit | 33.76 |
ENSRNOT00000001699
|
formimidoyltransferase cyclodeaminase |
|
| chr20_-_9876008 Show fit | 32.53 |
ENSRNOT00000001537
|
trefoil factor 2 |
|
| chr10_-_62273119 Show fit | 31.91 |
ENSRNOT00000004322
|
serpin family F member 2 |
|
| chr8_-_50531423 Show fit | 30.71 |
ENSRNOT00000090985
ENSRNOT00000074942 |
apolipoprotein C3 |
|
| chr20_-_14193690 Show fit | 28.89 |
ENSRNOT00000058237
|
beta-ureidopropionase 1 |
|
| chr10_-_77512032 Show fit | 28.59 |
ENSRNOT00000003295
|
phosphatidylcholine transfer protein |
|
| chr3_-_55587946 Show fit | 27.67 |
ENSRNOT00000075107
|
ATP binding cassette subfamily B member 11 |
|
| chr6_-_138093643 Show fit | 27.54 |
ENSRNOT00000045874
|
immunoglobulin heavy chain 6 |
|
| chr15_+_18710492 Show fit | 27.51 |
ENSRNOT00000012532
|
deoxyribonuclease 1-like 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Esr2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.4 | 121.0 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 16.4 | 65.7 | GO:0010901 | regulation of very-low-density lipoprotein particle remodeling(GO:0010901) |
| 7.8 | 62.5 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 7.3 | 58.4 | GO:1902222 | L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222) |
| 1.7 | 57.0 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 5.8 | 52.3 | GO:0046618 | drug export(GO:0046618) |
| 1.2 | 51.1 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.0 | 50.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 5.0 | 49.5 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 2.7 | 49.5 | GO:0042832 | defense response to protozoan(GO:0042832) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 204.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 193.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.5 | 150.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.5 | 128.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.5 | 110.3 | GO:0045095 | keratin filament(GO:0045095) |
| 0.9 | 107.1 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.2 | 101.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 7.6 | 98.3 | GO:0042627 | chylomicron(GO:0042627) |
| 4.3 | 85.7 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 9.5 | 76.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 437.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.1 | 121.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 2.6 | 93.2 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 3.5 | 89.9 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 3.6 | 85.5 | GO:0070330 | aromatase activity(GO:0070330) |
| 2.2 | 67.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.3 | 66.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.0 | 63.9 | GO:0020037 | heme binding(GO:0020037) |
| 4.2 | 58.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 4.5 | 54.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 231.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 2.1 | 114.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 3.6 | 111.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.0 | 79.9 | PID BCR 5PATHWAY | BCR signaling pathway |
| 1.5 | 64.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 1.1 | 44.9 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.6 | 40.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.3 | 40.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.8 | 31.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.5 | 28.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 252.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 5.1 | 87.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 1.8 | 79.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.9 | 75.9 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 7.2 | 71.9 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 3.7 | 70.0 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 1.3 | 66.1 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 2.1 | 63.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 1.3 | 60.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 3.0 | 59.6 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |