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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Esr1

Z-value: 1.89

Motif logo

Transcription factors associated with Esr1

Gene Symbol Gene ID Gene Info
ENSRNOG00000019358 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Esr1rn6_v1_chr1_+_41325462_41325531-0.263.5e-06Click!

Activity profile of Esr1 motif

Sorted Z-values of Esr1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_138250089 103.03 ENSRNOT00000048378
immunoglobulin heavy constant mu
chr3_-_17081510 70.59 ENSRNOT00000063862

chr3_+_19495628 64.51 ENSRNOT00000077990
immunoglobulin kappa variable 4-57
chr17_-_31780120 56.83 ENSRNOT00000058388

chr3_+_16817051 55.09 ENSRNOT00000071666

chr6_-_138249382 52.84 ENSRNOT00000085678
ENSRNOT00000006912
immunoglobulin heavy constant mu
chr3_+_18706988 48.42 ENSRNOT00000074650

chr6_-_140102325 48.10 ENSRNOT00000072238

chr7_-_118840634 43.71 ENSRNOT00000031568
apolipoprotein L 11a
chr7_-_107391184 40.06 ENSRNOT00000056793
transmembrane protein 71
chr3_+_16753703 40.05 ENSRNOT00000077741

chr5_-_152324469 39.50 ENSRNOT00000020688
CD52 molecule
chr4_+_98457810 39.06 ENSRNOT00000074175

chr6_-_137664133 37.91 ENSRNOT00000018613
G protein-coupled receptor 132
chr7_+_70614617 37.88 ENSRNOT00000035382
Rho GTPase activating protein 9
chr1_-_219438779 37.14 ENSRNOT00000029237
TBC1 domain family, member 10C
chr15_-_34647421 36.56 ENSRNOT00000072426
mast cell protease 8
chr12_+_19680712 36.22 ENSRNOT00000081310

chr3_+_19045214 35.12 ENSRNOT00000070878

chr9_-_16795887 34.21 ENSRNOT00000071609
Cd79a molecule-like
chr1_+_81763614 33.91 ENSRNOT00000027254
CD79a molecule
chr3_-_16750564 33.58 ENSRNOT00000084111

chr4_-_103369224 33.32 ENSRNOT00000075709

chr15_-_34625121 32.33 ENSRNOT00000073555
mast cell protease 8-like 2
chr1_-_85317968 32.28 ENSRNOT00000026891
glia maturation factor, gamma
chrX_+_96991658 32.07 ENSRNOT00000049969

chr20_+_3945601 31.95 ENSRNOT00000075342
RT1 class II, locus DMb
chr3_+_19174027 31.32 ENSRNOT00000074445

chr15_-_28081465 30.85 ENSRNOT00000033739
ribonuclease, RNase A family, 6
chr6_-_139997537 30.73 ENSRNOT00000073207

chr16_-_75481115 30.69 ENSRNOT00000035128
defensin alpha 7
chr4_+_106323089 30.08 ENSRNOT00000091402

chr3_+_19441604 29.93 ENSRNOT00000090581

chr20_+_4039413 28.39 ENSRNOT00000082136
RT1 class II, locus Bb
chr3_-_123631109 27.30 ENSRNOT00000091493
sialic acid binding Ig like lectin 1
chr1_-_98521551 27.13 ENSRNOT00000081922
sialic acid binding Ig-like lectin 10
chr3_-_2853272 26.97 ENSRNOT00000023022
ficolin A
chr11_+_85618714 26.50 ENSRNOT00000074614

chr4_+_101645731 26.36 ENSRNOT00000087901

chr2_+_87418517 26.11 ENSRNOT00000048046
tyrosine-protein phosphatase non-receptor type substrate 1-like
chr15_-_34479741 26.07 ENSRNOT00000027759
receptor-interacting serine-threonine kinase 3
chr11_+_85508300 25.96 ENSRNOT00000038646

chr6_-_138852571 25.81 ENSRNOT00000081803

chr3_-_16537433 25.75 ENSRNOT00000048523

chr9_+_9761536 25.65 ENSRNOT00000074247
tumor necrosis factor superfamily member 14
chr3_-_16753987 25.48 ENSRNOT00000091257

chr19_-_37907714 25.04 ENSRNOT00000026361
chymotrypsin-like
chr1_+_64074231 24.81 ENSRNOT00000077327
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like
chr5_+_151172206 24.58 ENSRNOT00000013778
FGR proto-oncogene, Src family tyrosine kinase
chr11_-_60547201 24.03 ENSRNOT00000093151
B and T lymphocyte associated
chr4_+_14151343 23.97 ENSRNOT00000061687
ENSRNOT00000076573
ENSRNOT00000077219
ENSRNOT00000008319
CD36 molecule
chr10_-_87067456 23.94 ENSRNOT00000014163
C-C motif chemokine receptor 7
chr10_+_45258887 23.93 ENSRNOT00000048642
butyrophilin like 10
chr10_-_66858598 23.78 ENSRNOT00000018898
ecotropic viral integration site 2B
chr14_-_71814523 23.77 ENSRNOT00000004094
bone marrow stromal cell antigen 1
chr6_-_139142218 23.47 ENSRNOT00000006975
Immunoglobulin heavy chain (gamma polypeptide)
chr1_-_99587205 23.44 ENSRNOT00000048947
sialic acid binding Ig-like lectin 8
chr4_+_14070553 23.35 ENSRNOT00000077505
CD36 molecule
chr5_-_160383782 23.33 ENSRNOT00000018349
chymotrypsin-like elastase family, member 2A
chr6_-_142676432 22.73 ENSRNOT00000074947

chr1_-_169534896 22.57 ENSRNOT00000082645
tripartite motif-containing 30C
chr16_+_20027348 22.14 ENSRNOT00000034589
family with sequence similarity 129, member C
chr1_+_63842277 21.95 ENSRNOT00000087957
ENSRNOT00000080820
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3A
chr20_-_9876008 21.94 ENSRNOT00000001537
trefoil factor 2
chr9_-_9675110 21.92 ENSRNOT00000073294
vav guanine nucleotide exchange factor 1
chr15_+_32811135 21.91 ENSRNOT00000067689

chr4_-_103145058 21.91 ENSRNOT00000073076

chr20_-_5179217 21.78 ENSRNOT00000065940
ENSRNOT00000092443
leukocyte specific transcript 1
chr7_-_18793289 21.77 ENSRNOT00000036375

chr4_+_102351036 21.75 ENSRNOT00000079277

chr3_-_80012750 21.72 ENSRNOT00000018154
nuclear receptor subfamily 1, group H, member 3
chr3_+_17107861 21.48 ENSRNOT00000043097

chr12_-_21923281 21.38 ENSRNOT00000075641
similar to cell surface receptor FDFACT
chr11_-_60546997 21.09 ENSRNOT00000083124
ENSRNOT00000050092
B and T lymphocyte associated
chr1_+_64506735 20.94 ENSRNOT00000086331
NLR family, pyrin domain containing 12
chr6_-_138772736 20.93 ENSRNOT00000071492

chr20_-_27682861 20.80 ENSRNOT00000057317
family with sequence similarity 26, member F
chr2_+_186555632 20.79 ENSRNOT00000052347
Fc receptor-like 1
chr10_-_29026002 20.75 ENSRNOT00000005070
pituitary tumor-transforming 1
chr8_+_96551245 20.33 ENSRNOT00000039850
BCL2-related protein A1
chr4_-_157252104 20.27 ENSRNOT00000082739
protein tyrosine phosphatase, non-receptor type 6
chr4_-_157252565 20.16 ENSRNOT00000079947
protein tyrosine phosphatase, non-receptor type 6
chr5_-_160405050 20.06 ENSRNOT00000081899
chymotrypsin C
chr17_-_12669573 19.94 ENSRNOT00000016942
ENSRNOT00000041726
spleen associated tyrosine kinase
chr3_+_19141133 19.88 ENSRNOT00000058323

chr4_+_119225040 19.82 ENSRNOT00000012365
bone morphogenetic protein 10
chr6_-_143590448 19.74 ENSRNOT00000056771
immunoglobulin heavy variable V8-4
chr1_-_73682247 19.53 ENSRNOT00000079498
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
chr11_+_85992696 19.46 ENSRNOT00000084433

chr6_-_138662365 19.26 ENSRNOT00000066209
ENSRNOT00000084892
immunoglobulin heavy constant mu
chr16_-_81309954 19.24 ENSRNOT00000092361
similar to RIKEN cDNA 1700029H14
chr1_+_101249522 19.15 ENSRNOT00000033882
solute carrier family 6, member 16
chr4_+_70614524 19.00 ENSRNOT00000041100
protease, serine 3
chr6_-_142993147 19.00 ENSRNOT00000044381
mCG1038839-like
chr20_-_4943564 18.93 ENSRNOT00000049310
RT1 class I, locus1
chr6_+_138432550 18.85 ENSRNOT00000056829
a disintegrin and metallopeptidase domain 6
chr3_+_16413080 18.69 ENSRNOT00000040386
Ig kappa chain V19-17-like
chr3_+_19366370 18.64 ENSRNOT00000086557

chr13_-_27653839 18.43 ENSRNOT00000071638
signal-regulatory protein alpha-like
chr8_-_66893083 18.41 ENSRNOT00000037028
ENSRNOT00000091755
kinesin family member 23
chr7_-_54778848 18.41 ENSRNOT00000005399
GLI pathogenesis-related 1
chr6_+_139209936 17.94 ENSRNOT00000087620

chr17_-_44793927 17.86 ENSRNOT00000086309
histone cluster 1 H2B family member o
chr15_-_34670217 17.82 ENSRNOT00000049315
mast cell protease 8
chr6_-_140485913 17.80 ENSRNOT00000048463

chr10_-_31493419 17.79 ENSRNOT00000009211
IL2-inducible T-cell kinase
chr5_-_155252003 17.68 ENSRNOT00000017060
complement C1q B chain
chr10_-_34242985 17.60 ENSRNOT00000046438
similar to novel protein
chr1_+_247562202 17.51 ENSRNOT00000021614
programmed cell death 1 ligand 2
chr6_+_139158334 17.40 ENSRNOT00000089227

chr9_+_112293388 17.37 ENSRNOT00000020767
mannosidase, alpha, class 2A, member 1
chr6_-_138685656 17.26 ENSRNOT00000041706

chr20_-_5166252 17.26 ENSRNOT00000001138
allograft inflammatory factor 1
chr13_-_89306219 17.23 ENSRNOT00000004183
ENSRNOT00000079247
Fc receptor-like A
chr9_-_54457753 17.13 ENSRNOT00000020032
signal transducer and activator of transcription 1
chr17_-_8429338 16.90 ENSRNOT00000016390
transforming growth factor, beta induced
chr17_-_31916553 16.86 ENSRNOT00000074220
uncharacterized LOC100911032
chr3_+_19690016 16.85 ENSRNOT00000085460

chr6_-_25211494 16.60 ENSRNOT00000009634
xanthine dehydrogenase
chr14_+_17195014 16.52 ENSRNOT00000031667
C-X-C motif chemokine ligand 11
chr20_-_3397039 16.50 ENSRNOT00000001084
ENSRNOT00000085259
protein phosphatase 1, regulatory subunit 18
chr9_-_52912293 16.48 ENSRNOT00000005228
solute carrier family 40 member 1
chr6_-_128727374 16.40 ENSRNOT00000082152
spectrin repeat containing, nuclear envelope family member 3
chr1_-_73399579 16.28 ENSRNOT00000077186
leukocyte immunoglobulin like receptor B4
chr16_-_31301880 16.26 ENSRNOT00000084847
ENSRNOT00000083943

chr10_-_70339578 16.10 ENSRNOT00000076618
schlafen family member 13
chr12_+_1903165 15.99 ENSRNOT00000083947

chr10_-_89900131 15.92 ENSRNOT00000028238
sclerostin
chr2_-_30458542 15.90 ENSRNOT00000072926
NLR family, apoptosis inhibitory protein 6
chr4_-_164536556 15.81 ENSRNOT00000087796
Ly49 inhibitory receptor 2
chr12_-_18274515 15.74 ENSRNOT00000078075
sialophorin-like
chr19_+_50045020 15.65 ENSRNOT00000090165
phospholipase C, gamma 2
chr4_-_163954817 15.58 ENSRNOT00000079951
immunoreceptor Ly49si3
chr14_+_46649971 15.54 ENSRNOT00000085875

chr4_-_157408176 15.50 ENSRNOT00000021915
Cd4 molecule
chr11_+_84506703 15.44 ENSRNOT00000066953
cytochrome P450, family 2, subfamily ab, polypeptide 1
chr7_+_125288081 15.44 ENSRNOT00000085216
parvin, gamma
chr6_+_139405966 15.42 ENSRNOT00000088974

chr20_-_30888735 15.40 ENSRNOT00000090004
ENSRNOT00000063875
ADAM metallopeptidase with thrombospondin type 1 motif, 14
chr15_-_34694180 15.40 ENSRNOT00000079505
ENSRNOT00000027950
ENSRNOT00000079782
ENSRNOT00000080221
mast cell protease 8
chr20_-_5166448 15.36 ENSRNOT00000076331
allograft inflammatory factor 1
chr3_+_171037957 15.34 ENSRNOT00000008764
RNA binding motif protein 38
chr15_+_32809069 15.33 ENSRNOT00000070848

chr19_-_10620671 15.25 ENSRNOT00000021842
C-C motif chemokine ligand 17
chr7_-_126701872 15.24 ENSRNOT00000041057
polycystin (PKD) family receptor for egg jelly
chr6_-_139637354 15.23 ENSRNOT00000072900
Ighg protein-like
chr11_+_67465236 15.22 ENSRNOT00000042374
stefin A2
chr11_+_84745904 15.16 ENSRNOT00000002617
kelch-like family member 6
chr5_-_138239306 15.14 ENSRNOT00000039305
erythroblast membrane-associated protein
chr7_-_14435967 15.13 ENSRNOT00000074801
peptidoglycan recognition protein 2
chr10_-_15125408 15.07 ENSRNOT00000026395
mesothelin
chr10_+_12046701 15.06 ENSRNOT00000011073
ENSRNOT00000084004
MEFV, pyrin innate immunity regulator
chr6_-_138068648 15.01 ENSRNOT00000081908
immunoglobulin heavy constant mu
chr11_+_85633243 14.98 ENSRNOT00000045807
Ig lambda chain V-VI region AR-like
chr3_+_19071980 14.94 ENSRNOT00000079487
immunoglobulin kappa variable 4-81
chr9_-_10897240 14.92 ENSRNOT00000074502
TNF alpha induced protein 8 like 1
chr4_-_28437676 14.84 ENSRNOT00000012995
HEPACAM family member 2
chr10_+_91254058 14.80 ENSRNOT00000087218
ENSRNOT00000065373
formin-like 1
chr1_-_173528943 14.63 ENSRNOT00000020393
NLR family, pyrin domain containing 10
chr3_+_19128400 14.58 ENSRNOT00000074272

chr5_-_166628028 14.53 ENSRNOT00000066179
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr10_-_75171774 14.52 ENSRNOT00000011735
eosinophil peroxidase
chr10_+_14689094 14.38 ENSRNOT00000036630
similar to implantation serine proteinase 2
chr6_-_138550417 14.37 ENSRNOT00000071945

chr18_+_56431820 14.33 ENSRNOT00000079360
ENSRNOT00000049357
colony stimulating factor 1 receptor
chr3_-_123630929 14.30 ENSRNOT00000028855
sialic acid binding Ig like lectin 1
chr20_-_4921348 14.24 ENSRNOT00000082497
ENSRNOT00000041151
RT1 class I, locus CE4
chr6_-_139710905 14.15 ENSRNOT00000077430

chr6_-_143131118 14.07 ENSRNOT00000074930

chr5_+_173460354 13.97 ENSRNOT00000038747
TNF receptor superfamily member 18
chr1_-_208020454 13.97 ENSRNOT00000038176
marker of proliferation Ki-67
chr3_-_105298108 13.94 ENSRNOT00000010994
Rho GTPase activating protein 11A
chr12_-_22126350 13.91 ENSRNOT00000076328
Sin3A-associated protein 25
chr2_-_250778269 13.89 ENSRNOT00000085670
ENSRNOT00000083535
ENSRNOT00000017824
chloride channel accessory 5
chr3_-_20457554 13.89 ENSRNOT00000074237

chr6_-_138764901 13.85 ENSRNOT00000075175

chr15_-_44411004 13.80 ENSRNOT00000031163
cell division cycle associated 2
chr6_-_138954741 13.74 ENSRNOT00000083278

chr13_-_83425641 13.45 ENSRNOT00000063870
T-box 19
chr12_+_19714324 13.43 ENSRNOT00000072303
similar to cell surface receptor FDFACT
chr1_+_100830064 13.36 ENSRNOT00000027320
interleukin 4 induced 1
chr1_-_190914610 13.33 ENSRNOT00000023189
cerebellar degeneration-related protein 2
chr18_+_12056113 13.25 ENSRNOT00000038450
desmoglein 4
chr1_-_47502952 13.15 ENSRNOT00000025580
T-cell activation RhoGTPase activating protein
chr20_-_2191640 13.12 ENSRNOT00000001016
tripartite motif-containing 10
chr1_+_63964155 12.93 ENSRNOT00000078512

chr15_+_52234563 12.85 ENSRNOT00000015169
receptor accessory protein 4
chr6_-_51498337 12.83 ENSRNOT00000012487
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr1_+_213040024 12.77 ENSRNOT00000050237
olfactory receptor 300
chr13_-_36101411 12.76 ENSRNOT00000074471
transmembrane protein 37
chr10_+_90192627 12.75 ENSRNOT00000080965
ENSRNOT00000065182
E2F1-inducible gene
chr13_+_92136290 12.73 ENSRNOT00000049819
olfactory receptor 1587
chr17_-_43614844 12.70 ENSRNOT00000023054
histone cluster 1 H1 family member a
chr8_+_116708027 12.69 ENSRNOT00000047309
actin-like 11
chr8_-_33661049 12.66 ENSRNOT00000068037
Fli-1 proto-oncogene, ETS transcription factor
chr6_+_139412328 12.56 ENSRNOT00000070810

chr7_+_118692851 12.55 ENSRNOT00000091911
apolipoprotein L3-like
chr20_-_3793985 12.50 ENSRNOT00000049540
ENSRNOT00000086293
RT1 class I, locus CE16
chr15_+_60084918 12.43 ENSRNOT00000012632
epithelial stromal interaction 1
chr1_+_226077120 12.38 ENSRNOT00000027611
RAB3A interacting protein-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Esr1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.5 46.6 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
10.9 32.6 GO:0014739 positive regulation of muscle hyperplasia(GO:0014739)
10.5 41.9 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
10.1 40.4 GO:0033277 abortive mitotic cell cycle(GO:0033277)
10.0 19.9 GO:0071226 cellular response to molecule of fungal origin(GO:0071226)
9.6 28.9 GO:2000449 regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449)
8.3 33.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
8.2 41.1 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
7.9 47.3 GO:0072564 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
7.8 23.5 GO:0001788 antibody-dependent cellular cytotoxicity(GO:0001788)
7.8 23.4 GO:0060101 negative regulation of phagocytosis, engulfment(GO:0060101)
7.1 28.4 GO:0002343 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
6.7 27.0 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
6.1 18.4 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
5.7 17.0 GO:0060128 corticotropin hormone secreting cell differentiation(GO:0060128)
5.3 15.9 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
5.2 15.5 GO:0035723 interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350)
4.9 48.8 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
4.8 14.5 GO:0002215 defense response to nematode(GO:0002215)
4.8 43.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)
4.7 14.0 GO:1990705 cholangiocyte proliferation(GO:1990705)
4.4 8.8 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
4.3 13.0 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
4.3 21.5 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
4.3 17.1 GO:0034240 negative regulation of macrophage fusion(GO:0034240)
4.2 25.0 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
4.1 12.4 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
4.1 16.5 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) divalent metal ion export(GO:0070839)
4.1 12.3 GO:0043316 cytotoxic T cell degranulation(GO:0043316) constitutive secretory pathway(GO:0045054)
4.0 19.8 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
3.8 15.1 GO:0032824 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
3.7 14.6 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
3.6 10.8 GO:0046601 positive regulation of centriole replication(GO:0046601)
3.5 31.6 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
3.4 10.3 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
3.3 10.0 GO:0046967 cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
3.3 16.6 GO:0009115 xanthine catabolic process(GO:0009115)
3.2 12.8 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
3.2 6.4 GO:0002238 response to molecule of fungal origin(GO:0002238)
3.0 15.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
2.9 8.8 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
2.9 14.3 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
2.8 8.5 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417)
2.8 11.3 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
2.7 27.3 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
2.7 8.2 GO:0008594 photoreceptor cell morphogenesis(GO:0008594)
2.7 5.4 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
2.7 10.7 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
2.7 5.3 GO:0032258 CVT pathway(GO:0032258)
2.6 2.6 GO:1904975 response to bleomycin(GO:1904975)
2.6 34.1 GO:0010818 T cell chemotaxis(GO:0010818)
2.6 26.1 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
2.6 10.4 GO:0002184 cytoplasmic translational termination(GO:0002184)
2.6 41.6 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
2.5 5.0 GO:0043133 hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
2.4 12.2 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
2.4 11.9 GO:0072719 cellular response to cisplatin(GO:0072719)
2.4 9.5 GO:0097278 complement-dependent cytotoxicity(GO:0097278)
2.3 9.3 GO:1904009 cellular response to monosodium glutamate(GO:1904009)
2.3 15.9 GO:0070269 pyroptosis(GO:0070269)
2.2 8.6 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
2.2 6.5 GO:0001543 ovarian follicle rupture(GO:0001543)
2.1 8.2 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
2.0 12.3 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
2.0 8.0 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
2.0 6.0 GO:0002337 B-1a B cell differentiation(GO:0002337)
1.9 5.8 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
1.9 5.8 GO:1904404 traversing start control point of mitotic cell cycle(GO:0007089) response to formaldehyde(GO:1904404)
1.9 5.7 GO:0046671 regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) negative regulation of retinal cell programmed cell death(GO:0046671) cellular response to fluoride(GO:1902618)
1.9 7.5 GO:0060279 positive regulation of ovulation(GO:0060279)
1.9 7.5 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
1.8 12.8 GO:0032252 secretory granule localization(GO:0032252)
1.8 5.5 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
1.8 43.9 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
1.8 7.2 GO:1904373 response to kainic acid(GO:1904373)
1.8 5.4 GO:0071283 cellular response to iron(III) ion(GO:0071283)
1.8 19.7 GO:0085020 protein K6-linked ubiquitination(GO:0085020)
1.8 5.3 GO:1902304 positive regulation of potassium ion export(GO:1902304)
1.8 5.3 GO:0072702 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to methyl methanesulfonate(GO:0072702) cellular response to methyl methanesulfonate(GO:0072703) response to environmental enrichment(GO:0090648) positive regulation of peptidyl-serine dephosphorylation(GO:1902310) response to gold nanoparticle(GO:1990268)
1.8 14.1 GO:0042989 sequestering of actin monomers(GO:0042989)
1.7 13.8 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
1.7 10.2 GO:0010360 negative regulation of anion channel activity(GO:0010360)
1.7 53.0 GO:0035458 cellular response to interferon-beta(GO:0035458)
1.7 8.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
1.7 66.2 GO:0050853 B cell receptor signaling pathway(GO:0050853)
1.6 17.8 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
1.6 17.8 GO:0001865 NK T cell differentiation(GO:0001865)
1.6 17.4 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
1.6 17.4 GO:0006013 mannose metabolic process(GO:0006013)
1.5 4.6 GO:0009227 nucleotide-sugar catabolic process(GO:0009227)
1.5 4.6 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077)
1.5 5.9 GO:2001274 negative regulation of glucose import in response to insulin stimulus(GO:2001274)
1.5 20.5 GO:0043306 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
1.4 4.3 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
1.4 7.1 GO:0006548 histidine catabolic process(GO:0006548)
1.4 1.4 GO:0032741 positive regulation of interleukin-18 production(GO:0032741)
1.4 7.0 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
1.4 1.4 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609)
1.4 4.2 GO:0043605 cellular amide catabolic process(GO:0043605)
1.4 8.3 GO:0071918 urea transmembrane transport(GO:0071918)
1.4 5.5 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
1.4 18.0 GO:0043312 neutrophil degranulation(GO:0043312)
1.4 4.1 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
1.4 17.8 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
1.3 14.8 GO:0051014 actin filament severing(GO:0051014)
1.3 4.0 GO:0009182 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
1.3 9.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
1.3 5.2 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
1.3 6.5 GO:0006751 glutathione catabolic process(GO:0006751)
1.3 8.9 GO:0006685 sphingomyelin catabolic process(GO:0006685)
1.3 3.8 GO:1905225 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) response to thyrotropin-releasing hormone(GO:1905225)
1.3 10.0 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
1.2 2.5 GO:0030824 negative regulation of cGMP metabolic process(GO:0030824)
1.2 2.5 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
1.2 3.7 GO:0033364 mast cell secretory granule organization(GO:0033364)
1.2 12.3 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
1.2 9.8 GO:0001955 blood vessel maturation(GO:0001955)
1.2 2.4 GO:0001546 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
1.2 8.5 GO:0007144 female meiosis I(GO:0007144)
1.2 10.8 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
1.2 3.6 GO:0010133 proline catabolic process to glutamate(GO:0010133)
1.2 9.5 GO:0050916 sensory perception of sweet taste(GO:0050916)
1.2 10.6 GO:0007603 phototransduction, visible light(GO:0007603)
1.2 3.5 GO:0060112 generation of ovulation cycle rhythm(GO:0060112)
1.2 4.7 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
1.2 3.5 GO:0016267 O-glycan processing, core 1(GO:0016267)
1.2 4.6 GO:0072709 cellular response to sorbitol(GO:0072709)
1.1 3.4 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
1.1 8.0 GO:0006477 protein sulfation(GO:0006477)
1.1 3.4 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
1.1 3.3 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
1.1 7.7 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
1.1 4.3 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
1.1 11.8 GO:0014883 transition between fast and slow fiber(GO:0014883)
1.1 6.4 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
1.0 4.2 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
1.0 3.1 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
1.0 3.1 GO:2000360 regulation of binding of sperm to zona pellucida(GO:2000359) negative regulation of binding of sperm to zona pellucida(GO:2000360)
1.0 9.4 GO:0060700 regulation of ribonuclease activity(GO:0060700)
1.0 7.3 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
1.0 9.3 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235)
1.0 10.4 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
1.0 12.4 GO:0002176 male germ cell proliferation(GO:0002176)
1.0 5.2 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) Golgi reassembly(GO:0090168)
1.0 5.1 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
1.0 6.1 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
1.0 7.0 GO:1990822 basic amino acid transmembrane transport(GO:1990822)
1.0 5.0 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
1.0 12.0 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
1.0 4.0 GO:2000813 negative regulation of barbed-end actin filament capping(GO:2000813)
1.0 8.9 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
1.0 9.8 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.0 5.8 GO:0061737 leukotriene signaling pathway(GO:0061737)
1.0 4.8 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
1.0 12.5 GO:0007076 mitotic chromosome condensation(GO:0007076)
1.0 2.9 GO:0032430 regulation of renal output by angiotensin(GO:0002019) positive regulation of phospholipase A2 activity(GO:0032430) phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.9 40.6 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.9 17.5 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.9 2.7 GO:0071724 response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.9 4.6 GO:1904717 regulation of AMPA glutamate receptor clustering(GO:1904717)
0.9 23.3 GO:0061436 establishment of skin barrier(GO:0061436)
0.9 3.6 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.9 3.6 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.9 3.5 GO:0061055 myotome development(GO:0061055)
0.9 3.4 GO:0060155 platelet dense granule organization(GO:0060155)
0.9 64.9 GO:0030593 neutrophil chemotaxis(GO:0030593)
0.8 10.2 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.8 2.5 GO:0010813 neuropeptide catabolic process(GO:0010813)
0.8 6.6 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.8 3.3 GO:0035772 interleukin-13-mediated signaling pathway(GO:0035772)
0.8 4.1 GO:0036233 glycine import(GO:0036233)
0.8 30.0 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.8 3.2 GO:0030576 Cajal body organization(GO:0030576)
0.8 4.8 GO:0060312 regulation of blood vessel remodeling(GO:0060312)
0.8 12.7 GO:0035855 megakaryocyte development(GO:0035855)
0.8 2.3 GO:0070084 protein initiator methionine removal(GO:0070084)
0.8 1.5 GO:0021747 cochlear nucleus development(GO:0021747)
0.8 12.2 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.7 2.2 GO:0030242 pexophagy(GO:0030242)
0.7 2.2 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.7 4.5 GO:0014042 positive regulation of neuron maturation(GO:0014042)
0.7 2.2 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.7 2.9 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.7 2.9 GO:0044211 CTP salvage(GO:0044211)
0.7 2.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.7 2.8 GO:0060178 regulation of exocyst localization(GO:0060178)
0.7 6.3 GO:0071415 cellular response to purine-containing compound(GO:0071415)
0.7 3.5 GO:0060346 bone trabecula formation(GO:0060346)
0.7 6.3 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.7 1.4 GO:0060468 prevention of polyspermy(GO:0060468)
0.7 2.7 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.7 2.7 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.7 6.7 GO:0071284 cellular response to lead ion(GO:0071284)
0.7 6.0 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.7 4.0 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.7 19.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.6 1.9 GO:0002877 regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
0.6 17.5 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.6 16.1 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.6 3.2 GO:0043652 engulfment of apoptotic cell(GO:0043652) phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.6 3.8 GO:0042256 mature ribosome assembly(GO:0042256)
0.6 7.6 GO:0007379 segment specification(GO:0007379)
0.6 3.1 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.6 5.0 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.6 2.5 GO:0014064 positive regulation of serotonin secretion(GO:0014064) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.6 3.0 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055) positive regulation of protein localization to nucleolus(GO:1904751)
0.6 7.8 GO:0036035 osteoclast development(GO:0036035)
0.6 13.2 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.6 3.0 GO:2001270 regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.6 7.7 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.6 10.5 GO:0097435 fibril organization(GO:0097435)
0.6 2.3 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.6 1.7 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.6 1.2 GO:0045415 negative regulation of interleukin-8 biosynthetic process(GO:0045415)
0.6 4.0 GO:0070417 cellular response to cold(GO:0070417)
0.6 5.1 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.6 7.7 GO:1900048 positive regulation of blood coagulation(GO:0030194) positive regulation of hemostasis(GO:1900048)
0.6 3.3 GO:0006528 asparagine metabolic process(GO:0006528)
0.6 8.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.5 1.6 GO:1990167 protein K27-linked deubiquitination(GO:1990167)
0.5 1.6 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.5 4.3 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.5 4.3 GO:0050862 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857) positive regulation of T cell receptor signaling pathway(GO:0050862)
0.5 5.4 GO:0099638 endosome to plasma membrane protein transport(GO:0099638)
0.5 7.3 GO:0036065 fucosylation(GO:0036065)
0.5 1.5 GO:0042732 D-xylose metabolic process(GO:0042732)
0.5 8.2 GO:0046415 urate metabolic process(GO:0046415)
0.5 4.5 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.5 7.2 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.5 4.8 GO:0006265 DNA topological change(GO:0006265)
0.5 8.0 GO:0030261 chromosome condensation(GO:0030261)
0.5 2.3 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.5 5.9 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.5 5.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.5 6.3 GO:0042832 defense response to protozoan(GO:0042832)
0.4 1.3 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.4 4.3 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.4 3.9 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.4 1.7 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.4 2.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.4 0.8 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.4 4.6 GO:0030259 lipid glycosylation(GO:0030259)
0.4 1.6 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.4 9.5 GO:0060046 regulation of acrosome reaction(GO:0060046)
0.4 1.2 GO:0021898 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.4 1.2 GO:1990164 histone H2A phosphorylation(GO:1990164)
0.4 2.8 GO:0051531 NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.4 4.8 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.4 2.0 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.4 2.8 GO:0000103 sulfate assimilation(GO:0000103)
0.4 7.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.4 50.5 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
0.4 1.6 GO:0070662 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) negative regulation of mast cell apoptotic process(GO:0033026) mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.4 2.3 GO:0006561 proline biosynthetic process(GO:0006561)
0.4 2.3 GO:0015866 ADP transport(GO:0015866)
0.4 6.9 GO:0006907 pinocytosis(GO:0006907)
0.4 1.9 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.4 5.3 GO:0033622 integrin activation(GO:0033622)
0.4 1.1 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.4 10.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 2.6 GO:0015722 canalicular bile acid transport(GO:0015722)
0.4 6.2 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.4 5.4 GO:0002675 positive regulation of acute inflammatory response(GO:0002675)
0.4 6.1 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)
0.4 4.3 GO:0035634 response to stilbenoid(GO:0035634)
0.4 1.4 GO:1904252 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.4 5.3 GO:0019835 cytolysis(GO:0019835)
0.4 3.5 GO:0017121 phospholipid scrambling(GO:0017121)
0.4 6.7 GO:0008210 estrogen metabolic process(GO:0008210)
0.3 0.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3 12.5 GO:0030199 collagen fibril organization(GO:0030199)
0.3 1.0 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.3 4.5 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.3 1.7 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.3 17.5 GO:0019882 antigen processing and presentation(GO:0019882)
0.3 4.0 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.3 9.0 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.3 7.6 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.3 79.2 GO:0016485 protein processing(GO:0016485)
0.3 7.2 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.3 1.0 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.3 3.9 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.3 2.6 GO:0006545 glycine biosynthetic process(GO:0006545)
0.3 1.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.3 1.3 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.3 2.5 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.3 3.8 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.3 5.3 GO:0048240 sperm capacitation(GO:0048240)
0.3 3.7 GO:0055015 ventricular cardiac muscle cell development(GO:0055015)
0.3 3.7 GO:0006921 cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.3 4.8 GO:2000678 negative regulation of transcription regulatory region DNA binding(GO:2000678)
0.3 4.2 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.3 2.7 GO:0032790 ribosome disassembly(GO:0032790)
0.3 1.2 GO:0043301 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301) negative regulation of mast cell degranulation(GO:0043305)
0.3 3.6 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.3 11.8 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.3 0.3 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.3 13.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.3 1.4 GO:0061450 trophoblast cell migration(GO:0061450)
0.3 8.0 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.3 1.7 GO:0098535 de novo centriole assembly(GO:0098535)
0.3 7.1 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.3 2.7 GO:0046085 adenosine metabolic process(GO:0046085)
0.3 2.7 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3 0.8 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.3 2.8 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.3 2.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 3.0 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.2 3.1 GO:0006783 heme biosynthetic process(GO:0006783)
0.2 6.6 GO:0006458 'de novo' protein folding(GO:0006458)
0.2 2.1 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.2 6.0 GO:0035902 response to immobilization stress(GO:0035902)
0.2 2.3 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of adherens junction organization(GO:1903392)
0.2 2.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 1.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 9.8 GO:0051225 spindle assembly(GO:0051225)
0.2 3.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 7.1 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.2 12.4 GO:0006342 chromatin silencing(GO:0006342)
0.2 0.2 GO:0034021 response to silicon dioxide(GO:0034021)
0.2 12.9 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.2 1.1 GO:0035766 cell chemotaxis to fibroblast growth factor(GO:0035766) endothelial cell chemotaxis to fibroblast growth factor(GO:0035768) branch elongation involved in ureteric bud branching(GO:0060681) regulation of cell chemotaxis to fibroblast growth factor(GO:1904847) regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000544)
0.2 9.4 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.2 2.5 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.2 3.3 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 3.3 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.2 1.7 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.2 0.8 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.2 1.4 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.2 1.2 GO:0043686 co-translational protein modification(GO:0043686)
0.2 3.9 GO:0035196 dsRNA fragmentation(GO:0031050) production of miRNAs involved in gene silencing by miRNA(GO:0035196) production of small RNA involved in gene silencing by RNA(GO:0070918)
0.2 4.5 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.2 2.9 GO:0019236 response to pheromone(GO:0019236)
0.2 1.3 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.2 21.8 GO:0002250 adaptive immune response(GO:0002250)
0.2 0.5 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.2 5.8 GO:0051290 protein heterotetramerization(GO:0051290)
0.2 0.5 GO:0098507 polynucleotide 5' dephosphorylation(GO:0098507)
0.2 1.4 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.2 1.0 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.2 2.0 GO:0070266 necroptotic process(GO:0070266)
0.2 4.4 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.2 0.7 GO:0009597 detection of virus(GO:0009597)
0.2 8.9 GO:0006334 nucleosome assembly(GO:0006334)
0.2 6.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.2 2.8 GO:0036159 inner dynein arm assembly(GO:0036159)
0.2 7.9 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.2 3.9 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2 3.7 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.2 0.8 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.2 1.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.2 0.6 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 3.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 9.2 GO:0001942 hair follicle development(GO:0001942) skin epidermis development(GO:0098773)
0.1 0.4 GO:0071692 sequestering of BMP in extracellular matrix(GO:0035582) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.1 0.4 GO:0033869 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.1 2.8 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.1 1.5 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.1 0.4 GO:1901550 regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
0.1 9.0 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.1 2.1 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.4 GO:0046061 dATP catabolic process(GO:0046061)
0.1 1.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 1.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 1.3 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 4.0 GO:0006278 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004)
0.1 25.0 GO:0007059 chromosome segregation(GO:0007059)
0.1 0.4 GO:0010041 response to iron(III) ion(GO:0010041)
0.1 1.1 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 1.1 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.1 5.3 GO:0046834 lipid phosphorylation(GO:0046834)
0.1 0.3 GO:0032472 Golgi calcium ion transport(GO:0032472)
0.1 0.7 GO:0033572 transferrin transport(GO:0033572)
0.1 4.0 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 6.0 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 0.2 GO:0072003 kidney rudiment formation(GO:0072003) nephric duct formation(GO:0072179) mesonephric duct morphogenesis(GO:0072180) mesonephric duct formation(GO:0072181)
0.1 1.1 GO:0055012 ventricular cardiac muscle cell differentiation(GO:0055012)
0.1 6.0 GO:0031016 pancreas development(GO:0031016)
0.1 0.8 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.1 0.9 GO:0007602 phototransduction(GO:0007602)
0.1 0.2 GO:0032429 negative regulation of phospholipase activity(GO:0010519) regulation of phospholipase A2 activity(GO:0032429)
0.1 0.5 GO:0055091 phospholipid homeostasis(GO:0055091)
0.1 1.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 3.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.3 GO:0000255 allantoin metabolic process(GO:0000255)
0.1 0.8 GO:1902065 response to L-glutamate(GO:1902065)
0.1 4.0 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 0.2 GO:0042350 GDP-L-fucose biosynthetic process(GO:0042350) GDP-L-fucose metabolic process(GO:0046368)
0.1 0.5 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 1.4 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043280)
0.1 1.0 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.4 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.2 GO:0060296 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.1 1.9 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 0.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.2 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.1 2.4 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 1.1 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.1 2.9 GO:0032092 positive regulation of protein binding(GO:0032092)
0.1 0.3 GO:0046654 brainstem development(GO:0003360) 'de novo' IMP biosynthetic process(GO:0006189) tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.1 GO:0032823 regulation of natural killer cell differentiation(GO:0032823)
0.1 0.8 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 1.6 GO:0060711 labyrinthine layer development(GO:0060711)
0.0 1.8 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.5 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 1.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 2.6 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 1.3 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.6 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.0 1.2 GO:0006405 RNA export from nucleus(GO:0006405)
0.0 0.1 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 0.2 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0042226 interleukin-6 biosynthetic process(GO:0042226)
0.0 0.9 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 0.8 GO:0045727 positive regulation of translation(GO:0045727)
0.0 0.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.0 0.3 GO:0016925 protein sumoylation(GO:0016925)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
13.5 53.9 GO:0019815 B cell receptor complex(GO:0019815)
6.8 27.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
5.1 40.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
4.9 19.7 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
4.8 28.9 GO:0097342 ripoptosome(GO:0097342)
4.8 14.3 GO:1990682 CSF1-CSF1R complex(GO:1990682)
4.6 18.4 GO:0097149 centralspindlin complex(GO:0097149)
4.4 70.3 GO:0042613 MHC class II protein complex(GO:0042613)
4.3 12.8 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
3.3 16.6 GO:0020003 symbiont-containing vacuole(GO:0020003)
3.1 18.8 GO:0033093 Weibel-Palade body(GO:0033093)
3.1 15.5 GO:0072557 IPAF inflammasome complex(GO:0072557)
2.9 8.8 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
2.6 10.5 GO:0000444 MIS12/MIND type complex(GO:0000444)
2.6 10.4 GO:0018444 translation release factor complex(GO:0018444)
2.3 34.8 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
2.2 27.0 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
2.2 10.8 GO:0098536 deuterosome(GO:0098536)
2.2 6.5 GO:0046691 intracellular canaliculus(GO:0046691)
2.0 13.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
1.8 5.3 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
1.7 8.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.6 25.5 GO:0042612 MHC class I protein complex(GO:0042612)
1.6 40.6 GO:0097225 sperm midpiece(GO:0097225)
1.5 4.6 GO:0070557 PCNA-p21 complex(GO:0070557)
1.5 28.3 GO:0031527 filopodium membrane(GO:0031527)
1.4 10.0 GO:0042825 TAP complex(GO:0042825)
1.4 19.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.3 2.5 GO:1990462 omegasome membrane(GO:1903349) omegasome(GO:1990462)
1.2 10.9 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
1.2 14.3 GO:0005861 troponin complex(GO:0005861)
1.2 9.3 GO:0005638 lamin filament(GO:0005638)
1.1 10.3 GO:0000813 ESCRT I complex(GO:0000813)
1.1 16.8 GO:1990023 mitotic spindle midzone(GO:1990023)
1.1 3.3 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
1.1 3.2 GO:0032173 septin collar(GO:0032173)
1.0 3.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
1.0 17.3 GO:0042581 specific granule(GO:0042581)
1.0 23.3 GO:0030057 desmosome(GO:0030057)
1.0 8.9 GO:1990075 periciliary membrane compartment(GO:1990075)
1.0 3.9 GO:0070876 SOSS complex(GO:0070876)
1.0 6.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.9 6.3 GO:0090543 Flemming body(GO:0090543)
0.9 4.5 GO:1903768 sweet taste receptor complex(GO:1903767) taste receptor complex(GO:1903768)
0.9 17.6 GO:0010369 chromocenter(GO:0010369)
0.9 40.2 GO:0016235 aggresome(GO:0016235)
0.8 12.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.8 5.8 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.8 2.5 GO:0044611 nuclear pore inner ring(GO:0044611)
0.8 4.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.7 3.0 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
0.7 222.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.7 4.4 GO:0089701 U2AF(GO:0089701)
0.7 4.3 GO:0097512 cardiac myofibril(GO:0097512)
0.7 5.0 GO:0036449 microtubule minus-end(GO:0036449)
0.7 7.1 GO:0070652 HAUS complex(GO:0070652)
0.7 4.7 GO:0001652 granular component(GO:0001652)
0.7 9.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.7 7.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.7 63.9 GO:0000786 nucleosome(GO:0000786)
0.6 15.5 GO:0005839 proteasome core complex(GO:0005839)
0.6 2.6 GO:0070552 BRISC complex(GO:0070552)
0.6 4.1 GO:0031415 NatA complex(GO:0031415)
0.6 1.7 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.6 3.4 GO:0031904 endosome lumen(GO:0031904)
0.5 3.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.5 12.6 GO:0001891 phagocytic cup(GO:0001891)
0.5 7.4 GO:0000800 lateral element(GO:0000800)
0.5 7.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.5 4.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.5 4.2 GO:0031983 vesicle lumen(GO:0031983)
0.4 27.8 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.4 4.5 GO:0005796 Golgi lumen(GO:0005796)
0.4 3.0 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.4 1.7 GO:0032044 DSIF complex(GO:0032044)
0.4 2.9 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.4 29.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 4.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.4 2.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.3 2.1 GO:0002081 outer acrosomal membrane(GO:0002081)
0.3 2.7 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.3 3.0 GO:0071821 FANCM-MHF complex(GO:0071821)
0.3 8.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.3 2.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.3 5.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.3 2.4 GO:0044613 nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615)
0.3 28.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 5.3 GO:0043196 varicosity(GO:0043196)
0.3 1.5 GO:0005642 annulate lamellae(GO:0005642)
0.3 2.0 GO:0036128 CatSper complex(GO:0036128)
0.3 1.4 GO:0071203 WASH complex(GO:0071203)
0.3 1.4 GO:0042587 glycogen granule(GO:0042587)
0.3 5.1 GO:0033391 chromatoid body(GO:0033391)
0.3 2.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.3 1.0 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.3 2.5 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 1.0 GO:0097422 tubular endosome(GO:0097422)
0.2 11.3 GO:0005801 cis-Golgi network(GO:0005801)
0.2 1.6 GO:0000796 condensin complex(GO:0000796)
0.2 5.6 GO:0000145 exocyst(GO:0000145)
0.2 1.1 GO:0048476 Holliday junction resolvase complex(GO:0048476) ERCC4-ERCC1 complex(GO:0070522)
0.2 1.5 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.2 1.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 5.2 GO:0042629 mast cell granule(GO:0042629)
0.2 3.4 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.2 1.4 GO:0045293 mRNA editing complex(GO:0045293)
0.2 7.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 14.2 GO:0005776 autophagosome(GO:0005776)
0.2 1.9 GO:0042555 MCM complex(GO:0042555)
0.2 4.5 GO:0046930 pore complex(GO:0046930)
0.2 0.5 GO:0097543 ciliary inversin compartment(GO:0097543)
0.2 3.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 1.4 GO:0032009 early phagosome(GO:0032009)
0.2 2.7 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1 3.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.4 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.1 1.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 6.9 GO:0005876 spindle microtubule(GO:0005876)
0.1 0.8 GO:0000125 PCAF complex(GO:0000125)
0.1 12.4 GO:0000793 condensed chromosome(GO:0000793)
0.1 0.8 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 2.8 GO:1990752 microtubule end(GO:1990752)
0.1 2.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 15.5 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 2.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.3 GO:0005859 muscle myosin complex(GO:0005859)
0.1 1.0 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.2 GO:0071564 npBAF complex(GO:0071564)
0.1 1.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 1.7 GO:0001520 outer dense fiber(GO:0001520)
0.1 10.2 GO:0030496 midbody(GO:0030496)
0.1 3.6 GO:0002102 podosome(GO:0002102)
0.1 1.0 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 1.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 4.0 GO:0015030 Cajal body(GO:0015030)
0.1 1.4 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 7.0 GO:0072562 blood microparticle(GO:0072562)
0.1 1.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.2 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.1 GO:0045120 pronucleus(GO:0045120)
0.1 1.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.4 GO:1990635 proximal dendrite(GO:1990635)
0.1 90.3 GO:0005615 extracellular space(GO:0005615)
0.1 1.3 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.4 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.8 GO:0032420 stereocilium(GO:0032420)
0.0 1.8 GO:0005814 centriole(GO:0005814)
0.0 1.5 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.2 GO:0045095 keratin filament(GO:0045095)
0.0 3.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.9 GO:0015934 large ribosomal subunit(GO:0015934)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.5 47.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
8.7 26.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
7.9 23.8 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
7.2 21.7 GO:0032810 sterol response element binding(GO:0032810)
5.2 26.1 GO:0019770 IgG receptor activity(GO:0019770)
4.6 9.2 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
4.5 40.4 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
4.5 13.4 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
4.3 51.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
3.8 15.1 GO:0016019 peptidoglycan receptor activity(GO:0016019)
3.6 14.3 GO:0031686 A1 adenosine receptor binding(GO:0031686)
3.3 10.0 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
3.3 16.6 GO:0016726 xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
3.3 16.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
3.3 9.9 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
3.1 12.3 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
3.0 27.0 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
2.9 8.8 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
2.8 19.8 GO:0031433 telethonin binding(GO:0031433)
2.8 8.4 GO:0001847 opsonin receptor activity(GO:0001847)
2.7 10.8 GO:0004949 cannabinoid receptor activity(GO:0004949)
2.6 10.6 GO:0019862 IgA binding(GO:0019862)
2.6 7.9 GO:0070976 TIR domain binding(GO:0070976)
2.6 15.5 GO:0042289 MHC class II protein binding(GO:0042289)
2.5 12.7 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
2.4 21.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
2.4 12.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
2.4 23.9 GO:0019957 C-C chemokine binding(GO:0019957)
2.2 20.0 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
2.2 28.4 GO:1990405 protein antigen binding(GO:1990405)
2.2 6.5 GO:0015203 polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489)
2.2 32.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
2.1 8.5 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
2.1 38.0 GO:0023026 MHC class II protein complex binding(GO:0023026)
2.1 8.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
2.0 6.0 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
2.0 43.8 GO:0042288 MHC class I protein binding(GO:0042288)
2.0 5.9 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
2.0 9.8 GO:0005111 type 1 fibroblast growth factor receptor binding(GO:0005105) type 2 fibroblast growth factor receptor binding(GO:0005111)
1.9 13.6 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
1.8 16.5 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
1.8 23.0 GO:0033691 sialic acid binding(GO:0033691)
1.7 13.9 GO:0030274 LIM domain binding(GO:0030274)
1.7 12.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
1.7 8.5 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
1.5 12.4 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
1.5 7.7 GO:0001729 ceramide kinase activity(GO:0001729)
1.5 4.6 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
1.5 9.0 GO:0016493 C-C chemokine receptor activity(GO:0016493)
1.5 8.8 GO:0032051 clathrin light chain binding(GO:0032051)
1.4 5.8 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
1.4 2.9 GO:0031711 bradykinin receptor binding(GO:0031711)
1.4 5.7 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
1.4 17.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.4 4.1 GO:0048408 epidermal growth factor binding(GO:0048408)
1.3 12.1 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
1.3 4.0 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
1.3 17.4 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
1.3 8.0 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
1.3 6.5 GO:0030348 syntaxin-3 binding(GO:0030348)
1.3 20.6 GO:0051400 BH domain binding(GO:0051400)
1.3 3.8 GO:0070053 thrombospondin receptor activity(GO:0070053)
1.3 5.0 GO:0015265 urea channel activity(GO:0015265)
1.2 7.4 GO:0000150 recombinase activity(GO:0000150)
1.2 3.6 GO:0004657 proline dehydrogenase activity(GO:0004657)
1.2 4.8 GO:0089720 caspase binding(GO:0089720)
1.2 5.8 GO:0004974 leukotriene receptor activity(GO:0004974)
1.2 12.8 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
1.2 3.5 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
1.1 3.4 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
1.1 3.4 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
1.1 4.5 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
1.1 4.5 GO:0005163 nerve growth factor receptor binding(GO:0005163)
1.1 3.3 GO:0015204 urea transmembrane transporter activity(GO:0015204)
1.1 5.4 GO:0045322 unmethylated CpG binding(GO:0045322)
1.1 4.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.0 9.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
1.0 225.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.0 21.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
1.0 19.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
1.0 27.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
1.0 2.9 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
1.0 5.8 GO:0019788 NEDD8 transferase activity(GO:0019788)
1.0 8.6 GO:0008494 translation activator activity(GO:0008494)
0.9 44.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.9 16.6 GO:0008009 chemokine activity(GO:0008009)
0.9 2.8 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.9 3.6 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.9 8.0 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.9 3.5 GO:0050682 AF-2 domain binding(GO:0050682)
0.9 10.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.9 2.6 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.9 4.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.8 14.8 GO:0032794 GTPase activating protein binding(GO:0032794)
0.8 16.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.8 4.8 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.8 2.3 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.8 7.7 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.7 3.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.7 2.9 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.7 8.6 GO:0008097 5S rRNA binding(GO:0008097)
0.7 3.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.7 29.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.7 2.8 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.7 18.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.7 2.7 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.7 3.4 GO:0031404 chloride ion binding(GO:0031404)
0.7 2.7 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.7 3.3 GO:0001007 transcription factor activity, RNA polymerase III transcription factor binding(GO:0001007) RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.7 7.4 GO:0039706 co-receptor binding(GO:0039706)
0.7 3.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.7 3.9 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.7 4.6 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.6 3.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.6 15.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.6 2.5 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056) corticotropin-releasing hormone receptor activity(GO:0043404)
0.6 31.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.6 3.6 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.6 3.0 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.6 7.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.6 7.7 GO:0004954 prostanoid receptor activity(GO:0004954)
0.6 4.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.6 2.9 GO:0004849 uridine kinase activity(GO:0004849)
0.6 8.2 GO:0019865 immunoglobulin binding(GO:0019865)
0.6 7.0 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.6 11.1 GO:0001614 purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.6 4.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.6 6.7 GO:0042809 vitamin D receptor binding(GO:0042809)
0.6 3.3 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.5 12.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.5 17.6 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.5 23.4 GO:0004601 peroxidase activity(GO:0004601)
0.5 1.6 GO:0005135 interleukin-3 receptor binding(GO:0005135)
0.5 2.1 GO:0032190 acrosin binding(GO:0032190)
0.5 2.5 GO:0008502 melatonin receptor activity(GO:0008502)
0.5 2.5 GO:0043426 MRF binding(GO:0043426)
0.5 54.8 GO:0004540 ribonuclease activity(GO:0004540)
0.5 2.9 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.5 6.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.5 5.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.5 6.1 GO:0043274 phospholipase binding(GO:0043274)
0.5 3.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.5 0.9 GO:0005131 growth hormone receptor binding(GO:0005131)
0.4 1.3 GO:0030984 kininogen binding(GO:0030984)
0.4 1.3 GO:0050145 uridylate kinase activity(GO:0009041) nucleoside phosphate kinase activity(GO:0050145)
0.4 4.4 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.4 1.3 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.4 2.2 GO:0070513 death domain binding(GO:0070513)
0.4 2.6 GO:0036374 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.4 6.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.4 2.9 GO:0031014 troponin T binding(GO:0031014)
0.4 3.3 GO:0030957 Tat protein binding(GO:0030957)
0.4 1.6 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.4 2.8 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.4 8.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 5.1 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.4 3.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.4 3.9 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.4 1.9 GO:0008420 CTD phosphatase activity(GO:0008420)
0.4 3.9 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.4 4.4 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.4 11.6 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.4 1.4 GO:0038132 neuregulin binding(GO:0038132)
0.3 10.1 GO:0003785 actin monomer binding(GO:0003785)
0.3 1.0 GO:0043398 HLH domain binding(GO:0043398)
0.3 7.8 GO:0015288 porin activity(GO:0015288)
0.3 7.4 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.3 10.2 GO:0042605 peptide antigen binding(GO:0042605)
0.3 1.3 GO:0019002 GMP binding(GO:0019002)
0.3 9.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.3 4.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.3 0.6 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.3 2.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 4.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.3 8.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 1.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.3 2.5 GO:0043515 kinetochore binding(GO:0043515)
0.3 3.3 GO:0004000 adenosine deaminase activity(GO:0004000)
0.3 8.8 GO:0050699 WW domain binding(GO:0050699)
0.3 6.1 GO:0019825 oxygen binding(GO:0019825)
0.3 2.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.3 11.6 GO:0015485 cholesterol binding(GO:0015485)
0.3 4.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 2.3 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.3 4.8 GO:0031005 filamin binding(GO:0031005)
0.3 9.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 1.2 GO:0005499 vitamin D binding(GO:0005499)
0.2 4.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 2.9 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.2 8.5 GO:0005504 fatty acid binding(GO:0005504)
0.2 2.2 GO:0009881 photoreceptor activity(GO:0009881)
0.2 16.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.2 23.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 2.6 GO:0017127 cholesterol transporter activity(GO:0017127)
0.2 4.5 GO:0008199 ferric iron binding(GO:0008199)
0.2 0.7 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.2 2.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.2 2.3 GO:0016004 phospholipase activator activity(GO:0016004)
0.2 5.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 4.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 5.1 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.2 8.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 0.8 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.2 1.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.2 4.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 4.3 GO:0070840 dynein complex binding(GO:0070840)
0.2 2.9 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 2.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 2.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 6.4 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.2 0.5 GO:0004651 polynucleotide 5'-phosphatase activity(GO:0004651)
0.2 1.7 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.2 1.2 GO:0004111 creatine kinase activity(GO:0004111)
0.2 0.8 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 1.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.2 3.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.4 GO:0016015 morphogen activity(GO:0016015)
0.1 0.5 GO:0016492 G-protein coupled neurotensin receptor activity(GO:0016492)
0.1 1.8 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 4.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 1.1 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 0.5 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1 0.4 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 7.5 GO:0019955 cytokine binding(GO:0019955)
0.1 7.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 2.6 GO:0005355 glucose transmembrane transporter activity(GO:0005355) hexose transmembrane transporter activity(GO:0015149)
0.1 28.2 GO:0030246 carbohydrate binding(GO:0030246)
0.1 1.1 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.3 GO:0051371 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.1 8.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 1.2 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.3 GO:0004903 growth hormone receptor activity(GO:0004903)
0.1 0.3 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 2.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 4.0 GO:0000049 tRNA binding(GO:0000049)
0.1 3.0 GO:0043022 ribosome binding(GO:0043022)
0.1 18.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 0.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 8.1 GO:0019902 phosphatase binding(GO:0019902)
0.1 1.7 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 7.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.0 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 0.2 GO:0030350 iron-responsive element binding(GO:0030350)
0.1 2.0 GO:0005109 frizzled binding(GO:0005109)
0.1 0.5 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.4 GO:0019208 phosphatase regulator activity(GO:0019208)
0.1 12.9 GO:0005096 GTPase activator activity(GO:0005096)
0.1 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.2 GO:0008254 3'-nucleotidase activity(GO:0008254)
0.1 0.8 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 2.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:0070401 NADP+ binding(GO:0070401)
0.0 5.2 GO:0005125 cytokine activity(GO:0005125)
0.0 1.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
0.0 0.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.6 GO:0043531 ADP binding(GO:0043531)
0.0 0.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0030619 U1 snRNA binding(GO:0030619)
0.0 0.1 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.0 1.0 GO:0017022 myosin binding(GO:0017022)
0.0 2.0 GO:0042393 histone binding(GO:0042393)
0.0 0.6 GO:0070491 repressing transcription factor binding(GO:0070491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 122.5 PID PI3KCI PATHWAY Class I PI3K signaling events
1.7 66.4 PID EPO PATHWAY EPO signaling pathway
1.4 21.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
1.4 10.9 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
1.3 54.2 PID BCR 5PATHWAY BCR signaling pathway
1.0 28.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
1.0 27.6 PID CD40 PATHWAY CD40/CD40L signaling
1.0 18.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.8 36.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.8 26.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.8 30.0 PID BARD1 PATHWAY BARD1 signaling events
0.8 19.8 PID IL23 PATHWAY IL23-mediated signaling events
0.7 9.5 PID TRAIL PATHWAY TRAIL signaling pathway
0.7 31.1 PID AURORA B PATHWAY Aurora B signaling
0.7 30.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.7 11.2 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.6 23.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.6 12.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.5 4.8 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.5 4.6 PID FAS PATHWAY FAS (CD95) signaling pathway
0.5 20.7 PID ATR PATHWAY ATR signaling pathway
0.5 5.0 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.5 9.5 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.5 13.2 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.5 9.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 19.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.4 10.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.4 3.8 ST GA12 PATHWAY G alpha 12 Pathway
0.4 6.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.4 15.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 3.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.4 8.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3 12.3 PID FGF PATHWAY FGF signaling pathway
0.3 11.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.3 7.6 ST GA13 PATHWAY G alpha 13 Pathway
0.3 1.7 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.3 5.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 4.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 28.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 0.8 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.2 5.8 PID PLK1 PATHWAY PLK1 signaling events
0.2 4.8 SIG CHEMOTAXIS Genes related to chemotaxis
0.2 45.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 1.3 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 2.6 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 0.9 PID IFNG PATHWAY IFN-gamma pathway
0.1 4.3 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 1.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 10.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.3 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.4 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.2 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.4 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 73.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
2.9 113.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
2.1 21.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
1.8 87.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.6 27.0 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
1.5 26.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
1.5 16.9 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.5 7.5 REACTOME HEMOSTASIS Genes involved in Hemostasis
1.4 17.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
1.4 15.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
1.3 12.7 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
1.2 10.8 REACTOME P75NTR SIGNALS VIA NFKB Genes involved in p75NTR signals via NF-kB
1.2 14.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
1.2 45.1 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
1.1 10.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
1.1 11.0 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
1.1 48.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.1 19.6 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
1.0 13.6 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
1.0 20.7 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.9 68.3 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.9 12.8 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.9 2.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.9 12.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.9 7.8 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.8 5.7 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.8 5.5 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.8 12.8 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.7 4.2 REACTOME DEFENSINS Genes involved in Defensins
0.7 17.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.7 17.9 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.7 9.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.7 4.6 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.6 7.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.6 9.9 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.6 5.8 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.5 4.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.5 21.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.5 12.8 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.5 5.3 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.5 11.1 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.5 22.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.5 8.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.5 10.3 REACTOME MEIOSIS Genes involved in Meiosis
0.5 48.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.5 1.8 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.5 12.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.4 4.9 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.4 47.9 REACTOME MITOTIC M M G1 PHASES Genes involved in Mitotic M-M/G1 phases
0.4 9.1 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 8.9 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.4 4.8 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.4 7.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.4 2.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.4 15.6 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.4 11.3 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.4 5.5 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.4 1.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.3 9.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.3 3.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 8.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 5.2 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.3 2.0 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.3 2.2 REACTOME OPSINS Genes involved in Opsins
0.3 3.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.3 5.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.3 4.8 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.3 13.1 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 6.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 4.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 2.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 4.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.2 10.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 3.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 4.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 24.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 7.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 5.1 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 3.3 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.1 2.8 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.1 2.7 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 5.3 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 2.0 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.1 2.7 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 0.7 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 3.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 3.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 0.1 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 1.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.9 REACTOME RNA POL III TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.1 0.3 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 2.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway