ISMARA results: Esr1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Esr1

Z-value: 1.89

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Transcription factors associated with Esr1

Gene Symbol	Gene ID	Gene Info
Esr1 NCBI RGD Ensembl	ENSRNOG00000019358	estrogen receptor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Esr1	rn6_v1_chr1_+_41325462_41325531	-0.26	3.5e-06	Click!

Activity profile of Esr1 motif

Sorted Z-values of Esr1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_138250089 Show fit	103.03	ENSRNOT00000048378	Ighm NCBI RGD Ensembl Show fit	immunoglobulin heavy constant mu
chr3_-_17081510 Show fit	70.59	ENSRNOT00000063862	AABR07051562.1 NCBI RGD Ensembl Show fit
chr3_+_19495628 Show fit	64.51	ENSRNOT00000077990	Igkv4-57 NCBI RGD Ensembl Show fit	immunoglobulin kappa variable 4-57
chr17_-_31780120 Show fit	56.83	ENSRNOT00000058388	AABR07027450.1 NCBI RGD Ensembl Show fit
chr3_+_16817051 Show fit	55.09	ENSRNOT00000071666	AABR07051550.1 NCBI RGD Ensembl Show fit
chr6_-_138249382 Show fit	52.84	ENSRNOT00000085678 ENSRNOT00000006912	Ighm NCBI RGD Ensembl Show fit	immunoglobulin heavy constant mu
chr3_+_18706988 Show fit	48.42	ENSRNOT00000074650	AABR07051652.1 NCBI RGD Ensembl Show fit
chr6_-_140102325 Show fit	48.10	ENSRNOT00000072238	AABR07065750.2 NCBI RGD Ensembl Show fit
chr7_-_118840634 Show fit	43.71	ENSRNOT00000031568	Apol11a NCBI RGD Ensembl Show fit	apolipoprotein L 11a
chr7_-_107391184 Show fit	40.06	ENSRNOT00000056793	Tmem71 NCBI RGD Ensembl Show fit	transmembrane protein 71

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Esr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	79.2	GO:0016485	protein processing(GO:0016485)
1.7	66.2	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.9	64.9	GO:0030593	neutrophil chemotaxis(GO:0030593)
1.7	53.0	GO:0035458	cellular response to interferon-beta(GO:0035458)
0.4	50.5	GO:0090501	RNA phosphodiester bond hydrolysis(GO:0090501)
4.9	48.8	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
7.9	47.3	GO:0072564	blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
15.5	46.6	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
1.8	43.9	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)
4.8	43.2	GO:0043031	negative regulation of macrophage activation(GO:0043031)

Showing 1 to 10 of 420 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	222.8	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	90.3	GO:0005615	extracellular space(GO:0005615)
4.4	70.3	GO:0042613	MHC class II protein complex(GO:0042613)
0.7	63.9	GO:0000786	nucleosome(GO:0000786)
13.5	53.9	GO:0019815	B cell receptor complex(GO:0019815)
1.6	40.6	GO:0097225	sperm midpiece(GO:0097225)
5.1	40.4	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.9	40.2	GO:0016235	aggresome(GO:0016235)
2.3	34.8	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.4	29.4	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)

Showing 1 to 10 of 158 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	225.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.5	54.8	GO:0004540	ribonuclease activity(GO:0004540)
4.3	51.9	GO:0034987	immunoglobulin receptor binding(GO:0034987)
9.5	47.3	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.9	44.6	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
2.0	43.8	GO:0042288	MHC class I protein binding(GO:0042288)
4.5	40.4	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
2.1	38.0	GO:0023026	MHC class II protein complex binding(GO:0023026)
2.2	32.3	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.6	31.5	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)

Showing 1 to 10 of 267 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	122.5	PID PI3KCI PATHWAY	Class I PI3K signaling events
1.7	66.4	PID EPO PATHWAY	EPO signaling pathway
1.3	54.2	PID BCR 5PATHWAY	BCR signaling pathway
0.2	45.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.8	36.1	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.7	31.1	PID AURORA B PATHWAY	Aurora B signaling
0.7	30.4	PID IL4 2PATHWAY	IL4-mediated signaling events
0.8	30.0	PID BARD1 PATHWAY	BARD1 signaling events
0.2	28.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
1.0	28.2	PID CXCR3 PATHWAY	CXCR3-mediated signaling events

Showing 1 to 10 of 57 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	113.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.8	87.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
4.9	73.4	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.9	68.3	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
1.1	48.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.5	48.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.4	47.9	REACTOME MITOTIC M M G1 PHASES	Genes involved in Mitotic M-M/G1 phases
1.2	45.1	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
1.6	27.0	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
1.5	26.1	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI

Showing 1 to 10 of 97 entries

Results for Esr1

Z-value: 1.89

Motif logo

Transcription factors associated with Esr1

Activity-expression correlation:

Activity profile of Esr1 motif

Sorted Z-values of Esr1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Esr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: