ISMARA results: Erg

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Erg

Z-value: 2.20

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Transcription factors associated with Erg

Gene Symbol	Gene ID	Gene Info
Erg NCBI RGD Ensembl	ENSRNOG00000001652	ERG, ETS transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Erg	rn6_v1_chr11_-_35749464_35749594	0.71	1.3e-50	Click!

Activity profile of Erg motif

Sorted Z-values of Erg motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_11077411 Show fit	126.34	ENSRNOT00000007117	S1pr4 NCBI RGD Ensembl Show fit	sphingosine-1-phosphate receptor 4
chr13_+_47602692 Show fit	96.83	ENSRNOT00000038822	Fcmr NCBI RGD Ensembl Show fit	Fc fragment of IgM receptor
chr13_+_89774764 Show fit	91.86	ENSRNOT00000005619	Arhgap30 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 30
chr11_+_84745904 Show fit	84.06	ENSRNOT00000002617	Klhl6 NCBI RGD Ensembl Show fit	kelch-like family member 6
chr14_-_43992587 Show fit	78.69	ENSRNOT00000003425	Rhoh NCBI RGD Ensembl Show fit	ras homolog family member H
chr11_-_66759402 Show fit	76.47	ENSRNOT00000003326	Hcls1 NCBI RGD Ensembl Show fit	hematopoietic cell specific Lyn substrate 1
chr4_-_163227242 Show fit	74.36	ENSRNOT00000091552 ENSRNOT00000077793	Clec7a NCBI RGD Ensembl Show fit	C-type lectin domain family 7, member A
chr2_-_190100276 Show fit	74.08	ENSRNOT00000015351	S100a9 NCBI RGD Ensembl Show fit	S100 calcium binding protein A9
chrX_+_134979646 Show fit	71.11	ENSRNOT00000006035	Sash3 NCBI RGD Ensembl Show fit	SAM and SH3 domain containing 3
chr7_-_107392972 Show fit	70.73	ENSRNOT00000093425	Tmem71 NCBI RGD Ensembl Show fit	transmembrane protein 71

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Erg

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
20.1	200.8	GO:0090500	endocardial cushion to mesenchymal transition(GO:0090500)
11.5	171.8	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
0.3	143.3	GO:0043547	positive regulation of GTPase activity(GO:0043547)
1.9	142.5	GO:0045576	mast cell activation(GO:0045576)
7.4	103.4	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
8.8	96.8	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
6.8	94.8	GO:0002467	germinal center formation(GO:0002467)
2.3	77.4	GO:0050853	B cell receptor signaling pathway(GO:0050853)
19.1	76.5	GO:0042509	regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
18.6	74.4	GO:0071226	cellular response to molecule of fungal origin(GO:0071226)

Showing 1 to 10 of 206 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	338.9	GO:0009897	external side of plasma membrane(GO:0009897)
7.6	265.6	GO:0001772	immunological synapse(GO:0001772)
0.6	228.4	GO:0005667	transcription factor complex(GO:0005667)
0.3	134.7	GO:0009986	cell surface(GO:0009986)
1.2	130.5	GO:0016605	PML body(GO:0016605)
14.6	116.7	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.7	89.3	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3	87.4	GO:0031012	extracellular matrix(GO:0031012)
0.7	75.3	GO:0005884	actin filament(GO:0005884)
7.2	65.2	GO:0042101	T cell receptor complex(GO:0042101)

Showing 1 to 10 of 105 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	334.2	GO:0017124	SH3 domain binding(GO:0017124)
0.3	226.6	GO:0044212	transcription regulatory region DNA binding(GO:0044212)
5.1	137.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
22.7	136.1	GO:0098821	activin receptor activity, type I(GO:0016361) BMP receptor activity(GO:0098821)
12.6	126.3	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
0.3	98.3	GO:0005525	GTP binding(GO:0005525)
0.4	91.6	GO:0005096	GTPase activator activity(GO:0005096)
5.0	90.7	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
9.7	87.7	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.3	82.3	GO:0030246	carbohydrate binding(GO:0030246)

Showing 1 to 10 of 126 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.8	379.7	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
2.7	171.7	PID RHOA REG PATHWAY	Regulation of RhoA activity
1.0	160.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
4.9	157.7	PID ALK1 PATHWAY	ALK1 signaling events
6.6	132.9	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
7.7	115.4	PID S1P S1P4 PATHWAY	S1P4 pathway
3.7	107.6	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
2.3	106.7	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
5.8	99.3	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
2.1	91.7	PID ENDOTHELIN PATHWAY	Endothelins

Showing 1 to 10 of 60 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	339.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
18.7	205.5	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.9	149.3	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
3.2	139.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
5.7	114.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
3.3	98.1	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.6	85.8	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
5.2	78.7	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.8	74.3	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.8	69.3	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+

Showing 1 to 10 of 61 entries

Results for Erg

Z-value: 2.20

Motif logo

Transcription factors associated with Erg

Activity-expression correlation:

Activity profile of Erg motif

Sorted Z-values of Erg motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Erg

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: