ISMARA results: Epas1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Epas1_Bcl3

Z-value: 1.98

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Transcription factors associated with Epas1_Bcl3

Gene Symbol	Gene ID	Gene Info
Epas1 NCBI RGD Ensembl	ENSRNOG00000021318	endothelial PAS domain protein 1
Bcl3 NCBI RGD Ensembl	ENSRNOG00000043416	B-cell CLL/lymphoma 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Bcl3	rn6_v1_chr1_-_80744831_80744831	-0.44	1.6e-16	Click!
Epas1	rn6_v1_chr6_+_10306405_10306508	0.28	2.4e-07	Click!

Activity profile of Epas1_Bcl3 motif

Sorted Z-values of Epas1_Bcl3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_-_18079560 Show fit	165.73	ENSRNOT00000072093	AABR07031533.1 NCBI RGD Ensembl Show fit
chr8_+_39305128 Show fit	154.75	ENSRNOT00000008285	Fez1 NCBI RGD Ensembl Show fit	fasciculation and elongation protein zeta 1
chr5_-_130085838 Show fit	119.52	ENSRNOT00000035252	Elavl4 NCBI RGD Ensembl Show fit	ELAV like RNA binding protein 4
chr7_+_45328105 Show fit	104.58	ENSRNOT00000029208 ENSRNOT00000090641	Slc6a15 NCBI RGD Ensembl Show fit	solute carrier family 6 member 15
chr2_-_179704629 Show fit	100.67	ENSRNOT00000083361 ENSRNOT00000077941	Gria2 NCBI RGD Ensembl Show fit	glutamate ionotropic receptor AMPA type subunit 2
chr10_+_80790168 Show fit	97.61	ENSRNOT00000073315 ENSRNOT00000075163	Car10 NCBI RGD Ensembl Show fit	carbonic anhydrase 10
chr2_+_18354542 Show fit	90.03	ENSRNOT00000042958	Hapln1 NCBI RGD Ensembl Show fit	hyaluronan and proteoglycan link protein 1
chr9_+_73334618 Show fit	89.05	ENSRNOT00000092717	Map2 NCBI RGD Ensembl Show fit	microtubule-associated protein 2
chr3_+_71210301 Show fit	88.11	ENSRNOT00000006504	Fam171b NCBI RGD Ensembl Show fit	family with sequence similarity 171, member B
chr2_-_257864385 Show fit	82.89	ENSRNOT00000072048	Ak5 NCBI RGD Ensembl Show fit	adenylate kinase 5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Epas1_Bcl3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
12.9	154.7	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
1.6	119.5	GO:0042220	response to cocaine(GO:0042220)
34.9	104.6	GO:0015820	leucine transport(GO:0015820)
4.6	100.7	GO:0060992	response to fungicide(GO:0060992)
2.4	89.1	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
6.5	84.1	GO:1990834	response to odorant(GO:1990834)
2.3	83.7	GO:1900449	regulation of glutamate receptor signaling pathway(GO:1900449)
27.4	82.2	GO:1990926	short-term synaptic potentiation(GO:1990926)
10.8	75.4	GO:0016185	synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
1.0	73.1	GO:0051965	positive regulation of synapse assembly(GO:0051965)

Showing 1 to 10 of 160 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	193.8	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.5	191.1	GO:0005874	microtubule(GO:0005874)
12.0	119.5	GO:0042788	polysomal ribosome(GO:0042788)
8.4	100.7	GO:0098839	postsynaptic density membrane(GO:0098839)
9.9	89.1	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.2	85.7	GO:0005815	microtubule organizing center(GO:0005815)
7.5	82.2	GO:0032009	early phagosome(GO:0032009)
0.4	76.5	GO:0070382	exocytic vesicle(GO:0070382)
25.1	75.4	GO:0098830	presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
2.7	71.1	GO:0033268	node of Ranvier(GO:0033268)

Showing 1 to 10 of 76 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.3	185.6	GO:0043015	gamma-tubulin binding(GO:0043015)
2.9	159.9	GO:0001786	phosphatidylserine binding(GO:0001786)
4.4	119.5	GO:0017091	AU-rich element binding(GO:0017091)
10.5	104.6	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
3.6	100.9	GO:0005540	hyaluronic acid binding(GO:0005540)
20.1	100.7	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
3.9	89.1	GO:0002162	dystroglycan binding(GO:0002162)
8.4	83.9	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
7.5	82.9	GO:0004017	adenylate kinase activity(GO:0004017)
1.3	63.0	GO:0030507	spectrin binding(GO:0030507)

Showing 1 to 10 of 124 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	132.2	PID LKB1 PATHWAY	LKB1 signaling events
2.3	100.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
2.0	97.7	PID NCADHERIN PATHWAY	N-cadherin signaling events
1.7	85.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
1.4	83.0	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
1.4	40.6	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
1.6	38.1	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	32.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.4	25.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.8	23.7	PID WNT SIGNALING PATHWAY	Wnt signaling network

Showing 1 to 10 of 29 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.7	139.2	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
3.9	86.2	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
4.1	82.9	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
2.4	62.4	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
1.2	59.2	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
2.1	56.3	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
1.6	48.9	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
2.8	47.7	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
1.1	46.2	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.2	42.3	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives

Showing 1 to 10 of 54 entries

Results for Epas1_Bcl3

Z-value: 1.98

Motif logo

Transcription factors associated with Epas1_Bcl3

Activity-expression correlation:

Activity profile of Epas1_Bcl3 motif

Sorted Z-values of Epas1_Bcl3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Epas1_Bcl3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: