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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Epas1_Bcl3

Z-value: 1.98

Motif logo

Transcription factors associated with Epas1_Bcl3

Gene Symbol Gene ID Gene Info
ENSRNOG00000021318 endothelial PAS domain protein 1
ENSRNOG00000043416 B-cell CLL/lymphoma 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Bcl3rn6_v1_chr1_-_80744831_80744831-0.441.6e-16Click!
Epas1rn6_v1_chr6_+_10306405_103065080.282.4e-07Click!

Activity profile of Epas1_Bcl3 motif

Sorted Z-values of Epas1_Bcl3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_18079560 165.73 ENSRNOT00000072093

chr8_+_39305128 154.75 ENSRNOT00000008285
fasciculation and elongation protein zeta 1
chr5_-_130085838 119.52 ENSRNOT00000035252
ELAV like RNA binding protein 4
chr7_+_45328105 104.58 ENSRNOT00000029208
ENSRNOT00000090641
solute carrier family 6 member 15
chr2_-_179704629 100.67 ENSRNOT00000083361
ENSRNOT00000077941
glutamate ionotropic receptor AMPA type subunit 2
chr10_+_80790168 97.61 ENSRNOT00000073315
ENSRNOT00000075163
carbonic anhydrase 10
chr2_+_18354542 90.03 ENSRNOT00000042958
hyaluronan and proteoglycan link protein 1
chr9_+_73334618 89.05 ENSRNOT00000092717
microtubule-associated protein 2
chr3_+_71210301 88.11 ENSRNOT00000006504
family with sequence similarity 171, member B
chr2_-_257864385 82.89 ENSRNOT00000072048
adenylate kinase 5
chr1_+_226435979 82.17 ENSRNOT00000048704
ENSRNOT00000036232
ENSRNOT00000035576
ENSRNOT00000036180
ENSRNOT00000036168
ENSRNOT00000047964
ENSRNOT00000036283
ENSRNOT00000007429
synaptotagmin 7
chr3_-_64554953 76.48 ENSRNOT00000067452
serine/arginine repetitive matrix protein 1-like
chr8_-_94563760 75.41 ENSRNOT00000032792
synaptosomal-associated protein 91
chrX_+_151103576 73.08 ENSRNOT00000015401
SLIT and NTRK-like family, member 2
chr15_-_52317219 62.56 ENSRNOT00000016555
dematin actin binding protein
chr14_+_99529284 59.07 ENSRNOT00000006897
ENSRNOT00000067134
V-set and transmembrane domain containing 2A
chr10_-_8498422 56.39 ENSRNOT00000082332
RNA binding protein, fox-1 homolog 1
chr4_+_21317695 56.18 ENSRNOT00000007572
glutamate metabotropic receptor 3
chr12_+_31934343 54.48 ENSRNOT00000011181
transmembrane protein 132D
chr3_+_97723901 53.05 ENSRNOT00000080416
metallophosphoesterase domain containing 2
chr1_+_192613372 50.69 ENSRNOT00000016632
calcium voltage-gated channel auxiliary subunit gamma 3
chr6_+_83083740 49.28 ENSRNOT00000007600
leucine rich repeat and fibronectin type III domain containing 5
chr15_-_14737704 48.47 ENSRNOT00000011307
synaptoporin
chr10_+_27973681 47.67 ENSRNOT00000004970
gamma-aminobutyric acid type A receptor beta 2 subunit
chrX_-_124464963 47.24 ENSRNOT00000036472
ENSRNOT00000077697
transmembrane protein 255A
chr7_-_93280009 47.22 ENSRNOT00000064877
sterile alpha motif domain containing 12
chr17_-_6244612 46.84 ENSRNOT00000042145
ENSRNOT00000090914
ENSRNOT00000082611
neurotrophic receptor tyrosine kinase 2
chr3_-_52510507 46.79 ENSRNOT00000091259
sodium voltage-gated channel alpha subunit 1
chr1_-_260992291 46.17 ENSRNOT00000035415
ENSRNOT00000034758
slit guidance ligand 1
chr4_+_161720501 44.49 ENSRNOT00000008196
ENSRNOT00000055886
nuclear receptor interacting protein 2
chr5_+_148661070 43.61 ENSRNOT00000056229
Sodium/potassium transporting ATPase interacting 1
chr4_-_144869919 43.37 ENSRNOT00000009066
SLIT-ROBO Rho GTPase activating protein 3
chrX_-_142131545 42.88 ENSRNOT00000077402
fibroblast growth factor 13
chr7_+_79638046 42.78 ENSRNOT00000029419
zinc finger protein, multitype 2
chr15_+_34187223 42.08 ENSRNOT00000024978
copine 6
chr10_-_85084850 42.02 ENSRNOT00000012462
TBK1 binding protein 1
chr5_+_31568419 41.17 ENSRNOT00000050137
matrix metallopeptidase 16
chr10_+_17261541 40.96 ENSRNOT00000005478
SH3 and PX domains 2B
chr8_-_110813000 40.62 ENSRNOT00000010634
Eph receptor B1
chr4_+_29978739 39.67 ENSRNOT00000011756
protein phosphatase 1, regulatory subunit 9A
chr9_+_73529612 38.56 ENSRNOT00000032430
unc-80 homolog, NALCN activator
chr18_+_56193978 38.09 ENSRNOT00000041533
ENSRNOT00000080177
calcium/calmodulin-dependent protein kinase II alpha
chr1_+_82174451 38.01 ENSRNOT00000027783
transmembrane protein 145
chr18_+_59748444 37.58 ENSRNOT00000024752
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr8_+_27777179 37.29 ENSRNOT00000009825
beta-1,3-glucuronyltransferase 1
chr1_-_212548730 35.66 ENSRNOT00000089729
calcyon neuron-specific vesicular protein
chr1_+_72860218 35.64 ENSRNOT00000024547
synaptotagmin 5
chr15_-_34550850 35.05 ENSRNOT00000027794
ENSRNOT00000090228
cerebellin 3 precursor
chr5_-_7941822 34.64 ENSRNOT00000079917
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr7_+_123168811 34.61 ENSRNOT00000007091
cold shock domain containing C2
chr20_+_3558827 34.26 ENSRNOT00000088130
discoidin domain receptor tyrosine kinase 1
chr8_+_97277456 32.98 ENSRNOT00000082757
RAS protein-specific guanine nucleotide-releasing factor 1
chr4_-_114853868 32.74 ENSRNOT00000090828
WD repeat domain 54
chr3_+_177225737 32.49 ENSRNOT00000045845
opioid related nociceptin receptor 1
chr1_+_170262156 32.18 ENSRNOT00000024077
ENSRNOT00000085395
cholecystokinin B receptor
chr5_+_136683592 31.51 ENSRNOT00000085527
solute carrier family 6 member 9
chr4_+_41364441 31.00 ENSRNOT00000087146
forkhead box P2
chr7_-_112833083 30.32 ENSRNOT00000006966
family with sequence similarity 135, member B
chr15_-_58711872 30.26 ENSRNOT00000058204
stress-associated endoplasmic reticulum protein family member 2
chr10_-_89700283 30.17 ENSRNOT00000028213
ets variant 4
chr5_-_62621737 30.00 ENSRNOT00000011573
gamma-aminobutyric acid type B receptor subunit 2
chr2_+_198721724 29.71 ENSRNOT00000043535
ankyrin repeat domain 34A
chr2_-_96668222 28.63 ENSRNOT00000016567
cAMP-dependent protein kinase inhibitor alpha
chr6_+_126434226 28.31 ENSRNOT00000090857
chromogranin A
chr3_-_82856171 28.18 ENSRNOT00000088555
similar to LOC387763 protein
chr6_-_39363367 28.18 ENSRNOT00000088687
ENSRNOT00000065531
family with sequence similarity 84, member A
chr19_+_50848736 28.09 ENSRNOT00000077053
cadherin 13
chr16_+_23668595 27.39 ENSRNOT00000067886
pleckstrin and Sec7 domain containing 3
chr1_+_29191192 27.30 ENSRNOT00000018718
hes-related family bHLH transcription factor with YRPW motif 2
chr4_-_160334910 27.06 ENSRNOT00000086772
protein arginine methyltransferase 8
chr5_-_145418992 26.80 ENSRNOT00000037128
gap junction protein, beta 4
chr8_+_408001 26.52 ENSRNOT00000046058
guanylate cyclase 1 soluble subunit alpha 2
chr5_-_62186372 26.08 ENSRNOT00000089789
coronin 2A
chr13_-_105141030 26.06 ENSRNOT00000003313
transforming growth factor, beta 2
chr1_+_89491654 25.96 ENSRNOT00000028632
leucine-rich repeat LGI family, member 4
chr1_+_80954858 25.59 ENSRNOT00000030440
zinc finger protein 112
chr5_-_34813116 25.55 ENSRNOT00000017479
Sodium/potassium transporting ATPase interacting 3
chr6_-_136145837 25.29 ENSRNOT00000015122
creatine kinase B
chr1_-_59732409 25.18 ENSRNOT00000014824
hyaluronan synthase 1
chr1_+_87248489 25.01 ENSRNOT00000028091
double PHD fingers 1
chr1_-_72727112 24.92 ENSRNOT00000031172
BR serine/threonine kinase 1
chr5_+_60809762 24.87 ENSRNOT00000016839
FERM and PDZ domain containing 1
chr13_-_49313940 24.36 ENSRNOT00000012190
contactin 2
chr3_+_171832500 24.23 ENSRNOT00000007554
VAMP associated protein B and C
chr4_+_22445414 24.04 ENSRNOT00000087657
ENSRNOT00000030224
RUN domain containing 3B
chr11_-_84008946 24.00 ENSRNOT00000037612
von Willebrand factor A domain containing 5B2
chr14_+_36071376 23.97 ENSRNOT00000082183
ligand of numb-protein X 1
chr10_-_90994437 23.71 ENSRNOT00000093167
glial fibrillary acidic protein
chr11_+_60383431 23.66 ENSRNOT00000093295
Cd200 molecule
chr8_-_84522588 23.35 ENSRNOT00000076213
muscular LMNA-interacting protein
chr4_-_125958112 22.71 ENSRNOT00000071315
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr2_-_181026024 22.34 ENSRNOT00000064930
guanylate cyclase 1 soluble subunit beta 3
chr2_+_236625357 21.97 ENSRNOT00000081248
3'-phosphoadenosine 5'-phosphosulfate synthase 1
chr18_-_37819097 21.93 ENSRNOT00000025880
dihydropyrimidinase-like 3
chr1_+_175586097 21.36 ENSRNOT00000024933
adenosine monophosphate deaminase 3
chr17_-_9792007 21.35 ENSRNOT00000021596
regulator of G-protein signaling 14
chr14_+_17534412 20.69 ENSRNOT00000079304
ENSRNOT00000046771
cyclin dependent kinase like 2
chr2_-_173563273 20.54 ENSRNOT00000081423
zinc finger, B-box domain containing
chr1_-_220729000 20.48 ENSRNOT00000027727
cystatin E/M
chr3_+_160207913 20.39 ENSRNOT00000014346
WNT1 inducible signaling pathway protein 2
chr5_-_58078545 20.33 ENSRNOT00000075777
ciliary neurotrophic factor receptor
chr5_-_160179978 20.08 ENSRNOT00000022820
solute carrier family 25, member 34
chr7_+_141326321 20.02 ENSRNOT00000088191
acid sensing ion channel subunit 1
chr18_+_17043903 20.00 ENSRNOT00000068139
formin homology 2 domain containing 3
chr20_-_31956649 19.95 ENSRNOT00000072429
hexokinase 1
chr3_-_54593306 19.85 ENSRNOT00000087122
serine threonine kinase 39
chr15_-_100348760 19.80 ENSRNOT00000085607

chr4_-_45332420 19.55 ENSRNOT00000083039
wingless-type MMTV integration site family member 2
chr7_-_76035096 19.23 ENSRNOT00000072255

chr2_+_58448917 18.42 ENSRNOT00000082562
RAN binding protein 3-like
chr1_-_89488223 17.89 ENSRNOT00000028624
FXYD domain-containing ion transport regulator 1
chr5_-_7874909 17.82 ENSRNOT00000064774
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_202432366 17.63 ENSRNOT00000027681
phospholipid phosphatase 4
chr15_-_13228607 17.57 ENSRNOT00000042010
ENSRNOT00000088214
protein tyrosine phosphatase, receptor type, G
chr10_-_44746549 17.46 ENSRNOT00000003841
family with sequence similarity 183, member B
chr15_+_108908607 17.39 ENSRNOT00000089455
Zic family member 2
chr9_+_82700468 17.03 ENSRNOT00000027227
inhibin alpha subunit
chr1_+_251633199 16.87 ENSRNOT00000084785

chr20_-_6500523 16.53 ENSRNOT00000000629
copine 5
chr19_-_46101250 16.48 ENSRNOT00000015874
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr7_+_83113672 16.18 ENSRNOT00000006783
thyrotropin releasing hormone receptor
chr4_-_117153907 16.14 ENSRNOT00000091374
RAB11 family interacting protein 5
chr7_-_118396728 16.03 ENSRNOT00000066431
RNA binding protein, fox-1 homolog 2
chr4_-_157372861 15.96 ENSRNOT00000021578
prolyl 3-hydroxylase 3
chr3_+_110442637 15.85 ENSRNOT00000010471
p21 (RAC1) activated kinase 6
chr10_+_90731148 15.67 ENSRNOT00000093604
ADAM metallopeptidase domain 11
chr6_+_102311116 15.67 ENSRNOT00000083433
arginase 2
chr5_-_68139199 15.66 ENSRNOT00000009987
phospholipid phosphatase related 1
chr10_+_10555337 15.40 ENSRNOT00000032495
similar to MGC45438 protein
chr2_+_239415046 15.25 ENSRNOT00000072196
CXXC finger protein 4
chr1_+_84328114 14.96 ENSRNOT00000028266
homeodomain interacting protein kinase 4
chr14_+_17064353 14.90 ENSRNOT00000003052
scavenger receptor class B, member 2
chr12_-_5682608 14.38 ENSRNOT00000076483
FRY microtubule binding protein
chr1_+_80953275 14.07 ENSRNOT00000087253
zinc finger protein 112
chr2_-_210726179 14.05 ENSRNOT00000025689
glutathione S-transferase, mu 7
chr15_+_52241801 13.83 ENSRNOT00000082639
HR, lysine demethylase and nuclear receptor corepressor
chr3_+_3767394 13.62 ENSRNOT00000067840
G-protein signaling modulator 1
chr13_-_92988137 13.35 ENSRNOT00000004803
gremlin 2, DAN family BMP antagonist
chr14_-_20920286 13.17 ENSRNOT00000004391
solute carrier family 4 member 4
chr14_-_21127868 13.05 ENSRNOT00000020608
ENSRNOT00000092172
RUN and FYVE domain containing 3
chr11_+_80736576 12.49 ENSRNOT00000047678
mannan-binding lectin serine peptidase 1
chr10_-_105628091 12.46 ENSRNOT00000016067
cytoglobin
chr7_-_123445613 12.33 ENSRNOT00000070937
shisa family member 8
chr10_-_89699836 11.99 ENSRNOT00000084311
ets variant 4
chr10_+_46783979 11.79 ENSRNOT00000005237
GID complex subunit 4
chr1_+_192379543 11.71 ENSRNOT00000078705
protein kinase C, beta
chr8_-_7426611 11.68 ENSRNOT00000031492
Rho GTPase activating protein 42
chr12_+_48598647 11.49 ENSRNOT00000000889
transmembrane protein 119
chr15_-_42898150 11.40 ENSRNOT00000030036
protein tyrosine kinase 2 beta
chr2_-_5579894 11.17 ENSRNOT00000020044
nuclear receptor subfamily 2, group F, member 1
chr10_-_88389347 11.09 ENSRNOT00000022695
kelch-like family member 11
chr15_+_102164751 10.95 ENSRNOT00000076400
glypican 6
chr1_+_140792049 10.87 ENSRNOT00000049681
aggrecan
chr1_+_219250265 10.73 ENSRNOT00000024353
double C2-like domains, gamma
chr1_+_80920747 10.48 ENSRNOT00000026077
zinc finger protein 180
chr9_-_44419998 10.39 ENSRNOT00000091397
ENSRNOT00000083747
testis specific 10
chr16_-_930527 10.34 ENSRNOT00000014787
spindlin 1
chr3_+_111160205 10.18 ENSRNOT00000019392
ChaC glutathione-specific gamma-glutamylcyclotransferase 1
chr1_-_266333105 9.92 ENSRNOT00000027093
ADP ribosylation factor like GTPase 3
chr7_+_71023976 9.77 ENSRNOT00000005679
tachykinin 3
chr8_-_45137893 9.71 ENSRNOT00000010743
similar to hypothetical protein FLJ23554
chr3_-_162872831 9.53 ENSRNOT00000008478
sulfatase 2
chrX_-_70978952 9.44 ENSRNOT00000076910
solute carrier family 7 member 3
chr1_+_165625058 9.39 ENSRNOT00000025104
RAB6A, member RAS oncogene family
chr5_+_16463597 9.25 ENSRNOT00000091550

chr14_+_104250617 9.25 ENSRNOT00000079874
sprouty-related, EVH1 domain containing 2
chr1_+_165625350 9.24 ENSRNOT00000087534
RAB6A, member RAS oncogene family
chr8_-_123829749 9.24 ENSRNOT00000090467

chr1_+_164502389 8.52 ENSRNOT00000043554
arrestin, beta 1
chr20_+_6102277 8.50 ENSRNOT00000033064
patatin-like phospholipase domain containing 1
chrX_-_123601100 8.33 ENSRNOT00000092546
ENSRNOT00000092301
septin 6
chr3_-_12029877 8.26 ENSRNOT00000022327
solute carrier family 2 member 8
chr5_+_148923098 8.07 ENSRNOT00000048781
syndecan 3
chr6_+_21708487 7.80 ENSRNOT00000087358

chr2_+_30094421 7.61 ENSRNOT00000082226

chr2_+_2694480 7.51 ENSRNOT00000083565

chr1_-_188895223 7.48 ENSRNOT00000032796
G protein-coupled receptor 139
chr16_-_755990 7.47 ENSRNOT00000013501
RNA polymerase III subunit A
chr9_-_20528879 7.37 ENSRNOT00000085293

chr17_-_9791781 7.32 ENSRNOT00000090536
regulator of G-protein signaling 14
chrX_+_135348436 6.95 ENSRNOT00000008868
RAB33A, member RAS oncogene family
chr6_-_111015598 6.91 ENSRNOT00000015046
zinc finger, DHHC-type containing 22
chr3_-_46153371 6.89 ENSRNOT00000085885
bromodomain adjacent to zinc finger domain, 2B
chr17_-_77687456 6.89 ENSRNOT00000045765
ENSRNOT00000081645
FERM domain containing 4A
chr1_-_154111725 6.80 ENSRNOT00000055488
coiled-coil domain containing 81
chr7_+_25808419 6.75 ENSRNOT00000091571
regulatory factor X4
chr3_+_138770574 6.51 ENSRNOT00000012510
ENSRNOT00000066986
D-tyrosyl-tRNA deacylase 1
chr1_+_100577056 6.49 ENSRNOT00000026992
napsin A aspartic peptidase
chr16_-_81583916 6.45 ENSRNOT00000026281
transmembrane and coiled-coil domain-containing protein 3
chr17_-_1085885 6.24 ENSRNOT00000026287
patched 1
chr7_+_97559841 6.18 ENSRNOT00000007326
zinc fingers and homeoboxes 2
chr20_+_47779056 6.09 ENSRNOT00000090015

chr10_-_74070266 6.08 ENSRNOT00000005987
clathrin heavy chain
chr10_+_14136883 5.82 ENSRNOT00000082295

chr10_+_37724915 5.75 ENSRNOT00000008477
voltage-dependent anion channel 1
chr2_+_93827504 5.60 ENSRNOT00000032059
peripheral myelin protein 2
chr6_+_135610743 5.59 ENSRNOT00000010906
Tnf receptor-associated factor 3
chr17_+_21490402 5.57 ENSRNOT00000020244
glial cells missing homolog 2
chr16_-_6675746 5.47 ENSRNOT00000025858
protein kinase C, delta
chr15_+_103344476 5.20 ENSRNOT00000013329
ENSRNOT00000077047
ENSRNOT00000078103
G protein-coupled receptor 180

Network of associatons between targets according to the STRING database.

First level regulatory network of Epas1_Bcl3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
34.9 104.6 GO:0015820 leucine transport(GO:0015820)
27.4 82.2 GO:1990926 short-term synaptic potentiation(GO:1990926)
15.6 62.6 GO:0070560 protein secretion by platelet(GO:0070560)
14.3 42.8 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
13.3 53.4 GO:0035910 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
12.9 154.7 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
12.5 37.6 GO:1990743 protein sialylation(GO:1990743)
11.8 59.1 GO:0070343 white fat cell proliferation(GO:0070343) positive regulation of fat cell proliferation(GO:0070346) regulation of white fat cell proliferation(GO:0070350)
11.5 46.2 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
10.8 75.4 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
9.6 28.7 GO:0010070 zygote asymmetric cell division(GO:0010070)
9.4 28.3 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
8.1 32.5 GO:1904059 regulation of locomotor rhythm(GO:1904059)
8.1 24.4 GO:0060167 clustering of voltage-gated potassium channels(GO:0045163) regulation of adenosine receptor signaling pathway(GO:0060167)
7.6 38.1 GO:0098970 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) NMDA selective glutamate receptor signaling pathway(GO:0098989) neurotransmitter receptor diffusion trapping(GO:0099628)
6.8 41.0 GO:0002051 osteoblast fate commitment(GO:0002051) positive regulation of adipose tissue development(GO:1904179)
6.7 46.8 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
6.6 19.9 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
6.6 46.3 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
6.6 39.7 GO:1900272 negative regulation of long-term synaptic potentiation(GO:1900272)
6.5 19.5 GO:1904953 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904953) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
6.5 84.1 GO:1990834 response to odorant(GO:1990834)
6.3 25.2 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
5.1 56.2 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
5.0 19.9 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
4.8 24.2 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725)
4.7 18.6 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
4.6 100.7 GO:0060992 response to fungicide(GO:0060992)
4.5 27.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
4.5 17.9 GO:1903797 positive regulation of inorganic anion transmembrane transport(GO:1903797)
4.5 13.4 GO:0060300 regulation of cytokine activity(GO:0060300)
4.4 31.0 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
4.3 17.4 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
4.1 20.3 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
4.0 23.7 GO:0010625 positive regulation of Schwann cell proliferation(GO:0010625) regulation of chaperone-mediated autophagy(GO:1904714)
3.9 11.7 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
3.9 11.7 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
3.8 11.4 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
3.6 46.8 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
3.6 14.4 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
3.5 17.6 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
3.4 47.7 GO:0071420 cellular response to histamine(GO:0071420)
3.4 40.6 GO:0021631 optic nerve morphogenesis(GO:0021631)
3.2 9.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
3.1 22.0 GO:0000103 sulfate assimilation(GO:0000103)
3.1 15.7 GO:0010958 regulation of amino acid import(GO:0010958)
3.1 34.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
3.0 6.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
3.0 23.7 GO:0043031 negative regulation of macrophage activation(GO:0043031)
2.9 31.5 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
2.9 20.0 GO:0050915 sensory perception of sour taste(GO:0050915)
2.8 25.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
2.8 22.3 GO:0019934 cGMP-mediated signaling(GO:0019934)
2.7 16.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
2.7 26.8 GO:0042048 olfactory behavior(GO:0042048)
2.6 28.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
2.4 17.0 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
2.4 89.1 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
2.3 56.4 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
2.3 83.7 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
2.3 32.2 GO:0032230 positive regulation of synaptic transmission, GABAergic(GO:0032230)
2.3 16.0 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
2.2 35.7 GO:0048268 clathrin coat assembly(GO:0048268)
2.1 17.2 GO:0055096 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
2.1 8.5 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
2.1 6.2 GO:0021997 neural plate axis specification(GO:0021997)
2.0 20.0 GO:0051639 actin filament network formation(GO:0051639)
1.9 9.4 GO:1902022 lysine transport(GO:0015819) L-lysine transport(GO:1902022) L-lysine transmembrane transport(GO:1903401)
1.9 37.3 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
1.8 5.5 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
1.7 26.5 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
1.6 11.5 GO:1903012 positive regulation of bone development(GO:1903012)
1.6 9.8 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.6 50.3 GO:1903861 positive regulation of dendrite extension(GO:1903861)
1.6 16.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
1.6 119.5 GO:0042220 response to cocaine(GO:0042220)
1.6 12.5 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
1.5 13.3 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
1.5 21.9 GO:0051764 actin crosslink formation(GO:0051764)
1.4 6.8 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
1.3 46.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.3 10.2 GO:0006751 glutathione catabolic process(GO:0006751)
1.2 3.7 GO:0021564 vagus nerve development(GO:0021564)
1.2 4.9 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
1.2 4.7 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
1.2 30.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.1 27.4 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
1.1 16.0 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
1.0 12.5 GO:0045916 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
1.0 52.5 GO:0032007 negative regulation of TOR signaling(GO:0032007)
1.0 73.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
1.0 23.4 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.9 9.5 GO:0009169 ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.9 11.4 GO:0048875 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.9 11.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.8 33.3 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.8 3.3 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.8 5.6 GO:0060591 chondroblast differentiation(GO:0060591)
0.8 4.0 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.8 5.6 GO:0060017 parathyroid gland development(GO:0060017)
0.8 23.0 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.8 1.6 GO:0071504 cellular response to heparin(GO:0071504)
0.8 12.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.7 16.7 GO:0022011 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.7 2.8 GO:0052651 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.7 13.1 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.7 59.0 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.7 54.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.7 9.2 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.7 13.8 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.7 1.3 GO:0001966 thigmotaxis(GO:0001966)
0.6 3.2 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.6 5.6 GO:0008063 Toll signaling pathway(GO:0008063)
0.6 2.2 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.5 2.7 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.5 1.6 GO:0038091 VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.5 33.5 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.5 42.2 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.5 15.0 GO:0016572 histone phosphorylation(GO:0016572)
0.5 3.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.4 5.7 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.4 2.5 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.4 13.2 GO:0015701 bicarbonate transport(GO:0015701)
0.4 2.2 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.3 4.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.3 5.2 GO:0019236 response to pheromone(GO:0019236)
0.3 28.6 GO:0030010 establishment of cell polarity(GO:0030010)
0.3 2.2 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.3 6.9 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.3 2.4 GO:0019388 galactose catabolic process(GO:0019388)
0.3 6.5 GO:0006450 regulation of translational fidelity(GO:0006450)
0.3 10.3 GO:0009303 rRNA transcription(GO:0009303)
0.3 28.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.3 9.9 GO:0042073 intraciliary transport(GO:0042073)
0.3 44.5 GO:0007219 Notch signaling pathway(GO:0007219)
0.3 1.4 GO:0006566 L-serine biosynthetic process(GO:0006564) threonine metabolic process(GO:0006566)
0.3 2.9 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.3 8.5 GO:0019433 triglyceride catabolic process(GO:0019433)
0.2 6.9 GO:0018345 protein palmitoylation(GO:0018345)
0.2 2.4 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.2 2.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.2 4.4 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.2 3.4 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.2 2.7 GO:0006622 protein targeting to lysosome(GO:0006622)
0.2 4.6 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 15.9 GO:0007613 memory(GO:0007613)
0.1 1.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 16.4 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.1 9.2 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 20.1 GO:0006839 mitochondrial transport(GO:0006839)
0.1 1.6 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 7.5 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.1 3.4 GO:0032392 DNA geometric change(GO:0032392)
0.1 25.6 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.4 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.3 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.0 0.9 GO:0008542 visual learning(GO:0008542)
0.0 5.0 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 0.8 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
25.1 75.4 GO:0098830 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
20.9 62.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
12.0 119.5 GO:0042788 polysomal ribosome(GO:0042788)
10.0 30.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
9.9 39.7 GO:1990761 growth cone lamellipodium(GO:1990761)
9.9 89.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
9.5 38.1 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
8.4 100.7 GO:0098839 postsynaptic density membrane(GO:0098839)
7.5 82.2 GO:0032009 early phagosome(GO:0032009)
7.1 35.6 GO:1990769 proximal neuron projection(GO:1990769)
6.8 20.3 GO:0070110 ciliary neurotrophic factor receptor complex(GO:0070110)
5.9 23.7 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
5.7 17.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
3.3 56.2 GO:0097449 astrocyte projection(GO:0097449)
3.1 37.3 GO:0005796 Golgi lumen(GO:0005796)
2.7 71.1 GO:0033268 node of Ranvier(GO:0033268)
2.6 28.3 GO:0042583 chromaffin granule(GO:0042583)
2.3 47.7 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
2.2 48.5 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
2.2 10.9 GO:0072534 perineuronal net(GO:0072534)
2.1 40.6 GO:0032433 filopodium tip(GO:0032433)
2.1 63.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
2.0 48.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
1.8 27.3 GO:0016580 Sin3 complex(GO:0016580)
1.8 44.4 GO:0097440 apical dendrite(GO:0097440)
1.7 8.4 GO:0005927 muscle tendon junction(GO:0005927)
1.7 25.0 GO:0071565 nBAF complex(GO:0071565)
1.5 4.5 GO:0032173 septin collar(GO:0032173)
1.5 48.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
1.4 16.5 GO:0043202 lysosomal lumen(GO:0043202)
1.3 26.8 GO:0005922 connexon complex(GO:0005922)
1.2 24.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.9 46.8 GO:0048786 presynaptic active zone(GO:0048786)
0.8 20.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.7 42.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.7 18.7 GO:0001533 cornified envelope(GO:0001533)
0.7 8.5 GO:0031143 pseudopodium(GO:0031143)
0.7 8.7 GO:0071437 invadopodium(GO:0071437)
0.6 3.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.6 30.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.6 6.2 GO:0044294 dendritic growth cone(GO:0044294)
0.6 19.9 GO:0097228 sperm principal piece(GO:0097228)
0.6 26.8 GO:0002102 podosome(GO:0002102)
0.5 193.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 191.1 GO:0005874 microtubule(GO:0005874)
0.5 5.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.5 6.5 GO:0097208 alveolar lamellar body(GO:0097208)
0.4 76.5 GO:0070382 exocytic vesicle(GO:0070382)
0.4 7.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.4 35.1 GO:0005901 caveola(GO:0005901)
0.3 4.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 34.3 GO:0005923 bicellular tight junction(GO:0005923)
0.3 2.2 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 49.0 GO:0005802 trans-Golgi network(GO:0005802)
0.2 4.9 GO:0042588 zymogen granule(GO:0042588)
0.2 0.9 GO:0060091 kinocilium(GO:0060091)
0.2 3.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 25.4 GO:0005903 brush border(GO:0005903)
0.2 4.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 9.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 85.7 GO:0005815 microtubule organizing center(GO:0005815)
0.1 23.0 GO:0043209 myelin sheath(GO:0043209)
0.1 8.5 GO:0005811 lipid particle(GO:0005811)
0.1 5.4 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 8.4 GO:0016605 PML body(GO:0016605)
0.1 2.0 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 5.8 GO:0031514 motile cilium(GO:0031514)
0.1 2.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 2.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 3.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 4.7 GO:0005938 cell cortex(GO:0005938)
0.0 3.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.4 GO:0014069 postsynaptic density(GO:0014069)
0.0 9.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 4.7 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
20.1 100.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
18.7 56.2 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
12.5 37.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
12.4 37.3 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
10.5 104.6 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
9.4 46.8 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
9.1 27.3 GO:0035939 microsatellite binding(GO:0035939)
8.4 83.9 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
8.3 41.7 GO:0032051 clathrin light chain binding(GO:0032051)
7.5 82.9 GO:0004017 adenylate kinase activity(GO:0004017)
7.5 30.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
7.3 22.0 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
7.0 28.1 GO:0055100 adiponectin binding(GO:0055100)
6.8 40.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
6.7 20.0 GO:0044736 acid-sensing ion channel activity(GO:0044736)
6.6 46.2 GO:0048495 Roundabout binding(GO:0048495)
6.1 24.2 GO:0033149 FFAT motif binding(GO:0033149)
5.4 32.5 GO:0004985 opioid receptor activity(GO:0004985)
5.4 27.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
5.3 16.0 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
5.3 185.6 GO:0043015 gamma-tubulin binding(GO:0043015)
5.2 26.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
5.1 20.3 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
5.0 25.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
4.9 34.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
4.4 119.5 GO:0017091 AU-rich element binding(GO:0017091)
4.2 12.5 GO:0004096 catalase activity(GO:0004096)
4.0 24.3 GO:0035374 chondroitin sulfate binding(GO:0035374)
3.9 11.7 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
3.9 89.1 GO:0002162 dystroglycan binding(GO:0002162)
3.6 25.3 GO:0004111 creatine kinase activity(GO:0004111)
3.6 100.9 GO:0005540 hyaluronic acid binding(GO:0005540)
3.5 31.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
3.5 38.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
3.4 47.7 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
3.3 19.9 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
2.9 41.0 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
2.9 159.9 GO:0001786 phosphatidylserine binding(GO:0001786)
2.8 42.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
2.5 10.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
2.4 28.6 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
2.4 52.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
2.4 9.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
2.1 6.2 GO:0005119 smoothened binding(GO:0005119)
2.0 51.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
2.0 33.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
2.0 48.9 GO:0004383 guanylate cyclase activity(GO:0004383)
1.8 5.5 GO:0070976 TIR domain binding(GO:0070976)
1.8 41.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
1.7 46.8 GO:0031402 sodium ion binding(GO:0031402)
1.6 11.4 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
1.6 9.4 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
1.5 39.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.4 11.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.4 4.1 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
1.4 2.7 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
1.3 9.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
1.3 63.0 GO:0030507 spectrin binding(GO:0030507)
1.3 13.8 GO:0042809 vitamin D receptor binding(GO:0042809)
1.2 8.7 GO:0034711 inhibin binding(GO:0034711)
1.2 4.9 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.2 15.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
1.1 53.3 GO:0017080 sodium channel regulator activity(GO:0017080)
1.1 27.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.0 8.1 GO:0036122 BMP binding(GO:0036122)
1.0 19.5 GO:0048018 receptor agonist activity(GO:0048018)
1.0 50.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.9 31.0 GO:0050681 androgen receptor binding(GO:0050681)
0.8 18.6 GO:0001671 ATPase activator activity(GO:0001671)
0.8 32.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.8 35.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.8 20.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.7 8.3 GO:0005536 glucose binding(GO:0005536)
0.7 13.2 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.6 11.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.6 19.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.5 1.6 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.5 4.9 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.5 34.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.5 43.6 GO:0051117 ATPase binding(GO:0051117)
0.5 33.0 GO:0035254 glutamate receptor binding(GO:0035254)
0.5 7.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.5 2.9 GO:0043426 MRF binding(GO:0043426)
0.5 2.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.4 2.2 GO:0016936 galactoside binding(GO:0016936)
0.4 8.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.4 6.5 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.3 23.4 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.3 4.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 8.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.3 49.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 2.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 3.4 GO:0008061 chitin binding(GO:0008061)
0.3 1.6 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.2 5.7 GO:0015288 porin activity(GO:0015288)
0.2 22.1 GO:0001948 glycoprotein binding(GO:0001948)
0.2 3.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 28.6 GO:0030165 PDZ domain binding(GO:0030165)
0.2 2.8 GO:0070700 BMP receptor binding(GO:0070700)
0.2 10.7 GO:0030276 clathrin binding(GO:0030276)
0.2 25.4 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.2 3.2 GO:0035497 cAMP response element binding(GO:0035497)
0.2 41.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.2 6.9 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 4.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 17.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 8.4 GO:0046332 SMAD binding(GO:0046332)
0.2 17.6 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.2 5.6 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 3.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 2.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 4.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 2.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 5.4 GO:0035064 methylated histone binding(GO:0035064)
0.1 7.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 9.9 GO:0008017 microtubule binding(GO:0008017)
0.0 3.3 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.0 0.8 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 4.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 1.4 GO:0051287 NAD binding(GO:0051287)
0.0 4.2 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 100.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
2.0 97.7 PID NCADHERIN PATHWAY N-cadherin signaling events
1.9 132.2 PID LKB1 PATHWAY LKB1 signaling events
1.7 85.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
1.6 38.1 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
1.4 83.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
1.4 25.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.4 40.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
1.2 11.7 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.8 23.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.8 8.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.6 11.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5 15.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.5 15.9 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.4 14.0 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.4 19.9 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.3 6.1 PID FAS PATHWAY FAS (CD95) signaling pathway
0.3 4.9 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 5.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.2 2.7 ST ADRENERGIC Adrenergic Pathway
0.2 8.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 1.6 PID S1P S1P3 PATHWAY S1P3 pathway
0.2 10.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 32.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.0 PID CMYB PATHWAY C-MYB transcription factor network
0.1 2.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 139.2 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
5.5 33.0 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
4.1 82.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
3.9 86.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
2.8 47.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
2.4 62.4 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
2.1 56.3 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
1.8 30.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
1.7 22.0 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
1.6 48.9 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
1.5 26.8 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
1.3 25.2 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
1.2 4.9 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
1.2 21.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
1.2 23.7 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
1.2 59.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
1.1 12.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.1 46.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
1.1 24.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
1.0 18.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
1.0 6.1 REACTOME GAP JUNCTION TRAFFICKING Genes involved in Gap junction trafficking
0.9 25.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.9 10.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.9 11.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.9 8.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.8 22.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.7 17.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.6 24.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.5 13.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.4 8.5 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.4 15.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.4 19.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.4 5.6 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.4 35.6 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.4 7.5 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.4 5.5 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.3 23.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 4.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 9.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 0.3 REACTOME OPSINS Genes involved in Opsins
0.3 3.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 42.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 4.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 20.2 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 29.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.2 13.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 18.4 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.2 3.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 5.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 8.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.9 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.2 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.0 2.2 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway