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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for En2

Z-value: 0.42

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Transcription factors associated with En2

Gene Symbol Gene ID Gene Info
En2
ENSRNOG00000006846 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
En2rn6_v1_chr4_+_438668_438668-0.054.1e-01Click!

Activity profile of En2 motif

Sorted Z-values of En2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_78985990 19.91 ENSRNOT00000009248
Ambp
alpha-1-microglobulin/bikunin precursor
chr18_+_81694808 15.89 ENSRNOT00000020446
Cyb5a
cytochrome b5 type A
chr2_+_54466280 14.29 ENSRNOT00000033112
C6
complement C6
chr6_-_7058314 11.53 ENSRNOT00000045996
Haao
3-hydroxyanthranilate 3,4-dioxygenase
chr16_+_10267482 9.68 ENSRNOT00000085255
Gdf2
growth differentiation factor 2
chrM_+_11736 8.52 ENSRNOT00000048767
Mt-nd5
mitochondrially encoded NADH dehydrogenase 5
chr11_-_71284939 8.06 ENSRNOT00000002421
AABR07034428.1

chr16_+_50049828 6.27 ENSRNOT00000034448
Fam149a
family with sequence similarity 149, member A
chr11_-_60882379 6.05 ENSRNOT00000002799
Cd200r1
CD200 receptor 1
chr6_-_115616766 5.92 ENSRNOT00000006143
ENSRNOT00000045870
Sel1l
SEL1L ERAD E3 ligase adaptor subunit
chr20_-_45260119 5.84 ENSRNOT00000000718
Slc16a10
solute carrier family 16 member 10
chr7_-_126382449 5.83 ENSRNOT00000085540
7530416G11Rik
RIKEN cDNA 7530416G11 gene
chr6_+_73553210 5.79 ENSRNOT00000006562
Akap6
A-kinase anchoring protein 6
chrM_+_9451 5.55 ENSRNOT00000041241
Mt-nd3
mitochondrially encoded NADH dehydrogenase 3
chr7_+_41475163 5.48 ENSRNOT00000037844
Dusp6
dual specificity phosphatase 6
chr20_+_44680449 5.47 ENSRNOT00000000728
Traf3ip2
Traf3 interacting protein 2
chrM_+_7006 5.42 ENSRNOT00000043693
Mt-co2
mitochondrially encoded cytochrome c oxidase II
chr13_+_44424689 5.35 ENSRNOT00000005206
Acmsd
aminocarboxymuconate semialdehyde decarboxylase
chr19_-_17399548 5.13 ENSRNOT00000075991
Chd9
chromodomain helicase DNA binding protein 9
chrM_+_9870 5.10 ENSRNOT00000044582
Mt-nd4l
mitochondrially encoded NADH 4L dehydrogenase
chr18_+_31396922 5.07 ENSRNOT00000026273
RGD735029
SEL1 domain containing protein RGD735029
chr6_-_128149220 4.89 ENSRNOT00000014204
Gsc
goosecoid homeobox
chr20_-_157861 4.76 ENSRNOT00000084461
RT1-CE10
RT1 class I, locus CE10
chrM_+_7919 4.69 ENSRNOT00000046108
Mt-atp6
mitochondrially encoded ATP synthase 6
chr4_+_55772627 4.63 ENSRNOT00000048252
Snd1
staphylococcal nuclease and tudor domain containing 1
chr1_-_164101578 4.55 ENSRNOT00000022176
Uvrag
UV radiation resistance associated
chr20_-_157665 4.49 ENSRNOT00000048858
ENSRNOT00000079494
RT1-CE10
RT1 class I, locus CE10
chr1_-_218810118 4.32 ENSRNOT00000065950
ENSRNOT00000020886
Ppp6r3
protein phosphatase 6, regulatory subunit 3
chr13_+_91054974 4.24 ENSRNOT00000091089
Crp
C-reactive protein
chr14_-_2032593 4.20 ENSRNOT00000000037
Fgfrl1
fibroblast growth factor receptor-like 1
chr4_+_55772377 3.94 ENSRNOT00000047698
Snd1
staphylococcal nuclease and tudor domain containing 1
chr1_-_185143272 3.81 ENSRNOT00000027752
Nucb2
nucleobindin 2
chr19_-_24732024 3.70 ENSRNOT00000037608
Tecr
trans-2,3-enoyl-CoA reductase
chr7_-_70407177 3.70 ENSRNOT00000049895
Os9
OS9, endoplasmic reticulum lectin
chr6_+_128750795 3.61 ENSRNOT00000005781
Glrx5
glutaredoxin 5
chr10_-_87468711 3.48 ENSRNOT00000039983
Krtap3-3
keratin associated protein 3-3
chr10_+_5199226 3.45 ENSRNOT00000003544
Dexi
dexamethasone-induced transcript
chr4_-_100252755 3.41 ENSRNOT00000017301
Vamp8
vesicle-associated membrane protein 8
chrX_+_124321551 3.38 ENSRNOT00000074486
LOC100910807
transcriptional regulator Kaiso-like
chr2_-_138833933 3.36 ENSRNOT00000013343
Pcdh18
protocadherin 18
chr18_-_31343797 3.32 ENSRNOT00000081850
Pcdh1
protocadherin 1
chr1_-_101095594 3.15 ENSRNOT00000027944
Fcgrt
Fc fragment of IgG receptor and transporter
chr6_+_8886591 2.94 ENSRNOT00000091510
ENSRNOT00000089174
Six3
SIX homeobox 3
chr14_+_36216002 2.76 ENSRNOT00000038506
Scfd2
sec1 family domain containing 2
chr1_-_276228574 2.58 ENSRNOT00000021746
Gucy2g
guanylate cyclase 2G
chr3_-_43119159 2.55 ENSRNOT00000041394
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr4_+_6827429 2.52 ENSRNOT00000071737
Rheb
Ras homolog enriched in brain
chr11_-_60679555 2.50 ENSRNOT00000059735
Ccdc80
coiled-coil domain containing 80
chr9_+_49647257 2.42 ENSRNOT00000021899
Mrps9
mitochondrial ribosomal protein S9
chr7_-_143228060 2.39 ENSRNOT00000088923
ENSRNOT00000012640
Krt75
keratin 75
chr12_-_45801842 2.34 ENSRNOT00000078837
AABR07036513.1

chr1_+_60717386 2.29 ENSRNOT00000015019
Ppp2r1a
protein phosphatase 2 scaffold subunit A alpha
chr14_+_59611434 2.18 ENSRNOT00000065366
Cckar
cholecystokinin A receptor
chr6_-_11274932 2.17 ENSRNOT00000021538
Msh2
mutS homolog 2
chr17_+_78735598 2.17 ENSRNOT00000020854
Hspa14
heat shock protein family A, member 14
chr8_+_71514281 2.11 ENSRNOT00000022256
Ns5atp9
NS5A (hepatitis C virus) transactivated protein 9
chr11_+_28780446 2.11 ENSRNOT00000072546
Krtap15-1
keratin associated protein 15-1
chr8_+_116318963 2.07 ENSRNOT00000036556
Tusc2
tumor suppressor candidate 2
chr3_+_111160205 2.06 ENSRNOT00000019392
Chac1
ChaC glutathione-specific gamma-glutamylcyclotransferase 1
chr7_-_49732764 2.02 ENSRNOT00000006453
Myf5
myogenic factor 5
chrX_-_26376467 1.98 ENSRNOT00000051655
ENSRNOT00000036502
Arhgap6
Rho GTPase activating protein 6
chr12_-_24775891 1.96 ENSRNOT00000074851
Wbscr27
Williams Beuren syndrome chromosome region 27
chr11_+_13499164 1.96 ENSRNOT00000013159
LOC680121
similar to heat shock protein 8
chr18_+_16544508 1.94 ENSRNOT00000020601
Elp2
elongator acetyltransferase complex subunit 2
chr9_-_85243001 1.91 ENSRNOT00000020219
Scg2
secretogranin II
chr4_-_88684415 1.83 ENSRNOT00000009001
LOC500148
similar to 40S ribosomal protein S7 (S8)
chr3_+_78086943 1.78 ENSRNOT00000047425
Olr691
olfactory receptor 691
chr5_-_7941822 1.75 ENSRNOT00000079917
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr10_-_87521514 1.70 ENSRNOT00000084668
ENSRNOT00000071705
Krtap2-4l
keratin associated protein 2-4-like
chr7_+_71157664 1.55 ENSRNOT00000005919
Sdr9c7
short chain dehydrogenase/reductase family 9C, member 7
chr15_-_27590931 1.53 ENSRNOT00000080898
Olr1632
olfactory receptor 1632
chr3_+_73235594 1.44 ENSRNOT00000082357
Olr463
olfactory receptor 463
chr11_+_47924970 1.43 ENSRNOT00000060577
Zpld1
zona pellucida-like domain containing 1
chr2_+_189609800 1.43 ENSRNOT00000089016
Slc39a1
solute carrier family 39 member 1
chr14_-_6793558 1.41 ENSRNOT00000002927
Mepe
matrix extracellular phosphoglycoprotein
chr1_-_64147251 1.29 ENSRNOT00000088502
Cnot3
CCR4-NOT transcription complex, subunit 3
chr4_+_1566448 1.26 ENSRNOT00000088227
Olr1243
olfactory receptor 1243
chr5_+_68619202 1.25 ENSRNOT00000039903
Olr848
olfactory receptor 848
chr14_+_76732650 1.24 ENSRNOT00000088197
Clnk
cytokine-dependent hematopoietic cell linker
chr1_-_230649938 1.22 ENSRNOT00000017615
Olr377
olfactory receptor 377
chr4_+_1658278 1.21 ENSRNOT00000073845
Olr1250
olfactory receptor 1250
chr2_+_72006099 1.19 ENSRNOT00000034044
Cdh12
cadherin 12
chr11_-_29710849 1.17 ENSRNOT00000029345
Krtap11-1
keratin associated protein 11-1
chr1_-_219369587 1.17 ENSRNOT00000000599
Aip
aryl-hydrocarbon receptor-interacting protein
chr6_+_8219385 1.10 ENSRNOT00000040509
Ppm1b
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr1_-_103631235 1.08 ENSRNOT00000072393
Mrgprb13
MAS-related GPR, member B13
chr7_-_143967484 1.08 ENSRNOT00000081758
Sp7
Sp7 transcription factor
chr3_-_73475608 1.08 ENSRNOT00000049630
Olr480
olfactory receptor 480
chr7_+_17956631 0.99 ENSRNOT00000064298
Vom1r106
vomeronasal 1 receptor 106
chr12_-_47142852 0.95 ENSRNOT00000001591
Pop5
POP5 homolog, ribonuclease P/MRP subunit
chr3_-_90751055 0.95 ENSRNOT00000040741
LOC499843
LRRGT00091
chr1_+_243662823 0.94 ENSRNOT00000067372
Dmrt2
doublesex and mab-3 related transcription factor 2
chr2_+_66940057 0.87 ENSRNOT00000043050
Cdh9
cadherin 9
chr1_-_19376301 0.85 ENSRNOT00000015547
Arhgap18
Rho GTPase activating protein 18
chr8_+_42663633 0.84 ENSRNOT00000048537
Olr1266
olfactory receptor 1266
chr2_+_198417619 0.81 ENSRNOT00000085945
Hist2h3c2
histone cluster 2, H3c2
chr5_+_154668179 0.77 ENSRNOT00000015971
Hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr3_-_77605962 0.77 ENSRNOT00000090062
Olr665
olfactory receptor 665
chr5_+_137255924 0.76 ENSRNOT00000088022
ENSRNOT00000092755
Elovl1
ELOVL fatty acid elongase 1
chr2_-_210088949 0.74 ENSRNOT00000070994
Rbm15
RNA binding motif protein 15
chr7_-_143497108 0.72 ENSRNOT00000048613
Krt76
keratin 76
chr14_-_43694584 0.71 ENSRNOT00000041866
AABR07072400.1

chr9_+_15513063 0.69 ENSRNOT00000020499
Taf8
TATA-box binding protein associated factor 8
chr3_-_78790691 0.69 ENSRNOT00000008750
Olr724
olfactory receptor 724
chr2_+_51672722 0.65 ENSRNOT00000016485
Fgf10
fibroblast growth factor 10
chr4_+_10823281 0.64 ENSRNOT00000066739
Phtf2
putative homeodomain transcription factor 2
chr1_-_247821728 0.62 ENSRNOT00000021958
Ermp1
endoplasmic reticulum metallopeptidase 1
chr7_+_2752680 0.61 ENSRNOT00000033726
Cs
citrate synthase
chr1_+_13595295 0.61 ENSRNOT00000079250
Nhsl1
NHS-like 1
chr2_+_266315036 0.60 ENSRNOT00000055245
Wls
wntless Wnt ligand secretion mediator
chr14_+_43694183 0.56 ENSRNOT00000046342
RGD1563570
similar to ribosomal protein S23
chr7_-_6803318 0.56 ENSRNOT00000084203
Olr954
olfactory receptor 954
chr15_+_11298478 0.52 ENSRNOT00000007672
Lrrc3b
leucine rich repeat containing 3B
chrX_+_78042859 0.51 ENSRNOT00000003286
Lpar4
lysophosphatidic acid receptor 4
chr2_+_207930796 0.47 ENSRNOT00000047827
Kcnd3
potassium voltage-gated channel subfamily D member 3
chr4_-_170740274 0.45 ENSRNOT00000012212
Gucy2c
guanylate cyclase 2C
chr12_-_54885 0.44 ENSRNOT00000090447
AABR07034833.1

chr19_+_25043680 0.42 ENSRNOT00000043971
Adgrl1
adhesion G protein-coupled receptor L1
chr8_+_41252456 0.39 ENSRNOT00000071683
Olr1220
olfactory receptor 1220
chr3_-_77911561 0.36 ENSRNOT00000084947
Olr679
olfactory receptor 679
chr7_+_144865608 0.35 ENSRNOT00000091596
ENSRNOT00000055285
Hnrnpa1
heterogeneous nuclear ribonucleoprotein A1
chr8_+_47674321 0.35 ENSRNOT00000026170
ENSRNOT00000078776
Trim29
tripartite motif-containing 29
chr13_+_79378733 0.27 ENSRNOT00000039221
Tnfsf18
tumor necrosis factor superfamily member 18
chr11_+_58624198 0.27 ENSRNOT00000002091
Gap43
growth associated protein 43
chr10_+_63677396 0.23 ENSRNOT00000005100
Slc43a2
solute carrier family 43 member 2
chr6_-_36876805 0.17 ENSRNOT00000006482
Msgn1
mesogenin 1
chr3_-_160630457 0.17 ENSRNOT00000018420
Semg1
semenogelin I
chr8_+_40410604 0.13 ENSRNOT00000049392
Olr1202
olfactory receptor 1202
chr3_-_60765645 0.13 ENSRNOT00000050513
Atf2
activating transcription factor 2
chr11_-_70322690 0.02 ENSRNOT00000002443
Heg1
heart development protein with EGF-like domains 1

Network of associatons between targets according to the STRING database.

First level regulatory network of En2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.3 GO:0001905 activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
2.9 11.5 GO:0019805 quinolinate biosynthetic process(GO:0019805)
2.7 5.4 GO:0046874 quinolinate metabolic process(GO:0046874)
1.9 18.7 GO:0018298 protein-chromophore linkage(GO:0018298)
1.4 5.8 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
1.3 3.8 GO:2000845 positive regulation of testosterone secretion(GO:2000845)
1.2 3.6 GO:0009249 protein lipoylation(GO:0009249)
1.2 5.8 GO:0015801 aromatic amino acid transport(GO:0015801)
1.1 4.5 GO:0097680 maintenance of Golgi location(GO:0051684) double-strand break repair via classical nonhomologous end joining(GO:0097680)
1.1 3.4 GO:1903595 pancreatic amylase secretion(GO:0036395) regulation of pancreatic amylase secretion(GO:1902276) positive regulation of histamine secretion by mast cell(GO:1903595)
1.0 2.9 GO:0014016 neuroblast differentiation(GO:0014016)
0.9 5.5 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.7 4.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.7 2.1 GO:0052572 response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
0.5 2.2 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.5 3.7 GO:0006621 protein retention in ER lumen(GO:0006621)
0.5 2.6 GO:0051866 general adaptation syndrome(GO:0051866)
0.5 9.7 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.5 2.3 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.4 2.2 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.4 4.9 GO:0014029 neural crest formation(GO:0014029)
0.4 5.5 GO:0009642 response to light intensity(GO:0009642)
0.4 4.2 GO:0060539 diaphragm development(GO:0060539)
0.3 0.3 GO:1903936 cellular response to sodium arsenite(GO:1903936)
0.3 2.5 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.3 4.5 GO:0030497 fatty acid elongation(GO:0030497)
0.3 1.2 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.3 19.0 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 5.5 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.3 2.0 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.2 0.9 GO:0061055 myotome development(GO:0061055)
0.2 0.6 GO:0009946 proximal/distal axis specification(GO:0009946)
0.2 9.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.2 3.1 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.2 5.9 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.2 0.6 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.2 15.9 GO:0046686 response to cadmium ion(GO:0046686)
0.2 1.1 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.2 4.7 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.9 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.1 0.3 GO:2000328 regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.1 0.7 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 2.0 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.1 1.9 GO:0043248 proteasome assembly(GO:0043248)
0.1 8.6 GO:0031047 gene silencing by RNA(GO:0031047)
0.1 4.3 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 1.4 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.1 2.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 3.0 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 0.7 GO:0048733 sebaceous gland development(GO:0048733)
0.1 5.1 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 1.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 1.1 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 2.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 2.8 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 0.3 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.8 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.7 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.5 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 0.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.0 0.2 GO:1901318 negative regulation of sperm motility(GO:1901318)
0.0 0.4 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 5.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.7 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.6 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 1.4 GO:0048701 embryonic cranial skeleton morphogenesis(GO:0048701)
0.0 1.0 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 2.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 2.4 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.2 GO:0007379 segment specification(GO:0007379)
0.0 0.9 GO:0006334 nucleosome assembly(GO:0006334)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 14.3 GO:0005579 membrane attack complex(GO:0005579)
2.0 5.9 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
1.9 5.8 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
1.8 3.7 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
1.1 3.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.9 8.6 GO:0097433 dense body(GO:0097433)
0.7 2.2 GO:0032301 MutSalpha complex(GO:0032301)
0.6 9.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.4 1.9 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.4 19.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.4 5.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 3.8 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 4.7 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.3 1.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.2 1.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 1.0 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.2 19.9 GO:0072562 blood microparticle(GO:0072562)
0.1 9.5 GO:0045095 keratin filament(GO:0045095)
0.1 2.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.3 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
0.1 2.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 2.4 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 4.5 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 4.2 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.8 GO:0019013 viral nucleocapsid(GO:0019013)
0.0 0.4 GO:0031045 dense core granule(GO:0031045)
0.0 0.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 22.8 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.2 GO:0043195 terminal bouton(GO:0043195)
0.0 11.7 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 0.7 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 4.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 6.0 GO:0043235 receptor complex(GO:0043235)
0.0 4.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.1 GO:0030175 filopodium(GO:0030175)
0.0 3.3 GO:0005840 ribosome(GO:0005840)
0.0 4.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.1 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 19.9 GO:0019862 IgA binding(GO:0019862)
1.0 5.8 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.7 2.2 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139) single guanine insertion binding(GO:0032142)
0.7 19.2 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.6 5.8 GO:0043495 protein anchor(GO:0043495)
0.6 3.1 GO:0019770 IgG receptor activity(GO:0019770)
0.6 4.2 GO:0001849 complement component C1q binding(GO:0001849)
0.5 4.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.5 2.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.4 11.5 GO:0019825 oxygen binding(GO:0019825)
0.4 24.9 GO:0009055 electron carrier activity(GO:0009055)
0.3 5.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 1.2 GO:0036004 GAF domain binding(GO:0036004)
0.3 3.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.3 1.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.2 9.2 GO:0042605 peptide antigen binding(GO:0042605)
0.2 0.8 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.2 1.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.2 9.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.2 2.0 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 2.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 4.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.6 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 5.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 3.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 2.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.0 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 1.9 GO:0042056 chemoattractant activity(GO:0042056)
0.1 1.1 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.1 0.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 1.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 2.5 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.8 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 1.5 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 3.7 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.1 2.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 4.7 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.1 3.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0033592 RNA strand annealing activity(GO:0033592) G-rich strand telomeric DNA binding(GO:0098505)
0.0 1.5 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.0 8.6 GO:0004518 nuclease activity(GO:0004518)
0.0 2.5 GO:0019003 GDP binding(GO:0019003)
0.0 4.5 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.4 GO:0015643 toxic substance binding(GO:0015643)
0.0 4.3 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.3 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 2.4 GO:0002020 protease binding(GO:0002020)
0.0 7.4 GO:0005549 odorant binding(GO:0005549)
0.0 2.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 4.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.2 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.7 PID ALK1 PATHWAY ALK1 signaling events
0.2 3.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 5.5 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.9 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.1 19.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 5.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 2.3 PID ATR PATHWAY ATR signaling pathway
0.0 2.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 2.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 16.9 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.6 7.8 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.5 18.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.3 5.9 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.3 2.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.3 15.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 4.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 3.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 5.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.1 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.5 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.6 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 2.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.1 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 2.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors