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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for En2
Z-value: 0.42
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Transcription factors associated with En2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| En2 | rn6_v1_chr4_+_438668_438668 | -0.05 | 4.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_78985990 Show fit | 19.91 |
ENSRNOT00000009248
|
alpha-1-microglobulin/bikunin precursor |
|
| chr18_+_81694808 Show fit | 15.89 |
ENSRNOT00000020446
|
cytochrome b5 type A |
|
| chr2_+_54466280 Show fit | 14.29 |
ENSRNOT00000033112
|
complement C6 |
|
| chr6_-_7058314 Show fit | 11.53 |
ENSRNOT00000045996
|
3-hydroxyanthranilate 3,4-dioxygenase |
|
| chr16_+_10267482 Show fit | 9.68 |
ENSRNOT00000085255
|
growth differentiation factor 2 |
|
| chrM_+_11736 Show fit | 8.52 |
ENSRNOT00000048767
|
mitochondrially encoded NADH dehydrogenase 5 |
|
| chr11_-_71284939 Show fit | 8.06 |
ENSRNOT00000002421
|
|
|
| chr16_+_50049828 Show fit | 6.27 |
ENSRNOT00000034448
|
family with sequence similarity 149, member A |
|
| chr11_-_60882379 Show fit | 6.05 |
ENSRNOT00000002799
|
CD200 receptor 1 |
|
| chr6_-_115616766 Show fit | 5.92 |
ENSRNOT00000006143
ENSRNOT00000045870 |
SEL1L ERAD E3 ligase adaptor subunit |
Network of associatons between targets according to the STRING database.
First level regulatory network of En2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.0 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 1.9 | 18.7 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.2 | 15.9 | GO:0046686 | response to cadmium ion(GO:0046686) |
| 4.8 | 14.3 | GO:0001905 | activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969) |
| 2.9 | 11.5 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.5 | 9.7 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.2 | 9.2 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.1 | 8.6 | GO:0031047 | gene silencing by RNA(GO:0031047) |
| 0.2 | 5.9 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
| 1.4 | 5.8 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 19.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.4 | 19.2 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 2.0 | 14.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 11.7 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.1 | 9.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.6 | 9.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.9 | 8.6 | GO:0097433 | dense body(GO:0097433) |
| 0.0 | 6.0 | GO:0043235 | receptor complex(GO:0043235) |
| 2.0 | 5.9 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.9 | GO:0009055 | electron carrier activity(GO:0009055) |
| 4.0 | 19.9 | GO:0019862 | IgA binding(GO:0019862) |
| 0.7 | 19.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.4 | 11.5 | GO:0019825 | oxygen binding(GO:0019825) |
| 0.2 | 9.7 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.2 | 9.2 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 8.6 | GO:0004518 | nuclease activity(GO:0004518) |
| 0.0 | 7.4 | GO:0005549 | odorant binding(GO:0005549) |
| 1.0 | 5.8 | GO:0015173 | aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.6 | 5.8 | GO:0043495 | protein anchor(GO:0043495) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 9.7 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 5.5 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 5.0 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 4.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.2 | 3.7 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 2.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 2.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 2.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 2.0 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 18.5 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 1.9 | 16.9 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.3 | 15.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.6 | 7.8 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.3 | 5.9 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 5.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 4.5 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 3.4 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 2.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 2.5 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |