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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Elf5
Z-value: 1.32
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Transcription factors associated with Elf5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Elf5 | rn6_v1_chr3_+_93351619_93351619 | -0.13 | 1.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_61425746 Show fit | 36.31 |
ENSRNOT00000064113
|
hypothetical LOC298077 |
|
| chr8_-_114853103 Show fit | 35.60 |
ENSRNOT00000074595
|
glycerate kinase |
|
| chr1_+_148240504 Show fit | 25.26 |
ENSRNOT00000085373
|
Cytochrome P450, family 2, subfamily c, polypeptide 7-like |
|
| chr1_-_219682287 Show fit | 25.01 |
ENSRNOT00000026092
|
ras homolog family member D |
|
| chr4_+_154215250 Show fit | 24.11 |
ENSRNOT00000072465
|
murinoglobulin 2 |
|
| chr17_+_22619891 Show fit | 21.55 |
ENSRNOT00000060403
|
androgen-dependent TFPI-regulating protein |
|
| chr1_+_201620642 Show fit | 21.15 |
ENSRNOT00000093674
|
deleted in malignant brain tumors 1 |
|
| chr2_-_164684985 Show fit | 21.02 |
ENSRNOT00000057504
|
retinoic acid receptor responder 1 |
|
| chr17_+_22620721 Show fit | 20.87 |
ENSRNOT00000019478
|
androgen-dependent TFPI-regulating protein |
|
| chr1_-_258875572 Show fit | 19.67 |
ENSRNOT00000093005
|
cytochrome P450, family 2, subfamily c, polypeptide 13 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Elf5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 78.6 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 2.4 | 48.5 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 2.0 | 44.9 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 12.1 | 36.3 | GO:0046865 | isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) |
| 10.7 | 32.0 | GO:0002353 | kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.7 | 31.1 | GO:1901998 | toxin transport(GO:1901998) |
| 1.5 | 30.6 | GO:0097284 | hepatocyte apoptotic process(GO:0097284) |
| 1.0 | 29.8 | GO:0097502 | mannosylation(GO:0097502) |
| 0.7 | 28.1 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.4 | 27.5 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 71.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.7 | 51.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.5 | 48.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.4 | 46.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 2.3 | 43.5 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.8 | 40.0 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.5 | 38.4 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 1.3 | 34.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.5 | 34.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 28.6 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 79.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.3 | 68.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.0 | 58.7 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.2 | 53.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.0 | 42.6 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.5 | 41.4 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 1.3 | 39.9 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.6 | 39.0 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 1.8 | 38.7 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 5.5 | 38.5 | GO:0035375 | zymogen binding(GO:0035375) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 60.0 | PID EPO PATHWAY | EPO signaling pathway |
| 0.2 | 52.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 46.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 1.1 | 40.6 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 1.7 | 38.5 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.4 | 36.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.8 | 28.9 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.5 | 28.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.6 | 28.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.9 | 27.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 84.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 2.4 | 43.6 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 1.1 | 38.5 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 1.6 | 35.7 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.9 | 35.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.8 | 30.5 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 1.4 | 30.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 1.5 | 26.1 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.6 | 25.9 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 1.5 | 24.9 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |