ISMARA results: Elf1_Elf2_Etv2

Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation

Downloads

Results for Elf1_Elf2_Etv2_Elf4

Z-value: 4.14

Motif logo

Transcription factors associated with Elf1_Elf2_Etv2_Elf4

Gene Symbol	Gene ID	Gene Info
Elf1 NCBI RGD Ensembl	ENSRNOG00000011762	E74-like factor 1
Elf2 NCBI RGD Ensembl	ENSRNOG00000010815	E74-like factor 2
Etv2 NCBI RGD Ensembl	ENSRNOG00000024288	ets variant 2
Elf4 NCBI RGD Ensembl	ENSRNOG00000005352	E74 like ETS transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Elf1	rn6_v1_chr15_+_61826711_61826711	0.91	3.6e-125	Click!
Elf4	rn6_v1_chrX_-_135250519_135250519	0.74	4.0e-57	Click!
Elf2	rn6_v1_chr2_-_140334912_140334912	0.54	3.3e-25	Click!
Etv2	rn6_v1_chr1_-_89094530_89094530	-0.07	1.9e-01	Click!

Activity profile of Elf1_Elf2_Etv2_Elf4 motif

Sorted Z-values of Elf1_Elf2_Etv2_Elf4 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_+_89774764 Show fit	208.40	ENSRNOT00000005619	Arhgap30 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 30
chr1_+_198744050 Show fit	182.17	ENSRNOT00000024404	Itgal NCBI RGD Ensembl Show fit	integrin subunit alpha L
chr13_+_50164563 Show fit	170.25	ENSRNOT00000029533	Lax1 NCBI RGD Ensembl Show fit	lymphocyte transmembrane adaptor 1
chr5_-_58987760 Show fit	154.58	ENSRNOT00000035040	Sit1 NCBI RGD Ensembl Show fit	signaling threshold regulating transmembrane adaptor 1
chr10_+_39875371 Show fit	139.70	ENSRNOT00000013481	Rapgef6 NCBI RGD Ensembl Show fit	Rap guanine nucleotide exchange factor 6
chrX_-_71169038 Show fit	134.59	ENSRNOT00000005343	Il2rg NCBI RGD Ensembl Show fit	interleukin 2 receptor subunit gamma
chr4_+_157523320 Show fit	132.61	ENSRNOT00000023192	Zfp384 NCBI RGD Ensembl Show fit	zinc finger protein 384
chr5_+_154522119 Show fit	131.13	ENSRNOT00000072618	E2f2 NCBI RGD Ensembl Show fit	E2F transcription factor 2
chr7_-_107392972 Show fit	126.00	ENSRNOT00000093425	Tmem71 NCBI RGD Ensembl Show fit	transmembrane protein 71
chr13_-_90022269 Show fit	124.21	ENSRNOT00000035498	Ly9 NCBI RGD Ensembl Show fit	lymphocyte antigen 9

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Elf1_Elf2_Etv2_Elf4

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
8.5	498.8	GO:0070527	platelet aggregation(GO:0070527)
14.8	399.5	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
24.9	373.4	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
2.7	354.5	GO:0008380	RNA splicing(GO:0008380)
7.5	346.7	GO:0042274	ribosomal small subunit biogenesis(GO:0042274)
1.0	318.7	GO:0043547	positive regulation of GTPase activity(GO:0043547)
28.0	307.5	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
3.6	298.5	GO:0043484	regulation of RNA splicing(GO:0043484)
9.2	295.3	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
23.9	286.3	GO:0001771	immunological synapse formation(GO:0001771)

Showing 1 to 10 of 1,105 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
5.1	1499.6	GO:0009897	external side of plasma membrane(GO:0009897)
3.5	1049.4	GO:0000790	nuclear chromatin(GO:0000790)
7.3	682.7	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
2.6	658.4	GO:0016607	nuclear speck(GO:0016607)
0.6	656.2	GO:0005654	nucleoplasm(GO:0005654)
17.9	628.2	GO:0001772	immunological synapse(GO:0001772)
8.3	624.8	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
1.9	507.8	GO:0005925	focal adhesion(GO:0005925)
5.8	439.3	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
3.5	408.5	GO:0001650	fibrillar center(GO:0001650)

Showing 1 to 10 of 369 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.8	2077.2	GO:0003723	RNA binding(GO:0003723)
1.2	972.0	GO:0003677	DNA binding(GO:0003677)
4.9	800.8	GO:0042393	histone binding(GO:0042393)
3.2	711.8	GO:0003735	structural constituent of ribosome(GO:0003735)
5.1	577.9	GO:0017124	SH3 domain binding(GO:0017124)
1.6	425.9	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
2.3	364.4	GO:0001047	core promoter binding(GO:0001047)
5.4	358.0	GO:0004004	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.8	350.9	GO:0003676	nucleic acid binding(GO:0003676)
8.3	341.8	GO:0042169	SH2 domain binding(GO:0042169)

Showing 1 to 10 of 600 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
16.7	1099.8	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
11.4	537.3	PID BCR 5PATHWAY	BCR signaling pathway
10.6	507.8	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
8.5	389.1	PID AURORA B PATHWAY	Aurora B signaling
7.5	351.9	PID PLK1 PATHWAY	PLK1 signaling events
12.1	349.9	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
14.5	304.7	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
6.2	290.9	PID RAC1 PATHWAY	RAC1 signaling pathway
7.7	269.5	PID FANCONI PATHWAY	Fanconi anemia pathway
9.1	262.6	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events

Showing 1 to 10 of 133 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
12.4	694.8	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
13.6	611.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
8.5	526.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
6.6	502.6	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
5.9	453.3	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
3.2	436.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
12.1	399.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
12.4	384.0	REACTOME KINESINS	Genes involved in Kinesins
42.7	341.8	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
7.1	298.4	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere

Showing 1 to 10 of 189 entries

Results for Elf1_Elf2_Etv2_Elf4

Z-value: 4.14

Motif logo

Transcription factors associated with Elf1_Elf2_Etv2_Elf4

Activity-expression correlation:

Activity profile of Elf1_Elf2_Etv2_Elf4 motif

Sorted Z-values of Elf1_Elf2_Etv2_Elf4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Elf1_Elf2_Etv2_Elf4

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: