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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Egr3

Z-value: 0.28

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Transcription factors associated with Egr3

Gene Symbol Gene ID Gene Info
Egr3
ENSRNOG00000017828 early growth response 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Egr3rn6_v1_chr15_+_51756978_51756978-0.018.3e-01Click!

Activity profile of Egr3 motif

Sorted Z-values of Egr3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_180914940 17.09 ENSRNOT00000015732
Tdo2
tryptophan 2,3-dioxygenase
chr1_-_256813711 12.86 ENSRNOT00000021055
Rbp4
retinol binding protein 4
chr15_+_42653148 5.41 ENSRNOT00000022095
Clu
clusterin
chr15_+_34187223 5.21 ENSRNOT00000024978
Cpne6
copine 6
chr3_-_102151489 4.27 ENSRNOT00000006349
Ano3
anoctamin 3
chr10_-_98018014 3.45 ENSRNOT00000005367
Fam20a
FAM20A, golgi associated secretory pathway pseudokinase
chr13_-_79705705 2.69 ENSRNOT00000003998
Faslg
Fas ligand
chr1_+_31124825 2.48 ENSRNOT00000092105
AABR07000989.1

chr20_-_6500523 2.40 ENSRNOT00000000629
Cpne5
copine 5
chr1_-_215846911 2.29 ENSRNOT00000089171
Igf2
insulin-like growth factor 2
chr8_-_59629133 1.90 ENSRNOT00000019458
Chrnb4
cholinergic receptor nicotinic beta 4 subunit
chr13_-_48284990 1.80 ENSRNOT00000086928
Srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr13_-_48284408 1.78 ENSRNOT00000085967
Srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr3_+_94530586 1.67 ENSRNOT00000067860
Cstf3
cleavage stimulation factor subunit 3
chr6_-_142993147 1.53 ENSRNOT00000044381
LOC100359978
mCG1038839-like
chr20_-_11528332 1.36 ENSRNOT00000038419
Tspear
thrombospondin-type laminin G domain and EAR repeats
chr20_+_48503973 1.35 ENSRNOT00000064081
Cdc40
cell division cycle 40
chr10_+_14945265 1.16 ENSRNOT00000000246
Lmf1
lipase maturation factor 1
chr10_-_87335823 1.12 ENSRNOT00000079297
Krt12
keratin 12
chr18_+_24540659 0.89 ENSRNOT00000061074
Ammecr1l
AMMECR1 like
chr8_+_36909433 0.77 ENSRNOT00000074169
LOC100359924
prostate and testis expressed N-like
chr10_-_108425206 0.72 ENSRNOT00000073140
Eif4a3
eukaryotic translation initiation factor 4A3
chrX_-_17486721 0.51 ENSRNOT00000014611
Smptb
polypyrimidine tract-binding protein
chr10_+_84979717 0.49 ENSRNOT00000065555
Mrpl10
mitochondrial ribosomal protein L10
chr12_-_35906382 0.45 ENSRNOT00000072179
Rack1
receptor for activated C kinase 1
chr18_+_44468784 0.31 ENSRNOT00000031812
Dmxl1
Dmx-like 1
chr9_-_113331319 0.27 ENSRNOT00000020681
Vapa
VAMP associated protein A
chr3_-_98092131 0.22 ENSRNOT00000006512
Fshb
follicle stimulating hormone beta subunit
chr4_+_117215064 0.17 ENSRNOT00000020909
Smyd5
SMYD family member 5
chr1_+_174702373 0.13 ENSRNOT00000013733
Zfp143
zinc finger protein 143
chr11_+_34598492 0.12 ENSRNOT00000065600
Ttc3
tetratricopeptide repeat domain 3
chr1_+_218058405 0.12 ENSRNOT00000028365
Fgf19
fibroblast growth factor 19
chr17_+_42168263 0.12 ENSRNOT00000047422
LOC100360654
ribosomal protein L37-like
chr1_-_179010257 0.11 ENSRNOT00000017199
Rras2
related RAS viral (r-ras) oncogene homolog 2
chr4_-_120390164 0.06 ENSRNOT00000017323
ENSRNOT00000063950
Eefsec
eukaryotic elongation factor, selenocysteine-tRNA-specific
chr10_+_64336200 0.06 ENSRNOT00000046519
Rpl37
ribosomal protein L37
chr11_-_17340373 0.05 ENSRNOT00000089762
AABR07033324.1

chr5_+_18963937 0.05 ENSRNOT00000082188
AABR07047089.1

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 12.9 GO:0046864 isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
2.4 17.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
1.8 5.4 GO:1902996 regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949) neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.2 3.6 GO:0003363 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.7 4.3 GO:0061590 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.7 3.4 GO:0044691 tooth eruption(GO:0044691)
0.6 1.9 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.3 2.7 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.3 2.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 0.7 GO:0072714 response to selenite ion(GO:0072714) regulation of selenocysteine incorporation(GO:1904569)
0.2 1.2 GO:0033578 protein glycosylation in Golgi(GO:0033578)
0.2 7.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 0.4 GO:0033123 positive regulation of purine nucleotide catabolic process(GO:0033123)
0.1 1.1 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.1 0.5 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.3 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.1 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0 0.3 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.2 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.1 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.4 2.7 GO:0060205 cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
0.3 3.6 GO:0044327 dendritic spine head(GO:0044327)
0.2 5.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.4 GO:1990630 IRE1-RACK1-PP2A complex(GO:1990630)
0.1 1.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.4 GO:0032420 stereocilium(GO:0032420)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
1.0 12.9 GO:0019841 retinol binding(GO:0019841)
0.3 5.4 GO:0051787 misfolded protein binding(GO:0051787)
0.2 4.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 5.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.8 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.1 2.7 GO:0005123 death receptor binding(GO:0005123)
0.1 1.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 5.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 3.6 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 0.3 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.4 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.5 GO:0036002 pre-mRNA binding(GO:0036002)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 5.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 3.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 17.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 2.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 1.9 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 2.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.7 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 3.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.4 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 5.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones