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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Egr1

Z-value: 1.41

Motif logo

Transcription factors associated with Egr1

Gene Symbol Gene ID Gene Info
ENSRNOG00000019422 early growth response 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Egr1rn6_v1_chr18_+_27657628_276576280.376.4e-12Click!

Activity profile of Egr1 motif

Sorted Z-values of Egr1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_22211071 69.15 ENSRNOT00000087817
ENSRNOT00000001910
actin-like 6B
chr14_-_86297623 57.92 ENSRNOT00000067162
ENSRNOT00000081607
ENSRNOT00000085265
calcium/calmodulin-dependent protein kinase II beta
chr11_+_86512797 55.44 ENSRNOT00000051680
glycoprotein Ib platelet beta subunit
chr8_+_22050222 53.53 ENSRNOT00000028096
intercellular adhesion molecule 5
chr1_-_103256823 48.86 ENSRNOT00000018860
protein tyrosine phosphatase, non-receptor type 5
chr3_+_155103150 48.78 ENSRNOT00000020720
solute carrier family 32 member 1
chr1_+_144070754 48.13 ENSRNOT00000079989
SH3 domain-containing GRB2-like 3
chr12_-_22680630 46.49 ENSRNOT00000041808
VGF nerve growth factor inducible
chr7_-_119768082 46.15 ENSRNOT00000009612
somatostatin receptor 3
chrX_+_157150655 45.21 ENSRNOT00000090795
pregnancy up-regulated nonubiquitous CaM kinase
chr1_-_101360971 42.72 ENSRNOT00000028164
lin-7 homolog B, crumbs cell polarity complex component
chr8_-_40023193 42.63 ENSRNOT00000014404
neurogranin
chrX_+_122808605 42.03 ENSRNOT00000017567
zinc finger CCHC-type containing 12
chr1_+_165237847 41.31 ENSRNOT00000022963
phosphoglucomutase 2-like 1
chr6_+_132246602 40.60 ENSRNOT00000009896
cytochrome P450, family 46, subfamily a, polypeptide 1
chrX_+_1321315 40.43 ENSRNOT00000014250
synapsin I
chr3_-_2534663 37.68 ENSRNOT00000049297
ENSRNOT00000044246
glutamate ionotropic receptor NMDA type subunit 1
chr4_-_90882285 36.82 ENSRNOT00000039247
synuclein alpha
chr2_-_188645196 36.79 ENSRNOT00000083793
ephrin A3
chr7_-_59514939 36.13 ENSRNOT00000085579
potassium calcium-activated channel subfamily M regulatory beta subunit 4
chr3_-_66417741 36.05 ENSRNOT00000007662
neuronal differentiation 1
chr10_-_85517683 35.64 ENSRNOT00000016070
SRC kinase signaling inhibitor 1
chr8_-_120446455 35.30 ENSRNOT00000085161
ENSRNOT00000042854
ENSRNOT00000037199
cAMP regulated phosphoprotein 21
chr7_-_105592804 35.06 ENSRNOT00000006789
adenylate cyclase 8
chr13_-_15395617 34.21 ENSRNOT00000046060
similar to contactin associated protein-like 5 isoform 1
chr10_+_86303727 34.07 ENSRNOT00000037752
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr7_+_122456799 33.91 ENSRNOT00000025564
melanin-concentrating hormone receptor 1
chr9_+_73493027 33.84 ENSRNOT00000074427
ENSRNOT00000089478
unc-80 homolog, NALCN activator
chr10_+_55940533 33.83 ENSRNOT00000012061
similar to RIKEN cDNA A030009H04
chr3_-_1924827 33.33 ENSRNOT00000006162
calcium voltage-gated channel subunit alpha1 B
chr8_-_97115027 32.98 ENSRNOT00000018685
ankyrin repeat domain 34C
chr1_-_72727112 32.93 ENSRNOT00000031172
BR serine/threonine kinase 1
chr3_+_177188044 32.88 ENSRNOT00000022073
transcription elongation factor A2
chr3_-_176644951 32.85 ENSRNOT00000049961
potassium voltage-gated channel subfamily Q member 2
chr12_-_22478752 32.83 ENSRNOT00000089392
ENSRNOT00000086915
acetylcholinesterase
chr7_+_73588163 32.28 ENSRNOT00000015707
potassium voltage-gated channel, modifier subfamily S, member 2
chr3_+_154395187 31.97 ENSRNOT00000050810
V-set and transmembrane domain containing 2 like
chr1_-_64350338 31.70 ENSRNOT00000078444
calcium voltage-gated channel auxiliary subunit gamma 8
chr1_+_263186235 28.34 ENSRNOT00000021876
cyclin and CBS domain divalent metal cation transport mediator 1
chr8_-_110813000 27.42 ENSRNOT00000010634
Eph receptor B1
chr2_+_113984824 27.13 ENSRNOT00000086399
TRAF2 and NCK interacting kinase
chrX_+_39711201 26.69 ENSRNOT00000080512
ENSRNOT00000009802
connector enhancer of kinase suppressor of Ras 2
chr7_+_78092037 25.98 ENSRNOT00000050753
regulating synaptic membrane exocytosis 2
chr2_+_113984646 25.04 ENSRNOT00000016799
TRAF2 and NCK interacting kinase
chr14_+_60123169 25.04 ENSRNOT00000006610
SEL1L family member 3
chr7_-_140437467 24.87 ENSRNOT00000087181
FK506 binding protein 11
chr1_-_94494980 24.69 ENSRNOT00000020014
cyclin E1
chr7_-_115910522 23.99 ENSRNOT00000076998
ENSRNOT00000067442
activity-regulated cytoskeleton-associated protein
chr5_-_144779212 23.98 ENSRNOT00000016230
neurochondrin
chr11_+_83975367 23.91 ENSRNOT00000058131
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr1_-_78440738 23.80 ENSRNOT00000020855
neuronal PAS domain protein 1
chr1_-_198454914 23.17 ENSRNOT00000049044
proline-rich transmembrane protein 2
chrX_-_15467875 23.09 ENSRNOT00000011207
Pim-2 proto-oncogene, serine/threonine kinase
chr10_-_65766050 23.04 ENSRNOT00000013639
sterile alpha and TIR motif containing 1
chr1_-_64405149 22.18 ENSRNOT00000089944
calcium voltage-gated channel auxiliary subunit gamma 7
chr10_+_56627411 22.05 ENSRNOT00000089108
ENSRNOT00000068493
discs large MAGUK scaffold protein 4
chr2_+_34186091 21.47 ENSRNOT00000016129
small glutamine rich tetratricopeptide repeat containing beta
chr2_+_198721724 21.41 ENSRNOT00000043535
ankyrin repeat domain 34A
chr2_-_26699333 21.35 ENSRNOT00000024459
synaptic vesicle glycoprotein 2c
chr2_-_186245771 20.02 ENSRNOT00000066004
ENSRNOT00000079954
doublecortin-like kinase 2
chr7_-_84023316 19.49 ENSRNOT00000005556
potassium voltage-gated channel modifier subfamily V member 1
chr1_-_220467159 19.04 ENSRNOT00000075365
transmembrane protein 151A
chr10_-_88667345 18.68 ENSRNOT00000025518
potassium voltage-gated channel subfamily H member 4
chr2_-_186245342 18.67 ENSRNOT00000057062
ENSRNOT00000022292
doublecortin-like kinase 2
chr4_-_153028129 18.55 ENSRNOT00000074558
cat eye syndrome chromosome region, candidate 6
chr5_-_63192025 18.16 ENSRNOT00000008913
ALG2, alpha-1,3/1,6-mannosyltransferase
chr4_+_154309426 18.06 ENSRNOT00000019346
alpha-2-macroglobulin
chr8_+_65611570 17.86 ENSRNOT00000017147
La ribonucleoprotein domain family, member 6
chr1_-_143278485 17.58 ENSRNOT00000026009
cytoplasmic polyadenylation element binding protein 1
chr2_-_184263564 17.20 ENSRNOT00000015279
F-box and WD repeat domain containing 7
chr6_-_1319541 16.23 ENSRNOT00000006527
striatin
chr2_-_147959567 15.50 ENSRNOT00000063986
profilin-2-like
chr16_-_20860767 15.36 ENSRNOT00000027275
ENSRNOT00000092417
growth differentiation factor 1
ceramide synthase 1
chr16_-_22350155 15.30 ENSRNOT00000015931
ATPase H+ transporting V1 subunit B2
chr3_+_146546387 15.30 ENSRNOT00000009946
ectonucleoside triphosphate diphosphohydrolase 6
chr6_+_135856218 14.64 ENSRNOT00000066715
similar to novel protein
chr5_+_1417478 14.48 ENSRNOT00000008153
ENSRNOT00000085564
junctophilin 1
chrX_+_136466779 14.45 ENSRNOT00000093268
ENSRNOT00000068717
Rho GTPase activating protein 36
chr14_-_11198194 14.34 ENSRNOT00000003083
enolase-phosphatase 1
chr1_-_162300515 14.32 ENSRNOT00000031161
ubiquitin specific peptidase 35
chr2_+_116416507 14.17 ENSRNOT00000030700
actin-related protein T3
chr5_+_162031722 13.92 ENSRNOT00000020483
leucine rich repeat containing 38
chr3_-_114307250 13.84 ENSRNOT00000064592
Src homology 2 domain containing F
chr4_+_71675383 13.76 ENSRNOT00000051265
chloride voltage-gated channel 1
chr7_+_11201690 13.39 ENSRNOT00000005624
fizzy/cell division cycle 20 related 1
chr9_+_81783349 13.28 ENSRNOT00000021548
CCR4-NOT transcription complex subunit 9
chr4_+_154423209 12.55 ENSRNOT00000075799
alpha-2-macroglobulin-like
chr5_-_166726794 12.37 ENSRNOT00000022799
solute carrier family 25 member 33
chr16_-_9709347 12.12 ENSRNOT00000083933
mitogen-activated protein kinase 8
chr3_-_111560556 12.06 ENSRNOT00000030532
leukocyte receptor tyrosine kinase
chr10_+_55675575 12.04 ENSRNOT00000057295
vesicle-associated membrane protein 2
chr1_-_142164007 11.48 ENSRNOT00000078982
mannosidase, alpha, class 2A, member 2
chrX_-_30831483 11.37 ENSRNOT00000004443
glycine receptor, alpha 2
chr3_-_92290919 11.13 ENSRNOT00000007077
four jointed box 1
chr9_-_44456554 11.07 ENSRNOT00000080011
testis specific 10
chr15_-_61772516 10.93 ENSRNOT00000015605
ENSRNOT00000093399
WW domain binding protein 4
chr10_+_13836128 10.92 ENSRNOT00000012720
phosphoglycolate phosphatase
chr9_+_82033543 10.47 ENSRNOT00000023439
wingless-type MMTV integration site family, member 6
chr3_-_171134655 10.19 ENSRNOT00000028960
similar to Ubiquitin carboxyl-terminal hydrolase isozyme L3 (Ubiquitin thiolesterase L3)
chr1_-_142164263 9.68 ENSRNOT00000016281
mannosidase, alpha, class 2A, member 2
chr5_-_101588598 9.46 ENSRNOT00000082239
PC4 and SFRS1 interacting protein 1
chr5_-_142845116 9.46 ENSRNOT00000065105
RGD1559909
chr7_-_144109116 9.32 ENSRNOT00000020437
mitogen activated protein kinase kinase kinase 12
chr4_-_16130563 9.26 ENSRNOT00000090240
ENSRNOT00000034969
calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr12_-_46920952 9.20 ENSRNOT00000001532
musashi RNA-binding protein 1
chr1_+_220335254 9.13 ENSRNOT00000072261
Ras and Rab interactor 1
chrX_+_17540458 9.01 ENSRNOT00000045710
nudix hydrolase 11
chr4_+_56744561 8.82 ENSRNOT00000009737
ATPase H+ transporting V1 subunit F
chr10_+_109107389 8.73 ENSRNOT00000068437
ENSRNOT00000005687
BAI1-associated protein 2
chr11_+_69484293 8.68 ENSRNOT00000049292
kalirin, RhoGEF kinase
chr8_+_63379087 8.51 ENSRNOT00000012091
ENSRNOT00000012295
neuroplastin
chr9_-_119818310 8.45 ENSRNOT00000019359
structural maintenance of chromosomes flexible hinge domain containing 1
chr6_+_27975849 8.34 ENSRNOT00000060810
dystrobrevin, beta
chr1_-_198128857 8.28 ENSRNOT00000026496
coronin 1A
chr3_+_151553578 8.16 ENSRNOT00000045484
ERGIC and golgi 3
chr15_+_33121273 8.15 ENSRNOT00000016020
RRAD and GEM like GTPase 2
chr1_+_220428481 7.98 ENSRNOT00000027335
ras and Rab interactor 1
chr12_+_2589818 7.95 ENSRNOT00000087848

chr5_+_147246037 7.89 ENSRNOT00000089457
ring finger protein 19B
chr4_+_117215064 7.80 ENSRNOT00000020909
SMYD family member 5
chr15_+_86153628 7.73 ENSRNOT00000012842
ubiquitin C-terminal hydrolase L3
chrX_-_156379189 7.61 ENSRNOT00000083148
plexin A3
chr12_+_7865938 7.52 ENSRNOT00000061229
ubiquitin-like 3
chr10_-_83128297 7.41 ENSRNOT00000082160
lysine acetyltransferase 7
chr6_-_99783047 7.35 ENSRNOT00000009028
spectrin, beta, erythrocytic
chr3_-_110492398 7.31 ENSRNOT00000056450
ankyrin repeat domain 63
chr4_-_16130848 7.21 ENSRNOT00000042914
calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr5_-_99033107 7.16 ENSRNOT00000041306
heat shock protein family A (Hsp70) member 8
chr8_+_116154736 7.10 ENSRNOT00000021218
calcium voltage-gated channel auxiliary subunit alpha2delta 2
chr6_+_27975417 7.10 ENSRNOT00000077830
dystrobrevin, beta
chr1_-_215836641 6.95 ENSRNOT00000080246
insulin-like growth factor 2
chr1_+_193335645 6.80 ENSRNOT00000019640
leucine carboxyl methyltransferase 1
chr7_+_41115154 6.76 ENSRNOT00000066174
ATPase plasma membrane Ca2+ transporting 1
chr6_-_6842758 6.73 ENSRNOT00000006094
potassium voltage-gated channel modifier subfamily G member 3
chr11_-_17340373 6.68 ENSRNOT00000089762

chr8_+_128577345 6.57 ENSRNOT00000082356
WD repeat domain 48
chr1_+_98440186 6.31 ENSRNOT00000024150
IgLON family member 5
chr20_+_32509598 6.27 ENSRNOT00000046268
karyopherin subunit alpha 5
chr10_-_105552986 6.17 ENSRNOT00000014699
ubiquitin-conjugating enzyme E2O
chr16_-_61753476 6.13 ENSRNOT00000016792
store-operated calcium entry-associated regulatory factor
chr1_+_64031859 5.91 ENSRNOT00000090873
membrane bound O-acyltransferase domain containing 7-like 1
chr8_+_44990014 5.78 ENSRNOT00000044608
heat shock protein family A (Hsp70) member 8
chr7_+_12006710 5.63 ENSRNOT00000045421
Kruppel-like factor 16
chr7_+_11545024 5.55 ENSRNOT00000073221
solute carrier family 39 member 3
chr8_+_128577080 5.32 ENSRNOT00000024172
WD repeat domain 48
chr15_+_27850151 5.25 ENSRNOT00000087958
apurinic/apyrimidinic endodeoxyribonuclease 1
chr7_-_94755924 5.16 ENSRNOT00000040836
TATA-box binding protein associated factor 2
chr10_+_63731959 4.93 ENSRNOT00000090554
phosphatidylinositol transfer protein, alpha
chr9_-_11240282 4.93 ENSRNOT00000070920
UDP-glucuronate decarboxylase 1
chr3_+_71020534 4.87 ENSRNOT00000007276
zinc finger CCCH-type containing 15
chr8_-_82351108 4.86 ENSRNOT00000013053
mitogen-activated protein kinase 6
chr10_-_13515448 4.79 ENSRNOT00000067660
3-phosphoinositide dependent protein kinase-1
chr4_-_87111025 4.75 ENSRNOT00000018442
kelch repeat and BTB domain containing 2
chr3_-_163935617 4.73 ENSRNOT00000074023
potassium voltage-gated channel subfamily B member 1
chr1_-_220203532 4.72 ENSRNOT00000079984
pellino E3 ubiquitin protein ligase family member 3
chr3_+_8534440 4.57 ENSRNOT00000045827
ENSRNOT00000082672
spectrin, alpha, non-erythrocytic 1
chr9_+_47386626 4.48 ENSRNOT00000021270
solute carrier family 9 member A2
chr18_+_27554062 4.25 ENSRNOT00000088432
stem-loop binding protein-like
chr1_-_82108083 4.25 ENSRNOT00000027677
ENSRNOT00000084530
glycogen synthase kinase 3 alpha
chr10_-_47857326 4.05 ENSRNOT00000085703
ENSRNOT00000091963
epsin 2
chr3_+_176093640 4.04 ENSRNOT00000086541
opioid growth factor receptor
chr20_+_13940877 3.92 ENSRNOT00000093587
calcineurin binding protein 1
chr16_+_27399467 3.89 ENSRNOT00000065642
tolloid-like 1
chr6_-_80334522 3.85 ENSRNOT00000059316
F-box protein 33
chr1_-_36319896 3.82 ENSRNOT00000023641
ENSRNOT00000090884
NOP2/Sun RNA methyltransferase family, member 2
chr16_+_53957858 3.74 ENSRNOT00000013078
FSHD region gene 1
chr14_+_11198896 3.68 ENSRNOT00000079767
heterogeneous nuclear ribonucleoprotein D-like
chr7_-_117722703 3.68 ENSRNOT00000093083
ENSRNOT00000092789
cysteine and histidine rich 1
chr10_-_104263071 3.43 ENSRNOT00000005347
growth factor receptor bound protein 2
chr8_-_36467627 3.33 ENSRNOT00000082346
family with sequence similarity 118, member B
chr8_-_48762342 3.33 ENSRNOT00000049125
forkhead box R1
chr1_-_226353611 3.24 ENSRNOT00000037624
diacylglycerol lipase, alpha
chr1_-_219422268 3.13 ENSRNOT00000025092
carnosine synthase 1
chr5_+_58393233 3.07 ENSRNOT00000000142
DnaJ heat shock protein family (Hsp40) member B5
chr8_+_75516904 3.05 ENSRNOT00000013142
RAR-related orphan receptor A
chr5_+_58393603 2.99 ENSRNOT00000080082
DnaJ heat shock protein family (Hsp40) member B5
chrX_-_14890606 2.99 ENSRNOT00000049864
similar to RIKEN cDNA B630019K06
chr13_+_51958834 2.94 ENSRNOT00000007833
protein tyrosine phosphatase, non-receptor type 7
chr13_+_74154835 2.91 ENSRNOT00000059524
ABL proto-oncogene 2, non-receptor tyrosine kinase
chr7_+_123381077 2.91 ENSRNOT00000082603
ENSRNOT00000056041
sterol regulatory element binding transcription factor 2
chr3_+_175930505 2.89 ENSRNOT00000012611
opioid growth factor receptor
chr17_+_6785428 2.84 ENSRNOT00000026070
G kinase anchoring protein 1
chr12_+_22726643 2.82 ENSRNOT00000040015
zinc finger, HIT-type containing 1
chr1_-_114371897 2.80 ENSRNOT00000018028
non imprinted in Prader-Willi/Angelman syndrome 2
chrX_+_120859968 2.69 ENSRNOT00000085185
WD repeat domain 44
chr2_+_209433103 2.69 ENSRNOT00000024036
ligand dependent nuclear receptor interacting factor 1
chr1_+_116587815 2.55 ENSRNOT00000021366
ubiquitin protein ligase E3A
chr1_+_220009397 2.44 ENSRNOT00000084410
RNA binding motif protein 4B
chr10_+_61685241 2.41 ENSRNOT00000092606
MAX network transcriptional repressor
chr12_-_9331195 2.05 ENSRNOT00000044134
PAN3 poly(A) specific ribonuclease subunit
chrX_+_120860178 2.02 ENSRNOT00000088661
WD repeat domain 44
chr3_+_62648447 1.89 ENSRNOT00000002111
alkylglycerone phosphate synthase
chr11_+_34101197 1.83 ENSRNOT00000002299
chromatin assembly factor 1 subunit B
chr13_+_56015901 1.74 ENSRNOT00000043907
DENN domain containing 1B
chr18_+_36596585 1.65 ENSRNOT00000036613
RNA binding motif protein 27
chr5_-_136112344 1.63 ENSRNOT00000050195
RGD1563714
chr6_-_26497328 1.62 ENSRNOT00000074938
nuclear receptor binding protein 1
chr14_-_17436897 1.57 ENSRNOT00000003277
USO1 vesicle transport factor
chr8_-_48564722 1.51 ENSRNOT00000067902
Cbl proto-oncogene
chr3_-_15433252 1.37 ENSRNOT00000008817
LIM homeobox 6

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
19.3 57.9 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
15.4 15.4 GO:0036146 cellular response to mycotoxin(GO:0036146)
12.6 37.7 GO:1900673 olefin metabolic process(GO:1900673)
12.3 36.8 GO:2000468 regulation of hydrogen peroxide catabolic process(GO:2000295) regulation of peroxidase activity(GO:2000468)
11.1 55.3 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
8.1 48.9 GO:2001025 positive regulation of response to drug(GO:2001025)
7.7 46.1 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
7.6 61.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
7.2 36.1 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
7.1 42.7 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
5.7 17.2 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
5.4 48.8 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
4.9 34.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
4.4 22.0 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
4.4 8.7 GO:1905232 cellular response to L-glutamate(GO:1905232)
4.3 8.7 GO:0099645 protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645)
4.0 40.4 GO:0097091 synaptic vesicle clustering(GO:0097091)
4.0 12.1 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
3.7 52.2 GO:0007256 activation of JNKK activity(GO:0007256)
3.7 7.4 GO:0072720 response to dithiothreitol(GO:0072720)
3.6 32.8 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
3.6 18.1 GO:0010037 response to carbon dioxide(GO:0010037)
3.2 3.2 GO:0098917 retrograde trans-synaptic signaling(GO:0098917)
3.1 40.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
2.8 8.5 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
2.8 8.5 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
2.7 16.5 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
2.7 10.9 GO:0006114 glycerol biosynthetic process(GO:0006114)
2.7 70.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
2.7 18.7 GO:0000160 phosphorelay signal transduction system(GO:0000160)
2.4 46.3 GO:0021860 pyramidal neuron development(GO:0021860)
2.4 14.3 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
2.4 11.9 GO:1902525 regulation of protein monoubiquitination(GO:1902525)
2.3 27.4 GO:0021631 optic nerve morphogenesis(GO:0021631)
2.3 43.4 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
2.3 9.0 GO:1901909 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
2.1 4.2 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
2.1 44.3 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
2.1 10.5 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
2.1 33.3 GO:0001956 positive regulation of neurotransmitter secretion(GO:0001956)
2.1 24.7 GO:0001547 antral ovarian follicle growth(GO:0001547)
2.0 36.1 GO:0005513 detection of calcium ion(GO:0005513)
2.0 14.0 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
2.0 26.0 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
2.0 37.5 GO:0043084 penile erection(GO:0043084)
2.0 17.6 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
1.9 23.0 GO:0042711 maternal behavior(GO:0042711)
1.8 9.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
1.8 10.9 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
1.8 18.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
1.7 6.8 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
1.6 4.7 GO:0045751 regulation of Toll signaling pathway(GO:0008592) negative regulation of Toll signaling pathway(GO:0045751) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
1.5 12.4 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
1.4 7.1 GO:0060024 rhythmic synaptic transmission(GO:0060024)
1.4 8.3 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
1.3 15.5 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
1.3 11.4 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
1.2 37.1 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
1.2 23.2 GO:0050884 neuromuscular process controlling posture(GO:0050884)
1.2 9.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
1.1 3.3 GO:0030576 Cajal body organization(GO:0030576)
1.1 13.8 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
1.0 17.0 GO:0060081 membrane hyperpolarization(GO:0060081)
1.0 7.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.0 2.9 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
1.0 32.7 GO:0007616 long-term memory(GO:0007616)
0.8 10.9 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.8 15.3 GO:0007035 vacuolar acidification(GO:0007035)
0.6 7.7 GO:1903504 regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.6 15.3 GO:0032026 response to magnesium ion(GO:0032026)
0.6 24.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.5 32.9 GO:0051298 centrosome duplication(GO:0051298)
0.5 10.8 GO:0072643 interferon-gamma secretion(GO:0072643)
0.5 4.8 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.5 6.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.5 11.1 GO:0010842 retina layer formation(GO:0010842)
0.4 3.8 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.4 51.1 GO:0006338 chromatin remodeling(GO:0006338)
0.4 33.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.4 8.8 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.3 23.1 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.3 4.5 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.3 22.3 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.3 6.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 0.6 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.3 7.7 GO:0042755 eating behavior(GO:0042755)
0.3 1.1 GO:0015746 citrate transport(GO:0015746)
0.3 5.2 GO:0080111 DNA demethylation(GO:0080111)
0.3 1.4 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.3 4.9 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.3 23.0 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.3 1.9 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.3 4.9 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.3 23.9 GO:0048167 regulation of synaptic plasticity(GO:0048167)
0.3 4.2 GO:0010663 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.3 1.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 3.1 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.3 7.4 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.2 11.6 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.2 22.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.2 1.2 GO:0044026 DNA hypermethylation(GO:0044026)
0.2 32.0 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.2 2.5 GO:0060736 prostate gland growth(GO:0060736)
0.2 0.4 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.2 5.5 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.2 2.0 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.2 3.9 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.2 1.4 GO:0006013 mannose metabolic process(GO:0006013)
0.2 1.6 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 6.2 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.2 1.0 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.2 5.6 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.2 5.2 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 0.4 GO:1990166 protein localization to site of double-strand break(GO:1990166)
0.1 1.7 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.1 13.7 GO:0016358 dendrite development(GO:0016358)
0.1 21.5 GO:0007596 blood coagulation(GO:0007596)
0.1 4.6 GO:0051693 actin filament capping(GO:0051693)
0.1 0.9 GO:0034063 stress granule assembly(GO:0034063)
0.1 4.9 GO:0015914 phospholipid transport(GO:0015914)
0.1 11.6 GO:0006909 phagocytosis(GO:0006909)
0.1 3.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.5 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) selenocysteine metabolic process(GO:0016259)
0.1 1.0 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle checkpoint(GO:0031577) spindle assembly checkpoint(GO:0071173) mitotic spindle checkpoint(GO:0071174)
0.1 0.2 GO:0098972 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.1 0.7 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 6.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.3 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.4 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.0 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 1.7 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 2.1 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 0.1 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.0 0.2 GO:0010829 negative regulation of glucose transport(GO:0010829) negative regulation of glucose import(GO:0046325)
0.0 0.4 GO:0060976 coronary vasculature development(GO:0060976)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
9.8 48.8 GO:0044316 cone cell pedicle(GO:0044316)
9.4 37.7 GO:0044307 dendritic branch(GO:0044307)
9.2 36.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
4.8 14.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
4.8 66.6 GO:0016514 SWI/SNF complex(GO:0016514)
4.6 23.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
4.4 48.9 GO:1990635 proximal dendrite(GO:1990635)
4.3 12.9 GO:1990836 lysosomal matrix(GO:1990836)
3.4 17.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
3.3 36.4 GO:0044327 dendritic spine head(GO:0044327)
2.7 32.8 GO:0043083 synaptic cleft(GO:0043083)
2.7 13.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
2.4 22.0 GO:0098839 postsynaptic density membrane(GO:0098839)
2.4 12.0 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
2.0 24.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
1.9 53.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.8 57.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
1.5 27.4 GO:0032433 filopodium tip(GO:0032433)
1.4 35.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
1.4 66.4 GO:0048786 presynaptic active zone(GO:0048786)
1.3 11.9 GO:0008091 spectrin(GO:0008091)
1.3 72.5 GO:0060170 ciliary membrane(GO:0060170)
1.3 32.9 GO:0043194 node of Ranvier(GO:0033268) axon initial segment(GO:0043194)
1.2 17.6 GO:0072687 meiotic spindle(GO:0072687)
1.1 6.8 GO:0032591 dendritic spine membrane(GO:0032591)
1.1 45.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.1 8.5 GO:0001740 Barr body(GO:0001740)
1.0 7.9 GO:0044194 cytolytic granule(GO:0044194)
1.0 2.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.9 3.4 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.8 81.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.8 164.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.8 17.3 GO:0019013 viral nucleocapsid(GO:0019013)
0.7 13.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.6 48.1 GO:0031901 early endosome membrane(GO:0031901)
0.6 14.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.6 1.8 GO:0033186 CAF-1 complex(GO:0033186)
0.6 11.2 GO:0001891 phagocytic cup(GO:0001891)
0.6 46.5 GO:0030667 secretory granule membrane(GO:0030667)
0.5 12.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.5 12.5 GO:0034707 chloride channel complex(GO:0034707)
0.4 9.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.4 4.9 GO:0032156 septin cytoskeleton(GO:0032156)
0.4 5.2 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.4 21.4 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 4.1 GO:0030128 clathrin coat of endocytic vesicle(GO:0030128)
0.2 0.7 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.2 0.4 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.2 3.8 GO:0033391 chromatoid body(GO:0033391)
0.2 9.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 2.2 GO:0000812 Swr1 complex(GO:0000812)
0.2 8.7 GO:0097060 synaptic membrane(GO:0097060)
0.1 13.7 GO:0008021 synaptic vesicle(GO:0008021)
0.1 6.3 GO:0005643 nuclear pore(GO:0005643)
0.1 34.3 GO:0005874 microtubule(GO:0005874)
0.1 11.1 GO:0031514 motile cilium(GO:0031514)
0.1 11.4 GO:0030426 growth cone(GO:0030426)
0.1 4.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 5.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 24.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.3 GO:0015030 Cajal body(GO:0015030)
0.1 0.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 25.9 GO:0045202 synapse(GO:0045202)
0.1 2.9 GO:0005844 polysome(GO:0005844)
0.1 6.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 15.3 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 2.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 2.0 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 1.0 GO:0000776 kinetochore(GO:0000776)
0.0 0.4 GO:0035861 site of double-strand break(GO:0035861)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
11.4 34.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
10.9 32.8 GO:0003990 acetylcholinesterase activity(GO:0003990)
9.8 48.8 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
7.7 46.1 GO:0004994 somatostatin receptor activity(GO:0004994)
7.5 37.7 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
6.1 18.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
6.0 23.9 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
5.8 35.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
5.5 16.5 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
4.5 18.1 GO:0019959 interleukin-8 binding(GO:0019959)
4.3 99.5 GO:0043274 phospholipase binding(GO:0043274)
3.8 15.3 GO:0045134 uridine-diphosphatase activity(GO:0045134)
3.8 11.4 GO:0022852 glycine-gated chloride ion channel activity(GO:0022852)
3.7 22.0 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
3.4 41.3 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
3.4 17.2 GO:0050816 phosphothreonine binding(GO:0050816)
3.2 12.9 GO:0031686 A1 adenosine receptor binding(GO:0031686)
2.8 42.6 GO:0070300 phosphatidic acid binding(GO:0070300)
2.8 36.4 GO:0050321 tau-protein kinase activity(GO:0050321)
2.7 13.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
2.7 18.7 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
2.4 33.9 GO:0016500 protein-hormone receptor activity(GO:0016500)
2.3 27.8 GO:0008046 axon guidance receptor activity(GO:0008046)
2.3 9.0 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
1.9 15.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.8 42.0 GO:0032183 SUMO binding(GO:0032183)
1.8 10.9 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
1.7 5.2 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
1.7 8.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.7 8.5 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
1.6 83.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.6 16.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
1.5 15.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
1.5 46.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
1.5 12.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
1.4 45.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
1.4 17.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
1.2 36.1 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
1.2 9.5 GO:0097100 supercoiled DNA binding(GO:0097100)
1.1 48.9 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
1.0 40.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
1.0 5.2 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
1.0 3.1 GO:0008142 oxysterol binding(GO:0008142)
1.0 4.9 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
1.0 6.8 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
1.0 3.8 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.8 36.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.8 78.1 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.8 30.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.8 8.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.7 52.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.7 13.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.6 20.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.6 24.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.5 7.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.5 7.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 4.5 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.5 10.9 GO:0070064 proline-rich region binding(GO:0070064)
0.4 57.0 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.4 53.5 GO:0005178 integrin binding(GO:0005178)
0.4 8.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.4 8.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.4 7.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.4 14.7 GO:0030544 Hsp70 protein binding(GO:0030544)
0.4 3.9 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.4 3.1 GO:0034046 poly(G) binding(GO:0034046)
0.4 6.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.3 4.9 GO:0070403 NAD+ binding(GO:0070403)
0.3 1.1 GO:0015137 citrate transmembrane transporter activity(GO:0015137)
0.3 10.3 GO:0005109 frizzled binding(GO:0005109)
0.2 4.6 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.2 6.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 5.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 14.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 2.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 3.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 16.5 GO:0000287 magnesium ion binding(GO:0000287)
0.1 4.6 GO:0030507 spectrin binding(GO:0030507)
0.1 32.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 1.9 GO:0071949 FAD binding(GO:0071949)
0.1 0.5 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.1 0.4 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 1.4 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.1 0.7 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 1.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.6 GO:0070410 co-SMAD binding(GO:0070410)
0.0 2.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 5.2 GO:0003924 GTPase activity(GO:0003924)
0.0 3.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 57.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
1.7 35.8 PID LPA4 PATHWAY LPA4-mediated signaling events
1.5 24.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.2 34.2 ST GA12 PATHWAY G alpha 12 Pathway
1.0 27.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
1.0 36.8 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.9 86.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.9 17.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.9 8.7 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.7 28.8 PID AURORA A PATHWAY Aurora A signaling
0.6 15.7 PID MYC PATHWAY C-MYC pathway
0.6 12.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.6 18.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.6 9.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.5 28.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.5 4.8 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5 16.2 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.5 2.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.4 9.1 PID RAS PATHWAY Regulation of Ras family activation
0.4 4.0 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.4 16.7 PID LKB1 PATHWAY LKB1 signaling events
0.3 5.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.3 4.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.2 11.9 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 8.7 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 0.7 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.2 1.5 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.2 10.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.9 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 7.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 3.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 2.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 3.8 PID AURORA B PATHWAY Aurora B signaling
0.1 3.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 1.6 PID ARF 3PATHWAY Arf1 pathway
0.1 1.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 2.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.2 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.4 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.4 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.3 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 96.3 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
4.1 61.7 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
3.7 55.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
3.5 52.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
3.4 40.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
2.3 35.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
1.9 9.5 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
1.9 96.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
1.4 36.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
1.3 36.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
1.3 32.8 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
1.3 18.1 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
1.2 34.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
1.1 24.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.0 31.7 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.9 24.1 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.9 36.8 REACTOME AMYLOIDS Genes involved in Amyloids
0.8 14.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.8 12.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.7 15.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.6 18.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.5 7.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.5 17.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.5 4.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.5 4.9 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.5 4.7 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.5 80.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.4 4.8 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.4 11.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.4 5.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.4 4.9 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.3 7.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 31.5 REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES Genes involved in Transmission across Chemical Synapses
0.3 5.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 5.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 7.4 REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH Genes involved in NCAM signaling for neurite out-growth
0.1 10.5 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.9 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 7.3 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.0 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 2.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 6.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 4.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.8 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 3.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation