ISMARA results: Egr1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Egr1

Z-value: 1.41

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Transcription factors associated with Egr1

Gene Symbol	Gene ID	Gene Info
Egr1 NCBI RGD Ensembl	ENSRNOG00000019422	early growth response 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Egr1	rn6_v1_chr18_+_27657628_27657628	0.37	6.4e-12	Click!

Activity profile of Egr1 motif

Sorted Z-values of Egr1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_22211071 Show fit	69.15	ENSRNOT00000087817 ENSRNOT00000001910	Actl6b NCBI RGD Ensembl Show fit	actin-like 6B
chr14_-_86297623 Show fit	57.92	ENSRNOT00000067162 ENSRNOT00000081607 ENSRNOT00000085265	Camk2b NCBI RGD Ensembl Show fit	calcium/calmodulin-dependent protein kinase II beta
chr11_+_86512797 Show fit	55.44	ENSRNOT00000051680	Gp1bb NCBI RGD Ensembl Show fit	glycoprotein Ib platelet beta subunit
chr8_+_22050222 Show fit	53.53	ENSRNOT00000028096	Icam5 NCBI RGD Ensembl Show fit	intercellular adhesion molecule 5
chr1_-_103256823 Show fit	48.86	ENSRNOT00000018860	Ptpn5 NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, non-receptor type 5
chr3_+_155103150 Show fit	48.78	ENSRNOT00000020720	Slc32a1 NCBI RGD Ensembl Show fit	solute carrier family 32 member 1
chr1_+_144070754 Show fit	48.13	ENSRNOT00000079989	Sh3gl3 NCBI RGD Ensembl Show fit	SH3 domain-containing GRB2-like 3
chr12_-_22680630 Show fit	46.49	ENSRNOT00000041808	Vgf NCBI RGD Ensembl Show fit	VGF nerve growth factor inducible
chr7_-_119768082 Show fit	46.15	ENSRNOT00000009612	Sstr3 NCBI RGD Ensembl Show fit	somatostatin receptor 3
chrX_+_157150655 Show fit	45.21	ENSRNOT00000090795	Pnck NCBI RGD Ensembl Show fit	pregnancy up-regulated nonubiquitous CaM kinase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	70.3	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
7.6	61.1	GO:0016191	synaptic vesicle uncoating(GO:0016191)
19.3	57.9	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
11.1	55.3	GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
3.7	52.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.4	51.1	GO:0006338	chromatin remodeling(GO:0006338)
8.1	48.9	GO:2001025	positive regulation of response to drug(GO:2001025)
5.4	48.8	GO:0098700	neurotransmitter loading into synaptic vesicle(GO:0098700)
2.4	46.3	GO:0021860	pyramidal neuron development(GO:0021860)
7.7	46.1	GO:0038170	somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)

Showing 1 to 10 of 135 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	164.7	GO:0045211	postsynaptic membrane(GO:0045211)
0.8	81.4	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
1.3	72.5	GO:0060170	ciliary membrane(GO:0060170)
4.8	66.6	GO:0016514	SWI/SNF complex(GO:0016514)
1.4	66.4	GO:0048786	presynaptic active zone(GO:0048786)
1.8	57.9	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
1.9	53.9	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
4.4	48.9	GO:1990635	proximal dendrite(GO:1990635)
9.8	48.8	GO:0044316	cone cell pedicle(GO:0044316)
0.6	48.1	GO:0031901	early endosome membrane(GO:0031901)

Showing 1 to 10 of 74 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	99.5	GO:0043274	phospholipase binding(GO:0043274)
1.6	83.2	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.8	78.1	GO:0005249	voltage-gated potassium channel activity(GO:0005249)
0.4	57.0	GO:0004702	receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.4	53.5	GO:0005178	integrin binding(GO:0005178)
0.7	52.5	GO:0048306	calcium-dependent protein binding(GO:0048306)
1.1	48.9	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
9.8	48.8	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
1.5	46.5	GO:0005184	neuropeptide hormone activity(GO:0005184)
7.7	46.1	GO:0004994	somatostatin receptor activity(GO:0004994)

Showing 1 to 10 of 95 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	86.3	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
2.2	57.9	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
1.0	36.8	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
1.7	35.8	PID LPA4 PATHWAY	LPA4-mediated signaling events
1.2	34.2	ST GA12 PATHWAY	G alpha 12 Pathway
0.7	28.8	PID AURORA A PATHWAY	Aurora A signaling
0.5	28.5	PID ATF2 PATHWAY	ATF-2 transcription factor network
1.0	27.4	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
1.5	24.7	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.6	18.1	PID IL6 7 PATHWAY	IL6-mediated signaling events

Showing 1 to 10 of 42 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	96.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
5.4	96.3	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.5	80.1	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
4.1	61.7	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
3.7	55.4	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
3.5	52.5	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
3.4	40.6	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.9	36.8	REACTOME AMYLOIDS	Genes involved in Amyloids
1.4	36.1	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
1.3	36.1	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells

Showing 1 to 10 of 50 entries

Results for Egr1

Z-value: 1.41

Motif logo

Transcription factors associated with Egr1

Activity-expression correlation:

Activity profile of Egr1 motif

Sorted Z-values of Egr1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: