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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Ebf3

Z-value: 1.33

Motif logo

Transcription factors associated with Ebf3

Gene Symbol Gene ID Gene Info
ENSRNOG00000016102 early B-cell factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ebf3rn6_v1_chr1_-_209641123_2096411230.284.5e-07Click!

Activity profile of Ebf3 motif

Sorted Z-values of Ebf3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_98371184 55.10 ENSRNOT00000086911

chr13_+_52667969 47.63 ENSRNOT00000084986
ENSRNOT00000050284
troponin T2, cardiac type
chr2_+_205160405 45.25 ENSRNOT00000035605
tetraspanin 2
chr10_-_15603649 43.48 ENSRNOT00000051483
hemoglobin alpha, adult chain 2
chr4_+_98370797 39.91 ENSRNOT00000031991

chr9_+_82596355 39.80 ENSRNOT00000065076
SPEG complex locus
chr6_-_138632159 39.42 ENSRNOT00000082921
ENSRNOT00000040702
immunoglobulin heavy constant mu
chr1_+_80321585 37.32 ENSRNOT00000022895
creatine kinase, M-type
chr9_-_19372673 33.09 ENSRNOT00000073667
ENSRNOT00000079517
chloride intracellular channel 5
chr3_+_19045214 33.08 ENSRNOT00000070878

chr4_+_101645731 31.78 ENSRNOT00000087901

chr4_+_102147211 29.46 ENSRNOT00000083239

chr6_+_139405966 28.17 ENSRNOT00000088974

chrX_+_159158194 27.03 ENSRNOT00000043820
ENSRNOT00000001169
ENSRNOT00000083502
four and a half LIM domains 1
chr1_+_81763614 24.79 ENSRNOT00000027254
CD79a molecule
chr6_-_138900915 24.38 ENSRNOT00000075363

chr7_-_119716238 23.39 ENSRNOT00000075678
interleukin 2 receptor subunit beta
chr6_-_138631997 23.37 ENSRNOT00000073304

chr1_-_82580007 22.34 ENSRNOT00000078668
Axl receptor tyrosine kinase
chr12_-_16126953 22.06 ENSRNOT00000001682
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr6_-_138685656 21.75 ENSRNOT00000041706

chr7_+_121841855 21.27 ENSRNOT00000024673
GRB2-related adaptor protein 2
chr6_-_138736203 21.17 ENSRNOT00000052021
rCG21044-like
chr3_+_19128400 20.99 ENSRNOT00000074272

chr4_-_103145058 20.97 ENSRNOT00000073076

chr4_+_102351036 20.46 ENSRNOT00000079277

chr9_+_47536824 20.44 ENSRNOT00000049349
transmembrane protein 182
chr3_+_41019898 19.66 ENSRNOT00000007335
potassium voltage-gated channel subfamily J member 3
chr4_+_49369296 19.59 ENSRNOT00000007822
wingless-type MMTV integration site family, member 16
chr3_+_19141133 19.47 ENSRNOT00000058323

chrX_+_159112880 18.76 ENSRNOT00000084594
four and a half LIM domains 1
chr3_+_19690016 18.60 ENSRNOT00000085460

chr6_-_140880070 18.45 ENSRNOT00000073779
uncharacterized LOC691828
chr3_+_19174027 18.39 ENSRNOT00000074445

chr14_+_84306466 18.11 ENSRNOT00000006116
SEC14-like lipid binding 4
chr13_-_91872954 18.07 ENSRNOT00000004613
ENSRNOT00000079263
cell adhesion molecule 3
chr20_+_29897594 18.03 ENSRNOT00000057752
V-set immunoregulatory receptor
chrX_+_134979646 17.97 ENSRNOT00000006035
SAM and SH3 domain containing 3
chr10_+_77537340 17.95 ENSRNOT00000003297
transmembrane protein 100
chr4_+_102643934 17.77 ENSRNOT00000058389
uncharacterized LOC100911032
chr6_-_141198565 17.59 ENSRNOT00000064361

chr1_+_199495298 17.39 ENSRNOT00000086003
ENSRNOT00000026748
integrin subunit alpha D
chr20_+_46199981 17.38 ENSRNOT00000000337
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr16_-_39719187 16.93 ENSRNOT00000092971
glycoprotein m6a
chr6_-_140642221 16.80 ENSRNOT00000081996

chr20_+_4363508 16.61 ENSRNOT00000077205
advanced glycosylation end product-specific receptor
chr17_-_79676499 16.42 ENSRNOT00000022711
integrin subunit alpha 8
chr9_+_17340341 16.03 ENSRNOT00000026637
ENSRNOT00000026559
ENSRNOT00000042790
ENSRNOT00000044163
ENSRNOT00000083811
vascular endothelial growth factor A
chr6_-_139710905 16.01 ENSRNOT00000077430

chr18_-_6781841 15.74 ENSRNOT00000077606
ENSRNOT00000048109
aquaporin 4
chr3_+_19366370 15.27 ENSRNOT00000086557

chr6_-_139004980 14.90 ENSRNOT00000085427
ENSRNOT00000087351

chr2_+_41442241 14.83 ENSRNOT00000067546
phosphodiesterase 4D
chr4_+_103495993 14.81 ENSRNOT00000072325

chr1_-_98521551 14.81 ENSRNOT00000081922
sialic acid binding Ig-like lectin 10
chr6_+_139560028 14.60 ENSRNOT00000072633
rCG58847-like
chr3_+_18787606 14.49 ENSRNOT00000090508

chr6_-_138954577 14.43 ENSRNOT00000042728

chr1_-_267245636 14.32 ENSRNOT00000082799
SH3 and PX domains 2A
chr8_-_116361343 13.98 ENSRNOT00000066296
semaphorin 3B
chr6_-_139660666 13.81 ENSRNOT00000086098

chr6_-_138931429 13.64 ENSRNOT00000090584
Ighg protein-like
chr8_-_63092009 13.53 ENSRNOT00000034300
lysyl oxidase-like 1
chr5_+_156026911 13.50 ENSRNOT00000046802
Rap1 GTPase-activating protein
chr6_-_142353308 13.45 ENSRNOT00000066416

chr13_+_85818427 13.44 ENSRNOT00000077227
ENSRNOT00000006117
retinoid X receptor gamma
chr2_+_187347602 13.41 ENSRNOT00000025384
nestin
chr1_+_264893162 13.30 ENSRNOT00000021714
T-cell leukemia, homeobox 1
chr2_-_210550490 13.19 ENSRNOT00000081835
ENSRNOT00000025222
ENSRNOT00000086403
colony stimulating factor 1
chr5_-_141363524 13.17 ENSRNOT00000084109
microtubule-actin crosslinking factor 1
chr4_-_122741110 12.79 ENSRNOT00000008888
nucleoporin 210
chr6_+_139293294 12.64 ENSRNOT00000050297
ENSRNOT00000081817
Ighg protein-like
chr18_+_65388685 12.62 ENSRNOT00000080844
transcription factor 4
chr16_-_20686317 12.56 ENSRNOT00000060097
cytokine receptor-like factor 1
chr7_+_143707237 12.49 ENSRNOT00000074212
tensin 2
chr18_+_17043903 12.46 ENSRNOT00000068139
formin homology 2 domain containing 3
chr4_-_159079003 12.28 ENSRNOT00000026691
potassium voltage-gated channel subfamily A member 5
chr6_-_139637187 12.13 ENSRNOT00000089454
Ighg protein-like
chr5_+_140692779 12.08 ENSRNOT00000019101
v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
chr3_-_7795758 11.37 ENSRNOT00000045919
netrin G2
chr10_+_92288910 10.92 ENSRNOT00000006947
ENSRNOT00000045127
microtubule-associated protein tau
chr18_-_77322690 10.76 ENSRNOT00000058382
nuclear factor of activated T-cells 1
chr2_+_54191538 10.64 ENSRNOT00000019524
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr8_-_48619592 10.45 ENSRNOT00000012534
ATP binding cassette subfamily G member 4
chr17_-_67945037 10.45 ENSRNOT00000023033
Kruppel-like factor 6
chr15_+_52148379 10.44 ENSRNOT00000074912
phytanoyl-CoA 2-hydroxylase interacting protein
chrX_+_15273933 10.38 ENSRNOT00000075082
erythroid transcription factor
chr15_+_52767442 10.25 ENSRNOT00000014441
phytanoyl-CoA hydroxylase-interacting protein
chr14_+_77712240 10.24 ENSRNOT00000009101
msh homeobox 1
chr12_-_21760292 10.22 ENSRNOT00000059592
TSC22 domain family protein 4-like
chr10_+_92289107 9.95 ENSRNOT00000050070
microtubule-associated protein tau
chr3_+_148234193 9.94 ENSRNOT00000010418
cytochrome c oxidase subunit 4i2
chr1_+_81230612 9.91 ENSRNOT00000026489
potassium calcium-activated channel subfamily N member 4
chr9_+_81656116 9.81 ENSRNOT00000083421
solute carrier family 11 member 1
chr5_-_173611202 9.76 ENSRNOT00000047854
agrin
chr10_-_83655182 9.71 ENSRNOT00000007897
ABI family, member 3
chr6_-_142060032 9.65 ENSRNOT00000064717

chr16_-_10941414 9.62 ENSRNOT00000086627
ENSRNOT00000085414
ENSRNOT00000081631
ENSRNOT00000087521
ENSRNOT00000083623
LIM domain binding 3
chr13_+_92146586 9.55 ENSRNOT00000004659
olfactory receptor 1588
chr4_-_150185044 9.28 ENSRNOT00000019778
chondroitin sulfate N-acetylgalactosaminyltransferase 2
chr15_-_34469350 9.15 ENSRNOT00000067536
adenylate cyclase 4
chr14_+_34727623 9.04 ENSRNOT00000071405
ENSRNOT00000090183
kinase insert domain receptor
chr4_+_123118468 8.87 ENSRNOT00000010895
transmembrane protein 43
chr2_-_54963448 8.77 ENSRNOT00000017886
prostaglandin E receptor 4
chr1_+_81230989 8.65 ENSRNOT00000077952
potassium calcium-activated channel subfamily N member 4
chr6_-_51019407 8.47 ENSRNOT00000011659
G protein-coupled receptor 22
chr13_-_112099336 8.31 ENSRNOT00000009158
ENSRNOT00000044161
calcium/calmodulin-dependent protein kinase IG
chr4_+_101909389 8.21 ENSRNOT00000086458

chr7_-_71048383 8.13 ENSRNOT00000005693
G protein-coupled receptor 182
chr2_+_187977008 7.81 ENSRNOT00000081531
ENSRNOT00000092951
Rho/Rac guanine nucleotide exchange factor 2
chrX_+_105573909 7.80 ENSRNOT00000029664
armadillo repeat containing, X-linked 3
chr6_-_140805551 7.58 ENSRNOT00000080018

chr11_-_37993204 7.58 ENSRNOT00000077050
ENSRNOT00000091614
ENSRNOT00000002683
family with sequence similarity 3, member B
chr7_-_140356209 7.51 ENSRNOT00000077856
Rho family GTPase 1
chr14_+_80248140 7.41 ENSRNOT00000010852
HtrA serine peptidase 3
chr10_-_103919605 7.20 ENSRNOT00000004718
HID1 domain containing
chr6_-_142251976 7.20 ENSRNOT00000051475

chr7_+_59200918 7.13 ENSRNOT00000085073
protein tyrosine phosphatase, receptor type, R
chr4_+_7076759 7.08 ENSRNOT00000066598
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr10_-_57822498 6.77 ENSRNOT00000037546
NLR family, pyrin domain containing 1A
chr1_+_80279706 6.74 ENSRNOT00000047105
protein phosphatase 1, regulatory subunit 13 like
chr10_-_88754829 6.71 ENSRNOT00000026354
signal transducer and activator of transcription 5B
chr9_-_19749145 6.56 ENSRNOT00000013956
regulator of calcineurin 2
chr1_+_266053002 6.56 ENSRNOT00000026235
nuclear factor kappa B subunit 2
chr13_+_83531018 6.55 ENSRNOT00000004104
G protein-coupled receptor 161
chr4_-_155421998 6.41 ENSRNOT00000041552
growth differentiation factor 3
chr3_-_2411544 6.37 ENSRNOT00000012406
torsin family 4, member A
chr10_+_13736313 6.31 ENSRNOT00000079700
ATP binding cassette subfamily A member 3
chr3_+_159995064 6.20 ENSRNOT00000012606
alpha tocopherol transfer protein like
chr9_+_81655629 6.16 ENSRNOT00000088679
ENSRNOT00000057472
solute carrier family 11 member 1
chr13_+_88265331 6.13 ENSRNOT00000031190
coiled-coil domain containing 190
chr2_+_189423559 6.03 ENSRNOT00000029076
tropomyosin 3
chr1_-_72464492 6.02 ENSRNOT00000068550
N-acetyltransferase 14
chr1_+_213766758 5.93 ENSRNOT00000005645
interferon induced transmembrane protein 1
chr3_+_152857592 5.81 ENSRNOT00000027445
myosin light chain 9
chr6_-_146195819 5.75 ENSRNOT00000007625
Sp4 transcription factor
chr3_+_168345152 5.71 ENSRNOT00000017654
docking protein 5
chr13_-_94289333 5.65 ENSRNOT00000078195
phospholipase D family, member 5
chr15_-_51485692 5.61 ENSRNOT00000023876
Rho-related BTB domain containing 2
chr7_-_31824064 5.61 ENSRNOT00000011494
ENSRNOT00000080824
solute carrier family 25 member 3
chr1_+_165189985 5.51 ENSRNOT00000048437
potassium voltage-gated channel subfamily E regulatory subunit 3
chr10_-_110232843 5.50 ENSRNOT00000054934
Cd7 molecule
chr1_+_215609645 5.41 ENSRNOT00000076140
ENSRNOT00000027487
troponin I2, fast skeletal type
chr19_-_19376789 5.35 ENSRNOT00000065103
nucleotide-binding oligomerization domain containing 2
chr10_-_56444847 5.29 ENSRNOT00000056872
ENSRNOT00000092662
neuroligin 2
chr1_+_84364368 5.25 ENSRNOT00000024829
similar to CG16812-PA
chr10_+_57040267 5.19 ENSRNOT00000026207
arrestin, beta 2
chr10_-_82326771 5.16 ENSRNOT00000004673
acyl-CoA synthetase family member 2
chr14_-_46153212 5.10 ENSRNOT00000079269
NACHT and WD repeat domain containing 2
chr1_+_257157264 5.09 ENSRNOT00000067149
ENSRNOT00000079219
phospholipase C, epsilon 1
chr2_-_250981623 5.04 ENSRNOT00000018435
chloride channel accessory 2
chr1_-_78180216 4.89 ENSRNOT00000071576
complement component 5a receptor 2
chr15_-_8989580 4.86 ENSRNOT00000061402
thyroid hormone receptor beta
chr16_-_69965224 4.81 ENSRNOT00000093000
proline rich and Gla domain 3
chr5_+_151436464 4.80 ENSRNOT00000012463
mitogen-activated protein kinase kinase kinase 6
chr14_-_38575785 4.74 ENSRNOT00000003146
ATPase phospholipid transporting 10D (putative)
chr8_-_71055969 4.73 ENSRNOT00000075734
ankyrin repeat and death domain containing 1A
chr5_+_22380334 4.71 ENSRNOT00000009744
clavesin 1
chr1_-_221015929 4.58 ENSRNOT00000028137
signal-induced proliferation-associated 1
chr3_+_173953869 4.56 ENSRNOT00000091212
family with sequence similarity 217, member B
chr20_+_46429222 4.53 ENSRNOT00000076818
forkhead box O3
chr18_+_30114708 4.51 ENSRNOT00000027343
protocadherin alpha 4
chr18_+_52550739 4.48 ENSRNOT00000037529
cortexin 3
chr9_-_82008620 4.46 ENSRNOT00000023365
protein kinase AMP-activated non-catalytic subunit gamma 3
chr4_+_118852062 4.37 ENSRNOT00000090827
ENSRNOT00000025070
glutamine fructose-6-phosphate transaminase 1
chr14_-_78707861 4.36 ENSRNOT00000091927
protein phosphatase 2, regulatory subunit B, gamma
chr7_-_141136700 4.30 ENSRNOT00000091538
BCDIN3 domain containing RNA methyltransferase
chr5_+_169338097 4.25 ENSRNOT00000014035
hes family bHLH transcription factor 2
chr4_+_155653718 4.12 ENSRNOT00000065419
forkhead box J2
chr10_+_59539405 4.10 ENSRNOT00000077107
integrin subunit alpha E
chr20_+_4355175 4.08 ENSRNOT00000000510
G-protein signaling modulator 3
chr2_-_187863503 4.08 ENSRNOT00000093036
ENSRNOT00000026705
ENSRNOT00000082174
lamin A/C
chr20_-_3438389 4.06 ENSRNOT00000001098
ENSRNOT00000090039
flotillin 1
chr14_-_83776863 4.02 ENSRNOT00000026481
smoothelin
chr6_-_141715846 4.01 ENSRNOT00000044966

chr3_-_79390956 3.94 ENSRNOT00000077943
protein tyrosine phosphatase, receptor type, J
chr4_-_71713063 3.91 ENSRNOT00000059447
family with sequence similarity 131, member B
chr4_+_153805993 3.81 ENSRNOT00000056174
ubiquitin specific peptidase 18
chr6_-_141957537 3.80 ENSRNOT00000090358
immunoglobulin heavy variable 13-2
chr6_-_132972511 3.76 ENSRNOT00000082216
brain-enriched guanylate kinase-associated
chr6_-_61405195 3.73 ENSRNOT00000008655
leucine rich repeat neuronal 3
chr1_+_99505677 3.69 ENSRNOT00000024645
zinc finger protein 719
chr1_-_77830399 3.61 ENSRNOT00000052231
ribosomal protein L9-like
chr3_-_38090526 3.58 ENSRNOT00000059430
calcium voltage-gated channel auxiliary subunit beta 4
chr1_+_212181374 3.56 ENSRNOT00000085921
adhesion G protein-coupled receptor A1
chr6_+_29518416 3.53 ENSRNOT00000078660

chr7_+_142905758 3.47 ENSRNOT00000078663
nuclear receptor subfamily 4, group A, member 1
chrX_+_39711201 3.47 ENSRNOT00000080512
ENSRNOT00000009802
connector enhancer of kinase suppressor of Ras 2
chr10_-_38838272 3.44 ENSRNOT00000089495
sosondowah ankyrin repeat domain family member A
chr12_-_22138382 3.40 ENSRNOT00000001899
leucine rich repeats and calponin homology domain containing 4
chr10_-_63491713 3.36 ENSRNOT00000063941
tumor suppressor candidate 5
chr20_-_3397039 3.24 ENSRNOT00000001084
ENSRNOT00000085259
protein phosphatase 1, regulatory subunit 18
chr13_+_90692666 3.23 ENSRNOT00000010028
immunoglobulin superfamily, member 8
chr20_-_11528332 3.17 ENSRNOT00000038419
thrombospondin-type laminin G domain and EAR repeats
chr8_+_102304095 3.16 ENSRNOT00000011358
solute carrier family 9 member A9
chr1_+_192025710 3.16 ENSRNOT00000077457
ubiquitin family domain containing 1
chr1_-_197885031 3.11 ENSRNOT00000071241
SH2B adaptor protein 1
chr2_+_78103387 3.09 ENSRNOT00000063951
protein FAM134B
chr2_+_210880777 3.06 ENSRNOT00000026237
G protein subunit alpha transducin 2
chr1_+_64506735 2.92 ENSRNOT00000086331
NLR family, pyrin domain containing 12

Network of associatons between targets according to the STRING database.

First level regulatory network of Ebf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.9 47.6 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
8.0 16.0 GO:0060948 cardiac vascular smooth muscle cell development(GO:0060948)
6.6 13.2 GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
5.8 17.4 GO:0019417 sulfur oxidation(GO:0019417)
5.6 22.3 GO:2000669 negative regulation of dendritic cell apoptotic process(GO:2000669)
5.5 16.6 GO:1905204 response to selenite ion(GO:0072714) negative regulation of connective tissue replacement(GO:1905204)
5.5 22.1 GO:0007386 compartment pattern specification(GO:0007386)
5.5 16.4 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
5.3 16.0 GO:0055073 cadmium ion homeostasis(GO:0055073)
4.9 14.8 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
4.7 23.4 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
4.5 13.5 GO:1990790 response to glial cell derived neurotrophic factor(GO:1990790) cellular response to glial cell derived neurotrophic factor(GO:1990792)
4.5 17.9 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
3.9 15.7 GO:0060354 negative regulation of cell adhesion molecule production(GO:0060354)
3.4 10.2 GO:2001055 embryonic nail plate morphogenesis(GO:0035880) positive regulation of mesenchymal cell apoptotic process(GO:2001055)
3.4 13.4 GO:0045105 intermediate filament polymerization or depolymerization(GO:0045105)
3.3 19.7 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
3.3 9.8 GO:2000539 positive regulation of synaptic growth at neuromuscular junction(GO:0045887) regulation of sodium:potassium-exchanging ATPase activity(GO:1903406) regulation of protein geranylgeranylation(GO:2000539) positive regulation of protein geranylgeranylation(GO:2000541)
3.0 18.0 GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
2.9 14.6 GO:0045631 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
2.9 8.8 GO:2000417 negative regulation of eosinophil migration(GO:2000417)
2.9 43.5 GO:0015671 oxygen transport(GO:0015671)
2.8 19.6 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
2.7 10.8 GO:0002337 B-1a B cell differentiation(GO:0002337)
2.6 26.2 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
2.6 5.2 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
2.6 10.4 GO:0030221 basophil differentiation(GO:0030221)
2.5 12.6 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
2.5 12.3 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
2.4 14.3 GO:0072675 osteoclast fusion(GO:0072675)
2.4 7.1 GO:0003219 cardiac right ventricle formation(GO:0003219)
2.2 33.1 GO:0002024 diet induced thermogenesis(GO:0002024) auditory receptor cell stereocilium organization(GO:0060088)
2.0 17.8 GO:0010668 ectodermal cell differentiation(GO:0010668)
2.0 7.8 GO:0071802 negative regulation of podosome assembly(GO:0071802)
1.9 9.3 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
1.8 5.5 GO:1902303 negative regulation of potassium ion export(GO:1902303)
1.8 9.0 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
1.8 5.4 GO:0002780 antimicrobial peptide biosynthetic process(GO:0002777) antibacterial peptide biosynthetic process(GO:0002780) detection of peptidoglycan(GO:0032499) activation of MAPK activity involved in innate immune response(GO:0035419)
1.8 7.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
1.7 18.6 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
1.7 6.7 GO:0046544 development of secondary male sexual characteristics(GO:0046544)
1.7 45.2 GO:0014002 astrocyte development(GO:0014002)
1.6 13.2 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
1.6 4.9 GO:0090024 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024)
1.5 4.6 GO:0042631 cellular response to water deprivation(GO:0042631)
1.4 18.0 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
1.4 4.1 GO:1904178 sterol regulatory element binding protein import into nucleus(GO:0035105) negative regulation of adipose tissue development(GO:1904178)
1.3 10.4 GO:0071409 cellular response to cycloheximide(GO:0071409)
1.3 8.9 GO:0071763 nuclear membrane organization(GO:0071763)
1.2 1.2 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
1.1 4.4 GO:1901073 glucosamine-containing compound biosynthetic process(GO:1901073)
1.1 6.5 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
1.0 10.2 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
1.0 4.1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
1.0 2.9 GO:0045751 release of cytoplasmic sequestered NF-kappaB(GO:0008588) regulation of Toll signaling pathway(GO:0008592) negative regulation of Toll signaling pathway(GO:0045751)
1.0 45.8 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.9 6.4 GO:0048859 formation of anatomical boundary(GO:0048859)
0.9 2.6 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.8 12.6 GO:0042118 endothelial cell activation(GO:0042118)
0.8 12.5 GO:0051639 actin filament network formation(GO:0051639)
0.8 9.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.8 4.9 GO:0007621 negative regulation of female receptivity(GO:0007621) female courtship behavior(GO:0008050)
0.8 4.5 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.6 38.7 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
0.6 1.9 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
0.6 3.1 GO:0061709 reticulophagy(GO:0061709)
0.6 2.5 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.6 3.5 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.6 6.8 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.5 6.6 GO:0002467 germinal center formation(GO:0002467)
0.5 8.2 GO:0016322 neuron remodeling(GO:0016322)
0.5 24.8 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.5 19.3 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.5 6.7 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.5 2.6 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.5 6.6 GO:0007614 short-term memory(GO:0007614)
0.5 39.8 GO:0055013 cardiac muscle cell development(GO:0055013)
0.4 3.9 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.4 12.5 GO:0014850 response to muscle activity(GO:0014850)
0.4 8.9 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.4 16.9 GO:0048536 spleen development(GO:0048536)
0.4 2.5 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.4 2.9 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.4 1.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.4 4.3 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.4 2.0 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.4 0.8 GO:1900114 positive regulation of histone H3-K9 trimethylation(GO:1900114)
0.4 5.7 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.3 2.3 GO:0097264 self proteolysis(GO:0097264)
0.3 3.2 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.3 1.2 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.3 2.8 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.3 0.8 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633)
0.3 3.1 GO:0009642 response to light intensity(GO:0009642)
0.3 2.7 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.3 3.4 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.3 13.5 GO:0035904 aorta development(GO:0035904)
0.3 5.9 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.3 4.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.2 0.7 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.2 10.4 GO:0033344 cholesterol efflux(GO:0033344)
0.2 3.8 GO:0035634 response to stilbenoid(GO:0035634)
0.2 1.0 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 4.7 GO:0045332 phospholipid translocation(GO:0045332)
0.2 9.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 1.0 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 7.6 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.2 5.5 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.2 6.9 GO:0003009 skeletal muscle contraction(GO:0003009)
0.2 3.4 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.2 1.1 GO:0021637 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.2 1.5 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 1.1 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 1.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 2.1 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 5.8 GO:0070527 platelet aggregation(GO:0070527)
0.1 0.9 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.1 4.5 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 1.6 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1 8.3 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 5.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.9 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 2.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 4.7 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 0.6 GO:0097113 AMPA glutamate receptor clustering(GO:0097113)
0.1 3.1 GO:0045840 positive regulation of mitotic nuclear division(GO:0045840)
0.1 2.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 3.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 1.7 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 2.4 GO:0001510 RNA methylation(GO:0001510)
0.0 7.2 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 1.2 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 0.5 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 1.4 GO:0000768 syncytium formation by plasma membrane fusion(GO:0000768)
0.0 0.7 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.0 1.1 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 1.7 GO:0048278 vesicle docking(GO:0048278)
0.0 0.2 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.4 GO:0006415 translational termination(GO:0006415)
0.0 0.3 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 1.6 GO:0006414 translational elongation(GO:0006414)
0.0 1.0 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.0 0.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.9 GO:0007229 integrin-mediated signaling pathway(GO:0007229)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
11.9 47.6 GO:1990584 cardiac Troponin complex(GO:1990584)
10.9 43.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
6.2 24.8 GO:0019815 B cell receptor complex(GO:0019815)
5.3 16.0 GO:0070821 tertiary granule membrane(GO:0070821)
5.2 20.9 GO:0045298 tubulin complex(GO:0045298)
4.4 13.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
4.2 12.6 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
4.1 12.3 GO:0046691 intracellular canaliculus(GO:0046691)
2.4 7.2 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
2.1 6.3 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
1.7 22.6 GO:0033643 host cell part(GO:0033643)
1.4 6.8 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
1.1 23.9 GO:0005865 striated muscle thin filament(GO:0005865)
1.1 9.0 GO:0097443 sorting endosome(GO:0097443)
1.1 16.4 GO:0032591 dendritic spine membrane(GO:0032591)
0.7 36.4 GO:0032420 stereocilium(GO:0032420)
0.7 6.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.7 10.4 GO:0043083 synaptic cleft(GO:0043083)
0.7 37.1 GO:0009925 basal plasma membrane(GO:0009925)
0.7 21.5 GO:0008305 integrin complex(GO:0008305)
0.6 9.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.6 7.3 GO:0071564 npBAF complex(GO:0071564)
0.5 4.1 GO:0005638 lamin filament(GO:0005638)
0.5 8.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.5 23.2 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.4 16.9 GO:0044295 axonal growth cone(GO:0044295)
0.4 18.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 9.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.4 16.7 GO:0002102 podosome(GO:0002102)
0.4 2.5 GO:0000137 Golgi cis cisterna(GO:0000137)
0.3 4.1 GO:0016600 flotillin complex(GO:0016600)
0.3 2.6 GO:0005610 laminin-5 complex(GO:0005610)
0.3 5.3 GO:0097470 ribbon synapse(GO:0097470)
0.3 5.8 GO:0016460 myosin II complex(GO:0016460)
0.3 0.9 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
0.3 28.4 GO:0005604 basement membrane(GO:0005604)
0.3 7.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.3 4.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.3 11.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 18.2 GO:0030315 T-tubule(GO:0030315)
0.2 47.2 GO:0043209 myelin sheath(GO:0043209)
0.2 12.9 GO:0032587 ruffle membrane(GO:0032587)
0.2 11.4 GO:0005643 nuclear pore(GO:0005643)
0.2 4.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 2.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.2 2.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.6 GO:0031045 dense core granule(GO:0031045)
0.2 5.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 17.4 GO:0043195 terminal bouton(GO:0043195)
0.2 58.0 GO:0005925 focal adhesion(GO:0005925)
0.2 5.4 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.4 GO:0008537 proteasome activator complex(GO:0008537)
0.1 5.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 9.5 GO:0044306 neuron projection terminus(GO:0044306)
0.1 5.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 9.0 GO:0031985 Golgi cisterna(GO:0031985)
0.1 1.2 GO:0001891 phagocytic cup(GO:0001891)
0.1 6.7 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.8 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.3 GO:0030478 actin cap(GO:0030478)
0.1 7.4 GO:0055037 recycling endosome(GO:0055037)
0.1 19.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 7.4 GO:0005912 adherens junction(GO:0005912)
0.1 1.2 GO:0031941 filamentous actin(GO:0031941)
0.1 1.7 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 1.3 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.1 2.4 GO:0005884 actin filament(GO:0005884)
0.1 9.1 GO:0005769 early endosome(GO:0005769)
0.1 1.6 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 18.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.9 GO:0000145 exocyst(GO:0000145)
0.0 0.9 GO:0097440 apical dendrite(GO:0097440)
0.0 6.3 GO:0001650 fibrillar center(GO:0001650)
0.0 3.7 GO:0030027 lamellipodium(GO:0030027)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 3.4 GO:0016605 PML body(GO:0016605)
0.0 13.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.6 GO:0019012 virion(GO:0019012) virion part(GO:0044423)
0.0 1.0 GO:0005902 microvillus(GO:0005902)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 9.3 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.1 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.5 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.4 GO:0030133 transport vesicle(GO:0030133)
0.0 0.9 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
14.5 43.5 GO:0031720 haptoglobin binding(GO:0031720)
11.9 47.6 GO:0030172 troponin C binding(GO:0030172)
7.8 23.4 GO:0004911 interleukin-2 receptor activity(GO:0004911)
5.3 37.3 GO:0004111 creatine kinase activity(GO:0004111)
5.2 20.9 GO:0099609 microtubule lateral binding(GO:0099609)
4.4 13.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
4.2 12.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
4.1 12.3 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
3.9 19.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
3.5 10.4 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
3.3 16.6 GO:0050785 advanced glycation end-product receptor activity(GO:0050785)
2.7 8.1 GO:0001605 adrenomedullin receptor activity(GO:0001605)
2.7 10.8 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
2.7 18.6 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
2.6 28.1 GO:0032036 myosin heavy chain binding(GO:0032036)
2.2 13.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
2.1 12.6 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
1.8 16.0 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
1.7 5.2 GO:0031762 follicle-stimulating hormone receptor binding(GO:0031762) type 2A serotonin receptor binding(GO:0031826)
1.6 6.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
1.6 4.9 GO:0001847 opsonin receptor activity(GO:0001847)
1.6 11.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
1.5 4.4 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
1.4 14.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
1.3 14.8 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
1.3 8.8 GO:0004957 prostaglandin E receptor activity(GO:0004957)
1.1 9.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021) vascular endothelial growth factor binding(GO:0038085)
1.1 15.7 GO:0015250 water channel activity(GO:0015250)
1.1 13.4 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.1 5.4 GO:0031014 troponin T binding(GO:0031014)
1.1 10.8 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
1.0 2.9 GO:0004995 tachykinin receptor activity(GO:0004995)
0.9 2.6 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.8 2.4 GO:0032427 GBD domain binding(GO:0032427)
0.8 5.4 GO:0050700 CARD domain binding(GO:0050700)
0.7 2.8 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.7 9.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.7 17.4 GO:0071949 FAD binding(GO:0071949)
0.6 13.5 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.6 12.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.6 2.3 GO:0002046 opsin binding(GO:0002046)
0.5 12.2 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.5 3.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.5 2.7 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.5 22.1 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.4 4.9 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.4 10.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.4 2.0 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.4 9.3 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.4 5.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 7.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.4 10.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 14.8 GO:0005109 frizzled binding(GO:0005109)
0.4 7.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3 6.7 GO:0008171 O-methyltransferase activity(GO:0008171)
0.3 3.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.3 1.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.3 51.0 GO:0044325 ion channel binding(GO:0044325)
0.3 3.9 GO:0070097 delta-catenin binding(GO:0070097)
0.3 4.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 7.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 2.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 5.1 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.3 5.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 2.5 GO:0008432 JUN kinase binding(GO:0008432)
0.2 5.6 GO:0015295 solute:proton symporter activity(GO:0015295)
0.2 4.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 4.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 5.7 GO:0005057 receptor signaling protein activity(GO:0005057)
0.2 3.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 15.7 GO:0005254 chloride channel activity(GO:0005254)
0.2 10.7 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.2 6.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 1.6 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.2 16.9 GO:0005262 calcium channel activity(GO:0005262)
0.1 5.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 16.2 GO:0031072 heat shock protein binding(GO:0031072)
0.1 1.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 2.0 GO:0070412 R-SMAD binding(GO:0070412)
0.1 6.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 55.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 2.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 2.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 4.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 0.4 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.1 1.2 GO:0031005 filamin binding(GO:0031005)
0.1 0.8 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 2.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 1.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.9 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.9 GO:0035254 glutamate receptor binding(GO:0035254)
0.1 3.1 GO:0035591 signaling adaptor activity(GO:0035591)
0.1 4.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 6.0 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 1.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 26.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 0.1 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.1 3.6 GO:0019843 rRNA binding(GO:0019843)
0.0 5.7 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 12.3 GO:0003924 GTPase activity(GO:0003924)
0.0 0.9 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 4.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 3.8 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 16.0 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 3.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 5.9 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 0.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 2.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.1 GO:0016874 ligase activity(GO:0016874)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 25.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
1.7 23.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
1.6 20.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
1.3 38.3 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.7 13.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.6 6.7 PID IL5 PATHWAY IL5-mediated signaling events
0.6 34.2 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.5 10.9 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.5 5.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.5 21.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.5 17.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.5 10.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.5 23.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.5 9.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.4 31.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.4 24.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 9.0 ST GAQ PATHWAY G alpha q Pathway
0.4 20.6 PID BCR 5PATHWAY BCR signaling pathway
0.4 16.6 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.4 6.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.3 12.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 16.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.3 4.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.3 6.0 PID RAS PATHWAY Regulation of Ras family activation
0.2 5.7 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 13.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 7.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 2.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.2 2.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 3.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 6.7 PID P53 REGULATION PATHWAY p53 pathway
0.2 10.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 5.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 3.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 2.3 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 6.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 5.6 PID CMYB PATHWAY C-MYB transcription factor network
0.1 14.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 3.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 14.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.9 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 3.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 5.2 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
2.1 25.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
1.5 59.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
1.3 22.9 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
1.3 6.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
1.3 15.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
1.2 22.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
1.1 8.8 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
1.1 18.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.9 16.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.8 21.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.8 23.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.7 20.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.7 19.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.6 8.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.6 9.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.6 20.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.6 14.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.5 9.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.5 14.8 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.5 4.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.4 15.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.4 5.4 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.4 11.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.4 9.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.4 6.1 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.3 7.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.3 29.0 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.3 21.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 20.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 3.8 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.2 2.6 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.2 4.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.2 3.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.2 39.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 3.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.2 14.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 5.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 1.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 8.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 5.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.0 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 4.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 2.5 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 3.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines