ISMARA results: Ebf3

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Ebf3

Z-value: 1.33

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Transcription factors associated with Ebf3

Gene Symbol	Gene ID	Gene Info
Ebf3 NCBI RGD Ensembl	ENSRNOG00000016102	early B-cell factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Ebf3	rn6_v1_chr1_-_209641123_209641123	0.28	4.5e-07	Click!

Activity profile of Ebf3 motif

Sorted Z-values of Ebf3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_98371184 Show fit	55.10	ENSRNOT00000086911	AABR07060872.1 NCBI RGD Ensembl Show fit
chr13_+_52667969 Show fit	47.63	ENSRNOT00000084986 ENSRNOT00000050284	Tnnt2 NCBI RGD Ensembl Show fit	troponin T2, cardiac type
chr2_+_205160405 Show fit	45.25	ENSRNOT00000035605	Tspan2 NCBI RGD Ensembl Show fit	tetraspanin 2
chr10_-_15603649 Show fit	43.48	ENSRNOT00000051483	Hba-a2 NCBI RGD Ensembl Show fit	hemoglobin alpha, adult chain 2
chr4_+_98370797 Show fit	39.91	ENSRNOT00000031991	AABR07060872.1 NCBI RGD Ensembl Show fit
chr9_+_82596355 Show fit	39.80	ENSRNOT00000065076	Speg NCBI RGD Ensembl Show fit	SPEG complex locus
chr6_-_138632159 Show fit	39.42	ENSRNOT00000082921 ENSRNOT00000040702	Ighm NCBI RGD Ensembl Show fit	immunoglobulin heavy constant mu
chr1_+_80321585 Show fit	37.32	ENSRNOT00000022895	Ckm NCBI RGD Ensembl Show fit	creatine kinase, M-type
chr9_-_19372673 Show fit	33.09	ENSRNOT00000073667 ENSRNOT00000079517	Clic5 NCBI RGD Ensembl Show fit	chloride intracellular channel 5
chr3_+_19045214 Show fit	33.08	ENSRNOT00000070878	AABR07051670.1 NCBI RGD Ensembl Show fit

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Ebf3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
15.9	47.6	GO:0032972	regulation of muscle filament sliding speed(GO:0032972)
1.0	45.8	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
1.7	45.2	GO:0014002	astrocyte development(GO:0014002)
2.9	43.5	GO:0015671	oxygen transport(GO:0015671)
0.5	39.8	GO:0055013	cardiac muscle cell development(GO:0055013)
0.6	38.7	GO:0042398	cellular modified amino acid biosynthetic process(GO:0042398)
2.2	33.1	GO:0002024	diet induced thermogenesis(GO:0002024) auditory receptor cell stereocilium organization(GO:0060088)
2.6	26.2	GO:1902474	positive regulation of protein localization to synapse(GO:1902474)
0.5	24.8	GO:0050853	B cell receptor signaling pathway(GO:0050853)
4.7	23.4	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)

Showing 1 to 10 of 148 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	58.0	GO:0005925	focal adhesion(GO:0005925)
11.9	47.6	GO:1990584	cardiac Troponin complex(GO:1990584)
0.2	47.2	GO:0043209	myelin sheath(GO:0043209)
10.9	43.5	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.7	37.1	GO:0009925	basal plasma membrane(GO:0009925)
0.7	36.4	GO:0032420	stereocilium(GO:0032420)
0.3	28.4	GO:0005604	basement membrane(GO:0005604)
6.2	24.8	GO:0019815	B cell receptor complex(GO:0019815)
1.1	23.9	GO:0005865	striated muscle thin filament(GO:0005865)
0.5	23.2	GO:0031228	intrinsic component of Golgi membrane(GO:0031228)

Showing 1 to 10 of 89 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	55.5	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.3	51.0	GO:0044325	ion channel binding(GO:0044325)
11.9	47.6	GO:0030172	troponin C binding(GO:0030172)
14.5	43.5	GO:0031720	haptoglobin binding(GO:0031720)
5.3	37.3	GO:0004111	creatine kinase activity(GO:0004111)
2.6	28.1	GO:0032036	myosin heavy chain binding(GO:0032036)
0.1	26.8	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
7.8	23.4	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.5	22.1	GO:0008375	acetylglucosaminyltransferase activity(GO:0008375)
5.2	20.9	GO:0099609	microtubule lateral binding(GO:0099609)

Showing 1 to 10 of 116 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	38.3	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.6	34.2	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.4	31.9	PID RB 1PATHWAY	Regulation of retinoblastoma protein
2.3	25.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.4	24.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
1.7	23.8	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.5	23.7	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.5	21.8	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
1.6	20.9	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.4	20.6	PID BCR 5PATHWAY	BCR signaling pathway

Showing 1 to 10 of 45 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	59.1	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.2	39.0	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.3	29.0	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
2.1	25.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.8	23.4	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
1.3	22.9	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
1.2	22.1	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.3	21.8	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.8	21.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.6	20.6	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers

Showing 1 to 10 of 51 entries

Results for Ebf3

Z-value: 1.33

Motif logo

Transcription factors associated with Ebf3

Activity-expression correlation:

Activity profile of Ebf3 motif

Sorted Z-values of Ebf3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Ebf3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: