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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Ebf1
Z-value: 2.22
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Transcription factors associated with Ebf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ebf1 | rn6_v1_chr10_+_23661343_23661343 | 0.22 | 5.1e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_139997537 Show fit | 77.63 |
ENSRNOT00000073207
|
|
|
| chr6_-_140572023 Show fit | 54.32 |
ENSRNOT00000072338
|
|
|
| chr7_-_119716238 Show fit | 51.72 |
ENSRNOT00000075678
|
interleukin 2 receptor subunit beta |
|
| chr16_+_10417185 Show fit | 51.59 |
ENSRNOT00000082186
|
annexin A8 |
|
| chr7_-_119712888 Show fit | 50.72 |
ENSRNOT00000077438
|
interleukin 2 receptor subunit beta |
|
| chr17_-_31780120 Show fit | 49.11 |
ENSRNOT00000058388
|
|
|
| chr1_+_219403970 Show fit | 48.48 |
ENSRNOT00000029607
|
protein tyrosine phosphatase, receptor type, C-associated protein |
|
| chr6_-_143195143 Show fit | 47.49 |
ENSRNOT00000081337
|
|
|
| chr20_+_4043741 Show fit | 46.70 |
ENSRNOT00000000525
|
RT1 class II, locus Bb |
|
| chr10_+_84309430 Show fit | 44.77 |
ENSRNOT00000030159
|
src kinase associated phosphoprotein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ebf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 120.9 | GO:0048002 | antigen processing and presentation of peptide antigen(GO:0048002) |
| 22.8 | 114.2 | GO:0038110 | interleukin-2-mediated signaling pathway(GO:0038110) |
| 4.0 | 75.2 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 7.3 | 65.9 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 2.0 | 62.7 | GO:0002548 | monocyte chemotaxis(GO:0002548) |
| 15.4 | 61.5 | GO:0030221 | basophil differentiation(GO:0030221) |
| 6.0 | 60.3 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 6.5 | 58.5 | GO:0010668 | ectodermal cell differentiation(GO:0010668) |
| 8.2 | 57.7 | GO:0032429 | regulation of phospholipase A2 activity(GO:0032429) |
| 14.2 | 56.7 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 530.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.8 | 240.5 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.6 | 206.1 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 4.0 | 142.5 | GO:0008305 | integrin complex(GO:0008305) |
| 7.5 | 119.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.6 | 103.4 | GO:0030027 | lamellipodium(GO:0030027) |
| 3.1 | 95.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.7 | 90.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 4.8 | 82.2 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 1.6 | 72.6 | GO:0000791 | euchromatin(GO:0000791) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 201.2 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 3.0 | 161.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 6.0 | 150.6 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 4.5 | 120.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 4.6 | 116.2 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 36.9 | 110.7 | GO:0004911 | interleukin-2 receptor activity(GO:0004911) |
| 2.1 | 87.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 1.8 | 82.9 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 1.0 | 77.9 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 2.1 | 73.1 | GO:0042605 | peptide antigen binding(GO:0042605) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 194.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 1.1 | 168.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 3.1 | 159.4 | PID BCR 5PATHWAY | BCR signaling pathway |
| 4.0 | 139.3 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 4.1 | 119.0 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 3.2 | 92.6 | PID EPO PATHWAY | EPO signaling pathway |
| 1.4 | 85.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.5 | 78.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 5.3 | 74.0 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 1.3 | 71.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 187.6 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 3.4 | 147.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 3.1 | 147.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 3.3 | 109.4 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.9 | 89.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 2.2 | 78.2 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 2.9 | 71.8 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.9 | 70.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.6 | 69.0 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.5 | 63.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |