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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for E2f7
Z-value: 1.46
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Transcription factors associated with E2f7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f7 | rn6_v1_chr7_+_53275676_53275676 | 0.84 | 6.1e-87 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_44841382 Show fit | 92.22 |
ENSRNOT00000080119
|
histone cluster 1, H2ak |
|
| chr17_+_44738643 Show fit | 88.60 |
ENSRNOT00000087643
|
histone H2A type 1-like |
|
| chr17_+_44763598 Show fit | 77.51 |
ENSRNOT00000079880
|
histone cluster 1, H3b |
|
| chr17_-_44738330 Show fit | 75.81 |
ENSRNOT00000072195
|
histone cluster 1, H2bd-like |
|
| chr17_-_44793927 Show fit | 71.82 |
ENSRNOT00000086309
|
histone cluster 1 H2B family member o |
|
| chr17_+_44520537 Show fit | 65.37 |
ENSRNOT00000077985
|
histone cluster 1, H2ai-like2 |
|
| chr17_+_44528125 Show fit | 64.96 |
ENSRNOT00000084538
|
similar to Histone H2A type 1 |
|
| chr6_+_43884678 Show fit | 64.59 |
ENSRNOT00000091551
|
ribonucleotide reductase regulatory subunit M2 |
|
| chr19_+_14523554 Show fit | 63.54 |
ENSRNOT00000084271
ENSRNOT00000064731 |
minichromosome maintenance complex component 5 |
|
| chr17_+_44794130 Show fit | 62.40 |
ENSRNOT00000077571
|
histone cluster 1, H2ac |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 312.7 | GO:0006342 | chromatin silencing(GO:0006342) |
| 3.2 | 259.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 11.2 | 78.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 4.3 | 72.7 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 4.0 | 64.6 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 2.5 | 63.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 7.4 | 59.2 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 8.1 | 56.7 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 13.7 | 54.9 | GO:0002331 | pre-B cell allelic exclusion(GO:0002331) |
| 0.4 | 53.8 | GO:0007586 | digestion(GO:0007586) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.0 | 779.4 | GO:0000786 | nucleosome(GO:0000786) |
| 13.0 | 142.5 | GO:0042555 | MCM complex(GO:0042555) |
| 16.1 | 64.6 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 18.9 | 56.7 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 3.4 | 44.5 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 4.7 | 37.2 | GO:0000796 | condensin complex(GO:0000796) |
| 0.6 | 37.2 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 29.5 | GO:0005615 | extracellular space(GO:0005615) |
| 1.3 | 22.1 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 20.4 | GO:0005794 | Golgi apparatus(GO:0005794) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 709.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 6.8 | 95.7 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 10.8 | 64.6 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.6 | 59.2 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 2.8 | 56.7 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.5 | 54.9 | GO:0004519 | endonuclease activity(GO:0004519) |
| 1.6 | 46.1 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 6.4 | 44.5 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.2 | 40.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.9 | 37.2 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 59.3 | PID E2F PATHWAY | E2F transcription factor network |
| 1.2 | 58.4 | PID ATR PATHWAY | ATR signaling pathway |
| 5.6 | 55.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 8.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 5.7 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.2 | 5.4 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.2 | 5.2 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.2 | 3.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 2.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.4 | 321.5 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 12.9 | 141.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 5.5 | 122.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 2.1 | 27.1 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.5 | 23.8 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.2 | 22.1 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 1.1 | 12.3 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.5 | 9.7 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.2 | 6.8 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.2 | 6.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |