ISMARA results: E2f6

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for E2f6

Z-value: 1.23

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Transcription factors associated with E2f6

Gene Symbol	Gene ID	Gene Info
E2f6 NCBI RGD Ensembl	ENSRNOG00000004449	E2F transcription factor 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2f6	rn6_v1_chr6_+_42092467_42092467	-0.29	1.5e-07	Click!

Activity profile of E2f6 motif

Sorted Z-values of E2f6 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_71514281 Show fit	36.87	ENSRNOT00000022256	Ns5atp9 NCBI RGD Ensembl Show fit	NS5A (hepatitis C virus) transactivated protein 9
chr7_-_12741296 Show fit	30.42	ENSRNOT00000060648	Arhgap45 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 45
chr4_+_71740532 Show fit	28.93	ENSRNOT00000023537	Zyx NCBI RGD Ensembl Show fit	zyxin
chr18_+_51785111 Show fit	28.02	ENSRNOT00000019351	Lmnb1 NCBI RGD Ensembl Show fit	lamin B1
chr1_+_81230989 Show fit	27.75	ENSRNOT00000077952	Kcnn4 NCBI RGD Ensembl Show fit	potassium calcium-activated channel subfamily N member 4
chr1_+_81230612 Show fit	27.43	ENSRNOT00000026489	Kcnn4 NCBI RGD Ensembl Show fit	potassium calcium-activated channel subfamily N member 4
chr9_-_10757720 Show fit	27.26	ENSRNOT00000083848	Uhrf1 NCBI RGD Ensembl Show fit	ubiquitin-like with PHD and ring finger domains 1
chr9_-_10757954 Show fit	26.00	ENSRNOT00000075265	Uhrf1 NCBI RGD Ensembl Show fit	ubiquitin-like with PHD and ring finger domains 1
chr12_-_21720094 Show fit	24.95	ENSRNOT00000032838	LOC100910636 NCBI RGD Ensembl Show fit	zinc finger CW-type PWWP domain protein 1-like
chr9_-_26932201 Show fit	23.98	ENSRNOT00000017081	Mcm3 NCBI RGD Ensembl Show fit	minichromosome maintenance complex component 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.9	63.0	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
5.0	55.2	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
6.7	53.3	GO:0010216	maintenance of DNA methylation(GO:0010216)
1.8	42.7	GO:0006270	DNA replication initiation(GO:0006270)
1.3	34.8	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
5.4	27.0	GO:0072697	protein localization to cell cortex(GO:0072697)
6.1	24.6	GO:1904009	cellular response to monosodium glutamate(GO:1904009)
1.7	24.3	GO:0000076	DNA replication checkpoint(GO:0000076)
0.9	23.0	GO:0060445	branching involved in salivary gland morphogenesis(GO:0060445)
2.5	22.6	GO:1900264	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)

Showing 1 to 10 of 282 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	92.4	GO:0000791	euchromatin(GO:0000791)
0.7	64.0	GO:0000786	nucleosome(GO:0000786)
13.5	53.8	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1	48.0	GO:0016604	nuclear body(GO:0016604)
0.5	45.7	GO:0016605	PML body(GO:0016605)
0.5	43.9	GO:0032432	actin filament bundle(GO:0032432)
0.4	38.5	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.2	36.8	GO:0000790	nuclear chromatin(GO:0000790)
0.1	32.0	GO:0016323	basolateral plasma membrane(GO:0016323)
3.5	28.0	GO:0005638	lamin filament(GO:0005638)

Showing 1 to 10 of 135 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
14.7	58.7	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
7.9	55.2	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
9.0	53.8	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3	53.5	GO:0042393	histone binding(GO:0042393)
0.0	43.6	GO:0003723	RNA binding(GO:0003723)
2.3	34.3	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.6	28.2	GO:0070888	E-box binding(GO:0070888)
0.7	26.8	GO:0003678	DNA helicase activity(GO:0003678)
0.3	25.7	GO:0003725	double-stranded RNA binding(GO:0003725)
1.6	25.3	GO:0008143	poly(A) binding(GO:0008143)

Showing 1 to 10 of 191 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	134.3	PID E2F PATHWAY	E2F transcription factor network
1.5	49.5	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
1.2	49.4	PID ATR PATHWAY	ATR signaling pathway
0.6	33.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.9	27.9	PID ATM PATHWAY	ATM pathway
0.7	26.7	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.9	23.2	PID IL27 PATHWAY	IL27-mediated signaling events
0.4	21.7	PID NOTCH PATHWAY	Notch signaling pathway
0.7	20.9	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.2	19.3	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors

Showing 1 to 10 of 49 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	52.5	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
2.3	50.7	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.6	49.9	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
1.5	37.8	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.7	30.0	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
1.9	28.1	REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	Genes involved in Processive synthesis on the lagging strand
2.4	26.8	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
1.1	25.8	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
2.0	23.5	REACTOME SIGNALING BY NOTCH3	Genes involved in Signaling by NOTCH3
1.2	22.9	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates

Showing 1 to 10 of 93 entries

Results for E2f6

Z-value: 1.23

Motif logo

Transcription factors associated with E2f6

Activity-expression correlation:

Activity profile of E2f6 motif

Sorted Z-values of E2f6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: